Standard name
Human Ortholog
Description Large subunit of trehalose 6-phosphate synthase/phosphatase complex; Tps1p-Tps2p complex converts uridine-5'-diphosphoglucose and glucose 6-phosphate to trehalose; contributes to survival to acute lethal heat stress; mutant has aneuploidy tolerance; protein abundance increases in response to DNA replication stress; TSL1 has a paralog, TPS3, that arose from the whole genome duplication
DOWNLOAD

Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0.06 0 0 0 0 0 0 0.05 0.05 0.09 0.11 0.08 0 0 0 0 0.12 0 0 0 0 0 0 0
Cytoplasm 0.98 0.96 0.97 0.96 0.94 0.82 0.74 0.63 0.64 0.55 0.56 0.55 0.98 0.98 0.96 0.95 0.77 0.89 0.92 0.92 0.89 0.91 0.86 0.86
Endoplasmic Reticulum 0 0 0 0 0 0 0.05 0 0.05 0.08 0.08 0.06 0 0 0 0.06 0 0.05 0 0 0 0 0.06 0.07
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.06 0.05 0 0 0 0 0 0
Mitochondria 0 0 0 0.18 0.12 0.28 0.25 0.24 0.25 0.34 0.31 0.37 0 0 0 0 0 0 0 0 0 0 0 0
Nucleus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vac/Vac Membrane 0 0 0 0 0 0 0 0.13 0.11 0.12 0.09 0.12 0 0 0 0 0.17 0.11 0 0 0 0 0 0
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 2 1 5 8 11 9 7 13 0 1 2 0 0 0 0 0 0 1 0 0
Bud 1 0 10 3 4 3 6 13 13 5 5 7 2 1 3 0 0 0 2 1 2 3 2 4
Bud Neck 0 1 0 0 0 0 0 1 1 0 0 0 0 0 0 0 0 0 1 0 1 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 8 0 3 2 9 12 13 22 22 27 26 24 1 3 2 2 8 0 0 0 0 0 0 0
Cytoplasm 131 149 284 246 323 223 282 268 268 170 138 160 219 208 204 59 53 17 133 150 277 122 201 216
Endoplasmic Reticulum 1 1 2 4 2 5 20 19 21 26 19 17 5 4 6 4 2 1 2 0 4 3 13 18
Endosome 0 1 0 0 0 1 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 1 0 1 1 3 0 0 0 1 4 1 0 0 0 0 0 1
Mitochondria 0 4 10 45 40 77 95 104 104 104 75 107 1 0 4 2 1 0 0 0 13 0 0 2
Nucleus 0 0 0 0 0 0 1 6 6 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0
Nuclear Periphery 0 0 0 0 0 0 2 0 0 1 1 1 0 0 0 0 0 0 1 0 0 0 0 0
Nucleolus 0 0 0 1 0 0 0 1 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 1 0 0 0 0 0 1 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vac/Vac Membrane 2 4 2 0 7 5 17 55 44 37 22 34 0 1 2 2 12 2 0 5 5 2 7 4
Unique Cell Count 133 156 293 256 344 273 380 425 418 309 245 289 224 212 213 62 69 19 145 163 312 135 233 252
Labelled Cell Count 143 161 311 301 387 327 441 499 493 380 294 366 228 218 223 70 80 21 145 163 312 135 233 252


Cytoplasm

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 8.3 8.9 5.7 4.8 6.4 6.9 7.9 9.0 9.0 10.2 10.0 11.8 13.4 18.4 19.3 28.6 31.7 31.1 13.3 15.3 13.0
Std Deviation (1e-4) 3.1 3.1 2.2 1.4 2.1 2.1 2.5 3.0 3.0 4.3 4.2 5.8 5.0 8.2 8.4 10.1 15.3 11.4 4.3 6.5 4.3
Intensity Change (Log2) – – – -0.26 0.16 0.26 0.47 0.65 0.65 0.84 0.81 1.04 1.23 1.69 1.75 2.32 2.47 2.44 1.22 1.42 1.18


Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches 0 0 0 0 0 0 0 0 3.7 0 0 0 0 0 0
Bud 0 -1.9 -1.8 -1.5 -0.3 -0.2 -1.4 -1.0 -0.7 -1.9 0 -1.4 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cell Periphery 0 1.5 2.5 2.0 3.0 3.0 4.3 4.9 4.2 0 0 0 0 0 0
Cytoplasm -0.5 -1.8 -5.9 -8.0 -10.6 -10.3 -11.9 -11.4 -11.8 0.6 0.8 -0.7 -0.7 -5.9 -1.7
Endoplasmic Reticulum 0 0 0 3.3 3.0 3.2 4.5 4.2 3.5 0 0 0 0 0 0
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0 3.8 8.2 7.7 7.6 7.7 9.5 8.6 10.1 0 0 -1.0 0 0 0
Nucleus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vacuole 0 0 0 2.9 6.0 5.3 5.6 4.6 5.5 0 0 0 0 0 0

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 8.5751 12.0254 11.4497 10.2003 8.25 11.2524 17.2445 23.0095 18.6384 16.1111 15.2346 21.2014 21.0353 24.3405 23.9012 17.9262 25.0284 21.136
Actin 0.0533 0.005 0.0161 0.0066 0.0214 0.003 0.0331 0.0004 0.03 0.0068 0.062 0.0164 0.0161 0.0046 0.0038 0.0028 0.0002 0.0012
Bud 0.0032 0.0014 0.0014 0.004 0.0383 0.0025 0.0015 0.0008 0.0007 0.0014 0.0052 0.0005 0.0014 0.0009 0.0026 0.0101 0.0003 0.0008
Bud Neck 0.0042 0.0006 0.0008 0.0014 0.0053 0.0016 0.0011 0.0003 0.0008 0.0018 0.002 0.0014 0.0005 0.0003 0.0007 0.0008 0.0004 0.001
Bud Periphery 0.0052 0.0011 0.0008 0.0042 0.0288 0.0067 0.0015 0.0003 0.0005 0.0007 0.004 0.0004 0.0011 0.0003 0.0012 0.0265 0 0.0006
Bud Site 0.0096 0.0036 0.0017 0.0026 0.0071 0.0006 0.0035 0.0019 0.0018 0.0203 0.0039 0.0007 0.001 0.0034 0.0033 0.0011 0.0001 0.0001
Cell Periphery 0.0023 0.0013 0.0007 0.0015 0.0008 0.0012 0.0007 0.0008 0.0002 0.0002 0.0007 0.0002 0.0005 0.0002 0.0004 0.0017 0.0001 0.0002
Cytoplasm 0.5547 0.9177 0.8375 0.7403 0.6896 0.8174 0.739 0.966 0.8394 0.8949 0.6921 0.8506 0.8015 0.935 0.891 0.8474 0.9056 0.9142
Cytoplasmic Foci 0.0447 0.0051 0.0116 0.0062 0.0331 0.0093 0.0152 0.0031 0.0156 0.0104 0.0411 0.0162 0.0131 0.0069 0.0127 0.0129 0.0087 0.0096
Eisosomes 0.0005 0 0.0002 0.0001 0.0001 0 0.0005 0 0.0003 0.0001 0.0005 0.0001 0.0001 0 0 0 0 0
Endoplasmic Reticulum 0.07 0.0247 0.0139 0.0397 0.0086 0.0586 0.0518 0.011 0.0115 0.0029 0.0081 0.0453 0.046 0.0064 0.0208 0.0256 0.041 0.0182
Endosome 0.069 0.0078 0.03 0.0427 0.0374 0.0308 0.0402 0.0042 0.0264 0.0227 0.0317 0.0306 0.0347 0.0124 0.0354 0.0346 0.0218 0.0308
Golgi 0.0361 0.0026 0.0105 0.0027 0.0109 0.006 0.0055 0.0005 0.0096 0.0038 0.0294 0.0057 0.0151 0.0045 0.0025 0.0023 0.0006 0.0038
Lipid Particles 0.0201 0.0004 0.0028 0.001 0.0041 0.0082 0.0122 0.0001 0.0054 0.0019 0.0143 0.0049 0.0028 0.0006 0.0003 0.0002 0 0.0001
Mitochondria 0.0466 0.0012 0.0036 0.0111 0.0141 0.0188 0.0069 0.0001 0.0149 0.0008 0.0435 0.0025 0.0361 0.0101 0.0007 0.0019 0.0002 0.0095
None 0.0056 0.0079 0.0023 0.0021 0.0027 0.0059 0.0094 0.0015 0.0016 0.0007 0.0173 0.0026 0.001 0.0005 0.0007 0.0007 0.0003 0.0004
Nuclear Periphery 0.0095 0.002 0.0096 0.0203 0.0281 0.0044 0.0163 0.0009 0.0112 0.002 0.004 0.0056 0.0052 0.0019 0.0019 0.0072 0.0018 0.0013
Nucleolus 0.0012 0.0001 0.0002 0.0011 0.0004 0.0001 0.0024 0 0.0005 0.0002 0.0008 0.0001 0.0003 0 0 0 0 0
Nucleus 0.0054 0.0017 0.0054 0.0151 0.005 0.0023 0.0073 0.001 0.0048 0.0022 0.0023 0.0038 0.0025 0.0011 0.0012 0.0032 0.001 0.0009
Peroxisomes 0.0107 0.0003 0.0008 0.0002 0.0325 0.0004 0.004 0 0.0044 0.0023 0.0108 0.0016 0.0016 0.0003 0.0002 0.0001 0 0.0001
Punctate Nuclear 0.0205 0.0001 0.0012 0.0005 0.0007 0.0003 0.0073 0.0001 0.0042 0.0007 0.0029 0.0012 0.0004 0.0001 0.0002 0.0002 0.0001 0.0001
Vacuole 0.0235 0.0141 0.0404 0.0843 0.0168 0.0177 0.0351 0.0065 0.0136 0.0186 0.0194 0.0074 0.0134 0.0089 0.0172 0.0165 0.0147 0.0051
Vacuole Periphery 0.0042 0.0011 0.0085 0.0122 0.0141 0.0041 0.0056 0.0006 0.0026 0.0046 0.0042 0.0023 0.0056 0.0015 0.0033 0.0043 0.0031 0.0021

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 13.7214 9.8727 16.206 63.6219 42.9574 39.4691 29.6444 48.6929 86.9624 65.1924
Translational Efficiency 0.7418 0.6222 0.85 0.8972 0.9001 0.8454 0.6936 0.9416 1.0715 0.8308

Hit Data

Dataset Hit
Protein Concentration ✔
Protein Localization ✘
Gene Expression ✔
Translational Efficiency ✔

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
1655 1458 1189 1491 1582 1844 1775 527 3237 3302 2964 2018

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 834.68 740.44 5505.17 1884.30 840.69 915.79 2368.40 1698.66 837.62 838.36 3626.71 1835.82
Standard Deviation 158.39 126.22 1396.82 631.83 237.44 200.96 611.04 669.82 200.97 192.80 1835.74 647.13
Intensity Change Log 2 — -0.172840 2.721492 1.174734 — 0.123443 1.494267 1.014751 — -0.016577 2.232538 1.096672

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.000232 0.000398 0.000229 0.000381 0.000155 0.000408 0.000141 0.000369 0.000195 0.000404 0.000176 0.000378
Bud Neck 0.004002 0.018033 0.003252 0.002733 0.005236 0.005724 0.001116 0.003156 0.004605 0.011159 0.001973 0.002843
Bud Site 0.039866 0.033284 0.004933 0.020600 0.031037 0.038237 0.007252 0.030332 0.035551 0.036050 0.006322 0.023142
Cell Periphery 0.000301 0.000110 0.023536 0.000860 0.000313 0.000173 0.001273 0.002890 0.000307 0.000145 0.010204 0.001390
Cytoplasm 0.730134* 0.496263* 0.610515* 0.728642* 0.723573* 0.682787* 0.892881* 0.654885* 0.726927* 0.600427* 0.779611* 0.709380*
Cytoplasmic Foci 0.145134 0.226092* 0.017777 0.024421 0.123203 0.169134 0.012293 0.042792 0.134416 0.194284* 0.014493 0.029218
Eisosomes 0.000037 0.000068 0.000005 0.000005 0.000029 0.000037 0.000001 0.000008 0.000033 0.000051 0.000003 0.000005
Endoplasmic Reticulum 0.003405 0.001215 0.000646 0.001459 0.003244 0.001661 0.000446 0.000816 0.003326 0.001464 0.000526 0.001291
Endosome 0.011671 0.047991 0.001024 0.009131 0.011728 0.020658 0.001679 0.013370 0.011699 0.032727 0.001416 0.010238
Golgi 0.009318 0.010263 0.054976 0.010315 0.004792 0.010813 0.009762 0.010429 0.007106 0.010570 0.027900 0.010345
Lipid Particles 0.001270 0.003977 0.015915 0.004167 0.001668 0.001350 0.003267 0.005254 0.001465 0.002510 0.008341 0.004451
Mitochondria 0.002162 0.005883 0.000285 0.002814 0.001701 0.003698 0.000128 0.006671 0.001936 0.004663 0.000191 0.003822
Mitotic Spindle 0.000834 0.002176 0.005374 0.009036 0.002714 0.005624 0.003756 0.009048 0.001752 0.004102 0.004405 0.009039
None 0.004015 0.002192 0.002067 0.000908 0.004712 0.000962 0.000788 0.000512 0.004355 0.001505 0.001301 0.000804
Nuclear Periphery 0.000043 0.000187 0.003136 0.000147 0.000162 0.000088 0.000175 0.000156 0.000101 0.000132 0.001363 0.000149
Nuclear Periphery Foci 0.000334 0.000759 0.018374 0.002275 0.000658 0.000375 0.003946 0.002361 0.000493 0.000545 0.009734 0.002298
Nucleolus 0.000144 0.001767 0.000128 0.000249 0.000315 0.000226 0.000066 0.000376 0.000228 0.000907 0.000091 0.000282
Nucleus 0.005679 0.016574 0.026007 0.012255 0.018833 0.005852 0.010004 0.009416 0.012107 0.010586 0.016424 0.011513
Peroxisomes 0.000786 0.007860 0.000016 0.001039 0.000898 0.002724 0.000067 0.001193 0.000840 0.004992 0.000047 0.001079
Vacuole 0.031697 0.118236 0.140207 0.155174 0.055962 0.043457 0.040456 0.194187 0.043556 0.076476 0.080471 0.165362
Vacuole Periphery 0.008937 0.006670 0.071597 0.013391 0.009068 0.006012 0.010502 0.011779 0.009001 0.006303 0.035010 0.012970

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin -2.30 -1.52 -1.10 0.27 -0.62 -3.28 -0.09 -3.38 0.51 -3.13 -3.86 -0.69 -1.91 0.41 -1.72
Bud Neck -10.62 -0.70 1.09 11.11 1.95 -0.88 8.22 2.38 3.77 -6.06 -9.83 6.40 2.72 11.68 -3.61
Bud Site 2.55 17.15 7.95 5.19 -10.63 -2.55 11.22 0.79 2.70 -6.21 -0.20 19.84 6.61 6.83 -11.71
Cell Periphery 8.98 -17.59 -4.27 -5.92 17.13 3.48 -4.85 -3.06 -3.27 -1.57 6.93 -17.11 -4.62 -5.43 14.68
Cytoplasm 23.50 12.05 1.52 -19.88 -10.02 4.35 -20.49 5.01 2.32 16.51 18.20 -5.44 3.62 -11.33 7.76
Cytoplasmic Foci -12.02 28.65 28.58 36.89 -0.62 -7.47 26.46 16.25 23.43 -7.99 -13.14 39.55 33.87 44.73 -7.25
Eisosomes -6.48 10.05 10.84 16.79 3.28 -2.29 15.34 10.52 9.64 -5.81 -6.00 16.72 15.48 19.19 -3.74
Endoplasmic Reticulum 3.13 4.07 2.88 0.09 -1.47 2.61 5.18 4.64 3.07 -1.74 3.97 6.40 4.41 1.25 -1.88
Endosome -15.70 15.15 3.51 16.97 -7.69 -6.29 12.33 0.22 4.44 -5.44 -16.06 19.01 3.19 16.74 -9.03
Golgi -0.83 -21.32 0.71 1.23 20.14* -6.09 -5.42 -2.51 1.23 0.68 -4.77 -18.83 -1.70 1.90 14.43
Lipid Particles -6.47 -16.26 -7.44 -1.00 11.94 1.55 -4.95 -4.28 -4.61 -2.16 -4.81 -16.07 -8.36 -5.35 6.82
Mitochondria -3.42 3.29 -0.03 2.91 -2.18 -2.10 2.55 -1.41 -0.58 -2.11 -3.82 4.17 -1.06 1.59 -3.11
Mitotic Spindle -1.91 -6.44 -5.74 -4.64 -2.29 -2.39 -1.76 -2.12 -0.96 -1.51 -3.24 -5.55 -5.65 -3.79 -3.26
None 1.92 2.17 3.59 3.33 9.85 6.28 6.70 7.08 2.48 2.13 5.09 5.71 6.69 3.57 5.74
Nuclear Periphery -4.43 -8.53 -5.26 0.18 8.18 1.53 -0.78 -0.14 -1.86 0.68 -1.09 -8.51 -2.61 -1.62 8.05
Nuclear Periphery Foci -2.36 -18.44 -7.88 -4.80 15.99 1.93 -9.44 -4.67 -5.68 3.40 -0.63 -20.08 -8.55 -7.92 14.95
Nucleolus -3.12 -0.14 -3.52 2.87 -3.64 1.82 8.66 -0.31 -0.90 -2.11 -2.96 7.98 -1.53 2.63 -4.44
Nucleus -8.90 -13.88 -10.30 -0.12 7.45 11.63 6.03 2.69 -5.26 -1.52 1.68 -8.00 -4.02 -5.16 3.45
Peroxisomes -10.78 15.99 -0.23 9.23 -2.25 -4.59 12.27 -0.73 4.07 -6.37 -11.28 19.20 -0.24 8.83 -3.04
Vacuole -20.21 -20.67 -21.62 -6.82 -2.05 4.21 3.17 -13.48 -14.79 -14.45 -12.64 -13.39 -24.29 -17.78 -15.04
Vacuole Periphery 2.45 -19.08 -1.91 -4.37 18.13* 2.61 -1.01 -0.67 -2.78 0.13 3.59 -15.94 -2.00 -5.35 14.10
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Large subunit of trehalose 6-phosphate synthase/phosphatase complex; Tps1p-Tps2p complex converts uridine-5'-diphosphoglucose and glucose 6-phosphate to trehalose; contributes to survival to acute lethal heat stress; mutant has aneuploidy tolerance; protein abundance increases in response to DNA replication stress; TSL1 has a paralog, TPS3, that arose from the whole genome duplication
Localization
Cell Percentages cytoplasm (91%)
Cell Cycle Regulation No
Subcompartmental Group cytoplasm-4

Tsl1

Tsl1


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Tsl1-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available