Standard name
Human Ortholog
Description Major isoform of large subunit of ribonucleotide-diphosphate reductase; the RNR complex catalyzes rate-limiting step in dNTP synthesis, regulated by DNA replication and DNA damage checkpoint pathways via localization of small subunits; relative distribution to the nucleus increases upon DNA replication stress; RNR1 has a paralog, RNR3, that arose from the whole genome duplication
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches – – 0 0 – – 0 0 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0
Bud – – 0 0 – – 0 0 0 0.06 0 0 0 0 0 0 0 – 0.06 0 0.05 0 0 0
Bud Neck – – 0 0 – – 0 0 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0
Bud Site – – 0 0 – – 0 0 0 0 0 0 0 0 0 0 0 – – – – – – –
Cell Periphery – – 0.25 0.16 – – 0.1 0.05 0.06 0.22 0.15 0.11 0.46 0.2 0.21 0.24 0.06 – 0 0 0 0 0 0
Cytoplasm – – 0.65 0.89 – – 0.9 0.84 0.91 0.67 0.85 0.79 0.5 0.86 0.76 0.82 0.91 – 0.33 0.34 0.34 0.7 0.7 0.71
Endoplasmic Reticulum – – 0.05 0 – – 0 0 0.06 0.06 0 0.05 0.12 0 0.06 0.12 0.09 – 0.07 0.12 0.06 0.08 0.1 0.11
Endosome – – 0 0 – – 0 0 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0
Golgi – – 0 0 – – 0 0 0 0.06 0 0 0 0 0 0 0 – 0 0 0 0 0 0
Mitochondria – – 0 0 – – 0 0 0 0 0 0 0 0 0 0 0 – 0.05 0 0 0 0 0
Nucleus – – 0.1 0.05 – – 0.05 0 0 0.06 0 0.05 0 0 0 0 0 – 0.18 0.19 0.22 0 0 0
Nuclear Periphery – – 0 0 – – 0 0 0 0 0 0 0 0 0 0 0 – 0.09 0.1 0.08 0.05 0 0
Nucleolus – – 0.05 0 – – 0 0.11 0 0 0 0 0 0 0 0 0 – 0 0 0.06 0 0 0
Peroxisomes – – 0 0 – – 0 0 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0
SpindlePole – – 0 0 – – 0 0 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0
Vac/Vac Membrane – – 0.05 0 – – 0 0 0 0 0 0 0 0 0.06 0 0 – 0 0 0 0 0 0
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches – – 0 0 – – 0 0 0 0 0 0 0 0 0 0 0 – 1 1 1 0 2 1
Bud – – 1 0 – – 0 0 0 1 0 0 1 2 0 0 0 – 3 2 4 0 2 3
Bud Neck – – 0 0 – – 0 0 0 0 0 0 0 0 0 0 0 – 1 2 3 0 1 0
Bud Site – – 0 0 – – 0 0 0 0 0 0 0 0 0 0 0 – – – – – – –
Cell Periphery – – 10 3 – – 2 1 2 4 5 2 12 10 7 4 2 – 0 0 1 1 0 0
Cytoplasm – – 26 17 – – 19 16 29 12 28 15 13 42 25 14 31 – 18 23 33 29 85 83
Endoplasmic Reticulum – – 2 0 – – 0 0 2 1 0 1 3 0 2 2 3 – 4 8 5 3 12 13
Endosome – – 0 0 – – 0 0 0 0 0 0 0 0 0 0 0 – 1 2 2 0 1 0
Golgi – – 0 0 – – 0 0 0 1 0 0 0 0 0 0 0 – 0 0 0 0 1 2
Mitochondria – – 0 0 – – 0 0 0 0 0 0 0 0 0 0 0 – 2 0 0 1 0 0
Nucleus – – 4 1 – – 1 0 0 1 0 1 0 0 0 0 0 – 10 13 21 1 4 0
Nuclear Periphery – – 0 0 – – 0 0 0 0 0 0 0 0 0 0 0 – 4 7 8 2 1 1
Nucleolus – – 2 0 – – 0 2 0 0 1 0 1 0 0 0 1 – 1 1 5 0 0 1
Peroxisomes – – 0 0 – – 0 0 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0
SpindlePole – – 0 0 – – 0 0 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 1
Vac/Vac Membrane – – 2 0 – – 0 0 0 0 0 0 1 0 2 0 0 – 2 2 2 1 1 2
Unique Cell Count 40 19 21 19 32 18 33 19 26 49 33 17 34 56 69 97 43 122 118
Labelled Cell Count 47 21 22 19 33 20 34 19 31 54 36 20 37 56 69 97 43 122 118


Ambiguous

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) – – 206.4 165.8 – – 174.7 164.5 160.3 212.5 170.6 162.2 280.6 294.6 297.3 213.0 211.3 – – 198.4 245.0
Std Deviation (1e-4) – – 90.2 62.6 – – 97.0 93.2 70.7 87.1 73.4 71.1 93.7 107.3 131.5 61.8 93.9 – – 79.9 113.6
Intensity Change (Log2) – – – -0.32 – – -0.24 -0.33 -0.36 0.04 -0.27 -0.35 0.44 0.51 0.53 0.05 0.03 – – -0.06 0.25


Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches 0 – – 0 0 0 0 0 0 0 0 0 0 0 –
Bud 0 – – 0 0 0 0 0 0 0 0 0 0 0 –
Bud Neck 0 – – 0 0 0 0 0 0 0 0 0 0 0 –
Bud Site 0 – – 0 0 0 0 0 0 0 0 0 0 0 –
Cell Periphery 0 – – 0 0 -2.1 0 -1.0 0 1.8 -0.5 -0.4 0 -2.2 –
Cytoplasm 2.0 – – 2.1 1.5 2.5 0.1 1.9 1.1 -1.2 2.3 1.0 1.3 2.7 –
Endoplasmic Reticulum 0 – – 0 0 0 0 0 0 0 0 0 0 0 –
Endosome 0 – – 0 0 0 0 0 0 0 0 0 0 0 –
Golgi 0 – – 0 0 0 0 0 0 0 0 0 0 0 –
Mitochondria 0 – – 0 0 0 0 0 0 0 0 0 0 0 –
Nucleus 0 – – 0 0 0 0 0 0 0 0 0 0 0 –
Nuclear Periphery 0 – – 0 0 0 0 0 0 0 0 0 0 0 –
Nucleolus 0 – – 0 0 0 0 0 0 0 0 0 0 0 –
Peroxisomes 0 – – 0 0 0 0 0 0 0 0 0 0 0 –
SpindlePole 0 – – 0 0 0 0 0 0 0 0 0 0 0 –
Vacuole 0 – – 0 0 0 0 0 0 0 0 0 0 0 –

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration – – – – – – – – – – – – – – – – – –
Actin – – – – – – – – – – – – – – – – – –
Bud – – – – – – – – – – – – – – – – – –
Bud Neck – – – – – – – – – – – – – – – – – –
Bud Periphery – – – – – – – – – – – – – – – – – –
Bud Site – – – – – – – – – – – – – – – – – –
Cell Periphery – – – – – – – – – – – – – – – – – –
Cytoplasm – – – – – – – – – – – – – – – – – –
Cytoplasmic Foci – – – – – – – – – – – – – – – – – –
Eisosomes – – – – – – – – – – – – – – – – – –
Endoplasmic Reticulum – – – – – – – – – – – – – – – – – –
Endosome – – – – – – – – – – – – – – – – – –
Golgi – – – – – – – – – – – – – – – – – –
Lipid Particles – – – – – – – – – – – – – – – – – –
Mitochondria – – – – – – – – – – – – – – – – – –
None – – – – – – – – – – – – – – – – – –
Nuclear Periphery – – – – – – – – – – – – – – – – – –
Nucleolus – – – – – – – – – – – – – – – – – –
Nucleus – – – – – – – – – – – – – – – – – –
Peroxisomes – – – – – – – – – – – – – – – – – –
Punctate Nuclear – – – – – – – – – – – – – – – – – –
Vacuole – – – – – – – – – – – – – – – – – –
Vacuole Periphery – – – – – – – – – – – – – – – – – –

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 714.9167 141.6506 38.9706 103.48 438.249 463.5289 132.0043 75.8435 92.3539 498.2022
Translational Efficiency 0.7478 0.6616 0.6178 0.5857 0.7279 1.0293 0.7672 0.4898 0.5479 0.6349

Hit Data

Dataset Hit
Protein Concentration –
Protein Localization –
Gene Expression ✔
Translational Efficiency ✘

No result is found for the queried gene(s). Please try another query.


Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Rnr1-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available