ORF | |
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Human Ortholog | |
Description | Nuclear protein of unknown function; relocalizes to the cytosol in response to hypoxia; contains WD-40 domains; not an essential gene; protein abundance increases in response to DNA replication stress |
ensLOC | DeepLoc | |||||||||||||||||||||||
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Localization | WT1 | WT2 | WT3 | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 | WT1 | WT2 | WT3 | AF100 | AF140 | AF180 |
Cortical Patches | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 1 | 0 | 2 | 0 |
Bud | 0 | 0 | 0 | 0 | 0 | 1 | 4 | 4 | 1 | 2 | 2 | 1 | 0 | 2 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 6 | 3 |
Bud Neck | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Bud Site | 0 | 1 | 0 | 0 | 0 | 4 | 21 | 19 | 10 | 10 | 17 | 19 | 0 | 0 | 0 | 0 | 0 | 0 | – | – | – | – | – | – |
Cell Periphery | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Cytoplasm | 3 | 2 | 9 | 11 | 10 | 17 | 20 | 15 | 16 | 16 | 7 | 10 | 33 | 82 | 100 | 17 | 5 | 11 | 0 | 0 | 1 | 4 | 3 | 4 |
Endoplasmic Reticulum | 0 | 0 | 3 | 0 | 2 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 0 | 2 | 1 | 0 | 0 | 0 | 1 | 2 |
Endosome | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 3 | 9 | 0 | 0 | 0 | 0 | 0 | 2 | 2 | 4 | 6 |
Golgi | 0 | 0 | 3 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 4 | 1 | 3 | 1 |
Mitochondria | 15 | 4 | 0 | 1 | 14 | 49 | 76 | 59 | 56 | 140 | 85 | 101 | 1 | 0 | 3 | 1 | 1 | 2 | 0 | 1 | 3 | 1 | 3 | 6 |
Nucleus | 185 | 92 | 296 | 189 | 308 | 281 | 404 | 449 | 344 | 418 | 332 | 333 | 293 | 554 | 538 | 94 | 67 | 57 | 181 | 103 | 277 | 312 | 505 | 388 |
Nuclear Periphery | 0 | 1 | 2 | 0 | 3 | 4 | 14 | 16 | 17 | 5 | 3 | 6 | 5 | 19 | 10 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 3 |
Nucleolus | 2 | 3 | 4 | 4 | 10 | 22 | 56 | 92 | 54 | 91 | 60 | 84 | 0 | 5 | 7 | 2 | 0 | 1 | 0 | 0 | 7 | 4 | 21 | 36 |
Peroxisomes | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 9 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
SpindlePole | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 3 | 10 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 6 | 3 |
Vac/Vac Membrane | 0 | 3 | 3 | 0 | 4 | 1 | 9 | 6 | 6 | 9 | 1 | 9 | 2 | 10 | 10 | 5 | 5 | 5 | 2 | 2 | 10 | 24 | 107 | 151 |
Unique Cell Count | 191 | 99 | 315 | 200 | 337 | 328 | 486 | 543 | 425 | 532 | 407 | 425 | 327 | 651 | 667 | 114 | 78 | 71 | 190 | 112 | 316 | 359 | 673 | 613 |
Labelled Cell Count | 205 | 106 | 320 | 205 | 351 | 379 | 605 | 661 | 505 | 691 | 508 | 563 | 336 | 678 | 697 | 121 | 79 | 78 | 190 | 112 | 316 | 359 | 673 | 613 |
Screen | WT1 | WT2 | WT3 | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 | AF100 | AF140 | AF180 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Mean Cell GFP Intensity (1e-4) | 6.8 | 8.9 | 8.2 | 7.6 | 7.2 | 6.3 | 5.9 | 6.0 | 6.0 | 5.7 | 5.6 | 5.5 | 9.9 | 9.8 | 9.0 | 11.3 | 11.0 | 11.0 | 9.6 | 9.9 | 10.3 |
Std Deviation (1e-4) | 1.2 | 1.9 | 1.7 | 1.7 | 2.1 | 2.0 | 1.7 | 1.6 | 1.8 | 1.8 | 1.5 | 1.5 | 2.4 | 4.4 | 2.4 | 2.9 | 2.6 | 3.2 | 1.8 | 1.9 | 2.0 |
Intensity Change (Log2) | – | – | – | -0.11 | -0.19 | -0.38 | -0.47 | -0.45 | -0.44 | -0.52 | -0.54 | -0.58 | 0.28 | 0.27 | 0.14 | 0.47 | 0.43 | 0.43 | 0.23 | 0.28 | 0.34 |
Localization | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Cortical Patches | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Bud | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Bud Neck | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Bud Site | 0 | 0 | 0 | 3.7 | 3.4 | 0 | 0 | 3.7 | 3.8 | 0 | 0 | 0 | 0 | 0 | 0 |
Cell Periphery | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Cytoplasm | 1.5 | 0.1 | 1.5 | 0.9 | -0.1 | 0.7 | 0.1 | -1.0 | -0.4 | 3.7 | 4.9 | 5.7 | 4.6 | 0 | 0 |
Endoplasmic Reticulum | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Endosome | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Golgi | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Mitochondria | 0 | 3.7 | 7.1 | 7.4 | 6.1 | 6.7 | 10.0 | 8.6 | 9.3 | 0 | 0 | 0 | 0 | 0 | 0 |
Nucleus | 0.3 | -1.3 | -3.5 | -4.5 | -4.7 | -5.1 | -6.0 | -4.9 | -5.9 | -2.0 | -4.0 | -5.4 | -3.7 | -2.4 | -3.7 |
Nuclear Periphery | 0 | 0 | 0 | 2.2 | 2.3 | 2.9 | 0 | 0 | 0 | 0 | 2.3 | 0 | 0 | 0 | 0 |
Nucleolus | 0 | 1.5 | 3.5 | 5.4 | 7.0 | 5.7 | 7.1 | 6.3 | 7.7 | 0 | 0 | 0 | 0 | 0 | 0 |
Peroxisomes | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
SpindlePole | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Vacuole | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1.2 | 0 | 0 | 0 | 0 | 0 | 0 |
R1 | R2 | R3 | ||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | |
Concentration | 2.3518 | 2.9023 | 2.6271 | 2.5067 | 1.8003 | 2.6537 | 4.6532 | 4.5999 | 4.4118 | 4.1735 | 3.8692 | 4.285 | 4.0467 | 4.0359 | 3.4478 | 3.9219 | 3.5832 | 3.5231 |
Actin | 0.0002 | 0 | 0 | 0 | 0 | 0 | 0.015 | 0.0001 | 0.0026 | 0.0001 | 0.0118 | 0.0053 | 0.0051 | 0 | 0.0093 | 0.0046 | 0.0053 | 0.0062 |
Bud | 0.0001 | 0 | 0 | 0 | 0 | 0 | 0.0005 | 0 | 0.0003 | 0.0002 | 0.0004 | 0.0001 | 0.0004 | 0 | 0.0003 | 0.0002 | 0.0003 | 0.0001 |
Bud Neck | 0.0005 | 0.0001 | 0.0001 | 0.0002 | 0.0001 | 0.0006 | 0.0014 | 0.0001 | 0.0019 | 0.0007 | 0.0009 | 0.0011 | 0.0015 | 0 | 0.0018 | 0.0002 | 0.0006 | 0.0022 |
Bud Periphery | 0.0003 | 0 | 0 | 0 | 0 | 0.0001 | 0.0016 | 0.0001 | 0.0007 | 0.0013 | 0.0014 | 0.0002 | 0.0013 | 0 | 0.0008 | 0.0005 | 0.0016 | 0.0002 |
Bud Site | 0.0007 | 0 | 0 | 0 | 0 | 0 | 0.0012 | 0.0002 | 0.0032 | 0.0004 | 0.0006 | 0.0003 | 0.0014 | 0.0001 | 0.0022 | 0.0004 | 0.0004 | 0.0001 |
Cell Periphery | 0.0001 | 0 | 0 | 0 | 0 | 0 | 0.0005 | 0 | 0.0001 | 0.001 | 0.0003 | 0 | 0.0006 | 0 | 0.0004 | 0 | 0.0004 | 0.0001 |
Cytoplasm | 0.0006 | 0.0007 | 0.0001 | 0.0002 | 0 | 0.0001 | 0.0059 | 0.0003 | 0.0013 | 0.0003 | 0.0008 | 0.0003 | 0.004 | 0.0001 | 0.0019 | 0.0009 | 0.0011 | 0.0002 |
Cytoplasmic Foci | 0.0005 | 0.0003 | 0.0001 | 0 | 0 | 0 | 0.0097 | 0.0027 | 0.0112 | 0.0001 | 0.0041 | 0.0024 | 0.0073 | 0 | 0.0113 | 0.0028 | 0.0025 | 0.0004 |
Eisosomes | 0 | 0 | 0 | 0 | 0 | 0 | 0.0002 | 0 | 0.0001 | 0 | 0.0003 | 0 | 0.0001 | 0 | 0.0001 | 0.0001 | 0.0001 | 0 |
Endoplasmic Reticulum | 0.0001 | 0 | 0 | 0.0001 | 0 | 0 | 0.0051 | 0 | 0.0009 | 0.001 | 0.0051 | 0.0003 | 0.0031 | 0 | 0.002 | 0.0004 | 0.0034 | 0.0005 |
Endosome | 0.0005 | 0.0001 | 0.0001 | 0.0003 | 0 | 0 | 0.0174 | 0.0017 | 0.0123 | 0.0033 | 0.0202 | 0.0051 | 0.0151 | 0 | 0.0111 | 0.0034 | 0.0148 | 0.003 |
Golgi | 0.0001 | 0 | 0 | 0 | 0 | 0 | 0.0045 | 0.0018 | 0.0033 | 0.0003 | 0.0143 | 0.0031 | 0.0024 | 0 | 0.0035 | 0.0016 | 0.003 | 0.0014 |
Lipid Particles | 0.0003 | 0.0001 | 0.0002 | 0.0002 | 0 | 0 | 0.0159 | 0.0001 | 0.009 | 0.0003 | 0.0347 | 0.004 | 0.015 | 0 | 0.0185 | 0.0112 | 0.0078 | 0.0053 |
Mitochondria | 0.0009 | 0.0001 | 0.0001 | 0.0001 | 0.0001 | 0.0001 | 0.0081 | 0.0004 | 0.0147 | 0.001 | 0.051 | 0.0009 | 0.0072 | 0.0002 | 0.0041 | 0.0041 | 0.0233 | 0.0041 |
None | 0.001 | 0.0053 | 0.0001 | 0.0001 | 0 | 0.0007 | 0.0027 | 0 | 0.0015 | 0 | 0.0006 | 0.0001 | 0.0026 | 0 | 0.0014 | 0.001 | 0.0009 | 0.0003 |
Nuclear Periphery | 0.0029 | 0.0028 | 0.0057 | 0.0213 | 0.0019 | 0.0009 | 0.0211 | 0.002 | 0.0095 | 0.0012 | 0.0303 | 0.0009 | 0.0224 | 0.0007 | 0.0178 | 0.0095 | 0.0262 | 0.0056 |
Nucleolus | 0.0366 | 0.0371 | 0.0387 | 0.029 | 0.0398 | 0.0655 | 0.0136 | 0.0151 | 0.0135 | 0.0098 | 0.0266 | 0.0512 | 0.0188 | 0.0138 | 0.022 | 0.0115 | 0.0322 | 0.049 |
Nucleus | 0.9488 | 0.933 | 0.9519 | 0.9323 | 0.9566 | 0.9289 | 0.8535 | 0.9746 | 0.8973 | 0.9576 | 0.7787 | 0.9221 | 0.8699 | 0.9848 | 0.8708 | 0.9356 | 0.8521 | 0.9189 |
Peroxisomes | 0.0001 | 0 | 0 | 0 | 0 | 0 | 0.0087 | 0.0003 | 0.0047 | 0 | 0.0012 | 0.0009 | 0.0035 | 0 | 0.0063 | 0.006 | 0.0021 | 0.0002 |
Punctate Nuclear | 0.0049 | 0.0202 | 0.0024 | 0.0159 | 0.0015 | 0.0028 | 0.0055 | 0.0003 | 0.0062 | 0.0004 | 0.0103 | 0.0013 | 0.0092 | 0.0002 | 0.009 | 0.0047 | 0.0112 | 0.001 |
Vacuole | 0.0007 | 0.0001 | 0.0001 | 0.0001 | 0 | 0.0002 | 0.0052 | 0.0001 | 0.0039 | 0.0188 | 0.0024 | 0.0002 | 0.0054 | 0.0001 | 0.004 | 0.0007 | 0.0038 | 0.0005 |
Vacuole Periphery | 0.0002 | 0.0001 | 0.0002 | 0.0001 | 0 | 0.0001 | 0.0026 | 0.0002 | 0.0017 | 0.0022 | 0.0039 | 0.0001 | 0.0035 | 0 | 0.0015 | 0.0008 | 0.0066 | 0.0007 |
R1 | R2 | |||||||||
---|---|---|---|---|---|---|---|---|---|---|
G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | |
Gene Expression | 24.0486 | 16.0181 | 18.1419 | 22.3257 | 20.7867 | 22.6214 | 19.3924 | 20.4239 | 20.5715 | 23.3146 |
Translational Efficiency | 1.0162 | 1.2831 | 0.9849 | 0.9718 | 1.1525 | 1.1087 | 1.0604 | 0.8734 | 0.8952 | 0.9437 |
Dataset | Hit |
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Protein Concentration | ✘ |
Protein Localization | ✘ |
Gene Expression | ✘ |
Translational Efficiency | ✘ |
Temp | Actin Patch (Sac6-tdTomato) | Cortical Patch (Sla1-GFP) | Late Endosome (Snf7-GFP) | Vacuole (Vph1-GFP) |
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37℃ | ||||
RT |
Gene / Allele | Actin Patch (Sac6-tdTomato) | Cortical Patch (Sla1-GFP) | Late Endosome (Snf7-GFP) | Vacuole (Sac6-tdTomato) |
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Gene | Images |
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Gene | Images |
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