Standard name | |
---|---|
Human Ortholog | |
Description | ER-membrane protein; subunit of evolutionarily conserved EMC (Endoplasmic Reticulum Membrane Complex) implicated in ERAD (ER-associated degradation) and proper assembly of multi-pass transmembrane (TM) proteins; EMC acts in yeast as an ER-mitochondria tether that interacts with outer membrane protein Tom5 of TOM (Translocase of the Mitochondrial Outer Membrane) complex; suppressor of pma1-7, deletion of SOP4 slows down export of wild-type Pma1p and Pma1-7 from the ER |
ensLOC | DeepLoc | |||||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Localization | WT1 | WT2 | WT3 | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 | WT1 | WT2 | WT3 | AF100 | AF140 | AF180 |
Cortical Patches | 7 | 15 | 54 | 50 | 27 | 57 | 29 | 37 | 49 | 43 | 47 | 47 | 31 | 54 | 31 | 21 | 36 | 35 | 3 | 2 | 12 | 13 | 11 | 15 |
Bud | 2 | 1 | 1 | 2 | 3 | 11 | 4 | 12 | 9 | 15 | 6 | 16 | 3 | 0 | 0 | 3 | 3 | 3 | 0 | 0 | 0 | 0 | 1 | 3 |
Bud Neck | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Bud Site | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | – | – | – | – | – | – |
Cell Periphery | 6 | 8 | 42 | 32 | 21 | 32 | 24 | 25 | 46 | 41 | 56 | 41 | 89 | 115 | 158 | 51 | 56 | 52 | 0 | 0 | 5 | 5 | 6 | 17 |
Cytoplasm | 14 | 9 | 29 | 25 | 30 | 59 | 54 | 55 | 55 | 54 | 57 | 42 | 20 | 34 | 45 | 33 | 29 | 30 | 5 | 3 | 2 | 3 | 4 | 4 |
Endoplasmic Reticulum | 234 | 239 | 445 | 261 | 275 | 368 | 302 | 426 | 306 | 220 | 312 | 289 | 570 | 524 | 505 | 1 | 7 | 3 | 254 | 252 | 485 | 317 | 390 | 521 |
Endosome | 0 | 0 | 0 | 2 | 2 | 1 | 0 | 0 | 1 | 3 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 1 | 2 |
Golgi | 4 | 4 | 40 | 51 | 17 | 3 | 0 | 3 | 2 | 1 | 0 | 2 | 30 | 38 | 41 | 69 | 58 | 57 | 2 | 0 | 3 | 7 | 9 | 7 |
Mitochondria | 2 | 1 | 60 | 40 | 54 | 171 | 122 | 145 | 213 | 221 | 221 | 239 | 1 | 0 | 1 | 12 | 13 | 25 | 2 | 1 | 4 | 12 | 10 | 8 |
Nucleus | 2 | 1 | 1 | 0 | 0 | 2 | 0 | 2 | 2 | 5 | 0 | 3 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Nuclear Periphery | 8 | 2 | 24 | 6 | 10 | 21 | 18 | 46 | 28 | 33 | 38 | 30 | 13 | 8 | 14 | 6 | 9 | 8 | 1 | 0 | 3 | 0 | 2 | 2 |
Nucleolus | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 2 | 0 | 2 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Peroxisomes | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
SpindlePole | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Vac/Vac Membrane | 23 | 11 | 13 | 11 | 34 | 76 | 56 | 126 | 71 | 109 | 28 | 45 | 8 | 35 | 91 | 23 | 22 | 22 | 3 | 3 | 1 | 4 | 8 | 9 |
Unique Cell Count | 258 | 255 | 506 | 337 | 363 | 585 | 492 | 703 | 564 | 560 | 539 | 549 | 623 | 632 | 711 | 188 | 192 | 188 | 275 | 267 | 525 | 370 | 451 | 597 |
Labelled Cell Count | 302 | 291 | 709 | 480 | 474 | 802 | 610 | 881 | 782 | 747 | 765 | 757 | 765 | 809 | 886 | 220 | 233 | 235 | 275 | 267 | 525 | 370 | 451 | 597 |
Screen | WT1 | WT2 | WT3 | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 | AF100 | AF140 | AF180 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Mean Cell GFP Intensity (1e-4) | 18.2 | 21.1 | 13.8 | 13.4 | 11.5 | 10.3 | 9.5 | 9.7 | 9.4 | 8.5 | 8.9 | 8.8 | 19.6 | 18.9 | 19.0 | 21.1 | 21.8 | 22.2 | 20.8 | 20.8 | 21.7 |
Std Deviation (1e-4) | 3.9 | 3.9 | 2.5 | 2.4 | 1.9 | 1.7 | 1.7 | 1.8 | 1.8 | 2.1 | 1.8 | 1.8 | 3.7 | 3.6 | 3.3 | 4.8 | 4.8 | 5.0 | 4.1 | 5.8 | 4.5 |
Intensity Change (Log2) | – | – | – | -0.04 | -0.27 | -0.42 | -0.54 | -0.51 | -0.55 | -0.7 | -0.63 | -0.64 | 0.51 | 0.46 | 0.46 | 0.62 | 0.66 | 0.69 | 0.59 | 0.6 | 0.66 |
Localization | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Cortical Patches | 1.8 | -1.6 | -0.5 | -2.7 | -3.5 | -1.1 | -1.7 | -1.1 | -1.2 | -3.6 | -1.2 | -4.3 | 0.2 | 2.8 | 2.8 |
Bud | 0 | 0 | 2.7 | 0 | 2.5 | 0 | 3.3 | 0 | 3.5 | 0 | 0 | 0 | 0 | 0 | 0 |
Bud Neck | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Bud Site | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Cell Periphery | 0.6 | -1.4 | -1.9 | -2.2 | -3.6 | -0.1 | -0.6 | 1.2 | -0.5 | 3.1 | 4.8 | 6.5 | 6.5 | 7.1 | 6.6 |
Cytoplasm | 1.0 | 1.5 | 2.6 | 3.0 | 1.4 | 2.4 | 2.4 | 2.8 | 1.2 | -2.1 | -0.3 | 0.4 | 4.9 | 4.0 | 4.3 |
Endoplasmic Reticulum | -4.0 | -4.7 | -9.5 | -9.7 | -10.5 | -12.0 | -16.4 | -10.9 | -12.5 | 2.0 | -2.4 | -7.0 | -21.4 | -20.8 | -21.1 |
Endosome | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Golgi | 3.3 | -1.9 | -6.3 | -6.4 | -6.9 | -6.3 | -6.6 | -6.7 | -6.3 | -2.1 | -1.3 | -1.5 | 9.3 | 7.6 | 7.6 |
Mitochondria | 0 | 1.3 | 7.0 | 5.3 | 4.0 | 9.7 | 10.2 | 10.6 | 11.4 | -8.6 | -8.9 | -9.2 | -2.1 | -2.0 | 0.5 |
Nucleus | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Nuclear Periphery | -2.3 | -1.5 | -1.0 | -0.9 | 1.3 | 0.2 | 0.8 | 1.6 | 0.5 | -2.5 | -3.5 | -2.7 | -0.9 | 0 | -0.3 |
Nucleolus | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Peroxisomes | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
SpindlePole | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Vacuole | 0.6 | 4.4 | 6.3 | 5.5 | 8.3 | 6.1 | 8.7 | 2.2 | 4.0 | -1.6 | 2.5 | 6.3 | 5.1 | 4.8 | 4.9 |
R1 | R2 | R3 | ||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | |
Concentration | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
Actin | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
Bud | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
Bud Neck | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
Bud Periphery | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
Bud Site | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
Cell Periphery | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
Cytoplasm | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
Cytoplasmic Foci | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
Eisosomes | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
Endoplasmic Reticulum | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
Endosome | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
Golgi | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
Lipid Particles | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
Mitochondria | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
None | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
Nuclear Periphery | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
Nucleolus | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
Nucleus | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
Peroxisomes | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
Punctate Nuclear | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
Vacuole | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
Vacuole Periphery | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
R1 | R2 | |||||||||
---|---|---|---|---|---|---|---|---|---|---|
G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | |
Gene Expression | 108.7753 | 82.5478 | 89.2855 | 108.06 | 89.2864 | 68.8268 | 88.4152 | 84.9762 | 76.7524 | 102.5137 |
Translational Efficiency | 1.0511 | 0.9662 | 0.966 | 0.7889 | 1.081 | 1.65 | 1.0274 | 1.1494 | 1.1625 | 0.9644 |
Dataset | Hit |
---|---|
Protein Concentration | – |
Protein Localization | – |
Gene Expression | ✘ |
Translational Efficiency | ✘ |
Temp | Actin Patch (Sac6-tdTomato) | Cortical Patch (Sla1-GFP) | Late Endosome (Snf7-GFP) | Vacuole (Vph1-GFP) |
---|---|---|---|---|
37℃ | ||||
RT |
Gene / Allele | Actin Patch (Sac6-tdTomato) | Cortical Patch (Sla1-GFP) | Late Endosome (Snf7-GFP) | Vacuole (Sac6-tdTomato) |
---|
Gene | Images |
---|
Gene | Images |
---|