Standard name
Human Ortholog
Description Putative checkpoint factor in transcription; binds to U2 snRNA and Prp11p; regulates toggling of the U2 snRNA stem II region between different structures; contains two RNA recognition motifs (RRMs)
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0.05 0 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 0 0 0.05 0.08 0.09 0.08 0.13 0.08 0.07 0 0.06 0.05 0.11 0.17 0.15 0.14 0.14 0.13 0 0 0 0.05 0 0
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.05 0.05 0 0 0 0 0 0 0
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0 0.15 0 0.05 0.16 0.18 0.55 0.13 0.53 0.31 0.46 0.42 0 0 0 0.06 0 0 0 0 0 0 0 0
Nucleus 0.9 0.92 0.93 0.88 0.85 0.8 0.68 0.84 0.77 0.79 0.79 0.77 0.87 0.79 0.81 0.75 0.75 0.8 0.87 0.88 0.85 0.65 0.74 0.58
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.07
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vac/Vac Membrane 0 0 0 0 0 0.05 0 0 0 0 0 0 0 0 0 0.11 0.11 0.08 0.06 0 0.07 0.1 0.1 0.2
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 1 0 1 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0 2 0 2 0
Bud 0 0 0 1 3 1 10 1 7 5 6 6 0 0 0 0 1 2 4 0 5 1 1 3
Bud Neck 0 0 1 0 0 0 2 2 0 3 0 1 0 0 0 0 0 0 0 1 0 1 0 0
Bud Site 0 0 0 0 2 2 17 3 17 7 11 9 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 0 0 1 0 0 0 0 0 0 1 0 0 0 0 0 0 0 0 0
Cytoplasm 12 2 19 24 32 24 48 40 31 26 19 21 8 26 27 45 29 30 4 1 3 7 7 8
Endoplasmic Reticulum 0 0 3 0 0 0 0 0 0 1 0 0 0 0 0 15 10 8 0 0 1 2 1 1
Endosome 1 0 3 1 0 3 0 2 0 1 0 1 0 1 2 9 3 2 3 1 2 3 3 1
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 2 0 0 3 1 1 0
Mitochondria 12 24 4 14 57 57 206 63 245 183 158 175 2 1 0 18 4 3 2 4 3 1 2 8
Nucleus 266 152 386 261 297 254 255 406 361 466 271 324 61 123 145 238 159 181 271 153 373 86 184 131
Nuclear Periphery 0 0 0 2 0 4 1 3 0 6 1 6 0 0 0 5 0 1 0 0 1 0 2 0
Nucleolus 1 1 0 0 0 2 3 1 2 7 11 7 0 1 0 0 0 0 0 0 0 5 7 15
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 1 0 0 2 1 2 4 6 2 10 3 6 0 1 0 1 0 0 3 1 6 3 3 4
Vac/Vac Membrane 11 6 7 8 10 16 2 8 2 12 5 14 2 4 6 35 23 17 18 7 31 12 26 45
Unique Cell Count 294 165 417 297 351 316 375 486 466 588 343 421 70 155 178 319 211 226 314 174 442 132 250 226
Labelled Cell Count 304 185 424 313 403 365 548 536 667 727 485 570 73 157 181 366 230 247 314 174 442 132 250 226


Nucleus

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 5.6 4.5 6.3 5.9 5.1 5.1 3.4 5.3 4.2 4.6 4.2 4.5 6.2 6.3 5.8 5.9 7.3 7.1 7.0 7.2 7.3
Std Deviation (1e-4) 0.9 0.8 1.5 1.6 2.0 1.7 0.9 1.4 1.3 0.9 1.0 1.1 1.4 1.6 1.4 1.4 2.1 1.8 2.4 2.1 2.3
Intensity Change (Log2) – – – -0.08 -0.3 -0.29 -0.86 -0.24 -0.59 -0.46 -0.57 -0.48 -0.02 0.01 -0.12 -0.09 0.23 0.18 0.16 0.2 0.22

WT3RAP60RAP140RAP220RAP300RAP380RAP460RAP540RAP620RAP70002468WT3HU80HU120HU16002468WT3rpd3Δ_1rpd3Δ_2rpd3Δ_302468WT1AF100AF140AF18002468
rapamycinhydroxy-urearpd3 knockoutalpha-factorMultiple Condition Time-Course Intensity PlotsGFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)

Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Actin – – – – – – – – – – – – – – –
Bud – – – – – – – – – – – – 0 0 0
Bud Neck – – – – – – – – – – – – 0 0 0
Bud Site – – – – – – – – – – – – 0 0 0
Cell Periphery – – – – – – – – – – – – 0 0 0
Cyto – – – – – – – – – – – – – – –
Endoplasmic Reticulum – – – – – – – – – – – – 0 0 0
Endosome – – – – – – – – – – – – 0 0 0
Golgi – – – – – – – – – – – – 0 0 0
Mitochondria – – – – – – – – – – – – 0 0 0
Nuclear Periphery – – – – – – – – – – – – 0 0 0
Nuc – – – – – – – – – – – – – – –
Nucleolus – – – – – – – – – – – – 0 0 0
Peroxisomes – – – – – – – – – – – – 0 0 0
SpindlePole – – – – – – – – – – – – 0 0 0
Vac – – – – – – – – – – – – – – –
Cortical Patches – – – – – – – – – – – – 0 0 0
Cytoplasm – – – – – – – – – – – – 0 0 0
Nucleus – – – – – – – – – – – – 0 0 0
Vacuole – – – – – – – – – – – – 5.4 5.1 3.7

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 1.7134 2.4901 2.1476 1.8155 1.7516 2.0702 4.3879 5.3573 4.7011 4.4922 4.2854 4.855 2.2213 2.614 2.4334 2.8474 2.1644 2.6838
Actin 0.0215 0 0.0055 0.0006 0.001 0.0001 0.0044 0 0.0148 0.0001 0.0036 0.0001 0.0138 0.0009 0.0005 0 0.0049 0.0018
Bud 0.0002 0 0.0001 0 0.0002 0 0.0005 0 0.0003 0 0 0 0.0003 0.0001 0.0001 0 0.0002 0.0001
Bud Neck 0.0003 0.0005 0.0001 0.0001 0.0554 0.0022 0.0082 0.0001 0.0006 0.0004 0.0003 0.0015 0.0051 0.0001 0.0004 0.0001 0.0022 0.0013
Bud Periphery 0.0004 0 0.0001 0 0.0002 0 0.0019 0 0.0007 0 0 0 0.0009 0.0001 0.0003 0 0.0006 0.0004
Bud Site 0.0013 0.0008 0.0004 0 0.0021 0.0001 0.0009 0.0001 0.0008 0.0001 0.0001 0.0001 0.0031 0.0003 0.0003 0 0.0005 0.0001
Cell Periphery 0.0001 0.0001 0 0 0.0001 0 0.0002 0 0.0002 0 0 0 0.0002 0 0.0001 0 0.0001 0
Cytoplasm 0.0041 0.0048 0.0074 0.0136 0.0036 0.0028 0.0065 0.0037 0.009 0.0056 0.0058 0.015 0.0089 0.0091 0.0047 0.0019 0.0134 0.0016
Cytoplasmic Foci 0.0185 0.0001 0.0064 0.0002 0.0055 0.0001 0.0134 0 0.0006 0.0001 0.0025 0.0009 0.007 0.0017 0.0003 0 0.0061 0.0001
Eisosomes 0.0007 0 0.0001 0.0001 0 0 0.0001 0 0.0003 0.0001 0.0011 0 0.0002 0 0.0001 0 0.0001 0
Endoplasmic Reticulum 0.0017 0.0005 0.0015 0.0012 0.0005 0.0001 0.0021 0.0003 0.0032 0.0001 0.0004 0.0003 0.0014 0.0006 0.0008 0.0001 0.0032 0.0006
Endosome 0.0178 0.0003 0.0045 0.002 0.0046 0.0002 0.007 0.0002 0.0054 0.0001 0.0007 0.0005 0.0105 0.0018 0.0015 0.0001 0.0279 0.001
Golgi 0.0041 0 0.0023 0 0.0018 0 0.0011 0 0.0051 0 0.0001 0 0.0012 0.0004 0.0002 0 0.004 0.0005
Lipid Particles 0.0131 0.0001 0.0034 0.0002 0.0014 0 0.0058 0 0.0013 0 0.0013 0.0001 0.0028 0.0018 0.0015 0 0.0148 0.0002
Mitochondria 0.0348 0.0002 0.0102 0.0011 0.0002 0.0001 0.0029 0.0001 0.0043 0.0001 0.0004 0.0002 0.0114 0.0007 0.0028 0.0001 0.0095 0.0018
None 0.0029 0.0204 0.0181 0.0661 0.0005 0.0103 0.0044 0.0018 0.062 0.0763 0.1332 0.0721 0.0382 0.0367 0.0396 0.0005 0.0096 0.0028
Nuclear Periphery 0.0116 0.0032 0.0168 0.0364 0.004 0.0021 0.0231 0.0028 0.0145 0.0056 0.0086 0.0056 0.0098 0.0185 0.0096 0.0043 0.0387 0.0057
Nucleolus 0.005 0.0061 0.0034 0.0028 0.0121 0.0145 0.0081 0.0043 0.0059 0.0042 0.0072 0.0111 0.0062 0.012 0.005 0.0024 0.0161 0.0136
Nucleus 0.8325 0.96 0.9045 0.8656 0.8791 0.9554 0.8683 0.9837 0.8592 0.901 0.8274 0.8654 0.8494 0.8889 0.9209 0.9876 0.807 0.9551
Peroxisomes 0.015 0 0.0052 0.0001 0.0005 0 0.0011 0 0.0002 0 0.0007 0 0.0113 0.0051 0.0001 0 0.0058 0
Punctate Nuclear 0.0118 0.0014 0.0092 0.0071 0.0263 0.0115 0.0351 0.0022 0.0098 0.0058 0.0059 0.0265 0.0164 0.0199 0.0095 0.0027 0.0276 0.0123
Vacuole 0.0017 0.0014 0.0006 0.0015 0.0009 0.0002 0.003 0.0006 0.0011 0.0003 0.0005 0.0003 0.0013 0.0007 0.0012 0.0001 0.0046 0.0004
Vacuole Periphery 0.0009 0.0001 0.0003 0.001 0.0001 0 0.0018 0 0.0006 0.0001 0.0002 0.0001 0.0007 0.0005 0.0006 0 0.0033 0.0005

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 7.7161 9.197 5.9715 10.745 11.6717 11.5678 9.8802 10.1989 12.6951 9.7087
Translational Efficiency 1.3188 1.5497 2.1037 1.4282 1.2039 0.9427 1.2491 1.3851 1.1587 1.2023

Hit Data

Dataset Hit
Protein Concentration ✘
Protein Localization ✘
Gene Expression ✘
Translational Efficiency ✔

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
286 759 203 2125 2417 2423 2036 1643 2703 3182 2239 3768

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 715.61 789.94 923.98 903.18 716.88 886.64 931.59 944.72 716.75 863.57 930.90 921.29
Standard Deviation 84.26 121.50 123.36 133.48 93.97 109.64 127.33 130.47 93.00 119.89 127.00 133.77
Intensity Change Log 2 — 0.142570 0.368688 0.335840 — 0.306617 0.377964 0.398155 — 0.226996 0.373337 0.367362

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.000088 0.000417 0.000610 0.000881 0.000059 0.000115 0.000267 0.000742 0.000062 0.000187 0.000298 0.000820
Bud Neck 0.001357 0.005687 0.003753 0.021329 0.002361 0.004558 0.014121 0.021309 0.002255 0.004827 0.013181 0.021320
Bud Site 0.000305 0.003076 0.000799 0.006171 0.000776 0.001503 0.001367 0.009279 0.000726 0.001878 0.001316 0.007526
Cell Periphery 0.000103 0.000154 0.000080 0.000171 0.000123 0.000122 0.000092 0.000137 0.000121 0.000129 0.000091 0.000156
Cytoplasm 0.037876 0.032763 0.003671 0.029687 0.020785 0.013318 0.007249 0.024718 0.022593 0.017956 0.006924 0.027520
Cytoplasmic Foci 0.005922 0.003295 0.000966 0.003005 0.000991 0.002167 0.000021 0.001992 0.001513 0.002436 0.000106 0.002563
Eisosomes 0.000023 0.000020 0.000038 0.000023 0.000009 0.000012 0.000016 0.000020 0.000011 0.000014 0.000018 0.000022
Endoplasmic Reticulum 0.002254 0.006986 0.005233 0.005871 0.001684 0.003796 0.003759 0.007162 0.001744 0.004557 0.003893 0.006434
Endosome 0.000290 0.001113 0.000331 0.003909 0.000292 0.001157 0.000149 0.002688 0.000292 0.001146 0.000166 0.003377
Golgi 0.000040 0.000603 0.000068 0.004762 0.000182 0.000632 0.000024 0.000779 0.000167 0.000625 0.000028 0.003025
Lipid Particles 0.000878 0.000885 0.000552 0.000309 0.000366 0.001527 0.000029 0.000262 0.000420 0.001374 0.000076 0.000288
Mitochondria 0.000360 0.003096 0.000702 0.007258 0.001157 0.003971 0.000821 0.004045 0.001073 0.003762 0.000810 0.005857
Mitotic Spindle 0.000014 0.001566 0.000359 0.034426 0.000472 0.005030 0.001519 0.010619 0.000424 0.004203 0.001414 0.024045
None 0.010705 0.007744 0.004854 0.008768 0.005142 0.004387 0.002083 0.005541 0.005731 0.005188 0.002334 0.007361
Nuclear Periphery 0.000458 0.001310 0.000406 0.004032 0.000755 0.001771 0.000684 0.002059 0.000723 0.001661 0.000659 0.003172
Nuclear Periphery Foci 0.000137 0.000467 0.000179 0.001856 0.000097 0.000611 0.000037 0.001151 0.000102 0.000577 0.000049 0.001548
Nucleolus 0.003117 0.004387 0.006492 0.001628 0.002947 0.003288 0.000950 0.001269 0.002965 0.003550 0.001453 0.001471
Nucleus 0.934112 0.921573 0.967079 0.844002 0.960878 0.947827 0.965624 0.890587 0.958046 0.941565 0.965756 0.864315
Peroxisomes 0.000531 0.000784 0.000332 0.000358 0.000216 0.000871 0.000036 0.000542 0.000250 0.000851 0.000063 0.000438
Vacuole 0.001358 0.002985 0.003393 0.016501 0.000569 0.002581 0.001078 0.013012 0.000653 0.002678 0.001288 0.014980
Vacuole Periphery 0.000070 0.001091 0.000102 0.005054 0.000138 0.000756 0.000072 0.002088 0.000131 0.000836 0.000075 0.003761

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin -6.98 -4.69 -7.10 -3.42 -0.18 -3.82 -14.18 -7.05 -6.43 -4.70 -7.85 -13.82 -10.35 -8.35 -6.22
Bud Neck -4.57 -2.69 -13.71 -10.50 -8.03 -3.70 -13.60 -13.90 -11.89 -3.95 -5.09 -13.84 -19.53 -16.15 -5.44
Bud Site -2.89 -2.63 -9.07 -1.73 -6.12 -1.19 -1.25 -5.58 -4.60 -4.91 -2.20 -1.47 -8.60 -5.57 -6.87
Cell Periphery -2.27 0.75 -0.99 1.58 -1.66 0.11 2.19 0.47 0.45 -2.22 -0.57 2.27 0.16 0.96 -2.73
Cytoplasm 0.61 4.85 1.49 1.42 -11.29 3.91 7.59 -1.13 -4.98 -8.47 2.31 8.85 -1.50 -4.41 -12.75
Cytoplasmic Foci 1.37 2.66 2.42 2.22 -1.12 -3.30 5.82 -0.15 2.02 -2.23 -2.36 5.64 0.69 2.94 -4.45
Eisosomes 1.13 -3.48 -0.70 -4.05 3.79 -2.84 -7.04 -13.13 -11.75 -8.69 -3.20 -7.48 -14.09 -13.22 -7.81
Endoplasmic Reticulum -7.01 -5.08 -8.05 0.78 -0.81 -5.43 -13.54 -16.88 -8.04 -10.07 -8.69 -14.27 -22.28 -7.01 -11.41
Endosome -2.66 -1.02 -5.16 -2.12 -4.31 -3.47 1.36 -3.99 -1.25 -4.48 -4.14 1.16 -6.45 -2.41 -7.20
Golgi -1.84 -1.36 -2.96 -1.96 -2.91 -1.27 1.46 -1.15 0.55 -2.39 -1.63 1.43 -2.90 -1.60 -3.35
Lipid Particles -0.08 0.76 2.41 2.29 2.25 -3.55 5.12 0.66 3.74 -8.66 -3.70 5.06 1.59 4.19 -8.67
Mitochondria -2.40 -2.91 -6.74 -1.33 -5.59 -3.77 0.68 -3.95 0.52 -5.17 -4.13 0.47 -6.04 -0.64 -7.69
Mitotic Spindle -2.65 -1.68 -8.68 -7.79 -7.77 -4.32 -2.07 -5.67 -2.65 -4.52 -4.61 -2.26 -10.13 -6.97 -8.63
None 1.05 1.96 1.43 0.64 -1.21 0.88 5.77 0.06 -0.76 -4.70 0.71 5.99 -0.41 -1.09 -6.76
Nuclear Periphery -5.24 -0.88 -8.07 -5.58 -7.68 -4.54 -1.40 -11.07 -3.86 -10.60 -5.39 -1.61 -10.94 -5.77 -10.53
Nuclear Periphery Foci -2.88 -1.00 -3.43 -2.00 -2.55 -2.93 0.90 -2.10 -0.51 -2.19 -3.51 0.43 -4.06 -1.42 -4.13
Nucleolus -1.58 -1.94 2.00 5.26 2.83 -0.62 4.76 1.88 2.58 -2.68 -1.17 3.71 2.65 4.56 -1.78
Nucleus 1.13 -2.35 5.85 6.30 11.69 3.42 -0.58 13.52 10.13 14.21 4.65 -1.47 18.93 13.74 21.09
Peroxisomes -0.54 0.79 1.47 1.49 1.10 -3.24 2.51 -0.51 2.47 -1.85 -3.25 2.69 0.13 3.34 -2.65
Vacuole -2.45 -2.61 -11.40 -10.20 -6.65 -5.37 -4.47 -10.34 -9.13 -9.92 -6.65 -4.94 -16.22 -13.93 -15.17
Vacuole Periphery -2.21 -2.26 -4.38 -1.91 -4.28 -2.74 1.46 -2.68 -0.88 -2.87 -3.43 1.34 -5.01 -2.58 -5.20
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Putative checkpoint factor in transcription; binds to U2 snRNA and Prp11p; regulates toggling of the U2 snRNA stem II region between different structures; contains two RNA recognition motifs (RRMs)
Localization
Cell Percentages nucleus (95%)
Cell Cycle Regulation No
Subcompartmental Group nucleus-3

Cus2

Cus2


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Cus2-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available