Standard name
Human Ortholog
Description L-ornithine transaminase (OTAse); catalyzes the second step of arginine degradation, expression is dually-regulated by allophanate induction and a specific arginine induction process; not nitrogen catabolite repression sensitive; protein abundance increases in response to DNA replication stress; human homolog OAT complements yeast null mutant
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.07 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 0.97 0.99 0.98 0.93 0.88 0.82 0.73 0.67 0.66 0.66 0.69 0.58 0.98 0.98 0.95 0.99 0.98 0.99 0.83 0.92 0.94 0.94 0.92 0.91
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 0 0.06 0 0 0 0 0 0 0 0.07 0 0 0 0 0 0
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0 0 0 0 0 0.05 0.09 0.06 0.11 0.08 0.12 0.13 0 0 0 0 0 0 0 0 0 0 0 0
Nucleus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vac/Vac Membrane 0 0 0 0.07 0.1 0.13 0.18 0.27 0.22 0.21 0.22 0.27 0 0 0.06 0 0 0 0 0 0 0 0 0
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 1 1 2 4 3 3 2 0 0 0 0 0 0 1 0 1 1 1 0
Bud 0 1 0 0 0 1 9 7 1 3 5 6 0 1 1 0 0 0 19 9 10 8 10 14
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 2 1 1 3 9 7 14 13 21 22 15 22 3 3 2 1 0 0 0 0 1 0 0 0
Cytoplasm 289 272 471 325 412 441 435 412 369 514 323 350 290 409 405 145 211 175 245 249 440 285 377 366
Endoplasmic Reticulum 1 2 2 4 5 8 19 13 14 47 5 23 1 3 4 6 8 12 9 0 6 0 4 2
Endosome 0 0 0 0 1 1 1 0 0 0 0 0 1 0 1 0 0 0 1 0 0 0 0 0
Golgi 0 0 0 1 0 0 0 3 2 2 0 0 0 0 0 0 1 0 1 0 0 0 0 0
Mitochondria 0 0 0 2 5 25 55 38 59 59 56 78 2 1 0 0 0 0 0 0 1 0 0 0
Nucleus 0 1 1 1 2 1 2 6 9 15 4 6 0 0 0 0 0 1 2 5 0 3 5 4
Nuclear Periphery 0 0 0 0 0 0 1 1 0 2 1 1 0 0 0 0 0 0 1 0 0 0 0 0
Nucleolus 1 0 0 0 0 2 1 1 2 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 1 0 1 3
Vac/Vac Membrane 8 2 9 23 47 68 109 168 124 163 105 160 3 10 27 2 3 2 5 2 0 1 7 4
Unique Cell Count 297 275 482 349 466 535 597 616 557 779 471 603 296 419 428 147 215 177 295 272 469 303 412 402
Labelled Cell Count 301 279 484 359 481 555 647 664 605 831 517 648 300 427 440 154 223 190 295 272 469 303 412 402


Cytoplasm, Nucleus

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 15.8 22.9 17.6 15.5 15.2 13.5 13.4 13.7 13.5 13.6 12.7 12.7 19.0 23.2 26.5 62.1 59.6 60.2 20.1 18.1 17.7
Std Deviation (1e-4) 6.4 8.2 5.9 5.6 4.9 4.3 4.3 4.2 4.5 4.6 4.7 4.8 7.5 10.1 14.0 23.4 23.2 20.6 6.6 5.8 5.6
Intensity Change (Log2) – – – -0.18 -0.21 -0.38 -0.4 -0.36 -0.38 -0.37 -0.47 -0.47 0.11 0.4 0.59 1.82 1.76 1.78 0.19 0.04 0.01

WT3RAP60RAP140RAP220RAP300RAP380RAP460RAP540RAP620RAP700020406080WT3HU80HU120HU160020406080WT3rpd3Δ_1rpd3Δ_2rpd3Δ_3020406080WT1AF100AF140AF180020406080
rapamycinhydroxy-urearpd3 knockoutalpha-factorMultiple Condition Time-Course Intensity PlotsGFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)

Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cell Periphery 0 0 0 3.0 2.8 4.0 3.4 3.6 3.9 0 0 0 0 0 0
Cytoplasm -3.3 -5.7 -8.0 -11.1 -12.8 -12.9 -13.2 -12.1 -15.1 0.2 -0.1 -2.5 0.7 0.4 0.9
Endoplasmic Reticulum 0 0 0 3.3 2.4 2.7 5.0 0 3.7 0 0 0 0 0 0
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0 0 4.8 6.8 5.5 7.4 6.2 7.8 8.2 0 0 0 0 0 0
Nucleus 0 0 0 0 0 0 2.6 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vacuole 3.5 5.4 6.5 8.6 11.4 9.8 9.6 9.7 11.1 0 0.5 3.4 0 0 0

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 9.2929 11.1568 9.9819 10.8289 10.6766 10.0648 6.3503 8.6162 7.6494 7.8549 9.1247 7.3146 5.9131 8.2588 7.4559 5.4437 4.8131 7.737
Actin 0.0282 0.0007 0.0127 0.0136 0.0005 0.003 0.006 0.0007 0.012 0.0015 0.0001 0.0001 0.0248 0.0005 0.0089 0.03 0.0005 0.0027
Bud 0.0005 0.0013 0.0012 0.0014 0.0001 0.0006 0.0022 0.001 0.0043 0.0005 0.0001 0.0001 0.0009 0.0004 0.0011 0.002 0.0005 0.0002
Bud Neck 0.0008 0.0003 0.0005 0.0005 0.0005 0.0024 0.001 0.0001 0.0007 0.0004 0.0003 0.0007 0.0037 0.0002 0.0004 0.0007 0.0008 0.0008
Bud Periphery 0.0004 0.0005 0.0008 0.0016 0.0001 0.0004 0.0025 0.0002 0.0037 0.0006 0.0001 0.0001 0.0008 0.0001 0.0004 0.0011 0.0004 0.0002
Bud Site 0.002 0.0045 0.0038 0.0129 0.0001 0.0002 0.0032 0.0007 0.0087 0.0002 0 0.0004 0.0025 0.0009 0.0009 0.0011 0.0002 0.0001
Cell Periphery 0.0002 0.0001 0.0002 0.0004 0 0.0001 0.0002 0 0.0005 0 0 0.0001 0.0002 0 0 0.0001 0.0001 0
Cytoplasm 0.8498 0.9764 0.9055 0.8916 0.8824 0.9466 0.8404 0.9874 0.9152 0.862 0.8439 0.957 0.8371 0.975 0.9467 0.8323 0.9265 0.943
Cytoplasmic Foci 0.023 0.0024 0.0097 0.008 0.007 0.0085 0.0187 0.0013 0.0078 0.0039 0.0014 0.0019 0.0171 0.0016 0.0077 0.0079 0.0042 0.0053
Eisosomes 0.0012 0 0.0009 0.0002 0 0.0001 0 0 0 0 0 0 0.0002 0 0 0.0001 0 0
Endoplasmic Reticulum 0.0118 0.0008 0.0031 0.0112 0.0055 0.0033 0.003 0.0005 0.0011 0.0009 0.0044 0.0011 0.005 0.0008 0.0033 0.0018 0.0032 0.0016
Endosome 0.0262 0.0008 0.0169 0.0161 0.0298 0.0037 0.0151 0.0002 0.021 0.0193 0.0911 0.0048 0.0286 0.0004 0.009 0.0106 0.0267 0.0045
Golgi 0.0032 0.0001 0.0074 0.0059 0.0009 0.0009 0.0026 0 0.0068 0.0384 0.0056 0.0002 0.0058 0 0.0011 0.0087 0.0017 0.002
Lipid Particles 0.0029 0 0.005 0.0019 0.0022 0.0002 0.0115 0 0.0006 0.0002 0.0001 0.0003 0.0017 0 0.0005 0.0028 0.0001 0.0023
Mitochondria 0.0017 0.0002 0.0035 0.0134 0.0004 0.0009 0.0056 0.0001 0.0027 0.0612 0.0073 0.0002 0.0136 0.0001 0.0003 0.0713 0.0067 0.0022
None 0.0101 0.0028 0.0108 0.004 0.0452 0.0119 0.0069 0.003 0.0034 0.0022 0.0006 0.0018 0.0116 0.0119 0.0028 0.0095 0.0076 0.0039
Nuclear Periphery 0.0087 0.0008 0.0025 0.0028 0.0073 0.0015 0.0308 0.0005 0.0011 0.001 0.005 0.002 0.0158 0.0008 0.0038 0.0019 0.002 0.0057
Nucleolus 0.0003 0 0.0001 0.0001 0.0001 0.0001 0.0008 0 0.0002 0 0 0.0013 0.0004 0 0.0001 0.0001 0.0001 0
Nucleus 0.0098 0.0066 0.0065 0.0098 0.0137 0.0108 0.0322 0.0035 0.005 0.0051 0.0111 0.0125 0.0207 0.0062 0.0099 0.0098 0.0092 0.0192
Peroxisomes 0.0061 0.0002 0.004 0.002 0.0002 0.0029 0.0051 0 0.0005 0.0001 0 0 0.0013 0 0.0007 0.0044 0.0001 0.0041
Punctate Nuclear 0.0097 0.0008 0.0035 0.0007 0.0017 0.0006 0.0045 0.0003 0.0028 0.0002 0.0003 0.0005 0.0022 0.0004 0.0011 0.0014 0.0006 0.0011
Vacuole 0.0029 0.0006 0.0009 0.0013 0.0019 0.0009 0.0037 0.0003 0.0015 0.0008 0.0102 0.0134 0.0043 0.0006 0.0009 0.0016 0.0065 0.0007
Vacuole Periphery 0.0008 0.0001 0.0003 0.0005 0.0006 0.0003 0.0039 0 0.0004 0.0016 0.0181 0.0013 0.0016 0.0001 0.0003 0.0009 0.0024 0.0004

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 20.77 51.8331 88.4061 86.1469 55.5414 31.1377 56.1239 65.2009 75.2338 40.3046
Translational Efficiency 1.1078 1.3161 1.3861 1.8104 1.4744 0.9559 1.4431 1.6128 1.2637 1.2107

Hit Data

Dataset Hit
Protein Concentration ✘
Protein Localization ✘
Gene Expression ✔
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
1584 1101 1148 92 1754 1499 261 1086 3338 2600 1409 1178

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 1234.87 1847.70 1098.83 1492.66 1238.82 1645.49 1413.60 1605.62 1236.95 1731.12 1157.14 1596.80
Standard Deviation 333.96 567.98 242.51 576.88 321.35 460.49 352.42 705.65 327.40 518.51 293.05 697.11
Intensity Change Log 2 — 0.581371 -0.168391 0.273526 — 0.409551 0.190407 0.374164 — 0.497880 0.022419 0.324803

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.000191 0.000172 0.000367 0.001115 0.000184 0.000275 0.000492 0.001036 0.000187 0.000231 0.000390 0.001043
Bud Neck 0.000669 0.000581 0.003047 0.003339 0.001098 0.000903 0.002380 0.004537 0.000895 0.000766 0.002924 0.004443
Bud Site 0.005527 0.002926 0.003417 0.021642 0.006283 0.004269 0.005975 0.019638 0.005924 0.003701 0.003891 0.019795
Cell Periphery 0.000101 0.000156 0.000142 0.000276 0.000112 0.000143 0.000204 0.000224 0.000107 0.000148 0.000153 0.000228
Cytoplasm 0.888478 0.838159 0.443923 0.552462 0.863500 0.853995 0.509592 0.666791 0.875353 0.847289 0.456087 0.657862
Cytoplasmic Foci 0.031093 0.013586 0.005495 0.009474 0.027794 0.015305 0.016393 0.018066 0.029359 0.014577 0.007514 0.017395
Eisosomes 0.000004 0.000002 0.000019 0.000029 0.000004 0.000003 0.000043 0.000017 0.000004 0.000003 0.000024 0.000018
Endoplasmic Reticulum 0.000416 0.000355 0.002854 0.002081 0.001494 0.000477 0.002962 0.000592 0.000983 0.000425 0.002874 0.000709
Endosome 0.000768 0.000318 0.001338 0.001765 0.000801 0.000825 0.004402 0.011009 0.000785 0.000610 0.001905 0.010287
Golgi 0.000898 0.000769 0.000138 0.000397 0.000671 0.001375 0.000228 0.005762 0.000779 0.001118 0.000155 0.005343
Lipid Particles 0.000363 0.000428 0.000843 0.001420 0.000472 0.000415 0.001886 0.001281 0.000420 0.000420 0.001037 0.001292
Mitochondria 0.000129 0.000187 0.000833 0.035318 0.000704 0.000674 0.000301 0.003840 0.000431 0.000468 0.000734 0.006298
Mitotic Spindle 0.002568 0.003537 0.007762 0.047019 0.004367 0.014947 0.008826 0.057232 0.003513 0.010115 0.007959 0.056435
None 0.007212 0.011139 0.007280 0.005714 0.008674 0.009080 0.011172 0.006070 0.007980 0.009952 0.008001 0.006042
Nuclear Periphery 0.000052 0.000102 0.001461 0.000684 0.000139 0.000197 0.001408 0.000456 0.000098 0.000157 0.001451 0.000474
Nuclear Periphery Foci 0.002120 0.002859 0.001579 0.004606 0.002541 0.002942 0.006047 0.002663 0.002341 0.002907 0.002407 0.002815
Nucleolus 0.000101 0.000111 0.000310 0.000230 0.000125 0.000288 0.000295 0.000317 0.000113 0.000213 0.000307 0.000311
Nucleus 0.048957 0.116326 0.478333 0.140639 0.069493 0.084125 0.237809 0.120826 0.059748 0.097761 0.433779 0.122374
Peroxisomes 0.000141 0.000051 0.000120 0.000285 0.000119 0.000131 0.000179 0.001772 0.000130 0.000097 0.000131 0.001655
Vacuole 0.009181 0.007459 0.040572 0.171332 0.010360 0.008546 0.189169 0.075115 0.009800 0.008086 0.068098 0.082630
Vacuole Periphery 0.001031 0.000777 0.000165 0.000173 0.001065 0.001086 0.000239 0.002755 0.001049 0.000955 0.000178 0.002553

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin -0.30 -6.54 -4.01 -4.01 -1.75 -2.21 -6.89 -3.70 -2.36 0.29 -2.08 -9.35 -4.12 -3.27 -0.70
Bud Neck -0.70 -14.14 -6.50 -6.40 -0.60 -0.30 -8.55 -7.60 -7.36 -0.12 -0.85 -15.47 -9.39 -9.09 1.66
Bud Site 3.14 2.07 -2.48 -3.18 -2.94 2.28 -0.32 -4.16 -5.99 -4.08 3.66 2.58 -5.02 -7.20 -6.65
Cell Periphery -5.38 -6.02 -3.74 -2.80 -3.10 -2.04 -5.90 -5.97 -3.76 -2.76 -4.24 -7.89 -6.88 -4.39 -4.80
Cytoplasm 10.55 61.29 16.87 14.63 -0.40 4.78 30.19 32.97 28.42 -10.74 10.52 68.34 38.35 31.95 -16.86
Cytoplasmic Foci 6.96 13.02 4.36 -0.65 -4.91 5.93 9.60 6.22 0.26 -4.64 9.05 18.10 8.23 -0.26 -10.50
Eisosomes 3.42 -15.38 -7.18 -7.62 -1.25 1.05 -11.25 -13.32 -13.17 7.53 2.69 -18.87 -15.20 -16.20 7.79
Endoplasmic Reticulum 0.54 -14.59 -3.89 -3.88 4.67 2.26 -3.09 2.16 -0.58 8.00 2.29 -9.11 1.44 -2.09 15.07
Endosome 3.94 -7.33 -4.41 -6.20 -0.49 0.17 -7.70 -2.27 -2.28 0.68 1.89 -10.38 -2.45 -2.72 -0.59
Golgi 0.48 4.25 3.56 2.57 -2.70 -1.40 3.44 -1.09 0.08 -1.96 -1.02 5.86 -0.78 -0.16 -2.17
Lipid Particles -2.34 -10.43 -6.33 -5.53 -4.61 -1.48 -9.81 -8.14 -7.47 -1.20 -2.85 -12.74 -9.47 -8.22 -5.10
Mitochondria -0.83 -9.47 -1.03 -1.01 -0.86 0.23 0.72 -0.35 -0.66 -1.29 0.04 -1.81 -1.43 -1.50 -0.76
Mitotic Spindle -1.26 -5.61 -2.36 -2.08 -1.14 -4.95 -2.52 -7.23 -3.13 -2.90 -5.14 -5.56 -7.89 -4.97 -5.05
None -2.94 1.04 2.19 5.01 1.85 0.21 0.99 3.96 3.33 0.87 -1.68 2.35 3.96 6.17 1.89
Nuclear Periphery -3.83 -29.59 -9.09 -8.51 5.09 -2.34 -15.27 -18.83 -11.64 9.76 -3.58 -32.24 -24.22 -17.51 18.60
Nuclear Periphery Foci -3.33 0.68 -4.10 -1.95 -4.48 -1.24 -4.54 -0.91 0.70 4.21 -2.79 -0.84 -2.60 0.83 -1.85
Nucleolus -0.60 -7.91 -2.00 -1.71 2.16 -2.01 -6.04 -2.45 1.12 2.48 -2.12 -9.65 -3.18 0.39 4.61
Nucleus -16.34 -54.58 -6.18 -1.73 18.73 -6.47 -14.23 -14.99 -9.73 8.79 -16.25 -52.53 -18.75 -8.01 36.45
Peroxisomes 2.65 0.06 -0.92 -3.85 -1.28 -0.20 -1.71 -2.09 -1.96 -1.82 1.16 -0.65 -2.04 -2.29 -1.95
Vacuole -1.28 -16.75 -11.68 -11.61 -9.21 -3.16 -16.92 -25.91 -24.97 4.39 -3.43 -21.57 -28.12 -27.42 -10.97
Vacuole Periphery 0.45 1.34 1.39 1.43 1.96 0.25 1.96 0.96 0.67 -1.31 0.47 2.28 1.13 0.73 -1.37
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description L-ornithine transaminase (OTAse); catalyzes the second step of arginine degradation, expression is dually-regulated by allophanate induction and a specific arginine induction process; not nitrogen catabolite repression sensitive; protein abundance increases in response to DNA replication stress; human homolog OAT complements yeast null mutant
Localization
Cell Percentages cytoplasm (99%)
Cell Cycle Regulation No
Subcompartmental Group cytoplasm-7

Car2

Car2


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Car2-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available