Standard name | |
---|---|
Human Ortholog | |
Description | Heat shock protein regulator; binds to Hsp90p and may stimulate ATPase activity; originally identified as a high-copy number suppressor of a HSP90 loss-of-function mutation; role in regulating Hsp90 inhibitor drug sensitivity; GFP-fusion protein localizes to the cytoplasm and nucleus; protein abundance increases in response to DNA replication stress |
ensLOC | DeepLoc | |||||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Localization | WT1 | WT2 | WT3 | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 | WT1 | WT2 | WT3 | AF100 | AF140 | AF180 |
Cortical Patches | 0 | 0 | 0 | 0 | 0 | 0 | – | 6 | 6 | 3 | 1 | 5 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Bud | 2 | 0 | 2 | 0 | 0 | 0 | – | 3 | 0 | 1 | 2 | 1 | 0 | 1 | 0 | 1 | 1 | 0 | 3 | 0 | 0 | 0 | 2 | 5 |
Bud Neck | 0 | 0 | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Bud Site | 0 | 0 | 0 | 0 | 0 | 0 | – | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | – | – | – | – | – | – |
Cell Periphery | 2 | 1 | 0 | 0 | 0 | 4 | – | 7 | 11 | 11 | 5 | 9 | 3 | 0 | 1 | 3 | 6 | 2 | 0 | 0 | 0 | 0 | 0 | 0 |
Cytoplasm | 508 | 61 | 114 | 121 | 206 | 342 | – | 403 | 261 | 263 | 266 | 240 | 230 | 368 | 341 | 344 | 333 | 340 | 497 | 67 | 108 | 152 | 205 | 214 |
Endoplasmic Reticulum | 3 | 0 | 0 | 1 | 4 | 9 | – | 31 | 11 | 23 | 8 | 15 | 0 | 1 | 0 | 5 | 6 | 14 | 1 | 0 | 0 | 0 | 0 | 2 |
Endosome | 1 | 0 | 0 | 0 | 0 | 0 | – | 7 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Golgi | 1 | 0 | 0 | 0 | 0 | 0 | – | 0 | 0 | 2 | 1 | 2 | 0 | 0 | 0 | 1 | 2 | 1 | 0 | 0 | 0 | 0 | 0 | 1 |
Mitochondria | 0 | 0 | 0 | 0 | 1 | 1 | – | 13 | 20 | 17 | 19 | 20 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
Nucleus | 0 | 0 | 0 | 1 | 1 | 0 | – | 4 | 0 | 6 | 2 | 1 | 0 | 1 | 0 | 2 | 0 | 0 | 1 | 2 | 0 | 1 | 2 | 2 |
Nuclear Periphery | 0 | 0 | 0 | 0 | 0 | 0 | – | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Nucleolus | 0 | 0 | 0 | 0 | 0 | 0 | – | 2 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
Peroxisomes | 0 | 0 | 0 | 0 | 0 | 0 | – | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
SpindlePole | 0 | 0 | 0 | 0 | 0 | 0 | – | 1 | 0 | 2 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Vac/Vac Membrane | 2 | 0 | 0 | 0 | 3 | 1 | – | 59 | 54 | 41 | 15 | 28 | 0 | 0 | 1 | 20 | 32 | 40 | 1 | 0 | 1 | 0 | 3 | 2 |
Unique Cell Count | 513 | 61 | 114 | 123 | 214 | 352 | 517 | 346 | 351 | 304 | 308 | 230 | 368 | 342 | 363 | 352 | 371 | 509 | 76 | 113 | 157 | 218 | 232 | |
Labelled Cell Count | 519 | 62 | 116 | 123 | 215 | 357 | 538 | 365 | 370 | 321 | 321 | 233 | 371 | 344 | 378 | 380 | 398 | 509 | 76 | 113 | 157 | 218 | 232 |
Screen | WT1 | WT2 | WT3 | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 | AF100 | AF140 | AF180 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Mean Cell GFP Intensity (1e-4) | 30.6 | 32.9 | 19.4 | 24.0 | 25.5 | 23.3 | – | 20.8 | 20.0 | 19.7 | 18.6 | 18.6 | 31.9 | 33.0 | 31.4 | 40.2 | 40.4 | 38.6 | 29.4 | 32.1 | 34.4 |
Std Deviation (1e-4) | 6.5 | 7.8 | 4.6 | 5.5 | 5.9 | 5.8 | – | 6.7 | 6.8 | 6.0 | 6.3 | 6.3 | 8.5 | 12.4 | 7.1 | 18.6 | 21.9 | 22.8 | 8.3 | 11.2 | 12.5 |
Intensity Change (Log2) | – | – | – | 0.31 | 0.39 | 0.26 | – | 0.09 | 0.04 | 0.02 | -0.06 | -0.07 | 0.72 | 0.77 | 0.69 | 1.05 | 1.05 | 0.99 | 0.6 | 0.72 | 0.82 |
Localization | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Cortical Patches | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Bud | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Bud Neck | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Bud Site | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Cell Periphery | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Cytoplasm | -1.4 | -2.1 | -1.8 | – | -5.5 | -5.9 | -5.9 | -4.0 | -5.5 | 0 | 0 | -0.6 | -2.5 | -2.5 | -3.2 |
Endoplasmic Reticulum | 0 | 0 | 0 | – | 2.7 | 0 | 2.8 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Endosome | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Golgi | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Mitochondria | 0 | 0 | 0 | – | 0 | 0 | 0 | 2.7 | 2.8 | 0 | 0 | 0 | 0 | 0 | 0 |
Nucleus | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Nuclear Periphery | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Nucleolus | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Peroxisomes | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
SpindlePole | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Vacuole | 0 | 0 | 0 | – | 3.8 | 4.5 | 3.8 | 0 | 3.3 | 0 | 0 | 0 | 0 | 3.3 | 3.7 |
R1 | R2 | R3 | ||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | |
Concentration | 20.222 | 27.9651 | 22.5308 | 22.0637 | 15.9937 | 24.59 | 21.9226 | 27.6586 | 26.0218 | 23.1441 | 25.0368 | 25.0885 | 26.3448 | 30.8131 | 30.113 | 28.5531 | 26.835 | 28.3077 |
Actin | 0.0222 | 0.0026 | 0.0123 | 0.0396 | 0.0122 | 0.0005 | 0.0154 | 0.0017 | 0.0046 | 0.0015 | 0.0023 | 0.0016 | 0.0035 | 0.0001 | 0.0059 | 0.003 | 0.0059 | 0.0006 |
Bud | 0.0003 | 0.0002 | 0.0006 | 0.0007 | 0.0025 | 0.0001 | 0.0011 | 0.0007 | 0.0008 | 0.0001 | 0.0011 | 0.0001 | 0.0008 | 0 | 0.0001 | 0.0009 | 0.0004 | 0.0001 |
Bud Neck | 0.0005 | 0.0002 | 0.0006 | 0.0005 | 0.0007 | 0.0004 | 0.0013 | 0.0001 | 0.0004 | 0.0007 | 0.0003 | 0.0009 | 0.0003 | 0.0001 | 0.0002 | 0.0003 | 0.0003 | 0.0005 |
Bud Periphery | 0.0003 | 0.0001 | 0.0005 | 0.001 | 0.003 | 0.0001 | 0.0011 | 0.0008 | 0.0004 | 0.0001 | 0.002 | 0.0001 | 0.0005 | 0 | 0 | 0.0008 | 0.0002 | 0.0001 |
Bud Site | 0.0014 | 0.001 | 0.0048 | 0.0012 | 0.0045 | 0 | 0.0095 | 0.0039 | 0.0016 | 0.0004 | 0.0008 | 0.0001 | 0.0003 | 0 | 0.0001 | 0.0002 | 0.0005 | 0 |
Cell Periphery | 0.0002 | 0 | 0.0001 | 0.0001 | 0.0004 | 0 | 0.0003 | 0 | 0.0001 | 0 | 0.0001 | 0 | 0.0001 | 0 | 0 | 0.0001 | 0.0003 | 0.0001 |
Cytoplasm | 0.857 | 0.9797 | 0.9117 | 0.893 | 0.6346 | 0.947 | 0.8646 | 0.9819 | 0.9313 | 0.9049 | 0.9079 | 0.9576 | 0.9259 | 0.9824 | 0.9706 | 0.974 | 0.9109 | 0.9478 |
Cytoplasmic Foci | 0.0176 | 0.0008 | 0.0118 | 0.0045 | 0.0135 | 0.0006 | 0.0235 | 0.0003 | 0.0223 | 0.0208 | 0.0018 | 0.0017 | 0.0062 | 0.0002 | 0.0014 | 0.0007 | 0.0145 | 0.0007 |
Eisosomes | 0.0001 | 0 | 0.0001 | 0.0002 | 0.0002 | 0 | 0.0002 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0.0001 | 0 |
Endoplasmic Reticulum | 0.0044 | 0.0001 | 0.0028 | 0.0015 | 0.0061 | 0.0005 | 0.0022 | 0.0002 | 0.0007 | 0.0006 | 0.0029 | 0.0057 | 0.0015 | 0.0001 | 0.0011 | 0.0006 | 0.0027 | 0.0008 |
Endosome | 0.024 | 0.0014 | 0.0167 | 0.0139 | 0.1298 | 0.0042 | 0.0217 | 0.0003 | 0.0103 | 0.0041 | 0.0427 | 0.0024 | 0.0053 | 0 | 0.0024 | 0.0005 | 0.0038 | 0.0022 |
Golgi | 0.0081 | 0.0031 | 0.0078 | 0.0096 | 0.0454 | 0.006 | 0.0066 | 0.0002 | 0.0048 | 0.0049 | 0.0088 | 0.0005 | 0.001 | 0 | 0.0007 | 0.0001 | 0.0009 | 0.0003 |
Lipid Particles | 0.0107 | 0.0002 | 0.0025 | 0.0068 | 0.0088 | 0.0001 | 0.0052 | 0 | 0.0047 | 0.0047 | 0.0006 | 0.0004 | 0.0065 | 0 | 0.0012 | 0 | 0.0032 | 0.0005 |
Mitochondria | 0.0038 | 0.0043 | 0.0097 | 0.0091 | 0.102 | 0.0268 | 0.005 | 0.0002 | 0.002 | 0.0275 | 0.0129 | 0.0006 | 0.0023 | 0 | 0.0002 | 0.0008 | 0.0031 | 0.0007 |
None | 0.0036 | 0.0001 | 0.0006 | 0.001 | 0.0012 | 0.0003 | 0.0036 | 0.0002 | 0.0006 | 0.0007 | 0.0003 | 0.0004 | 0.0014 | 0.0002 | 0.0008 | 0.0005 | 0.0041 | 0.0004 |
Nuclear Periphery | 0.0098 | 0.0006 | 0.0039 | 0.0045 | 0.0045 | 0.0013 | 0.0041 | 0.0011 | 0.0011 | 0.0022 | 0.0019 | 0.0057 | 0.0038 | 0.0014 | 0.0025 | 0.0015 | 0.0056 | 0.0071 |
Nucleolus | 0.0003 | 0 | 0.0001 | 0.0002 | 0.0005 | 0 | 0.0014 | 0 | 0.0001 | 0.0002 | 0 | 0 | 0.0003 | 0 | 0 | 0 | 0.0041 | 0.0006 |
Nucleus | 0.0274 | 0.0047 | 0.0066 | 0.0052 | 0.0066 | 0.011 | 0.02 | 0.008 | 0.0085 | 0.0184 | 0.0072 | 0.0206 | 0.0282 | 0.0152 | 0.0107 | 0.015 | 0.0198 | 0.0321 |
Peroxisomes | 0.0016 | 0.0002 | 0.0036 | 0.0037 | 0.0026 | 0 | 0.0024 | 0 | 0.0039 | 0.0014 | 0.0001 | 0.0001 | 0.007 | 0 | 0.0005 | 0.0001 | 0.0008 | 0.0001 |
Punctate Nuclear | 0.0039 | 0.0001 | 0.0008 | 0.0024 | 0.0006 | 0.0002 | 0.0043 | 0.0001 | 0.0011 | 0.0061 | 0.0001 | 0.0009 | 0.0013 | 0.0001 | 0.0006 | 0.0001 | 0.0053 | 0.0004 |
Vacuole | 0.0019 | 0.0002 | 0.0012 | 0.0005 | 0.012 | 0.0004 | 0.0052 | 0.0002 | 0.0006 | 0.0003 | 0.004 | 0.0005 | 0.0029 | 0.0001 | 0.0007 | 0.0004 | 0.0072 | 0.0038 |
Vacuole Periphery | 0.0008 | 0.0001 | 0.0011 | 0.0007 | 0.0084 | 0.0005 | 0.0013 | 0 | 0.0003 | 0.0003 | 0.0019 | 0.0002 | 0.0008 | 0 | 0.0002 | 0.0001 | 0.0063 | 0.0012 |
R1 | R2 | |||||||||
---|---|---|---|---|---|---|---|---|---|---|
G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | |
Gene Expression | 169.5708 | 207.0963 | 205.9554 | 201.5881 | 182.6972 | 171.8639 | 236.3787 | 226.561 | 267.7078 | 187.7961 |
Translational Efficiency | 1.2729 | 1.4615 | 1.4386 | 1.7348 | 1.4849 | 1.586 | 1.4996 | 1.8768 | 1.549 | 1.6409 |
Dataset | Hit |
---|---|
Protein Concentration | ✘ |
Protein Localization | ✘ |
Gene Expression | ✘ |
Translational Efficiency | ✘ |
Temp | Actin Patch (Sac6-tdTomato) | Cortical Patch (Sla1-GFP) | Late Endosome (Snf7-GFP) | Vacuole (Vph1-GFP) |
---|---|---|---|---|
37℃ | ||||
RT |
Gene / Allele | Actin Patch (Sac6-tdTomato) | Cortical Patch (Sla1-GFP) | Late Endosome (Snf7-GFP) | Vacuole (Sac6-tdTomato) |
---|
Gene | Images |
---|
Gene | Images |
---|