Standard name
Description Peptidyl-prolyl cis-trans isomerase (cyclophilin); catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; has a potential role in the secretory pathway; CPR4 has a paralog, CPR8, that arose from the whole genome duplication

Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cell Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 0.35 0.5 0.62 0.77 0.82 0.83 0.87 0.9 0.91 0.88 0.86 0.82 0.87 0.95 0.3 0.27 0.3 0 0.1 0.05 0.06 0.12 0.1
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.05 0.05 0 0 0 0.06 0 0 0
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.05 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.07 0 0
Mitochondria 0.11 0 0.07 0 0 0.09 0.05 0 0.07 0.12 0.16 0 0 0 0 0 0 0 0 0 0 0 0
Nucleus 0.14 0 0 0 0 0 0 0 0 0 0 0 0 0 0.25 0.17 0.14 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vac/Vac Membrane 0.59 0.56 0.42 0.45 0.28 0.19 0.18 0.11 0.09 0.1 0.07 0.24 0.14 0 0.61 0.68 0.7 0.9 0.77 0.82 0.71 0.7 0.78
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 0 0 0 2 0 0 2 0 0 0 0 1 1 0 0 0
Bud 0 3 0 2 10 14 11 6 9 34 35 1 1 3 0 0 0 0 2 1 0 1 0
Bud Neck 0 0 0 0 0 0 0 0 1 0 0 0 0 1 0 0 0 0 0 0 0 0 2
Bud Site 0 0 0 0 0 0 0 1 0 1 0 0 0 0 0 0 0
Cell Periphery 0 1 0 0 1 1 0 2 1 1 1 0 0 3 0 0 0 0 0 0 0 0 0
Cytoplasm 28 70 82 359 690 818 1044 1028 1142 801 971 28 80 190 87 71 71 2 17 7 1 12 15
Endoplasmic Reticulum 0 2 3 0 1 1 1 1 0 1 2 0 1 2 15 13 6 1 2 9 0 3 1
Endosome 0 4 1 7 17 6 10 21 17 7 4 0 1 0 15 7 6 0 6 2 0 2 4
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 2 1 0 0 0 1 1 0 1
Mitochondria 9 0 9 5 16 87 61 27 85 110 185 0 1 0 9 4 3 1 2 1 0 4 4
Nucleus 11 2 0 6 1 15 15 17 9 3 7 0 1 0 72 45 33 3 0 0 0 0 1
Nuclear Periphery 0 1 0 0 4 2 11 11 2 0 4 0 0 0 0 2 0 0 0 0 0 0 1
Nucleolus 0 0 0 0 0 2 1 5 1 1 4 0 1 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 2 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 2 0 5 3 2 1 0 0 1 0 0 1 0 1 0 0 0 0
Vac/Vac Membrane 47 79 56 208 240 192 216 126 111 87 81 8 13 3 176 175 164 96 127 125 18 74 118
Unique Cell Count 79 140 132 464 843 986 1202 1141 1250 912 1134 34 92 199 287 259 235 107 166 152 26 107 152
Labelled Cell Count 95 162 151 587 980 1140 1370 1252 1381 1048 1297 37 99 205 376 318 284 107 166 152 26 107 152


Vacuole

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 5.5 7.0 5.7 6.3 6.1 4.6 4.2 4.8 3.9 3.9 3.6 6.7 6.6 4.9 8.6 8.4 8.8 7.6 7.4
Std Deviation (1e-4) 1.2 1.8 1.2 1.7 1.5 1.5 1.3 5.5 1.1 0.9 0.8 1.4 2.0 1.0 2.0 1.9 2.0 2.5 1.5
Intensity Change (Log2) 0.14 0.09 -0.29 -0.45 -0.26 -0.54 -0.56 -0.67 0.24 0.21 -0.22 0.59 0.56 0.64 0.42 0.38


Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cell Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 3.5 5.2 5.7 7.4 9.1 10.0 7.6 6.8 2.2 4.1 7.8 -6.2 -6.7 -5.9
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 0 0 0 1.4 1.3 0
Endosome 0 0 0 0 0 0 0 0 0 0 0 2.2 0 0
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0 0 0 0 0 0 0 0 0 0 0 -1.7 0 0
Nucleus 0 0 0 0 0 0 0 0 0 0 0 6.3 5.1 4.5
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vacuole 0.5 -3.2 -6.0 -6.6 -9.8 -11.2 -10.3 -12.3 -2.0 -4.5 -9.5 3.6 4.8 5.1