Standard name | |
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Human Ortholog | |
Description | Component of serine palmitoyltransferase; responsible along with Lcb1p for the first committed step in sphingolipid synthesis, which is the condensation of serine with palmitoyl-CoA to form 3-ketosphinganine |
ensLOC | DeepLoc | |||||||||||||||||||||||
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Localization | WT1 | WT2 | WT3 | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 | WT1 | WT2 | WT3 | AF100 | AF140 | AF180 |
Cortical Patches | 22 | 28 | 47 | 42 | 50 | 32 | 36 | 67 | – | 55 | 60 | 67 | 87 | 64 | 33 | 24 | 3 | 9 | 6 | 10 | 17 | 22 | 34 | 16 |
Bud | 1 | 4 | 1 | 1 | 4 | 2 | 3 | 2 | – | 9 | 18 | 12 | 5 | 5 | 6 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 |
Bud Neck | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 3 | 0 | 1 | 1 | 3 |
Bud Site | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | – | – | – | – | – | – |
Cell Periphery | 16 | 35 | 48 | 45 | 46 | 43 | 33 | 33 | – | 54 | 46 | 60 | 195 | 232 | 219 | 34 | 4 | 22 | 5 | 10 | 22 | 36 | 88 | 71 |
Cytoplasm | 22 | 27 | 16 | 18 | 21 | 31 | 36 | 45 | – | 36 | 40 | 41 | 65 | 82 | 103 | 24 | 9 | 27 | 1 | 6 | 1 | 2 | 7 | 8 |
Endoplasmic Reticulum | 155 | 135 | 200 | 137 | 241 | 233 | 244 | 224 | – | 258 | 161 | 233 | 742 | 805 | 851 | 1 | 0 | 2 | 188 | 165 | 195 | 283 | 465 | 415 |
Endosome | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 2 | – | 0 | 2 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 3 | 2 | 0 |
Golgi | 6 | 0 | 12 | 24 | 38 | 9 | 12 | 3 | – | 0 | 3 | 5 | 12 | 3 | 6 | 3 | 2 | 9 | 0 | 0 | 1 | 3 | 5 | 6 |
Mitochondria | 11 | 5 | 22 | 51 | 45 | 57 | 65 | 80 | – | 140 | 158 | 132 | 0 | 0 | 0 | 14 | 1 | 10 | 2 | 4 | 1 | 8 | 7 | 9 |
Nucleus | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | – | 0 | 0 | 0 | 0 | 0 | 3 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Nuclear Periphery | 1 | 2 | 0 | 2 | 2 | 3 | 6 | 10 | – | 23 | 7 | 13 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Nucleolus | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Peroxisomes | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
SpindlePole | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Vac/Vac Membrane | 5 | 0 | 0 | 0 | 3 | 11 | 5 | 22 | – | 8 | 10 | 25 | 10 | 7 | 6 | 7 | 1 | 3 | 3 | 6 | 0 | 1 | 2 | 5 |
Unique Cell Count | 189 | 183 | 241 | 191 | 311 | 298 | 331 | 343 | 411 | 355 | 414 | 911 | 1000 | 1040 | 96 | 17 | 72 | 213 | 211 | 246 | 367 | 620 | 541 | |
Labelled Cell Count | 240 | 236 | 347 | 320 | 452 | 422 | 440 | 489 | 583 | 505 | 589 | 1116 | 1199 | 1227 | 110 | 21 | 82 | 213 | 211 | 246 | 367 | 620 | 541 |
Screen | WT1 | WT2 | WT3 | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 | AF100 | AF140 | AF180 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Mean Cell GFP Intensity (1e-4) | 13.4 | 14.1 | 14.0 | 14.4 | 14.0 | 12.6 | 12.3 | 11.9 | – | 11.2 | 11.2 | 12.1 | 14.8 | 15.4 | 16.1 | 9.8 | 12.3 | 13.9 | 15.3 | 15.5 | 15.7 |
Std Deviation (1e-4) | 1.9 | 2.3 | 2.2 | 2.1 | 2.0 | 2.1 | 2.2 | 2.5 | – | 2.1 | 2.3 | 2.4 | 2.0 | 1.9 | 2.0 | 1.7 | 3.2 | 3.1 | 2.0 | 2.4 | 2.4 |
Intensity Change (Log2) | – | – | – | 0.04 | -0.0 | -0.14 | -0.19 | -0.24 | – | -0.32 | -0.31 | -0.21 | 0.08 | 0.14 | 0.21 | -0.51 | -0.18 | -0.01 | 0.14 | 0.15 | 0.17 |
Localization | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Cortical Patches | 0.6 | -1.0 | -2.9 | -2.9 | 0 | – | -2.1 | -0.8 | -1.1 | -4.3 | -6.4 | -9.4 | 1.1 | 0 | -1.4 |
Bud | 0 | 0 | 0 | 0 | 0 | – | 0 | 3.2 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Bud Neck | 0 | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Bud Site | 0 | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Cell Periphery | 0.9 | -1.6 | -1.7 | -3.4 | -3.5 | – | -2.3 | -2.3 | -1.8 | 0.5 | 1.1 | 0.4 | 3.0 | 0 | 1.9 |
Cytoplasm | 1.1 | 0.1 | 1.5 | 1.7 | 2.5 | – | 1.0 | 1.9 | 1.4 | 0.3 | 0.8 | 1.6 | 4.7 | 0 | 6.7 |
Endoplasmic Reticulum | -2.8 | -1.6 | -1.4 | -2.6 | -4.7 | – | -5.4 | -9.2 | -7.0 | -0.6 | -0.9 | -0.4 | -13.8 | -7.9 | -12.5 |
Endosome | 0 | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Golgi | 2.8 | 2.9 | -1.2 | -0.8 | -3.1 | – | 0 | -3.2 | -2.9 | -3.5 | 0 | 0 | 0 | 0 | 0 |
Mitochondria | 4.8 | 1.9 | 3.3 | 3.5 | 4.4 | – | 7.1 | 9.2 | 6.6 | 0 | 0 | 0 | 1.5 | 0 | 1.2 |
Nucleus | 0 | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Nuclear Periphery | 0 | 0 | 0 | 0 | 0 | – | 3.7 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Nucleolus | 0 | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Peroxisomes | 0 | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
SpindlePole | 0 | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Vacuole | 0 | 0 | 0 | 0 | 4.0 | – | 0 | 0 | 3.9 | 0 | 0 | 0 | 0 | 0 | 0 |
R1 | R2 | R3 | ||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | |
Concentration | 13.9117 | 15.438 | 15.1597 | 15.1418 | 15.2142 | 14.9838 | 14.618 | 17.7973 | 17.3161 | 16.2407 | 14.8978 | 15.863 | 18.9727 | 19.3225 | 18.5759 | 18.7494 | 17.7501 | 17.3587 |
Actin | 0.0304 | 0.0044 | 0.0154 | 0.004 | 0.0108 | 0.0017 | 0.0171 | 0.0037 | 0.0014 | 0.0006 | 0.0012 | 0.0026 | 0.003 | 0.0066 | 0.004 | 0.0019 | 0.0001 | 0.0027 |
Bud | 0.0005 | 0.0002 | 0.0009 | 0.0001 | 0.0001 | 0 | 0.0003 | 0.0002 | 0.0001 | 0.0004 | 0.0001 | 0.0001 | 0 | 0.0014 | 0.0005 | 0.0001 | 0 | 0 |
Bud Neck | 0.0013 | 0.001 | 0.0013 | 0.0007 | 0.0064 | 0.0019 | 0.0004 | 0.0006 | 0.0012 | 0.0007 | 0.0007 | 0.0032 | 0.0004 | 0.0006 | 0.0034 | 0.0046 | 0.0003 | 0.0048 |
Bud Periphery | 0.0013 | 0.0009 | 0.0019 | 0.0003 | 0.0008 | 0.0004 | 0.0006 | 0.0011 | 0.0014 | 0.0008 | 0.0003 | 0.0004 | 0.0002 | 0.003 | 0.0048 | 0.0016 | 0.0001 | 0.0004 |
Bud Site | 0.0025 | 0.0019 | 0.0047 | 0.0002 | 0.0002 | 0 | 0.0006 | 0.0004 | 0.0003 | 0.003 | 0.0006 | 0.0001 | 0.0001 | 0.0061 | 0.0009 | 0.0003 | 0 | 0.0001 |
Cell Periphery | 0.0184 | 0.0433 | 0.0211 | 0.0177 | 0.0163 | 0.0091 | 0.0199 | 0.0554 | 0.0362 | 0.0129 | 0.019 | 0.0157 | 0.0136 | 0.0248 | 0.0466 | 0.032 | 0.0207 | 0.0166 |
Cytoplasm | 0.0587 | 0.0658 | 0.0315 | 0.009 | 0.0533 | 0.0097 | 0.0209 | 0.0075 | 0.0063 | 0.0034 | 0.078 | 0.0096 | 0.0116 | 0.008 | 0.0145 | 0.0034 | 0.0029 | 0.0164 |
Cytoplasmic Foci | 0.0095 | 0.0023 | 0.0103 | 0.0037 | 0.0039 | 0.0006 | 0.012 | 0.0005 | 0.0008 | 0.0026 | 0.0019 | 0.0032 | 0.0104 | 0.0001 | 0.0004 | 0.0015 | 0.0001 | 0.0014 |
Eisosomes | 0.002 | 0.0018 | 0.0008 | 0.0002 | 0.0013 | 0.0006 | 0.0004 | 0.0009 | 0.0011 | 0.0003 | 0.0017 | 0.0027 | 0.0031 | 0.0007 | 0.0016 | 0.0023 | 0.0008 | 0.0014 |
Endoplasmic Reticulum | 0.7272 | 0.8195 | 0.8593 | 0.9134 | 0.8557 | 0.948 | 0.7435 | 0.8837 | 0.921 | 0.9065 | 0.7988 | 0.9038 | 0.9011 | 0.9372 | 0.9046 | 0.8765 | 0.9665 | 0.9361 |
Endosome | 0.0287 | 0.0063 | 0.0084 | 0.0137 | 0.0146 | 0.0076 | 0.0489 | 0.0022 | 0.0026 | 0.032 | 0.0041 | 0.0116 | 0.0136 | 0.0003 | 0.0006 | 0.009 | 0.0004 | 0.003 |
Golgi | 0.0131 | 0.0078 | 0.0092 | 0.0054 | 0.0177 | 0.0026 | 0.0171 | 0.0038 | 0.0077 | 0.004 | 0.0737 | 0.0142 | 0.0156 | 0.0013 | 0.0045 | 0.0486 | 0.0026 | 0.005 |
Lipid Particles | 0.0175 | 0.0274 | 0.0054 | 0.0181 | 0.0099 | 0.0044 | 0.0316 | 0.0258 | 0.0077 | 0.0029 | 0.0092 | 0.013 | 0.0125 | 0.0014 | 0.0035 | 0.0016 | 0.0009 | 0.0029 |
Mitochondria | 0.0144 | 0.0021 | 0.0017 | 0.0005 | 0.0006 | 0.0005 | 0.0071 | 0.0007 | 0.0004 | 0.0021 | 0.0001 | 0.0012 | 0.0037 | 0.0001 | 0.0002 | 0.001 | 0.0001 | 0.0002 |
None | 0.0097 | 0.0006 | 0.0148 | 0.0006 | 0.0002 | 0.0007 | 0.0118 | 0.0001 | 0.0001 | 0.0002 | 0.0014 | 0.0007 | 0.0002 | 0.0001 | 0.0001 | 0.0001 | 0.0001 | 0.0005 |
Nuclear Periphery | 0.0216 | 0.0069 | 0.0053 | 0.0058 | 0.0042 | 0.0079 | 0.0298 | 0.0075 | 0.0063 | 0.0049 | 0.0034 | 0.012 | 0.0068 | 0.006 | 0.0054 | 0.0092 | 0.003 | 0.0043 |
Nucleolus | 0.0008 | 0.0001 | 0.0003 | 0.0001 | 0 | 0.0001 | 0.0005 | 0 | 0 | 0.0002 | 0.0001 | 0 | 0 | 0 | 0 | 0.0001 | 0 | 0 |
Nucleus | 0.0178 | 0.0007 | 0.0007 | 0.0005 | 0.0004 | 0.0006 | 0.0119 | 0.0003 | 0.0003 | 0.0006 | 0.0007 | 0.0005 | 0.0002 | 0.0002 | 0.0002 | 0.0004 | 0.0001 | 0.0004 |
Peroxisomes | 0.0037 | 0.0001 | 0.0008 | 0.0007 | 0.0003 | 0.0001 | 0.0071 | 0 | 0 | 0.0002 | 0 | 0.0001 | 0.0004 | 0 | 0 | 0 | 0 | 0 |
Punctate Nuclear | 0.014 | 0.0003 | 0.0023 | 0.0029 | 0.0005 | 0.0006 | 0.0082 | 0.0001 | 0.0001 | 0.0001 | 0.0004 | 0.0003 | 0.0002 | 0 | 0 | 0 | 0 | 0.0011 |
Vacuole | 0.0056 | 0.0059 | 0.0034 | 0.0021 | 0.0024 | 0.0022 | 0.0083 | 0.0049 | 0.0045 | 0.0186 | 0.0044 | 0.0023 | 0.0025 | 0.0018 | 0.0036 | 0.0047 | 0.0012 | 0.0023 |
Vacuole Periphery | 0.0013 | 0.0005 | 0.0006 | 0.0003 | 0.0004 | 0.0006 | 0.0019 | 0.0005 | 0.0005 | 0.0028 | 0.0002 | 0.0027 | 0.0005 | 0.0002 | 0.0004 | 0.0009 | 0.0001 | 0.0003 |
R1 | R2 | |||||||||
---|---|---|---|---|---|---|---|---|---|---|
G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | |
Gene Expression | 118.4556 | 88.3409 | 98.1121 | 92.1931 | 81.8826 | 104.6542 | 95.2367 | 93.4232 | 84.1946 | 108.8353 |
Translational Efficiency | 0.8464 | 0.9668 | 0.7327 | 0.7966 | 0.9122 | 0.9421 | 0.9386 | 0.7122 | 0.8929 | 0.7852 |
Dataset | Hit |
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Protein Concentration | ✘ |
Protein Localization | ✘ |
Gene Expression | ✘ |
Translational Efficiency | ✘ |
Temp | Actin Patch (Sac6-tdTomato) | Cortical Patch (Sla1-GFP) | Late Endosome (Snf7-GFP) | Vacuole (Vph1-GFP) |
---|---|---|---|---|
37℃ | ||||
RT |
Gene / Allele | Actin Patch (Sac6-tdTomato) | Cortical Patch (Sla1-GFP) | Late Endosome (Snf7-GFP) | Vacuole (Sac6-tdTomato) |
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Gene | Images |
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Gene | Images |
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