Standard name | |
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Human Ortholog | |
Description | Lysine-specific metalloprotease of the pitrilysin family; metalloprotease of the intermembrane space; degrades proteins and presequence peptides cleaved from imported proteins; required for normal mitochondrial morphology |
ensLOC | DeepLoc | |||||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Localization | WT1 | WT2 | WT3 | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 | WT1 | WT2 | WT3 | AF100 | AF140 | AF180 |
Cortical Patches | 3 | 0 | 2 | 3 | 4 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 3 | 2 | 0 | 2 | 0 | 3 | 4 | 1 | 5 | 10 | 13 |
Bud | 0 | 4 | 17 | 18 | 15 | 14 | 15 | 14 | 9 | 13 | 16 | 27 | 3 | 4 | 8 | 10 | 0 | 5 | 0 | 1 | 0 | 1 | 2 | 1 |
Bud Neck | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 2 | 0 | 0 | 0 | 0 |
Bud Site | 0 | 1 | 4 | 1 | 1 | 3 | 4 | 2 | 5 | 5 | 5 | 4 | 0 | 0 | 1 | 3 | 1 | 0 | – | – | – | – | – | – |
Cell Periphery | 5 | 10 | 3 | 4 | 5 | 1 | 1 | 9 | 5 | 7 | 3 | 10 | 7 | 13 | 7 | 10 | 8 | 8 | 0 | 0 | 0 | 0 | 0 | 0 |
Cytoplasm | 1 | 8 | 2 | 17 | 7 | 9 | 15 | 10 | 12 | 7 | 6 | 4 | 7 | 9 | 9 | 6 | 5 | 16 | 0 | 2 | 0 | 0 | 0 | 0 |
Endoplasmic Reticulum | 0 | 0 | 1 | 2 | 2 | 2 | 4 | 5 | 4 | 0 | 7 | 10 | 1 | 1 | 0 | 4 | 5 | 4 | 0 | 0 | 0 | 0 | 1 | 2 |
Endosome | 21 | 7 | 3 | 1 | 9 | 3 | 6 | 3 | 0 | 0 | 0 | 2 | 14 | 10 | 7 | 19 | 9 | 9 | 13 | 17 | 17 | 11 | 8 | 5 |
Golgi | 30 | 1 | 0 | 0 | 2 | 1 | 1 | 2 | 0 | 0 | 0 | 0 | 4 | 23 | 4 | 22 | 42 | 28 | 14 | 17 | 7 | 19 | 36 | 25 |
Mitochondria | 192 | 269 | 325 | 297 | 334 | 385 | 474 | 527 | 384 | 383 | 320 | 499 | 202 | 264 | 292 | 8 | 19 | 11 | 242 | 233 | 292 | 152 | 143 | 164 |
Nucleus | 1 | 1 | 1 | 0 | 2 | 2 | 5 | 3 | 5 | 4 | 1 | 2 | 1 | 1 | 0 | 3 | 3 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Nuclear Periphery | 16 | 15 | 14 | 11 | 21 | 39 | 61 | 59 | 47 | 39 | 40 | 63 | 4 | 1 | 7 | 7 | 2 | 0 | 2 | 2 | 2 | 1 | 2 | 1 |
Nucleolus | 19 | 7 | 8 | 6 | 19 | 28 | 49 | 42 | 29 | 28 | 25 | 34 | 3 | 5 | 3 | 9 | 7 | 4 | 1 | 0 | 0 | 1 | 1 | 4 |
Peroxisomes | 19 | 11 | 19 | 6 | 15 | 6 | 5 | 6 | 0 | 6 | 5 | 2 | 13 | 24 | 8 | 48 | 38 | 26 | 14 | 11 | 19 | 12 | 20 | 31 |
SpindlePole | 5 | 1 | 5 | 1 | 1 | 6 | 6 | 2 | 1 | 2 | 3 | 6 | 5 | 2 | 2 | 28 | 22 | 12 | 1 | 1 | 2 | 0 | 0 | 0 |
Vac/Vac Membrane | 42 | 46 | 25 | 9 | 13 | 10 | 19 | 24 | 20 | 13 | 18 | 15 | 26 | 25 | 31 | 39 | 28 | 15 | 1 | 15 | 2 | 6 | 5 | 3 |
Unique Cell Count | 260 | 307 | 342 | 320 | 370 | 410 | 525 | 563 | 416 | 412 | 337 | 519 | 238 | 304 | 322 | 173 | 155 | 117 | 297 | 315 | 350 | 217 | 238 | 261 |
Labelled Cell Count | 354 | 381 | 430 | 376 | 450 | 509 | 666 | 709 | 521 | 507 | 449 | 678 | 290 | 385 | 381 | 216 | 192 | 138 | 297 | 315 | 350 | 217 | 238 | 261 |
Screen | WT1 | WT2 | WT3 | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 | AF100 | AF140 | AF180 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Mean Cell GFP Intensity (1e-4) | 10.1 | 7.7 | 5.7 | 6.1 | 7.2 | 7.2 | 7.0 | 7.0 | 6.5 | 6.3 | 6.1 | 5.9 | 8.6 | 7.9 | 6.8 | 9.2 | 10.5 | 10.5 | 9.1 | 9.5 | 10.1 |
Std Deviation (1e-4) | 1.9 | 1.7 | 1.0 | 1.4 | 1.4 | 1.7 | 1.8 | 1.6 | 1.9 | 1.9 | 1.6 | 1.6 | 6.5 | 1.4 | 1.4 | 1.9 | 2.6 | 2.7 | 2.0 | 2.3 | 2.2 |
Intensity Change (Log2) | – | – | – | 0.11 | 0.35 | 0.35 | 0.3 | 0.29 | 0.2 | 0.16 | 0.1 | 0.05 | 0.6 | 0.47 | 0.27 | 0.69 | 0.88 | 0.89 | 0.67 | 0.75 | 0.84 |
Localization | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Cortical Patches | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Bud | 0.4 | -0.6 | -1.1 | -1.6 | -2.0 | -2.1 | -1.3 | -0.1 | 0.2 | -2.4 | -2.6 | -1.7 | 0.4 | -2.8 | -0.3 |
Bud Neck | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Bud Site | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Cell Periphery | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1.2 | 0 | 2.8 | 0 | 0 | 0 | 0 |
Cytoplasm | 3.6 | 0 | 1.8 | 2.4 | 0 | 2.3 | 0 | 0 | 0 | 0 | 2.3 | 2.2 | 0 | 0 | 0 |
Endoplasmic Reticulum | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Endosome | 0 | 1.6 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 3.5 | 2.2 | 0 | 5.4 | 0 | 0 |
Golgi | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 5.2 | 0 | 6.7 | 10.1 | 9.3 |
Mitochondria | -1.2 | -2.4 | -0.7 | -2.5 | -0.9 | -1.5 | -1.2 | 0 | 0.8 | -4.2 | -3.7 | -2.2 | -20.3 | -18.5 | -18.1 |
Nucleus | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Nuclear Periphery | -0.4 | 1.0 | 2.9 | 3.9 | 3.4 | 3.6 | 2.9 | 3.7 | 4.0 | -1.6 | -3.2 | -1.4 | 0 | 0 | 0 |
Nucleolus | -0.4 | 2.0 | 2.9 | 4.1 | 3.3 | 2.9 | 2.9 | 3.1 | 2.8 | 0 | -0.6 | -1.4 | 1.7 | 0 | 0 |
Peroxisomes | -2.5 | -0.9 | -3.1 | -4.0 | -4.0 | -4.9 | -3.1 | -2.9 | -4.8 | 0 | 1.2 | -2.0 | 7.1 | 6.1 | 5.2 |
SpindlePole | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 6.4 | 5.8 | 0 |
Vacuole | -2.6 | -2.3 | -3.2 | -2.4 | -2.0 | -1.5 | -2.6 | -1.1 | -3.0 | 1.5 | 0.4 | 1.1 | 4.9 | 3.6 | 1.8 |
R1 | R2 | R3 | ||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | |
Concentration | 7.2608 | 7.7519 | 6.9814 | 6.7797 | 6.4527 | 7.2195 | 8.4353 | 9.2094 | 8.6326 | 8.1809 | 7.1004 | 8.6207 | 10.4799 | 10.4481 | 10.308 | 9.9381 | 10.086 | 9.873 |
Actin | 0.0172 | 0.0043 | 0.0068 | 0.0005 | 0.0124 | 0.0033 | 0.0161 | 0.0019 | 0.0034 | 0.0018 | 0.0037 | 0.0012 | 0.0183 | 0.0004 | 0.0007 | 0.0071 | 0.001 | 0.0014 |
Bud | 0.0002 | 0.0006 | 0.0001 | 0 | 0.0043 | 0 | 0.0002 | 0.0001 | 0.0004 | 0.0008 | 0.0001 | 0.0001 | 0.0001 | 0 | 0 | 0.0002 | 0.0001 | 0 |
Bud Neck | 0.0003 | 0.0002 | 0.0011 | 0 | 0.0002 | 0 | 0.0001 | 0.0003 | 0.0001 | 0.0001 | 0.0001 | 0 | 0.0002 | 0 | 0 | 0 | 0.0001 | 0 |
Bud Periphery | 0.0006 | 0.0016 | 0.0002 | 0.0001 | 0.0204 | 0.0001 | 0.0003 | 0.0003 | 0.001 | 0.0024 | 0.0002 | 0.0005 | 0.0003 | 0 | 0.0001 | 0.0008 | 0.0003 | 0.0001 |
Bud Site | 0.0005 | 0.0019 | 0.0006 | 0 | 0.0012 | 0.0001 | 0.0005 | 0.0002 | 0.0013 | 0.0003 | 0.0001 | 0.0001 | 0.0003 | 0 | 0.0001 | 0.0001 | 0.0001 | 0 |
Cell Periphery | 0.0002 | 0.0059 | 0.0001 | 0 | 0.0006 | 0 | 0.0002 | 0.0002 | 0.0005 | 0.0001 | 0.0001 | 0.0001 | 0.0002 | 0 | 0 | 0 | 0.0004 | 0 |
Cytoplasm | 0.0099 | 0.0001 | 0.0001 | 0 | 0.0002 | 0 | 0.0007 | 0 | 0.0007 | 0.0001 | 0 | 0 | 0.0001 | 0 | 0 | 0 | 0 | 0.0001 |
Cytoplasmic Foci | 0.0065 | 0.0011 | 0.008 | 0.0001 | 0.0158 | 0.0004 | 0.0065 | 0.0012 | 0.0099 | 0.0029 | 0.0013 | 0.0006 | 0.0043 | 0.0003 | 0.0013 | 0.0005 | 0.0007 | 0.0006 |
Eisosomes | 0.0003 | 0.0007 | 0.0002 | 0.0001 | 0.0003 | 0.0001 | 0.0003 | 0.0001 | 0.0003 | 0.0001 | 0.0002 | 0.0001 | 0.0004 | 0.0001 | 0.0001 | 0.0001 | 0.0002 | 0.0001 |
Endoplasmic Reticulum | 0.002 | 0.0001 | 0.0001 | 0 | 0.0002 | 0.0001 | 0.0003 | 0 | 0.0002 | 0.0002 | 0.0001 | 0.0001 | 0.0001 | 0 | 0 | 0 | 0.0001 | 0.0002 |
Endosome | 0.0078 | 0.0036 | 0.0086 | 0.0002 | 0.003 | 0.0012 | 0.0099 | 0.0042 | 0.0131 | 0.0129 | 0.0056 | 0.0028 | 0.0041 | 0.0013 | 0.0035 | 0.0002 | 0.0023 | 0.0033 |
Golgi | 0.0068 | 0.0083 | 0.008 | 0.0005 | 0.0063 | 0.004 | 0.0098 | 0.0171 | 0.0134 | 0.0078 | 0.017 | 0.0088 | 0.0106 | 0.0019 | 0.0139 | 0.0015 | 0.0148 | 0.0104 |
Lipid Particles | 0.0322 | 0.0063 | 0.0061 | 0.0004 | 0.0145 | 0.0044 | 0.0288 | 0.0128 | 0.0144 | 0.0142 | 0.0112 | 0.0048 | 0.0082 | 0.0006 | 0.0009 | 0.0002 | 0.012 | 0.0082 |
Mitochondria | 0.8818 | 0.9456 | 0.9442 | 0.9956 | 0.8535 | 0.9802 | 0.8811 | 0.9459 | 0.9221 | 0.9491 | 0.9533 | 0.9711 | 0.9419 | 0.9893 | 0.976 | 0.9834 | 0.9405 | 0.9667 |
None | 0.0009 | 0.0001 | 0.0001 | 0 | 0.0002 | 0 | 0.0018 | 0 | 0.0005 | 0.0001 | 0 | 0.0001 | 0.0002 | 0 | 0 | 0 | 0.0001 | 0.0002 |
Nuclear Periphery | 0.0018 | 0 | 0.0001 | 0 | 0.0002 | 0.0002 | 0.0023 | 0 | 0.0002 | 0.0001 | 0.0001 | 0.0015 | 0.0001 | 0 | 0 | 0 | 0.0008 | 0.0011 |
Nucleolus | 0.0002 | 0.0004 | 0.0003 | 0 | 0.0002 | 0 | 0.0012 | 0.0003 | 0.0009 | 0.0001 | 0.0001 | 0.0002 | 0.0005 | 0 | 0 | 0 | 0.005 | 0.0001 |
Nucleus | 0.0005 | 0.0002 | 0.0001 | 0 | 0.0003 | 0 | 0.0052 | 0.0001 | 0.0004 | 0.0001 | 0 | 0.0007 | 0.0002 | 0 | 0 | 0 | 0.0014 | 0.0001 |
Peroxisomes | 0.0208 | 0.0099 | 0.0102 | 0.0016 | 0.0557 | 0.0023 | 0.0227 | 0.0067 | 0.0081 | 0.0032 | 0.0043 | 0.0025 | 0.0037 | 0.0051 | 0.0019 | 0.0059 | 0.001 | 0.0048 |
Punctate Nuclear | 0.0017 | 0 | 0.0004 | 0 | 0.0005 | 0.0002 | 0.0019 | 0 | 0.0037 | 0.0001 | 0 | 0.0002 | 0.0021 | 0 | 0 | 0 | 0 | 0.0003 |
Vacuole | 0.0021 | 0.0062 | 0.0017 | 0.0001 | 0.0049 | 0.0002 | 0.0043 | 0.0045 | 0.0024 | 0.0009 | 0.0005 | 0.0013 | 0.0013 | 0.0002 | 0.0003 | 0 | 0.0036 | 0.0004 |
Vacuole Periphery | 0.0058 | 0.0029 | 0.0031 | 0.0006 | 0.0053 | 0.0031 | 0.006 | 0.004 | 0.003 | 0.0025 | 0.0021 | 0.0033 | 0.0028 | 0.0006 | 0.0012 | 0.0001 | 0.0155 | 0.002 |
R1 | R2 | |||||||||
---|---|---|---|---|---|---|---|---|---|---|
G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | |
Gene Expression | 19.1331 | 17.602 | 18.9761 | 27.1693 | 17.3408 | 29.7049 | 31.9849 | 33.7696 | 32.0016 | 27.5733 |
Translational Efficiency | 1.0345 | 0.9221 | 0.927 | 0.6688 | 0.705 | 0.826 | 0.7607 | 0.6814 | 0.7949 | 0.7863 |
Dataset | Hit |
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Protein Concentration | ✘ |
Protein Localization | ✘ |
Gene Expression | ✘ |
Translational Efficiency | ✘ |
Temp | Actin Patch (Sac6-tdTomato) | Cortical Patch (Sla1-GFP) | Late Endosome (Snf7-GFP) | Vacuole (Vph1-GFP) |
---|---|---|---|---|
37℃ | ||||
RT |
Gene / Allele | Actin Patch (Sac6-tdTomato) | Cortical Patch (Sla1-GFP) | Late Endosome (Snf7-GFP) | Vacuole (Sac6-tdTomato) |
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Gene | Images |
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Gene | Images |
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