Standard name
Human Ortholog
Description G1 cyclin involved in regulation of the cell cycle; activates Cdc28p kinase to promote the G1 to S phase transition; late G1 specific expression depends on transcription factor complexes, MBF (Swi6p-Mbp1p) and SBF (Swi6p-Swi4p); CLN1 has a paralog, CLN2, that arose from the whole genome duplication; cell cycle arrest phenotype of the cln1 cln2 cln3 triple null mutant is complemented by any of human cyclins CCNA2, CCNB1, CCNC, CCND1, or CCNE1
DOWNLOAD

Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 0.91 0.95 0.95 0.95 0.93 0.84 0.81 0.77 0.71 0.67 0.6 0.69 0.98 0.97 0.98 0.94 0.92 0.94 0.83 0.86 0.71 0.88 0.83 0.81
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.06 0.11 0.05 0 0 0 0 0 0
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0.16 0 0 0.08 0.05 0.29 0.27 0.36 0.54 0.52 0.62 0.53 0 0 0 0 0 0 0.05 0 0.14 0 0 0
Nucleus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vac/Vac Membrane 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 0 0 0 1 0 0 0 1 0 0 0 1 1 10 1 3 4
Bud 5 0 1 1 1 2 0 7 10 6 7 4 0 0 0 0 0 0 0 4 5 2 10 9
Bud Neck 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 1 1 0 1 1 3 0 2 2
Bud Site 0 0 0 0 0 0 0 0 1 1 0 1 0 0 0 0 0 0 – – – – – –
Cell Periphery 1 1 3 1 1 2 1 6 2 2 0 3 1 1 1 0 2 3 0 0 1 0 1 2
Cytoplasm 188 306 275 200 272 251 344 362 193 209 110 120 274 266 312 221 209 153 184 288 210 179 278 277
Endoplasmic Reticulum 0 1 3 1 0 0 0 0 2 0 0 0 2 1 2 15 25 8 1 1 2 0 2 1
Endosome 1 1 3 2 6 10 11 3 0 6 0 1 0 0 1 7 4 3 2 4 5 1 4 4
Golgi 0 2 0 0 0 0 0 0 0 0 0 0 0 0 0 3 3 2 0 2 1 0 3 1
Mitochondria 32 3 10 16 16 88 113 169 147 164 113 93 0 3 0 6 5 4 10 8 40 6 13 14
Nucleus 2 1 0 0 1 1 1 1 3 1 1 0 0 0 1 0 0 1 0 4 1 0 1 0
Nuclear Periphery 2 0 0 0 0 0 0 0 0 1 0 0 0 0 0 0 0 0 1 0 0 0 0 0
Nucleolus 0 0 1 0 0 0 0 0 0 1 1 0 0 0 1 0 1 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 1 2 1 0 2 0 0 0 1 1 0 0 0 0 0 1 0 0 0
SpindlePole 0 0 0 0 1 1 6 5 2 3 1 0 0 0 0 0 4 0 6 5 4 2 6 6
Vac/Vac Membrane 2 13 6 5 12 9 14 15 7 9 5 1 5 5 2 7 8 4 3 8 3 2 2 10
Unique Cell Count 206 322 290 211 292 300 423 473 271 313 182 175 281 275 318 236 226 162 223 337 297 204 337 342
Labelled Cell Count 233 329 302 226 310 365 492 569 367 405 239 223 282 277 322 260 262 178 223 337 297 204 337 342


Cytoplasm, Nucleus

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 3.4 4.5 4.7 4.2 4.6 3.7 3.7 3.6 3.4 3.0 3.4 3.2 4.7 4.8 4.7 6.0 6.6 6.4 4.3 4.3 5.0
Std Deviation (1e-4) 0.5 0.9 2.3 1.7 1.8 1.1 1.9 1.2 1.5 0.8 1.3 1.4 1.1 1.5 1.1 2.5 2.5 2.1 1.6 1.7 2.9
Intensity Change (Log2) – – – -0.17 -0.03 -0.32 -0.35 -0.37 -0.45 -0.65 -0.47 -0.54 0.01 0.03 0.0 0.35 0.49 0.44 -0.14 -0.11 0.08


Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Actin – – – – – – – – – – – – – – –
Bud – – – – – – – – – – – – 0 0 –
Bud Neck – – – – – – – – – – – – 0 0 –
Bud Site – – – – – – – – – – – – 0 0 –
Cell Periphery – – – – – – – – – – – – 0 0 –
Cyto – – – – – – – – – – – – – – –
Endoplasmic Reticulum – – – – – – – – – – – – 0 0 –
Endosome – – – – – – – – – – – – 0 0 –
Golgi – – – – – – – – – – – – 0 0 –
Mitochondria – – – – – – – – – – – – 0 0 –
Nuclear Periphery – – – – – – – – – – – – 0 0 –
Nuc – – – – – – – – – – – – – – –
Nucleolus – – – – – – – – – – – – 0 0 –
Peroxisomes – – – – – – – – – – – – 0 0 –
SpindlePole – – – – – – – – – – – – 0 0 –
Vac – – – – – – – – – – – – – – –
Cortical Patches – – – – – – – – – – – – 0 0 –
Cytoplasm – – – – – – – – – – – – 0 0 –
Nucleus – – – – – – – – – – – – 0 0 –
Vacuole – – – – – – – – – – – – 0.7 1.0 –

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 1.8767 1.3547 1.5023 0.4195 -0.0903 0.6891 1.4471 2.3542 2.2215 2.1953 0.6103 1.5846 2.0895 2.6673 3.6605 3.3703 2.0518 2.3964
Actin 0.3065 0.0008 0.0186 0.0006 0.0002 0.0128 0.032 0.0046 0.0039 0.0054 0.0001 0.0043 0.0098 0.003 0.0194 0.0062 0.0166 0.0011
Bud 0.0005 0 0.0006 0.0001 0 0.0007 0.0005 0.0014 0.0001 0.0012 0 0.0002 0.0002 0.0002 0.0033 0.0017 0.0004 0.0002
Bud Neck 0.0015 0.0001 0.0012 0.0001 0.0001 0.001 0.0001 0.0001 0.0017 0.0026 0.0001 0.0002 0.0006 0.0001 0.0006 0.0004 0.0005 0.0003
Bud Periphery 0.0007 0 0.0009 0.0001 0 0.0022 0.001 0.0012 0.0001 0.001 0 0.0002 0.0004 0.0004 0.0041 0.0014 0.0004 0.0008
Bud Site 0.0035 0.0007 0.0414 0.0001 0 0.0002 0.0008 0.0022 0.0135 0.0575 0 0.0002 0.0011 0.0004 0.0133 0.0056 0.0006 0.0001
Cell Periphery 0.0002 0.0001 0.0006 0 0.0001 0.0003 0.0001 0.0001 0.0001 0.0005 0 0 0.0003 0.0002 0.0005 0.0001 0.0001 0.0002
Cytoplasm 0.0081 0.2077 0.3005 0.2727 0.1773 0.2314 0.1817 0.2666 0.2359 0.1198 0.3334 0.2048 0.0966 0.2269 0.3319 0.1143 0.2894 0.2779
Cytoplasmic Foci 0.0021 0.0021 0.0107 0.0027 0.0028 0.0048 0.0208 0.0182 0.0776 0.0509 0.0016 0.0096 0.0096 0.0029 0.0216 0.0182 0.0274 0.0032
Eisosomes 0.0009 0.0002 0.0005 0.0001 0.0001 0.0001 0.0003 0.0001 0.0001 0.0004 0 0.0001 0.0021 0.0002 0.0002 0.0002 0.0007 0.0001
Endoplasmic Reticulum 0.0006 0.0011 0.0159 0.0033 0.0071 0.0023 0.01 0.0024 0.0018 0.0008 0.0009 0.0013 0.0362 0.0015 0.005 0.001 0.0011 0.0012
Endosome 0.0019 0.0002 0.0305 0.0014 0.0012 0.0046 0.0262 0.0301 0.0167 0.0612 0.0002 0.0069 0.015 0.0006 0.0173 0.0228 0.0049 0.0047
Golgi 0.0075 0.0001 0.0196 0.0001 0.0001 0.0143 0.0072 0.0038 0.006 0.0272 0 0.0035 0.0047 0.0002 0.0083 0.0185 0.0014 0.0004
Lipid Particles 0.0026 0.0001 0.017 0.0001 0.0003 0.001 0.0223 0.0053 0.0031 0.0144 0 0.0006 0.0226 0.0002 0.0026 0.0057 0.0066 0.0003
Mitochondria 0.0014 0.0001 0.012 0.0001 0.0001 0.0019 0.0039 0.0009 0.0006 0.0043 0.0001 0.0013 0.005 0.0003 0.0047 0.0241 0.001 0.0087
None 0.6587 0.7853 0.4426 0.7151 0.8094 0.7129 0.6281 0.6272 0.6181 0.6339 0.6628 0.7625 0.774 0.7576 0.5188 0.7308 0.6062 0.6865
Nuclear Periphery 0.0003 0.0003 0.0217 0.001 0.0004 0.0006 0.0191 0.0015 0.0006 0.0004 0.0002 0.0005 0.0055 0.0005 0.0142 0.0006 0.0026 0.0014
Nucleolus 0 0.0001 0.0113 0 0 0.0001 0.0003 0.0001 0.0004 0.0016 0 0 0.0005 0.0001 0.0004 0.0002 0.0013 0.0002
Nucleus 0.0001 0.0005 0.0251 0.0012 0.0003 0.007 0.0137 0.0082 0.0022 0.0008 0.0003 0.0008 0.0008 0.0037 0.0175 0.0022 0.0056 0.0011
Peroxisomes 0.0023 0.0001 0.0017 0.0001 0 0.0004 0.0241 0.0191 0.0125 0.0084 0 0.0013 0.0105 0.0002 0.0022 0.0421 0.0084 0.0001
Punctate Nuclear 0.0003 0.0003 0.0097 0.0004 0.0001 0.0007 0.0051 0.0015 0.0037 0.0041 0.0001 0.0011 0.0023 0.0003 0.0097 0.0018 0.0237 0.0005
Vacuole 0.0001 0.0002 0.0119 0.0006 0.0004 0.0006 0.0016 0.0033 0.0012 0.0029 0.0001 0.0003 0.0017 0.0004 0.0025 0.0015 0.0007 0.0105
Vacuole Periphery 0.0001 0 0.006 0.0001 0.0001 0.0002 0.0011 0.002 0.0001 0.0007 0 0.0001 0.0008 0 0.0021 0.0006 0.0002 0.0005

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 53.4556 21.0379 7.1365 24.1938 63.205 43.0096 24.3102 15.7924 15.8447 81.6842
Translational Efficiency 0.9562 0.9251 0.6346 0.495 0.8912 1.5678 0.8519 0.4127 0.7073 0.717

Hit Data

Dataset Hit
Protein Concentration ✔
Protein Localization ✘
Gene Expression ✔
Translational Efficiency ✔

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
1636 1296 138 939 1715 1594 112 624 3351 2890 250 1563

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 631.08 658.86 901.07 868.21 660.52 715.42 938.84 889.10 646.15 690.06 917.99 876.55
Standard Deviation 81.67 104.59 114.40 118.71 70.82 116.13 107.09 116.08 77.72 114.61 112.76 118.11
Intensity Change Log 2 — 0.062149 0.513816 0.460221 — 0.115188 0.507277 0.428743 — 0.089517 0.510476 0.444209

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.000072 0.000381 0.000326 0.004147 0.000084 0.000387 0.000587 0.002057 0.000078 0.000384 0.000443 0.003313
Bud Neck 0.012293 0.029261 0.000940 0.012706 0.012127 0.034382 0.001473 0.010794 0.012208 0.032086 0.001179 0.011943
Bud Site 0.002444 0.016092 0.005600 0.081815 0.003133 0.016972 0.002517 0.076219 0.002797 0.016577 0.004219 0.079581
Cell Periphery 0.000134 0.000171 0.000302 0.000190 0.000095 0.000137 0.000253 0.000160 0.000114 0.000152 0.000280 0.000178
Cytoplasm 0.552469* 0.438630* 0.232729* 0.411352* 0.505903* 0.481170* 0.285423* 0.452149* 0.528637* 0.462093* 0.256336* 0.427639*
Cytoplasmic Foci 0.164984 0.229018* 0.044970 0.029234 0.194164* 0.220537* 0.013491 0.021814 0.179918 0.224340* 0.030868 0.026272
Eisosomes 0.000118 0.000141 0.000174 0.000051 0.000121 0.000122 0.000103 0.000057 0.000119 0.000131 0.000142 0.000053
Endoplasmic Reticulum 0.000436 0.001217 0.003425 0.002668 0.000498 0.000519 0.009020 0.002185 0.000468 0.000832 0.005931 0.002475
Endosome 0.007840 0.022267 0.006751 0.023488 0.006031 0.014549 0.004415 0.010584 0.006914 0.018010 0.005704 0.018336
Golgi 0.001061 0.005385 0.000120 0.012220 0.000972 0.004327 0.000095 0.006743 0.001016 0.004801 0.000109 0.010033
Lipid Particles 0.005661 0.013053 0.006521 0.001375 0.006920 0.005932 0.002926 0.001093 0.006305 0.009125 0.004910 0.001262
Mitochondria 0.002076 0.011451 0.000360 0.007663 0.002089 0.008177 0.000358 0.002157 0.002083 0.009645 0.000359 0.005465
Mitotic Spindle 0.000496 0.006715 0.000198 0.077139 0.000882 0.005969 0.000554 0.063625 0.000693 0.006303 0.000357 0.071744
None 0.011542 0.009341 0.001659 0.005353 0.003421 0.004915 0.003697 0.007027 0.007386 0.006900 0.002572 0.006021
Nuclear Periphery 0.000340 0.000908 0.001477 0.001609 0.000533 0.000379 0.002267 0.003302 0.000438 0.000616 0.001831 0.002285
Nuclear Periphery Foci 0.000497 0.001306 0.001800 0.005196 0.000298 0.000398 0.003775 0.003733 0.000395 0.000805 0.002685 0.004612
Nucleolus 0.001571 0.003450 0.001159 0.003314 0.000975 0.002156 0.000405 0.000320 0.001266 0.002736 0.000821 0.002118
Nucleus 0.195382* 0.125789 0.579619* 0.174718* 0.224258* 0.130465* 0.508266* 0.162323* 0.210160* 0.128368 0.547653* 0.169770*
Peroxisomes 0.002846 0.014643 0.000749 0.008675 0.004593 0.014105 0.000242 0.001354 0.003740 0.014346 0.000522 0.005752
Vacuole 0.037200 0.068267 0.110852 0.132551 0.032475 0.052920 0.159964 0.166683 0.034782 0.059802 0.132854 0.146178
Vacuole Periphery 0.000539 0.002514 0.000270 0.004536 0.000429 0.001483 0.000171 0.005621 0.000482 0.001945 0.000225 0.004969

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin -7.49 -4.22 -3.59 -2.81 -2.43 -4.06 -7.73 -3.16 -2.16 -0.65 -6.90 -7.98 -4.62 -3.48 -2.41
Bud Neck -6.84 9.62 2.53 8.48 -6.88 -9.13 7.87 4.69 12.12 -2.71 -11.40 12.47 4.69 14.38 -7.06
Bud Site -8.72 -1.01 -8.01 -4.16 -5.58 -9.02 -1.01 -4.98 -1.75 -4.81 -12.62 -1.17 -9.35 -4.38 -7.44
Cell Periphery -2.74 -6.67 -1.65 1.01 5.62 -5.09 -6.76 -2.73 2.05 5.76 -4.99 -9.53 -3.18 1.31 7.78
Cytoplasm 11.62 17.94 22.61 10.47 -5.01 2.66 12.54 15.47 12.68 -3.90 9.73 21.44 26.74 16.86 -6.32
Cytoplasmic Foci -8.66 19.26 34.25 35.17 5.12 -3.53 35.07 37.04 36.33 -0.78 -8.43 34.72 50.03 50.28 4.20
Eisosomes -2.49 -4.98 8.60 8.78 8.53 -0.12 -1.81 7.10 5.62 6.03 -1.67 -5.09 11.29 10.07 10.34
Endoplasmic Reticulum -7.02 -5.97 -14.16 -9.70 2.64 -0.38 -8.83 -14.94 -15.27 6.70 -5.73 -10.27 -19.67 -16.82 6.60
Endosome -8.96 0.14 0.98 8.10 0.76 -9.15 2.33 3.88 10.91 1.70 -12.39 0.86 1.99 11.17 1.11
Golgi -4.35 4.76 -1.48 1.74 -2.34 -5.05 3.93 -0.32 3.39 -1.63 -6.56 6.07 -1.51 2.87 -2.78
Lipid Particles -5.22 -1.57 7.91 8.58 7.26 1.11 4.97 8.33 6.87 5.06 -3.50 1.51 11.38 10.81 8.30
Mitochondria -5.34 3.34 -0.24 4.88 -2.36 -5.71 7.82 4.26 6.90 -3.35 -7.67 6.28 0.60 7.37 -2.79
Mitotic Spindle -4.78 0.88 -7.45 -5.73 -7.52 -4.07 0.29 -6.23 -4.93 -6.28 -6.21 0.79 -9.67 -7.58 -9.76
None 1.27 6.99 4.46 3.42 -7.98 -2.69 1.01 -3.07 -0.46 -3.14 0.59 6.89 2.95 2.64 -7.08
Nuclear Periphery -4.36 -9.73 -14.68 -8.53 -3.18 1.31 -9.25 -7.20 -7.66 -0.59 -2.45 -12.73 -13.56 -12.10 -2.10
Nuclear Periphery Foci -2.58 -5.17 -2.88 -1.40 -0.11 -2.04 -7.02 -3.75 -3.44 3.45 -2.88 -8.63 -4.13 -2.91 1.83
Nucleolus -4.51 2.41 0.94 3.50 0.11 -2.71 3.41 4.92 4.26 0.72 -4.75 3.68 1.46 4.42 0.11
Nucleus 10.66 -13.30 -6.97 -14.38 10.60 14.37 -8.45 -1.09 -10.96 7.82 17.72 -15.38 -5.74 -18.12 12.98
Peroxisomes -8.98 3.92 0.30 8.59 -2.49 -7.20 7.15 6.84 11.92 -0.94 -11.40 7.91 3.48 13.44 -2.64
Vacuole -9.78 -8.10 -27.69 -23.40 -7.18 -8.20 -9.46 -26.95 -24.72 -2.91 -12.59 -12.22 -38.50 -34.11 -6.62
Vacuole Periphery -6.78 3.80 -0.95 2.13 -1.36 -6.21 6.10 -1.02 0.70 -1.46 -9.08 6.27 -1.39 1.88 -1.96
Standard name
Human Ortholog
Description G1 cyclin involved in regulation of the cell cycle; activates Cdc28p kinase to promote the G1 to S phase transition; late G1 specific expression depends on transcription factor complexes, MBF (Swi6p-Mbp1p) and SBF (Swi6p-Swi4p); CLN1 has a paralog, CLN2, that arose from the whole genome duplication; cell cycle arrest phenotype of the cln1 cln2 cln3 triple null mutant is complemented by any of human cyclins CCNA2, CCNB1, CCNC, CCND1, or CCNE1
Localization
Cell Percentages cytoplasm (15%)
Cell Cycle Regulation No
Subcompartmental Group cytoplasm-9

Cln1

Cln1


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Cln1-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available