Standard name | |
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Human Ortholog | |
Description | Aspartic protease; hyperglycosylated member of the yapsin family of proteases, attached to the plasma membrane via a glycosylphosphatidylinositol (GPI) anchor; involved in nutrient limitation-induced cleavage of the extracellular inhibitory domain of signaling mucin Msb2p, resulting in activation of the filamentous growth MAPK pathway; involved with other yapsins in the cell wall integrity response; role in KEX2-independent processing of the alpha factor precursor |
ensLOC | DeepLoc | |||||||||||||||||||||||
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Localization | WT1 | WT2 | WT3 | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 | WT1 | WT2 | WT3 | AF100 | AF140 | AF180 |
Cortical Patches | 1 | 3 | 4 | 5 | 11 | 15 | 20 | – | 4 | 6 | 6 | 7 | 0 | 0 | 0 | 0 | 3 | 3 | 10 | 11 | 9 | 1 | 2 | 5 |
Bud | 1 | 2 | 0 | 5 | 4 | 5 | 7 | – | 9 | 9 | 5 | 4 | 0 | 0 | 0 | 0 | 1 | 2 | 5 | 3 | 2 | 1 | 4 | 5 |
Bud Neck | 0 | 0 | 10 | 1 | 0 | 0 | 0 | – | 0 | 3 | 1 | 2 | 0 | 0 | 0 | 0 | 1 | 1 | 6 | 6 | 10 | 1 | 0 | 1 |
Bud Site | 0 | 0 | 0 | 0 | 0 | 0 | 0 | – | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | – | – | – | – | – | – |
Cell Periphery | 4 | 4 | 26 | 8 | 13 | 22 | 22 | – | 11 | 10 | 9 | 13 | 2 | 15 | 10 | 10 | 12 | 19 | 7 | 3 | 8 | 0 | 2 | 3 |
Cytoplasm | 285 | 206 | 249 | 274 | 303 | 320 | 372 | – | 239 | 263 | 210 | 244 | 18 | 102 | 152 | 75 | 83 | 94 | 146 | 116 | 127 | 15 | 6 | 20 |
Endoplasmic Reticulum | 26 | 35 | 9 | 20 | 32 | 70 | 127 | – | 12 | 29 | 42 | 41 | 8 | 48 | 11 | 3 | 4 | 6 | 128 | 107 | 69 | 16 | 54 | 63 |
Endosome | 0 | 3 | 1 | 0 | 2 | 2 | 5 | – | 0 | 3 | 0 | 1 | 0 | 1 | 1 | 1 | 1 | 1 | 2 | 2 | 3 | 1 | 0 | 0 |
Golgi | 1 | 2 | 0 | 0 | 0 | 0 | 1 | – | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 0 |
Mitochondria | 9 | 3 | 0 | 2 | 3 | 27 | 27 | – | 34 | 30 | 79 | 37 | 0 | 0 | 0 | 1 | 0 | 1 | 37 | 18 | 53 | 4 | 1 | 4 |
Nucleus | 1 | 1 | 0 | 3 | 3 | 4 | 6 | – | 3 | 3 | 3 | 4 | 2 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
Nuclear Periphery | 0 | 0 | 0 | 0 | 0 | 0 | 1 | – | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 |
Nucleolus | 0 | 0 | 0 | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Peroxisomes | 1 | 0 | 0 | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 |
SpindlePole | 3 | 0 | 0 | 0 | 3 | 0 | 1 | – | 2 | 0 | 1 | 3 | 0 | 1 | 0 | 0 | 0 | 1 | 2 | 0 | 1 | 0 | 1 | 0 |
Vac/Vac Membrane | 5 | 9 | 5 | 6 | 34 | 35 | 27 | – | 14 | 21 | 6 | 13 | 0 | 0 | 8 | 3 | 2 | 4 | 18 | 12 | 17 | 2 | 2 | 9 |
Unique Cell Count | 327 | 252 | 271 | 304 | 373 | 451 | 553 | 301 | 342 | 332 | 334 | 25 | 149 | 169 | 84 | 92 | 115 | 375 | 292 | 310 | 50 | 78 | 118 | |
Labelled Cell Count | 337 | 268 | 304 | 324 | 408 | 500 | 616 | 328 | 378 | 363 | 369 | 30 | 169 | 182 | 93 | 107 | 134 | 375 | 292 | 310 | 50 | 78 | 118 |
Screen | WT1 | WT2 | WT3 | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 | AF100 | AF140 | AF180 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Mean Cell GFP Intensity (1e-4) | 4.4 | 5.7 | 6.1 | 6.1 | 7.1 | 6.0 | 6.1 | – | 5.4 | 5.4 | 4.6 | 5.1 | 8.0 | 7.6 | 7.0 | 8.3 | 8.4 | 8.1 | – | 10.0 | 10.7 |
Std Deviation (1e-4) | 0.8 | 1.0 | 0.9 | 1.6 | 1.8 | 1.2 | 1.1 | – | 1.4 | 1.0 | 0.8 | 1.0 | 1.9 | 1.4 | 1.6 | 2.0 | 2.6 | 2.4 | – | 3.0 | 2.7 |
Intensity Change (Log2) | – | – | – | 0.02 | 0.23 | -0.0 | 0.01 | – | -0.18 | -0.18 | -0.39 | -0.25 | 0.39 | 0.33 | 0.2 | 0.45 | 0.47 | 0.42 | – | 0.72 | 0.82 |
Localization | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Cortical Patches | 0 | 1.2 | 1.5 | 1.7 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Bud | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Bud Neck | -2.9 | 0 | 0 | 0 | – | 0 | -2.4 | 0 | -2.7 | 0 | 0 | 0 | 0 | 0 | 0 |
Bud Site | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Cell Periphery | -3.5 | -3.2 | -2.5 | -3.2 | – | -2.9 | -3.5 | 0 | -2.8 | 0 | 0.2 | -1.4 | 0.6 | 0.9 | 1.9 |
Cytoplasm | -0.7 | -3.8 | -6.7 | -7.7 | – | -4.2 | -5.0 | -8.2 | -5.9 | -3.2 | -6.2 | -0.7 | -0.7 | -0.5 | -2.9 |
Endoplasmic Reticulum | 1.8 | 2.7 | 5.1 | 7.1 | – | 0.4 | 2.6 | 0 | 4.0 | 0 | 8.3 | 1.6 | 0 | 0 | 0 |
Endosome | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Golgi | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Mitochondria | 0 | 0 | 4.1 | 3.7 | – | 5.7 | 5.0 | 0 | 5.7 | 0 | 0 | 0 | 0 | 0 | 0 |
Nucleus | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Nuclear Periphery | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Nucleolus | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Peroxisomes | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
SpindlePole | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Vacuole | 0.1 | 3.8 | 3.4 | 2.1 | – | 1.9 | 2.6 | 0 | 1.5 | 0 | 0 | 0 | 0 | 0 | 0 |
R1 | R2 | R3 | ||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | |
Concentration | 1.2053 | 2.1984 | 1.8673 | 1.413 | 1.3432 | 1.7874 | 1.328 | 1.9047 | 2.177 | 1.6283 | 1.2501 | 1.6439 | 1.2258 | 2.0871 | 2.4209 | 1.4743 | 1.5451 | 1.7103 |
Actin | 0.0075 | 0.0064 | 0.0028 | 0.0033 | 0.0005 | 0.0022 | 0.1005 | 0.0009 | 0.0333 | 0.0901 | 0.0005 | 0.0132 | 0.0094 | 0.0016 | 0.026 | 0.0253 | 0.0501 | 0.0254 |
Bud | 0.0004 | 0.0009 | 0.0003 | 0.0005 | 0.0001 | 0.0001 | 0.0013 | 0.0012 | 0.0003 | 0.0006 | 0.0001 | 0.0017 | 0.0007 | 0.001 | 0.0042 | 0.0019 | 0.0007 | 0.002 |
Bud Neck | 0.0049 | 0.0007 | 0.0011 | 0.0019 | 0.0007 | 0.0013 | 0.0026 | 0.0003 | 0.0022 | 0.0102 | 0.0005 | 0.0117 | 0.0018 | 0.001 | 0.0018 | 0.0014 | 0.0016 | 0.0023 |
Bud Periphery | 0.0006 | 0.0012 | 0.0005 | 0.0009 | 0.0002 | 0.0003 | 0.0031 | 0.0059 | 0.0007 | 0.0013 | 0.0003 | 0.004 | 0.0015 | 0.0021 | 0.004 | 0.0025 | 0.0012 | 0.0043 |
Bud Site | 0.007 | 0.0165 | 0.0038 | 0.001 | 0.0008 | 0.0002 | 0.0148 | 0.0053 | 0.0013 | 0.0067 | 0.0002 | 0.002 | 0.0033 | 0.0235 | 0.0152 | 0.0047 | 0.0044 | 0.0011 |
Cell Periphery | 0.0009 | 0.0033 | 0.0014 | 0.001 | 0.0002 | 0.0005 | 0.0023 | 0.0044 | 0.0023 | 0.0033 | 0.0008 | 0.0024 | 0.0017 | 0.0033 | 0.0014 | 0.0017 | 0.0004 | 0.0006 |
Cytoplasm | 0.3173 | 0.4665 | 0.4388 | 0.3597 | 0.4913 | 0.5277 | 0.3099 | 0.4339 | 0.4223 | 0.3983 | 0.4687 | 0.4849 | 0.3931 | 0.5311 | 0.4015 | 0.4921 | 0.5397 | 0.5221 |
Cytoplasmic Foci | 0.0391 | 0.0251 | 0.0296 | 0.0139 | 0.017 | 0.0192 | 0.0364 | 0.0098 | 0.0101 | 0.0126 | 0.0093 | 0.0132 | 0.021 | 0.0073 | 0.0243 | 0.0154 | 0.025 | 0.017 |
Eisosomes | 0.0004 | 0.0002 | 0.0002 | 0.0001 | 0 | 0.0002 | 0.0009 | 0.0002 | 0.0004 | 0.0017 | 0.0001 | 0.0006 | 0.0003 | 0.0001 | 0.0002 | 0.0006 | 0.0002 | 0.0001 |
Endoplasmic Reticulum | 0.2248 | 0.2176 | 0.2271 | 0.2125 | 0.2265 | 0.1691 | 0.1372 | 0.2052 | 0.2294 | 0.1442 | 0.1439 | 0.1009 | 0.2475 | 0.2216 | 0.2102 | 0.1929 | 0.1342 | 0.2119 |
Endosome | 0.046 | 0.0238 | 0.0474 | 0.0612 | 0.0671 | 0.0267 | 0.015 | 0.015 | 0.0218 | 0.0252 | 0.0567 | 0.0076 | 0.02 | 0.0066 | 0.0357 | 0.0346 | 0.0656 | 0.014 |
Golgi | 0.009 | 0.0046 | 0.0099 | 0.0235 | 0.0114 | 0.0031 | 0.0061 | 0.003 | 0.0071 | 0.0085 | 0.016 | 0.0019 | 0.0034 | 0.0013 | 0.0087 | 0.0172 | 0.0179 | 0.0051 |
Lipid Particles | 0.0327 | 0.0101 | 0.0203 | 0.0295 | 0.0247 | 0.0182 | 0.0083 | 0.005 | 0.0069 | 0.008 | 0.0225 | 0.0033 | 0.0144 | 0.0067 | 0.0122 | 0.0353 | 0.0301 | 0.0084 |
Mitochondria | 0.0075 | 0.0072 | 0.0132 | 0.0244 | 0.0017 | 0.0024 | 0.0021 | 0.0008 | 0.0018 | 0.014 | 0.0025 | 0.0015 | 0.0031 | 0.0042 | 0.0098 | 0.0179 | 0.0062 | 0.0211 |
None | 0.2497 | 0.1907 | 0.1715 | 0.2199 | 0.1183 | 0.201 | 0.3197 | 0.2887 | 0.2433 | 0.2449 | 0.2604 | 0.3346 | 0.2274 | 0.1649 | 0.2174 | 0.1294 | 0.083 | 0.1295 |
Nuclear Periphery | 0.02 | 0.007 | 0.0086 | 0.0192 | 0.0147 | 0.0096 | 0.0064 | 0.0072 | 0.0059 | 0.0074 | 0.0052 | 0.0034 | 0.0234 | 0.0057 | 0.0065 | 0.0086 | 0.0056 | 0.007 |
Nucleolus | 0.0013 | 0.0005 | 0.0003 | 0.0005 | 0.0036 | 0.0018 | 0.0007 | 0.0002 | 0.0003 | 0.0008 | 0.0002 | 0.0009 | 0.001 | 0.0003 | 0.0007 | 0.0009 | 0.0005 | 0.0003 |
Nucleus | 0.0038 | 0.0043 | 0.0033 | 0.008 | 0.0055 | 0.0031 | 0.0032 | 0.0028 | 0.0035 | 0.0031 | 0.0026 | 0.003 | 0.0089 | 0.0048 | 0.0032 | 0.0033 | 0.0024 | 0.0048 |
Peroxisomes | 0.0053 | 0.0019 | 0.0103 | 0.0026 | 0.0023 | 0.0017 | 0.0164 | 0.0002 | 0.001 | 0.0077 | 0.0004 | 0.0012 | 0.004 | 0.0034 | 0.0036 | 0.0032 | 0.0221 | 0.0076 |
Punctate Nuclear | 0.0114 | 0.0022 | 0.002 | 0.0016 | 0.003 | 0.0014 | 0.0089 | 0.0006 | 0.0012 | 0.0036 | 0.0005 | 0.0031 | 0.0057 | 0.0017 | 0.0037 | 0.0015 | 0.0044 | 0.0084 |
Vacuole | 0.0078 | 0.0088 | 0.0065 | 0.0121 | 0.0087 | 0.0077 | 0.0038 | 0.0085 | 0.0042 | 0.0069 | 0.007 | 0.0042 | 0.007 | 0.0075 | 0.0076 | 0.0084 | 0.0036 | 0.0059 |
Vacuole Periphery | 0.0025 | 0.0005 | 0.0012 | 0.0026 | 0.0016 | 0.0027 | 0.0005 | 0.0009 | 0.0006 | 0.0011 | 0.0016 | 0.0006 | 0.0016 | 0.0003 | 0.0018 | 0.0011 | 0.001 | 0.0008 |
R1 | R2 | |||||||||
---|---|---|---|---|---|---|---|---|---|---|
G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | |
Gene Expression | 94.2088 | 41.5316 | 35.0986 | 46.725 | 42.6674 | 84.483 | 58.1772 | 54.9129 | 63.5953 | 67.7191 |
Translational Efficiency | 0.9298 | 0.9531 | 0.8734 | 1.0221 | 1.1566 | 1.5182 | 0.9964 | 1.0143 | 0.9653 | 0.9982 |
Dataset | Hit |
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Protein Concentration | ✘ |
Protein Localization | ✘ |
Gene Expression | ✔ |
Translational Efficiency | ✘ |
Temp | Actin Patch (Sac6-tdTomato) | Cortical Patch (Sla1-GFP) | Late Endosome (Snf7-GFP) | Vacuole (Vph1-GFP) |
---|---|---|---|---|
37℃ | ||||
RT |
Gene / Allele | Actin Patch (Sac6-tdTomato) | Cortical Patch (Sla1-GFP) | Late Endosome (Snf7-GFP) | Vacuole (Sac6-tdTomato) |
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Gene | Images |
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Gene | Images |
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