Standard name
Human Ortholog
Description Non-essential hydrolase involved in mRNA decapping; activates Xrn1p; may function in a feedback mechanism to regulate deadenylation, contains pyrophosphatase activity and a HIT (histidine triad) motif; acts as inhibitor of neutral trehalase Nth1p; required for growth on glycerol medium; protein abundance increases in response to DNA replication stress; DCS1 has a paralog, DCS2, that arose from the whole genome duplication
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.06 0.05
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 0.96 0.95 0.89 0.91 0.87 0.84 0.72 0.6 0.64 0.57 0.64 0.58 0.96 0.97 0.98 0.93 0.94 0.87 0.94 0.92 0.91 0.86 0.87 0.86
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0 0 0 0 0 0.05 0.09 0.08 0.17 0.11 0.24 0.09 0 0 0 0 0 0 0 0 0 0 0 0
Nucleus 0 0 0.07 0 0 0 0 0.05 0 0.06 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vac/Vac Membrane 0 0.05 0 0.12 0.15 0.09 0.22 0.32 0.25 0.33 0.17 0.33 0 0.05 0 0.08 0 0.09 0 0 0 0 0 0
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 2 0 0 0 3 0 0 0 0 0 1 0 1 0 0 0 2
Bud 0 0 0 1 0 0 1 2 1 3 3 2 0 0 0 0 0 0 0 1 0 2 12 9
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0 1 2 11 3 4 6 2 1 6 1 0 0 12 1 6 0 0 0 1 3 0
Cytoplasm 180 187 49 145 237 231 224 197 140 163 88 121 107 191 178 379 131 191 174 182 90 99 183 175
Endoplasmic Reticulum 0 1 1 1 0 6 1 1 5 5 1 3 0 0 0 8 4 3 0 0 1 0 1 2
Endosome 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 1 1 0 0 1 1
Golgi 0 0 0 0 1 0 0 0 0 0 0 1 0 1 0 1 1 6 0 0 0 0 0 0
Mitochondria 1 1 0 1 2 13 29 26 37 31 33 19 0 0 0 3 1 4 1 2 2 0 0 0
Nucleus 0 1 4 2 3 11 6 17 8 16 3 7 2 4 2 7 4 4 2 2 0 2 1 3
Nuclear Periphery 1 0 1 0 0 0 0 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 1 0
Nucleolus 1 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1
Vac/Vac Membrane 7 9 1 20 41 25 68 105 55 93 23 69 3 9 4 32 5 20 1 0 1 5 1 2
Unique Cell Count 188 197 55 160 273 275 311 330 219 284 137 210 111 197 181 409 139 220 186 199 99 116 210 204
Labelled Cell Count 190 199 56 171 288 297 332 354 252 313 152 232 113 205 184 442 147 236 186 199 99 116 210 204


Cytoplasm, Nucleus

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 6.8 9.2 7.9 7.8 9.5 9.3 9.6 9.8 9.0 10.2 10.5 11.4 9.4 13.2 14.9 21.8 21.2 21.2 13.0 12.2 15.9
Std Deviation (1e-4) 1.8 1.6 1.5 2.3 2.1 2.1 2.7 2.7 2.5 3.1 3.7 4.1 1.9 6.2 4.5 5.4 4.7 5.5 11.1 8.7 11.5
Intensity Change (Log2) – – – -0.03 0.26 0.22 0.28 0.3 0.18 0.36 0.41 0.52 0.25 0.74 0.91 1.46 1.42 1.42 0.71 0.62 1.0

WT3RAP60RAP140RAP220RAP300RAP380RAP460RAP540RAP620RAP70001020WT3HU80HU120HU16001020WT3rpd3Δ_1rpd3Δ_2rpd3Δ_301020WT1AF100AF140AF18001020
rapamycinhydroxy-urearpd3 knockoutalpha-factorMultiple Condition Time-Course Intensity PlotsGFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)

Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cell Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 0.3 -0.5 -1.0 -2.7 -4.2 -3.6 -4.4 -3.4 -4.3 1.9 2.4 3.1 0.9 1.3 -0.5
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0 0 0 0 0 3.3 2.6 4.0 0 0 0 0 0 0 0
Nucleus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vacuole 2.3 2.7 0 3.5 4.6 3.8 4.7 2.8 4.6 0 0 0 0 0 0

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 8.0283 11.5793 9.0099 8.3341 6.7892 8.7179 8.8666 8.926 8.9143 7.4518 6.3968 8.1206 6.2186 8.0968 8.0876 6.4209 5.8615 7.7373
Actin 0.0149 0.0006 0.0039 0.0225 0.0037 0.0008 0.0089 0.0004 0.0002 0.0012 0.0024 0.005 0.034 0.004 0.0235 0.0221 0.0731 0.0048
Bud 0.0004 0.0031 0.0004 0.0004 0.0009 0.0004 0.0003 0.0001 0.0001 0.0012 0.0002 0.0003 0.0018 0.0003 0.0005 0.0006 0.0002 0.0004
Bud Neck 0.0011 0.0004 0.001 0.0011 0.0012 0.0015 0.0005 0.0003 0.0004 0.001 0.001 0.0014 0.0014 0.0002 0.0004 0.0022 0.0006 0.0017
Bud Periphery 0.0005 0.0005 0.0004 0.0001 0.0013 0.0001 0.0003 0 0 0.0005 0.0001 0.0001 0.0029 0.0001 0.0006 0.0009 0.0003 0.0002
Bud Site 0.0023 0.001 0.0011 0.0003 0.0008 0.0001 0.0029 0.0002 0.0001 0.0007 0.0004 0.0002 0.0031 0.0003 0.0023 0.0018 0.0009 0.0009
Cell Periphery 0.0005 0.0001 0.0002 0 0.0001 0 0.0001 0 0 0.0001 0.0001 0 0.0005 0 0.0002 0.0002 0.0001 0
Cytoplasm 0.7765 0.9374 0.8572 0.8474 0.6697 0.8832 0.8756 0.9573 0.9288 0.8366 0.8033 0.8807 0.6863 0.9434 0.8845 0.7627 0.8067 0.8837
Cytoplasmic Foci 0.0232 0.0031 0.0137 0.0077 0.0598 0.0086 0.0037 0.002 0.0025 0.0165 0.016 0.0069 0.0359 0.0055 0.0105 0.0209 0.005 0.0075
Eisosomes 0.0006 0 0 0.0001 0 0 0.0001 0 0 0 0.0001 0 0.0002 0 0.0006 0.0002 0.0003 0
Endoplasmic Reticulum 0.0069 0.0012 0.0027 0.0024 0.0062 0.0022 0.0053 0.0011 0.0023 0.003 0.0381 0.0022 0.0078 0.0013 0.0024 0.0045 0.001 0.003
Endosome 0.0261 0.0014 0.0152 0.0033 0.0845 0.0068 0.0045 0.0006 0.0024 0.0026 0.0228 0.0062 0.053 0.003 0.0093 0.0271 0.0109 0.0182
Golgi 0.0102 0.0001 0.0081 0.0015 0.0386 0.0011 0.0016 0 0.0001 0.0003 0.0037 0.0015 0.0162 0.0023 0.0069 0.0127 0.0161 0.0047
Lipid Particles 0.0148 0 0.0019 0.0009 0.0057 0.0031 0.002 0 0 0.0017 0.0013 0.0003 0.0248 0.0011 0.0069 0.029 0.0357 0.0019
Mitochondria 0.0072 0.0002 0.0045 0.0009 0.0361 0.0041 0.0015 0.0001 0.0002 0.0004 0.0022 0.0019 0.0074 0.0021 0.004 0.0211 0.0135 0.0124
None 0.016 0.0081 0.0134 0.0197 0.0065 0.0071 0.0042 0.0019 0.0019 0.0054 0.0094 0.0021 0.007 0.0013 0.0026 0.0023 0.0012 0.0016
Nuclear Periphery 0.0077 0.0028 0.0051 0.0051 0.0112 0.0055 0.0073 0.0025 0.004 0.0078 0.0118 0.0046 0.0107 0.0029 0.0055 0.0232 0.0022 0.0081
Nucleolus 0.0005 0.0001 0.0001 0.0001 0.0011 0.0001 0.0001 0 0 0.0003 0.0002 0.0001 0.0005 0.0001 0.0002 0.0009 0.0001 0.0001
Nucleus 0.0728 0.0374 0.0627 0.0814 0.0418 0.0687 0.0731 0.0321 0.0551 0.0933 0.0738 0.0803 0.058 0.0284 0.0281 0.0398 0.0195 0.0443
Peroxisomes 0.011 0.0001 0.0033 0.001 0.0174 0.0019 0.0035 0.0001 0.0001 0.0017 0.0004 0.0015 0.0263 0.0023 0.0071 0.0151 0.0102 0.0006
Punctate Nuclear 0.0038 0.0013 0.0029 0.0027 0.0046 0.0029 0.002 0.0008 0.0009 0.024 0.0098 0.0032 0.0146 0.0007 0.0026 0.0084 0.0008 0.0029
Vacuole 0.0022 0.0009 0.0018 0.0011 0.0055 0.0012 0.0021 0.0004 0.0007 0.0015 0.0022 0.001 0.006 0.0005 0.0009 0.0025 0.0007 0.0017
Vacuole Periphery 0.0008 0.0001 0.0004 0.0002 0.0032 0.0003 0.0005 0.0001 0.0002 0.0003 0.0006 0.0003 0.0017 0.0002 0.0004 0.0017 0.0008 0.0012

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 33.5318 17.7979 23.6332 39.9161 22.417 29.324 33.8598 36.437 47.7164 37.1585
Translational Efficiency 1.6113 1.6653 1.5327 1.3873 1.8531 2.3076 1.3059 1.4085 1.5635 1.4377

Hit Data

Dataset Hit
Protein Concentration ✘
Protein Localization ✘
Gene Expression ✘
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
752 669 427 1976 1989 1734 104 1386 2741 2403 531 3362

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 774.49 958.57 912.79 1605.46 857.91 921.15 2063.32 1604.86 835.02 931.57 1138.13 1605.21
Standard Deviation 187.36 207.99 314.10 362.68 138.95 128.82 488.02 460.81 158.20 155.88 578.33 406.02
Intensity Change Log 2 — 0.307637 0.237036 1.051668 — 0.102610 1.266069 0.903549 — 0.203523 0.866433 0.975722

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.000172 0.000328 0.000481 0.000596 0.000114 0.000344 0.000593 0.003576 0.000130 0.000340 0.000503 0.001824
Bud Neck 0.005429 0.001452 0.001754 0.003087 0.002701 0.003239 0.039478 0.003600 0.003450 0.002741 0.009142 0.003299
Bud Site 0.005611 0.006695 0.005743 0.011016 0.004092 0.007468 0.060375 0.018745 0.004508 0.007253 0.016443 0.014202
Cell Periphery 0.000155 0.000111 0.000349 0.000133 0.000087 0.000052 0.000341 0.000130 0.000105 0.000068 0.000348 0.000131
Cytoplasm 0.603564 0.752298 0.625104 0.582525 0.730984 0.754463 0.280788 0.546363 0.696026 0.753861 0.557667 0.567617
Cytoplasmic Foci 0.192444 0.052256 0.014175 0.008659 0.068938 0.061778 0.037618 0.026248 0.102822 0.059127 0.018766 0.015910
Eisosomes 0.000088 0.000019 0.000027 0.000005 0.000022 0.000020 0.000021 0.000012 0.000040 0.000020 0.000025 0.000008
Endoplasmic Reticulum 0.000990 0.000954 0.002556 0.000368 0.001023 0.000556 0.001305 0.002130 0.001014 0.000667 0.002311 0.001094
Endosome 0.008164 0.002891 0.001765 0.005124 0.002389 0.003663 0.021088 0.016963 0.003973 0.003448 0.005550 0.010005
Golgi 0.001511 0.000390 0.000368 0.007328 0.000841 0.001242 0.003643 0.025314 0.001025 0.001005 0.001010 0.014743
Lipid Particles 0.004126 0.000714 0.000936 0.000845 0.001071 0.001074 0.003782 0.001558 0.001909 0.000973 0.001493 0.001139
Mitochondria 0.004401 0.000196 0.000304 0.000859 0.000751 0.001937 0.000452 0.005529 0.001752 0.001452 0.000333 0.002784
Mitotic Spindle 0.002086 0.008605 0.007214 0.081388 0.004447 0.007010 0.021099 0.151894 0.003799 0.007454 0.009933 0.110455
None 0.006478 0.017659 0.012003 0.009169 0.005078 0.003273 0.004673 0.008952 0.005462 0.007278 0.010568 0.009079
Nuclear Periphery 0.000241 0.000233 0.000715 0.000846 0.000259 0.000178 0.001412 0.001482 0.000254 0.000193 0.000851 0.001108
Nuclear Periphery Foci 0.001458 0.003608 0.005121 0.002150 0.000944 0.001117 0.012679 0.006946 0.001085 0.001811 0.006601 0.004127
Nucleolus 0.000596 0.001303 0.000493 0.000248 0.000300 0.000432 0.003370 0.000414 0.000381 0.000674 0.001056 0.000317
Nucleus 0.110770 0.105820 0.246044 0.247293 0.146822 0.098216 0.108364 0.104210 0.136931 0.100333 0.219078 0.188306
Peroxisomes 0.002177 0.000995 0.000187 0.000272 0.000843 0.001355 0.003524 0.001510 0.001209 0.001255 0.000840 0.000782
Vacuole 0.048720 0.043067 0.074454 0.036297 0.027899 0.051859 0.386062 0.055838 0.033612 0.049411 0.135485 0.044353
Vacuole Periphery 0.000819 0.000405 0.000208 0.001793 0.000394 0.000723 0.009334 0.018588 0.000511 0.000635 0.001995 0.008717

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin -1.89 -4.06 -2.02 -0.90 0.60 -1.57 -4.50 -1.46 -0.86 0.80 -1.94 -6.06 -2.32 -1.09 0.51
Bud Neck 6.22 2.48 2.54 -7.69 -0.30 -1.00 -7.07 -2.77 -1.44 6.91 1.87 -5.89 -1.16 -3.13 5.70
Bud Site -1.09 -1.85 -0.66 0.50 1.51 -2.76 -5.94 -5.49 -1.96 5.39 -2.97 -5.85 -4.75 -0.68 4.65
Cell Periphery 2.92 -2.25 0.98 -2.16 2.44 4.37 -5.05 -4.65 -10.78 4.50 5.17 -4.53 -4.27 -10.26 3.84
Cytoplasm -10.72 6.18 9.44 23.18 0.11 -1.68 19.76 21.51 21.99 -12.02 -7.24 18.48 28.47 35.24 -5.17
Cytoplasmic Foci 18.39 25.77 27.75 12.54 5.35 1.61 3.04 19.39 17.41 3.22 12.34 23.51 32.68 23.53 4.80
Eisosomes 12.25 9.41 15.41 6.33 10.62 0.82 -0.69 11.18 7.57 4.96 9.54 2.89 18.22 9.99 11.48
Endoplasmic Reticulum -0.31 -6.50 5.84 4.99 8.71 3.26 -1.06 2.35 0.12 2.63 2.89 -6.25 4.52 2.78 8.70
Endosome 6.82 8.88 9.36 4.40 1.91 -2.08 -5.82 -1.42 0.54 5.41 1.44 -0.94 5.66 3.07 4.35
Golgi 4.56 4.84 0.74 -1.65 -1.87 -0.69 -3.94 -2.55 -2.29 -0.62 0.24 0.80 -1.99 -2.22 -2.65
Lipid Particles 6.32 3.95 3.70 -7.81 -1.13 0.08 -5.20 -6.50 -3.49 3.73 2.78 -2.10 -1.96 -4.27 1.06
Mitochondria 2.21 2.11 1.96 -6.18 -3.71 -1.50 0.95 -0.64 1.05 -1.39 0.57 2.46 1.66 1.08 -2.70
Mitotic Spindle -1.96 -2.16 -12.14 -8.55 -9.09 -1.25 -1.91 -12.48 -11.84 -3.93 -2.11 -2.51 -17.07 -15.21 -10.99
None -3.17 -0.65 -2.33 2.16 -2.43 2.63 2.18 -5.02 -12.46 -5.92 -1.29 -1.11 -6.14 -4.37 -3.34
Nuclear Periphery -0.65 -12.52 -27.86 -27.73 -3.78 3.15 -6.67 -9.35 -10.11 1.43 2.53 -13.99 -22.19 -23.74 -1.62
Nuclear Periphery Foci -4.22 -4.04 -3.28 2.75 2.79 -1.66 -4.43 -6.56 -5.75 3.49 -4.42 -6.41 -8.67 -3.28 4.09
Nucleolus -1.58 2.11 2.01 2.10 -0.54 -1.07 -2.77 -1.38 0.53 2.73 -1.92 -2.53 -0.04 1.95 2.54
Nucleus -0.08 -14.49 -23.68 -22.54 1.49 11.14 1.75 -0.90 -10.50 -2.00 9.18 -11.22 -19.48 -28.84 3.11
Peroxisomes 2.59 5.51 5.80 2.52 1.50 -1.29 -2.64 1.23 2.74 3.55 -0.29 1.76 3.75 3.84 3.10
Vacuole -0.82 -10.26 -17.74 -15.96 0.54 -11.51 -12.86 -24.56 -17.91 7.42 -10.21 -15.88 -32.64 -23.72 3.63
Vacuole Periphery 2.40 4.06 2.63 0.43 -1.43 -1.50 -5.28 -2.87 -2.46 2.14 -0.56 -3.04 -2.28 -1.95 -0.33
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Non-essential hydrolase involved in mRNA decapping; activates Xrn1p; may function in a feedback mechanism to regulate deadenylation, contains pyrophosphatase activity and a HIT (histidine triad) motif; acts as inhibitor of neutral trehalase Nth1p; required for growth on glycerol medium; protein abundance increases in response to DNA replication stress; DCS1 has a paralog, DCS2, that arose from the whole genome duplication
Localization
Cell Percentages cytoplasm (92%)
Cell Cycle Regulation No
Subcompartmental Group cytoplasm-9

Dcs1

Dcs1


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Dcs1-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available