Standard name | |
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Human Ortholog | |
Description | Myosin-like protein associated with the nuclear envelope; nuclear basket protein that connects the nuclear pore complex with the nuclear interior; involved in the Tel1p pathway that controls telomere length; MLP2 has a paralog, MLP1, that arose from the whole genome duplication |
ensLOC | DeepLoc | |||||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Localization | WT1 | WT2 | WT3 | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 | WT1 | WT2 | WT3 | AF100 | AF140 | AF180 |
Cortical Patches | 0 | – | 0 | 0 | 0 | 0 | – | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 3 | 6 |
Bud | 0 | – | 2 | 2 | 2 | 1 | – | 15 | 9 | 17 | 11 | 19 | 1 | 0 | 2 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 6 | 5 |
Bud Neck | 0 | – | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 0 |
Bud Site | 0 | – | 0 | 1 | 4 | 4 | – | 9 | 14 | 15 | 12 | 39 | 1 | 0 | 2 | 0 | 0 | 0 | – | – | – | – | – | – |
Cell Periphery | 0 | – | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Cytoplasm | 3 | – | 3 | 11 | 18 | 16 | – | 19 | 11 | 17 | 11 | 16 | 14 | 76 | 109 | 16 | 16 | 21 | 0 | 0 | 0 | 1 | 2 | 1 |
Endoplasmic Reticulum | 1 | – | 2 | 3 | 0 | 1 | – | 0 | 0 | 0 | 0 | 2 | 1 | 1 | 0 | 4 | 4 | 5 | 0 | 0 | 0 | 0 | 0 | 1 |
Endosome | 4 | – | 0 | 12 | 50 | 9 | – | 22 | 5 | 11 | 4 | 8 | 22 | 96 | 124 | 55 | 25 | 39 | 25 | 5 | 17 | 10 | 98 | 127 |
Golgi | 0 | – | 0 | 1 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 2 | 1 | 0 | 0 | 0 | 3 | 12 |
Mitochondria | 89 | – | 112 | 315 | 300 | 339 | – | 500 | 482 | 531 | 559 | 659 | 84 | 137 | 119 | 14 | 19 | 21 | 8 | 2 | 9 | 5 | 28 | 45 |
Nucleus | 8 | – | 22 | 15 | 37 | 21 | – | 57 | 55 | 59 | 62 | 57 | 32 | 14 | 13 | 3 | 3 | 3 | 6 | 1 | 8 | 2 | 9 | 14 |
Nuclear Periphery | 71 | – | 31 | 160 | 161 | 147 | – | 153 | 146 | 130 | 139 | 153 | 167 | 297 | 324 | 61 | 30 | 41 | 115 | 6 | 75 | 42 | 206 | 245 |
Nucleolus | 32 | – | 4 | 90 | 59 | 56 | – | 110 | 97 | 110 | 123 | 147 | 31 | 93 | 117 | 46 | 20 | 45 | 4 | 0 | 7 | 6 | 21 | 11 |
Peroxisomes | 0 | – | 0 | 2 | 12 | 3 | – | 10 | 1 | 6 | 3 | 5 | 1 | 7 | 17 | 2 | 4 | 6 | 0 | 0 | 1 | 2 | 8 | 14 |
SpindlePole | 2 | – | 2 | 8 | 15 | 3 | – | 28 | 18 | 24 | 16 | 21 | 4 | 8 | 26 | 11 | 12 | 19 | 6 | 1 | 7 | 3 | 26 | 30 |
Vac/Vac Membrane | 22 | – | 8 | 14 | 40 | 16 | – | 22 | 18 | 5 | 21 | 15 | 84 | 80 | 132 | 55 | 28 | 34 | 5 | 0 | 6 | 3 | 12 | 21 |
Unique Cell Count | 146 | 134 | 385 | 479 | 418 | 681 | 573 | 663 | 657 | 766 | 325 | 582 | 688 | 176 | 115 | 160 | 180 | 20 | 139 | 81 | 439 | 546 | ||
Labelled Cell Count | 232 | 186 | 634 | 698 | 616 | 945 | 857 | 925 | 961 | 1141 | 442 | 809 | 985 | 267 | 162 | 236 | 180 | 20 | 139 | 81 | 439 | 546 |
Screen | WT1 | WT2 | WT3 | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 | AF100 | AF140 | AF180 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Mean Cell GFP Intensity (1e-4) | 5.6 | – | 3.9 | 4.5 | 5.0 | 4.1 | – | 4.2 | 3.6 | 3.8 | 3.8 | 3.6 | 6.6 | 6.7 | 6.4 | 9.1 | 9.7 | 9.2 | 5.6 | 6.5 | 6.8 |
Std Deviation (1e-4) | 0.7 | – | 0.7 | 1.0 | 1.1 | 1.1 | – | 0.9 | 0.9 | 0.6 | 0.8 | 0.8 | 1.2 | 1.3 | 1.4 | 1.8 | 1.9 | 1.9 | 0.8 | 1.2 | 1.1 |
Intensity Change (Log2) | – | – | – | 0.22 | 0.36 | 0.1 | – | 0.12 | -0.1 | -0.02 | -0.03 | -0.09 | 0.78 | 0.79 | 0.73 | 1.23 | 1.33 | 1.25 | 0.52 | 0.75 | 0.82 |
Localization | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Cortical Patches | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Bud | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Bud Neck | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Bud Site | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Cell Periphery | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Cytoplasm | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 3.6 | 4.2 | 2.5 | 3.5 | 3.4 |
Endoplasmic Reticulum | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Endosome | 0 | 3.9 | 0 | – | 0 | 0 | 0 | 0 | 0 | 3.1 | 5.1 | 5.3 | 7.1 | 5.7 | 6.1 |
Golgi | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Mitochondria | 0 | -4.6 | 0 | – | 0 | 0 | 0 | 0 | 0 | -11.4 | -13.2 | -15.6 | -13.4 | -10.6 | -12.1 |
Nucleus | -4.9 | -3.0 | -4.3 | – | -2.9 | -2.3 | -2.6 | -2.4 | -3.4 | -2.0 | -6.7 | -7.6 | -4.7 | -3.6 | -4.5 |
Nuclear Periphery | 0 | 2.3 | 0 | – | 0 | 0 | 0 | 0 | 0 | 5.6 | 5.8 | 5.1 | 2.2 | 0.5 | 0.5 |
Nucleolus | 0 | 3.1 | 0 | – | 0 | 0 | 0 | 0 | 0 | 2.4 | 4.0 | 4.2 | 5.5 | 3.8 | 5.8 |
Peroxisomes | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
SpindlePole | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 2.1 | 3.1 | 3.4 |
Vacuole | -1.2 | 0.9 | -1.1 | – | 0 | 0 | 0 | 0 | 0 | 4.8 | 2.5 | 3.7 | 5.5 | 4.1 | 3.7 |
R1 | R2 | R3 | ||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | |
Concentration | 2.8756 | 2.7998 | 2.6313 | 2.5894 | 2.0412 | 2.5856 | 2.0895 | 2.5593 | 2.0834 | 1.7833 | 1.9549 | 2.1395 | 3.7904 | 4.7968 | 4.0961 | 4.0822 | 4.0827 | 4.3192 |
Actin | 0.0052 | 0.0007 | 0.0119 | 0.0041 | 0.0238 | 0.0007 | 0.0135 | 0.0006 | 0.0025 | 0.0099 | 0.0017 | 0.0018 | 0.0201 | 0.0016 | 0.0014 | 0.01 | 0.0023 | 0.0013 |
Bud | 0.0001 | 0 | 0.0002 | 0.0001 | 0.0001 | 0 | 0.0002 | 0 | 0.0001 | 0.0019 | 0.0001 | 0.0001 | 0.0001 | 0.0001 | 0 | 0.0005 | 0 | 0 |
Bud Neck | 0.0002 | 0.0001 | 0.0002 | 0.0002 | 0.0003 | 0.0001 | 0.0002 | 0.0001 | 0.0003 | 0.0006 | 0.0005 | 0.0004 | 0.0003 | 0.0002 | 0.0001 | 0.0006 | 0.0003 | 0.0002 |
Bud Periphery | 0.0002 | 0.0001 | 0.0003 | 0.0005 | 0.0001 | 0.0001 | 0.0003 | 0.0001 | 0.0003 | 0.0021 | 0.0004 | 0.0002 | 0.0003 | 0.0003 | 0.0002 | 0.0022 | 0.0002 | 0.0002 |
Bud Site | 0.0003 | 0.0001 | 0.0003 | 0.0001 | 0.0002 | 0 | 0.0008 | 0.0001 | 0.0006 | 0.0024 | 0.0004 | 0.0002 | 0.0006 | 0.0003 | 0.0001 | 0.0009 | 0 | 0 |
Cell Periphery | 0.0001 | 0 | 0.0001 | 0.0001 | 0 | 0 | 0.0001 | 0 | 0.0001 | 0.0002 | 0.0002 | 0 | 0.0001 | 0.0001 | 0.0001 | 0.0002 | 0.0001 | 0.0001 |
Cytoplasm | 0.0064 | 0.0003 | 0.0026 | 0.0002 | 0.0009 | 0.0001 | 0.0101 | 0.0002 | 0.0015 | 0.0071 | 0.0036 | 0.0005 | 0.0015 | 0.0005 | 0.0002 | 0.0005 | 0.0001 | 0.0001 |
Cytoplasmic Foci | 0.0064 | 0.0007 | 0.0042 | 0.0018 | 0.002 | 0.0005 | 0.0057 | 0.0008 | 0.0047 | 0.022 | 0.0099 | 0.0012 | 0.0046 | 0.0012 | 0.001 | 0.0034 | 0.0022 | 0.0007 |
Eisosomes | 0.0001 | 0 | 0.0001 | 0.0002 | 0.0001 | 0 | 0.0002 | 0 | 0.0001 | 0.0001 | 0.0001 | 0 | 0.0002 | 0.0001 | 0.0001 | 0.0004 | 0.0001 | 0.0001 |
Endoplasmic Reticulum | 0.0024 | 0.0011 | 0.002 | 0.0013 | 0.0008 | 0.0006 | 0.0029 | 0.0008 | 0.0016 | 0.0053 | 0.002 | 0.001 | 0.0016 | 0.001 | 0.001 | 0.0026 | 0.0011 | 0.0015 |
Endosome | 0.0141 | 0.0017 | 0.0087 | 0.0027 | 0.0077 | 0.003 | 0.0176 | 0.0012 | 0.0164 | 0.0282 | 0.0451 | 0.0065 | 0.0071 | 0.0022 | 0.0012 | 0.004 | 0.0033 | 0.0017 |
Golgi | 0.0048 | 0.0011 | 0.0035 | 0.0023 | 0.0022 | 0.0021 | 0.0065 | 0.0006 | 0.0031 | 0.0182 | 0.0162 | 0.0024 | 0.0026 | 0.0015 | 0.0011 | 0.0039 | 0.0045 | 0.0013 |
Lipid Particles | 0.0582 | 0.0264 | 0.0342 | 0.0295 | 0.0383 | 0.0255 | 0.0293 | 0.0146 | 0.0202 | 0.0191 | 0.0528 | 0.017 | 0.0208 | 0.0225 | 0.0154 | 0.0407 | 0.1139 | 0.0309 |
Mitochondria | 0.0051 | 0.0011 | 0.0024 | 0.004 | 0.0017 | 0.0021 | 0.0034 | 0.0008 | 0.0071 | 0.0165 | 0.0035 | 0.0037 | 0.0015 | 0.0017 | 0.0021 | 0.0043 | 0.0014 | 0.0043 |
None | 0.0034 | 0.0004 | 0.0059 | 0.0015 | 0.002 | 0.0003 | 0.0062 | 0.0003 | 0.0019 | 0.0015 | 0.001 | 0.0004 | 0.0027 | 0.0009 | 0.0007 | 0.0027 | 0.0007 | 0.0005 |
Nuclear Periphery | 0.8349 | 0.882 | 0.8272 | 0.86 | 0.8766 | 0.9221 | 0.8117 | 0.83 | 0.8009 | 0.6338 | 0.7057 | 0.8953 | 0.8612 | 0.7877 | 0.8682 | 0.7813 | 0.7102 | 0.8863 |
Nucleolus | 0.005 | 0.0076 | 0.0153 | 0.0069 | 0.0046 | 0.007 | 0.0103 | 0.0357 | 0.0184 | 0.0621 | 0.07 | 0.0172 | 0.0106 | 0.0334 | 0.0184 | 0.0432 | 0.0731 | 0.0077 |
Nucleus | 0.0108 | 0.0214 | 0.0233 | 0.0085 | 0.0085 | 0.009 | 0.0393 | 0.0651 | 0.0649 | 0.0677 | 0.043 | 0.0232 | 0.0153 | 0.0832 | 0.0324 | 0.0242 | 0.0104 | 0.0177 |
Peroxisomes | 0.0021 | 0.0003 | 0.0011 | 0.0011 | 0.0038 | 0.0003 | 0.0012 | 0.0002 | 0.001 | 0.0203 | 0.0013 | 0.0005 | 0.0015 | 0.0007 | 0.0005 | 0.0033 | 0.0009 | 0.0005 |
Punctate Nuclear | 0.0276 | 0.0386 | 0.0405 | 0.0581 | 0.0152 | 0.0175 | 0.0245 | 0.0307 | 0.0374 | 0.0638 | 0.0289 | 0.0187 | 0.0356 | 0.0437 | 0.0374 | 0.051 | 0.0648 | 0.0329 |
Vacuole | 0.0011 | 0.0006 | 0.0014 | 0.0006 | 0.0009 | 0.0008 | 0.0017 | 0.0009 | 0.0021 | 0.0055 | 0.0027 | 0.0006 | 0.0007 | 0.001 | 0.0006 | 0.001 | 0.0008 | 0.0007 |
Vacuole Periphery | 0.0116 | 0.0155 | 0.0145 | 0.0163 | 0.0099 | 0.0083 | 0.0145 | 0.0171 | 0.0149 | 0.0117 | 0.0109 | 0.009 | 0.011 | 0.0161 | 0.0179 | 0.0193 | 0.0099 | 0.0114 |
R1 | R2 | |||||||||
---|---|---|---|---|---|---|---|---|---|---|
G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | |
Gene Expression | 17.5144 | 16.0482 | 19.1697 | 24.9795 | 18.7342 | 23.1937 | 24.4879 | 25.4426 | 23.5639 | 27.3875 |
Translational Efficiency | 0.6158 | 0.6857 | 0.5528 | 0.4184 | 0.4567 | 0.3958 | 0.3797 | 0.3608 | 0.4256 | 0.3505 |
Dataset | Hit |
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Protein Concentration | ✘ |
Protein Localization | ✘ |
Gene Expression | ✘ |
Translational Efficiency | ✘ |
Temp | Actin Patch (Sac6-tdTomato) | Cortical Patch (Sla1-GFP) | Late Endosome (Snf7-GFP) | Vacuole (Vph1-GFP) |
---|---|---|---|---|
37℃ | ||||
RT |
Gene / Allele | Actin Patch (Sac6-tdTomato) | Cortical Patch (Sla1-GFP) | Late Endosome (Snf7-GFP) | Vacuole (Sac6-tdTomato) |
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Gene | Images |
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Gene | Images |
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