Standard name | |
---|---|
Human Ortholog | |
Description | Component of the Rpd3L histone deacetylase complex; involved in transcriptional regulation of PHO5; affects termination of snoRNAs and cryptic unstable transcripts (CUTs); C-terminus shares significant sequence identity with the human candidate tumor suppressor p33-ING1 and its isoform ING3 |
ensLOC | DeepLoc | |||||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Localization | WT1 | WT2 | WT3 | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 | WT1 | WT2 | WT3 | AF100 | AF140 | AF180 |
Cortical Patches | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 1 |
Bud | 0 | 1 | 0 | 0 | 3 | 7 | 5 | 4 | 4 | 9 | 8 | 2 | 0 | 0 | 0 | 1 | 0 | 1 | 3 | 5 | 4 | 0 | 0 | 4 |
Bud Neck | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 3 | 2 | 1 | 1 | 2 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 2 | 1 |
Bud Site | 1 | 0 | 1 | 2 | 5 | 13 | 18 | 10 | 40 | 33 | 21 | 11 | 0 | 0 | 0 | 0 | 0 | 0 | – | – | – | – | – | – |
Cell Periphery | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Cytoplasm | 5 | 18 | 18 | 19 | 36 | 27 | 26 | 28 | 21 | 22 | 45 | 9 | 13 | 22 | 13 | 20 | 14 | 26 | 0 | 2 | 3 | 1 | 2 | 1 |
Endoplasmic Reticulum | 0 | 1 | 0 | 0 | 2 | 0 | 0 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 5 | 1 | 1 | 0 | 0 | 1 | 2 | 1 | 1 |
Endosome | 0 | 6 | 4 | 1 | 2 | 2 | 1 | 0 | 0 | 3 | 0 | 0 | 0 | 0 | 0 | 7 | 6 | 11 | 0 | 9 | 10 | 2 | 4 | 10 |
Golgi | 0 | 0 | 2 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 3 | 3 | 1 | 1 | 0 |
Mitochondria | 36 | 47 | 35 | 11 | 50 | 286 | 195 | 212 | 226 | 227 | 366 | 137 | 0 | 0 | 0 | 8 | 3 | 6 | 1 | 11 | 5 | 4 | 6 | 10 |
Nucleus | 288 | 807 | 560 | 362 | 484 | 500 | 522 | 560 | 630 | 663 | 568 | 558 | 131 | 111 | 60 | 79 | 55 | 81 | 269 | 763 | 465 | 154 | 141 | 158 |
Nuclear Periphery | 1 | 1 | 11 | 3 | 6 | 9 | 16 | 8 | 14 | 23 | 20 | 18 | 2 | 2 | 0 | 1 | 0 | 0 | 0 | 2 | 4 | 0 | 1 | 1 |
Nucleolus | 29 | 38 | 90 | 17 | 39 | 134 | 200 | 214 | 285 | 296 | 270 | 320 | 15 | 3 | 1 | 4 | 2 | 6 | 18 | 65 | 115 | 36 | 30 | 51 |
Peroxisomes | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 0 | 0 | 0 |
SpindlePole | 1 | 8 | 5 | 9 | 8 | 1 | 4 | 5 | 5 | 11 | 5 | 3 | 2 | 1 | 1 | 7 | 5 | 10 | 1 | 8 | 8 | 9 | 4 | 8 |
Vac/Vac Membrane | 3 | 13 | 1 | 3 | 2 | 3 | 6 | 2 | 6 | 5 | 2 | 1 | 0 | 0 | 1 | 12 | 17 | 19 | 15 | 40 | 21 | 16 | 16 | 22 |
Unique Cell Count | 309 | 873 | 631 | 392 | 560 | 664 | 706 | 767 | 866 | 913 | 899 | 817 | 147 | 136 | 74 | 121 | 89 | 137 | 314 | 918 | 658 | 235 | 215 | 280 |
Labelled Cell Count | 364 | 941 | 727 | 427 | 637 | 983 | 994 | 1047 | 1233 | 1295 | 1307 | 1062 | 163 | 139 | 76 | 144 | 104 | 161 | 314 | 918 | 658 | 235 | 215 | 280 |
Screen | WT1 | WT2 | WT3 | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 | AF100 | AF140 | AF180 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Mean Cell GFP Intensity (1e-4) | 5.8 | 6.1 | 5.7 | 5.4 | 5.3 | 4.3 | 4.9 | 4.9 | 4.7 | 5.0 | 4.2 | 5.2 | 7.0 | 6.9 | 6.9 | 6.1 | 6.5 | 6.4 | 6.0 | 6.2 | 6.4 |
Std Deviation (1e-4) | 0.9 | 1.1 | 1.2 | 1.6 | 1.8 | 1.5 | 4.4 | 1.5 | 1.3 | 1.4 | 1.3 | 1.4 | 1.2 | 1.6 | 1.3 | 1.3 | 1.5 | 1.4 | 1.2 | 1.2 | 1.0 |
Intensity Change (Log2) | – | – | – | -0.08 | -0.12 | -0.41 | -0.23 | -0.23 | -0.27 | -0.19 | -0.45 | -0.14 | 0.29 | 0.27 | 0.27 | 0.08 | 0.18 | 0.17 | 0.06 | 0.12 | 0.17 |
Localization | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Cortical Patches | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Bud | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Bud Neck | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Bud Site | 0 | 0 | 0 | 0 | 0 | 0 | 4.5 | 0 | 2.5 | 0 | 0 | 0 | 0 | 0 | 0 |
Cell Periphery | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Cytoplasm | 1.7 | 3.0 | 1.2 | 0.8 | 0.8 | -0.5 | -0.5 | 2.1 | -2.4 | 3.3 | 6.3 | 0 | 6.3 | 0 | 7.4 |
Endoplasmic Reticulum | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Endosome | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Golgi | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Mitochondria | -2.1 | 2.3 | 0 | 0 | 0 | 0 | 9.9 | 0 | 6.5 | -2.9 | -2.8 | 0 | 0.5 | 0 | -0.6 |
Nucleus | 1.9 | -1.2 | -6.3 | -6.9 | -7.3 | -7.6 | -7.7 | -11.2 | -9.2 | 0.1 | -2.3 | -1.9 | -6.6 | -6.7 | -8.5 |
Nuclear Periphery | -1.3 | -1.0 | 0 | 0 | 0 | 0 | 1.0 | 0 | 0.6 | 0 | 0 | 0 | 0 | 0 | 0 |
Nucleolus | -5.0 | -4.0 | 0 | 0 | 0 | 0 | 8.1 | 0 | 10.4 | -1.3 | -3.9 | -3.1 | -3.3 | -3.2 | -3.2 |
Peroxisomes | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
SpindlePole | 2.0 | 1.1 | 0 | 0 | 0 | 0 | 0.8 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Vacuole | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
R1 | R2 | R3 | ||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | |
Concentration | 2.6837 | 1.9074 | 2.2918 | 1.8708 | 2.4917 | 2.1871 | 4.8981 | 4.1967 | 4.3839 | 4.4299 | 3.923 | 4.3154 | 3.5381 | 2.9834 | 3.0221 | 3.2585 | 2.3705 | 2.6952 |
Actin | 0 | 0 | 0.0001 | 0 | 0.0002 | 0 | 0.0131 | 0 | 0.0111 | 0.008 | 0.0214 | 0.003 | 0.0401 | 0 | 0.0158 | 0.0009 | 0.061 | 0.0018 |
Bud | 0.0001 | 0 | 0 | 0 | 0.0001 | 0 | 0.0002 | 0 | 0.0003 | 0.0001 | 0.0003 | 0 | 0.0007 | 0 | 0.0004 | 0.0001 | 0.0001 | 0.0001 |
Bud Neck | 0.0002 | 0.0001 | 0.0002 | 0 | 0.001 | 0.0005 | 0.0009 | 0 | 0.0006 | 0.0001 | 0.0006 | 0.001 | 0.0009 | 0.0001 | 0.0014 | 0.0002 | 0.0005 | 0.0008 |
Bud Periphery | 0.0007 | 0 | 0 | 0 | 0.0004 | 0 | 0.0007 | 0 | 0.001 | 0.0001 | 0.0005 | 0.0001 | 0.0013 | 0 | 0.0009 | 0.0001 | 0.0001 | 0.0001 |
Bud Site | 0.0001 | 0 | 0.0002 | 0 | 0.0005 | 0 | 0.0012 | 0 | 0.001 | 0.0003 | 0.0008 | 0.0001 | 0.0024 | 0 | 0.0077 | 0.0001 | 0.0004 | 0.0001 |
Cell Periphery | 0.0002 | 0 | 0 | 0 | 0.0002 | 0 | 0.0003 | 0 | 0.0003 | 0 | 0.0001 | 0 | 0.0002 | 0 | 0.0008 | 0 | 0 | 0 |
Cytoplasm | 0.0001 | 0.0001 | 0.0002 | 0 | 0.0004 | 0 | 0.0021 | 0 | 0.0015 | 0.0002 | 0.0009 | 0.0002 | 0.0015 | 0 | 0.0006 | 0 | 0.0003 | 0.0001 |
Cytoplasmic Foci | 0 | 0 | 0.0001 | 0 | 0.001 | 0 | 0.0061 | 0 | 0.0042 | 0.0304 | 0.0035 | 0.0002 | 0.0102 | 0 | 0.0005 | 0.0014 | 0.0053 | 0.0019 |
Eisosomes | 0 | 0 | 0 | 0 | 0.0001 | 0 | 0.0001 | 0 | 0.0002 | 0.0001 | 0.0003 | 0.0001 | 0.0003 | 0 | 0.0005 | 0 | 0.0001 | 0 |
Endoplasmic Reticulum | 0.0001 | 0 | 0 | 0 | 0.0002 | 0 | 0.0026 | 0 | 0.0022 | 0.0004 | 0.0016 | 0.0007 | 0.0026 | 0 | 0.0006 | 0.0001 | 0.0004 | 0 |
Endosome | 0.0001 | 0 | 0.0002 | 0 | 0.0099 | 0 | 0.0089 | 0 | 0.0038 | 0.0102 | 0.0098 | 0.002 | 0.0124 | 0 | 0.0018 | 0.0084 | 0.0105 | 0.0013 |
Golgi | 0 | 0 | 0.0001 | 0 | 0.0016 | 0 | 0.0039 | 0 | 0.0015 | 0.0119 | 0.0098 | 0.0012 | 0.0055 | 0 | 0.0011 | 0.0072 | 0.0029 | 0.0006 |
Lipid Particles | 0 | 0 | 0.0007 | 0 | 0.0144 | 0 | 0.0125 | 0 | 0.0039 | 0.0371 | 0.0088 | 0.0019 | 0.0115 | 0 | 0.0022 | 0.0054 | 0.0339 | 0.0008 |
Mitochondria | 0.0005 | 0 | 0.0009 | 0 | 0.0072 | 0 | 0.0048 | 0 | 0.0045 | 0.0036 | 0.0225 | 0.0004 | 0.0045 | 0.0001 | 0.0038 | 0.0258 | 0.0008 | 0.0002 |
None | 0 | 0 | 0.0004 | 0 | 0.0008 | 0 | 0.0042 | 0 | 0.0009 | 0.0002 | 0.0009 | 0.0008 | 0.0031 | 0 | 0.0019 | 0.0001 | 0.0006 | 0.0003 |
Nuclear Periphery | 0.0025 | 0.0005 | 0.0009 | 0.0001 | 0.0093 | 0.0001 | 0.0123 | 0.0002 | 0.0093 | 0.0005 | 0.0166 | 0.0045 | 0.0147 | 0.0002 | 0.0038 | 0.0002 | 0.0069 | 0.0007 |
Nucleolus | 0.0287 | 0.0266 | 0.0272 | 0.0164 | 0.15 | 0.077 | 0.0408 | 0.0315 | 0.0275 | 0.0158 | 0.175 | 0.116 | 0.0361 | 0.0362 | 0.0299 | 0.035 | 0.1277 | 0.0923 |
Nucleus | 0.9648 | 0.9663 | 0.9634 | 0.9831 | 0.7559 | 0.9214 | 0.8663 | 0.9662 | 0.9159 | 0.859 | 0.7017 | 0.862 | 0.8306 | 0.9622 | 0.92 | 0.9118 | 0.7336 | 0.8952 |
Peroxisomes | 0 | 0 | 0.0003 | 0 | 0.0016 | 0 | 0.0072 | 0 | 0.0023 | 0.0205 | 0.0051 | 0.0001 | 0.0028 | 0 | 0.0004 | 0.0016 | 0.0028 | 0.002 |
Punctate Nuclear | 0.0006 | 0.0063 | 0.0049 | 0.0004 | 0.0394 | 0.0007 | 0.0077 | 0.0019 | 0.0032 | 0.0014 | 0.0173 | 0.0052 | 0.0154 | 0.001 | 0.001 | 0.0002 | 0.0104 | 0.0015 |
Vacuole | 0.0008 | 0 | 0.0002 | 0 | 0.0033 | 0 | 0.0024 | 0 | 0.0034 | 0.0002 | 0.0014 | 0.0002 | 0.0017 | 0 | 0.0037 | 0.0005 | 0.0009 | 0.0001 |
Vacuole Periphery | 0.0003 | 0 | 0.0001 | 0 | 0.0025 | 0 | 0.0016 | 0 | 0.0015 | 0.0002 | 0.0011 | 0.0003 | 0.0016 | 0 | 0.0009 | 0.0007 | 0.0007 | 0.0001 |
R1 | R2 | |||||||||
---|---|---|---|---|---|---|---|---|---|---|
G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | |
Gene Expression | 7.2227 | 18.8733 | 8.8451 | 12.928 | 15.1273 | 14.4374 | 11.299 | 11.8628 | 17.6922 | 14.5918 |
Translational Efficiency | 1.9059 | 0.6967 | 1.2466 | 1.0787 | 1.013 | 1.0215 | 1.243 | 1.4427 | 0.8226 | 1.089 |
Dataset | Hit |
---|---|
Protein Concentration | ✘ |
Protein Localization | ✘ |
Gene Expression | ✘ |
Translational Efficiency | ✘ |
Temp | Actin Patch (Sac6-tdTomato) | Cortical Patch (Sla1-GFP) | Late Endosome (Snf7-GFP) | Vacuole (Vph1-GFP) |
---|---|---|---|---|
37℃ | ||||
RT |
Gene / Allele | Actin Patch (Sac6-tdTomato) | Cortical Patch (Sla1-GFP) | Late Endosome (Snf7-GFP) | Vacuole (Sac6-tdTomato) |
---|
Gene | Images |
---|
Gene | Images |
---|