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Description | Protein disulfide isomerase; multifunctional oxidoreductase of the ER lumen, essential for disulfide bond formation in secretory and cell-surface proteins, processing of non-native disulfide bonds; Ero1p activator; complexes with exomannosidase, Mnl1p to facilitate the recognition of misfolded glycoproteins and the trimming of glycan Man8GlcNAc2 to Man7GlcNAc2 on substrates, thereby accelerating ERAD; PDI1 has a paralog, EUG1, that arose from the whole genome duplication |
ensLOC | DeepLoc | |||||||||||||||||||||||
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Localization | WT1 | WT2 | WT3 | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 | WT1 | WT2 | WT3 | AF100 | AF140 | AF180 |
Cortical Patches | – | 0 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | – | – | – | 0 | 0 | 0 | 0 | 1 | 0 |
Bud | – | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | – | – | – | 1 | 2 | 0 | 1 | 3 | 3 |
Bud Neck | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | – | – | – | 0 | 1 | 0 | 0 | 0 | 0 |
Bud Site | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | – | – | – | – | – | – | – | – | – |
Cell Periphery | – | 0 | 0 | 0 | 0 | 0 | 2 | 1 | 2 | 1 | 4 | 2 | 1 | 1 | 0 | – | – | – | 0 | 0 | 0 | 0 | 0 | 0 |
Cytoplasm | – | 12 | 5 | 15 | 39 | 36 | 40 | 43 | 62 | 67 | 79 | 71 | 56 | 94 | 138 | – | – | – | 0 | 2 | 0 | 1 | 5 | 3 |
Endoplasmic Reticulum | – | 1 | 0 | 2 | 3 | 2 | 3 | 0 | 2 | 0 | 1 | 1 | 1 | 3 | 0 | – | – | – | 0 | 0 | 0 | 1 | 0 | 2 |
Endosome | – | 4 | 0 | 1 | 4 | 4 | 2 | 3 | 0 | 0 | 0 | 0 | 21 | 4 | 0 | – | – | – | 3 | 6 | 2 | 5 | 13 | 15 |
Golgi | – | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 1 | – | – | – | 1 | 0 | 0 | 2 | 1 | 2 |
Mitochondria | – | 8 | 14 | 1 | 3 | 10 | 15 | 14 | 14 | 14 | 14 | 18 | 0 | 1 | 0 | – | – | – | 0 | 3 | 0 | 2 | 3 | 7 |
Nucleus | – | 37 | 30 | 15 | 9 | 25 | 53 | 40 | 34 | 22 | 14 | 18 | 28 | 11 | 8 | – | – | – | 3 | 2 | 1 | 1 | 0 | 0 |
Nuclear Periphery | – | 3 | 2 | 0 | 0 | 0 | 1 | 0 | 2 | 0 | 0 | 1 | 0 | 0 | 1 | – | – | – | 0 | 1 | 0 | 4 | 7 | 3 |
Nucleolus | – | 3 | 1 | 1 | 1 | 3 | 2 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | – | – | – | 2 | 0 | 0 | 0 | 0 | 1 |
Peroxisomes | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | – | – | – | 0 | 0 | 0 | 0 | 0 | 0 |
SpindlePole | – | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 2 | 0 | 0 | 0 | 5 | 0 | 0 | – | – | – | 1 | 0 | 0 | 0 | 1 | 2 |
Vac/Vac Membrane | – | 178 | 111 | 117 | 86 | 124 | 225 | 177 | 203 | 186 | 137 | 138 | 290 | 147 | 191 | – | – | – | 29 | 198 | 134 | 149 | 254 | 173 |
Unique Cell Count | 207 | 138 | 134 | 128 | 175 | 277 | 227 | 269 | 240 | 195 | 209 | 347 | 225 | 300 | 48 | 221 | 141 | 180 | 297 | 219 | ||||
Labelled Cell Count | 246 | 163 | 153 | 147 | 205 | 343 | 281 | 321 | 292 | 249 | 250 | 405 | 261 | 339 | 48 | 221 | 141 | 180 | 297 | 219 |
Screen | WT1 | WT2 | WT3 | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 | AF100 | AF140 | AF180 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Mean Cell GFP Intensity (1e-4) | – | 7.9 | 8.7 | 10.3 | 12.7 | 11.9 | 11.3 | 10.4 | 10.3 | 9.5 | 9.4 | 9.3 | 7.3 | 6.5 | 6.8 | – | – | – | 8.2 | 7.9 | 7.9 |
Std Deviation (1e-4) | – | 2.3 | 2.7 | 2.9 | 4.2 | 4.4 | 4.6 | 4.3 | 4.0 | 3.7 | 3.6 | 3.8 | 1.5 | 1.7 | 2.0 | – | – | – | 2.1 | 1.8 | 1.7 |
Intensity Change (Log2) | – | – | – | 0.25 | 0.54 | 0.45 | 0.37 | 0.26 | 0.23 | 0.13 | 0.1 | 0.1 | -0.26 | -0.42 | -0.36 | – | – | – | -0.09 | -0.14 | -0.14 |
Localization | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Cortical Patches | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | – | – | – |
Bud | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | – | – | – |
Bud Neck | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | – | – | – |
Bud Site | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | – | – | – |
Cell Periphery | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | – | – | – |
Cytoplasm | 0 | 2.3 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 2.4 | 1.4 | – | – | – |
Endoplasmic Reticulum | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | – | – | – |
Endosome | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 3.0 | 0 | 0 | – | – | – |
Golgi | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | – | – | – |
Mitochondria | -3.4 | -2.6 | -1.5 | -1.8 | -1.4 | -1.9 | -1.5 | -1.0 | -0.5 | 0 | -4.5 | 0 | – | – | – |
Nucleus | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | – | – | – |
Nuclear Periphery | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | – | – | – |
Nucleolus | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | – | – | – |
Peroxisomes | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | – | – | – |
SpindlePole | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | – | – | – |
Vacuole | 1.2 | -2.8 | -2.0 | 0.4 | -1.4 | -2.6 | -1.8 | -3.7 | -4.8 | 1.1 | -2.2 | -3.2 | – | – | – |