| Standard name | |
|---|---|
| Human Ortholog | |
| Description | Dihydrolipoamide acetyltransferase component (E2) of the PDC; the pyruvate dehydrogenase complex (PDC) catalyzes the oxidative decarboxylation of pyruvate to acetyl-CoA |
Micrographs
Sub-cellular Localization
Yeast GFP Assignment
Protein Abundance
Localization Change
External localization resources
| ensLOC | DeepLoc | |||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Localization | WT1 | WT2 | WT3 | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 | WT1 | WT2 | WT3 | AF100 | AF140 | AF180 |
| Cortical Patches | – | – | – | – | 0 | 1 | 0 | 0 | – | 0 | 0 | 0 | – | – | 0 | 0 | 0 | – | 0 | 0 | 0 | 1 | 2 | 4 |
| Bud | – | – | – | – | 0 | 1 | 1 | 2 | – | 1 | 1 | 1 | – | – | 0 | 2 | 1 | – | 0 | 1 | 0 | 1 | 0 | 0 |
| Bud Neck | – | – | – | – | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | – | – | 0 | 0 | 1 | – | 0 | 0 | 0 | 0 | 0 | 0 |
| Bud Site | – | – | – | – | 0 | 4 | 1 | 0 | – | 1 | 0 | 1 | – | – | 0 | 0 | 1 | – | – | – | – | – | – | – |
| Cell Periphery | – | – | – | – | 0 | 0 | 0 | 1 | – | 0 | 0 | 0 | – | – | 0 | 1 | 2 | – | 0 | 0 | 0 | 0 | 0 | 0 |
| Cytoplasm | – | – | – | – | 5 | 2 | 17 | 12 | – | 9 | 7 | 3 | – | – | 0 | 1 | 1 | – | 0 | 0 | 0 | 0 | 0 | 1 |
| Endoplasmic Reticulum | – | – | – | – | 0 | 0 | 2 | 0 | – | 0 | 1 | 1 | – | – | 0 | 1 | 0 | – | 0 | 0 | 0 | 1 | 0 | 1 |
| Endosome | – | – | – | – | 2 | 0 | 0 | 0 | – | 0 | 0 | 0 | – | – | 4 | 4 | 2 | – | 0 | 1 | 5 | 0 | 1 | 4 |
| Golgi | – | – | – | – | 1 | 0 | 0 | 0 | – | 0 | 0 | 1 | – | – | 6 | 6 | 0 | – | 0 | 1 | 3 | 1 | 9 | 16 |
| Mitochondria | – | – | – | – | 36 | 35 | 75 | 87 | – | 36 | 51 | 49 | – | – | 13 | 1 | 2 | – | 5 | 9 | 23 | 15 | 33 | 47 |
| Nucleus | – | – | – | – | 0 | 1 | 0 | 3 | – | 3 | 0 | 2 | – | – | 1 | 0 | 1 | – | 0 | 0 | 0 | 0 | 1 | 0 |
| Nuclear Periphery | – | – | – | – | 0 | 2 | 10 | 13 | – | 10 | 6 | 4 | – | – | 0 | 0 | 0 | – | 0 | 0 | 0 | 1 | 0 | 0 |
| Nucleolus | – | – | – | – | 8 | 4 | 12 | 16 | – | 13 | 6 | 8 | – | – | 1 | 1 | 2 | – | 0 | 0 | 0 | 0 | 1 | 0 |
| Peroxisomes | – | – | – | – | 2 | 3 | 1 | 0 | – | 0 | 1 | 1 | – | – | 2 | 4 | 5 | – | 0 | 0 | 3 | 1 | 5 | 5 |
| SpindlePole | – | – | – | – | 1 | 2 | 2 | 0 | – | 0 | 1 | 1 | – | – | 2 | 1 | 1 | – | 0 | 0 | 0 | 0 | 0 | 0 |
| Vac/Vac Membrane | – | – | – | – | 0 | 2 | 2 | 4 | – | 1 | 0 | 0 | – | – | 4 | 2 | 1 | – | 0 | 0 | 0 | 0 | 4 | 1 |
| Unique Cell Count | 46 | 39 | 97 | 105 | 54 | 60 | 56 | 25 | 20 | 17 | 10 | 15 | 37 | 30 | 63 | 87 | ||||||||
| Labelled Cell Count | 55 | 57 | 123 | 138 | 74 | 74 | 72 | 33 | 24 | 20 | 10 | 15 | 37 | 30 | 63 | 87 | ||||||||
Yeast GFP Assignment
Protein Abundance
| Screen | WT1 | WT2 | WT3 | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 | AF100 | AF140 | AF180 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Mean Cell GFP Intensity (1e-4) | – | – | – | – | 6.9 | 6.0 | 6.2 | 6.0 | – | 6.5 | 7.2 | 7.6 | – | – | 10.0 | 8.5 | 7.8 | – | – | 15.5 | 15.2 |
| Std Deviation (1e-4) | – | – | – | – | 3.0 | 1.5 | 2.5 | 1.8 | – | 1.8 | 2.6 | 2.5 | – | – | 2.3 | 2.1 | 2.4 | – | – | 9.5 | 6.1 |
| Intensity Change (Log2) | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
Localization Change
| Localization | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Actin | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
| Bud | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
| Bud Neck | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
| Bud Site | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
| Cell Periphery | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
| Cyto | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
| Endoplasmic Reticulum | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
| Endosome | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
| Golgi | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
| Mitochondria | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
| Nuclear Periphery | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
| Nuc | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
| Nucleolus | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
| Peroxisomes | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
| SpindlePole | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
| Vac | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
| Cortical Patches | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
| Cytoplasm | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
| Nucleus | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
| Vacuole | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
External localization resources
Images
Protein Concentration and Protein Localization Data
| R1 | R2 | R3 | ||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | |
| Concentration | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
| Actin | 0.0264 | 0.003 | 0.0113 | 0.0007 | 0.0056 | 0.0119 | 0.2453 | 0.0008 | 0.0064 | 0.0115 | 0.0001 | 0.0005 | – | – | – | – | – | – |
| Bud | 0.0004 | 0.0008 | 0.0001 | 0 | 0 | 0.0004 | 0.0003 | 0 | 0.0054 | 0.0004 | 0 | 0 | – | – | – | – | – | – |
| Bud Neck | 0.0006 | 0.0001 | 0.0001 | 0.0001 | 0 | 0.0001 | 0.0003 | 0 | 0.0003 | 0.0003 | 0 | 0 | – | – | – | – | – | – |
| Bud Periphery | 0.0007 | 0.0009 | 0.0002 | 0.0001 | 0.0001 | 0.0008 | 0.0006 | 0.0002 | 0.0104 | 0.0003 | 0 | 0 | – | – | – | – | – | – |
| Bud Site | 0.0011 | 0.0017 | 0.0005 | 0.0001 | 0.0001 | 0.0004 | 0.0011 | 0 | 0.0053 | 0.0024 | 0 | 0 | – | – | – | – | – | – |
| Cell Periphery | 0.0003 | 0.0004 | 0.0002 | 0.0001 | 0 | 0.0001 | 0.0003 | 0.0001 | 0.0007 | 0.0001 | 0 | 0 | – | – | – | – | – | – |
| Cytoplasm | 0.0019 | 0 | 0.0012 | 0 | 0.0024 | 0.0001 | 0.0004 | 0 | 0.0004 | 0.0004 | 0 | 0 | – | – | – | – | – | – |
| Cytoplasmic Foci | 0.0147 | 0.0014 | 0.0109 | 0.0011 | 0.0028 | 0.0007 | 0.0084 | 0.0004 | 0.0188 | 0.0355 | 0 | 0.0002 | – | – | – | – | – | – |
| Eisosomes | 0.0005 | 0.0004 | 0.0007 | 0.0001 | 0.0001 | 0.0001 | 0.001 | 0.0001 | 0.0002 | 0.0001 | 0.0001 | 0.0001 | – | – | – | – | – | – |
| Endoplasmic Reticulum | 0.0035 | 0.0001 | 0.0004 | 0 | 0.0051 | 0.0003 | 0.0023 | 0 | 0.0002 | 0.0001 | 0 | 0 | – | – | – | – | – | – |
| Endosome | 0.0266 | 0.0023 | 0.0077 | 0.0029 | 0.0483 | 0.0046 | 0.0055 | 0.0003 | 0.0189 | 0.0079 | 0 | 0.0004 | – | – | – | – | – | – |
| Golgi | 0.0183 | 0.0061 | 0.0257 | 0.0049 | 0.0064 | 0.011 | 0.0143 | 0.0007 | 0.0306 | 0.021 | 0.0002 | 0.0029 | – | – | – | – | – | – |
| Lipid Particles | 0.0256 | 0.0229 | 0.0243 | 0.0094 | 0.007 | 0.0018 | 0.0761 | 0.0072 | 0.0171 | 0.0139 | 0 | 0.0115 | – | – | – | – | – | – |
| Mitochondria | 0.8329 | 0.9311 | 0.8978 | 0.9727 | 0.8784 | 0.9652 | 0.3758 | 0.9646 | 0.8104 | 0.897 | 0.9994 | 0.9814 | – | – | – | – | – | – |
| None | 0.0021 | 0 | 0.0018 | 0 | 0.0029 | 0 | 0.0011 | 0 | 0.0007 | 0.0001 | 0 | 0 | – | – | – | – | – | – |
| Nuclear Periphery | 0.016 | 0.0001 | 0.0002 | 0 | 0.0265 | 0.0001 | 0.1659 | 0 | 0.0005 | 0.0001 | 0 | 0 | – | – | – | – | – | – |
| Nucleolus | 0.0006 | 0.0014 | 0.0007 | 0.0001 | 0.0001 | 0 | 0.0069 | 0.0002 | 0.002 | 0.0003 | 0 | 0 | – | – | – | – | – | – |
| Nucleus | 0.0044 | 0.0003 | 0.0002 | 0.0001 | 0.0013 | 0 | 0.0096 | 0.0001 | 0.0007 | 0.0002 | 0 | 0 | – | – | – | – | – | – |
| Peroxisomes | 0.0094 | 0.0135 | 0.0112 | 0.0042 | 0.007 | 0.0005 | 0.0362 | 0.0194 | 0.0559 | 0.0068 | 0.0002 | 0.0021 | – | – | – | – | – | – |
| Punctate Nuclear | 0.0011 | 0 | 0.0008 | 0 | 0.0022 | 0 | 0.0048 | 0 | 0.0111 | 0.0009 | 0 | 0 | – | – | – | – | – | – |
| Vacuole | 0.0061 | 0.0051 | 0.0011 | 0.0007 | 0.0008 | 0.0003 | 0.0032 | 0.0011 | 0.0023 | 0.0003 | 0 | 0.0001 | – | – | – | – | – | – |
| Vacuole Periphery | 0.0068 | 0.0084 | 0.0029 | 0.0028 | 0.0028 | 0.0014 | 0.0407 | 0.0046 | 0.0017 | 0.0004 | 0 | 0.0007 | – | – | – | – | – | – |
Sequencing Data
| R1 | R2 | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | |
| Gene Expression | 214.7412 | 214.4296 | 197.5059 | 217.7601 | 178.7031 | 231.3659 | 231.0914 | 233.6664 | 250.6124 | 231.6136 |
| Translational Efficiency | 1.6756 | 1.6399 | 1.8199 | 1.6765 | 1.9909 | 1.5516 | 1.4601 | 1.7213 | 1.6032 | 1.595 |
Hit Data
| Dataset | Hit |
|---|---|
| Protein Concentration | – |
| Protein Localization | ✘ |
| Gene Expression | ✘ |
| Translational Efficiency | ✘ |
Micrographs
Cell Count
| R1 | R2 | R1 & R2 | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| WT | UBP2 | UBP14 | UBP2UBP14 | WT | UBP2 | UBP14 | UBP2UBP14 | WT | UBP2 | UBP14 | UBP2UBP14 |
| 1110 | 451 | 1985 | 348 | 1361 | 748 | 2405 | 258 | 2471 | 1199 | 4390 | 606 |
Protein Abundance
| R1 | R2 | R1 & R2 | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| WT | UBP2 | UBP14 | UBP2UBP14 | WT | UBP2 | UBP14 | UBP2UBP14 | WT | UBP2 | UBP14 | UBP2UBP14 | |
| Mean | 751.42 | 998.15 | 1138.74 | 1729.54 | 866.77 | 898.74 | 1453.72 | 2000.88 | 814.95 | 936.13 | 1311.30 | 1845.06 |
| Standard Deviation | 113.65 | 209.01 | 178.33 | 356.13 | 166.25 | 169.16 | 299.70 | 458.64 | 155.94 | 191.32 | 296.92 | 424.72 |
| Intensity Change Log 2 | — | 0.409637 | 0.599747 | 1.202697 | — | 0.052255 | 0.746028 | 1.206914 | — | 0.229255 | 0.679941 | 1.204957 |
Localization Score (DeepLoc)
| R1 | R2 | R1 & R2 | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| WT | UBP2 | UBP14 | UBP2UBP14 | WT | UBP2 | UBP14 | UBP2UBP14 | WT | UBP2 | UBP14 | UBP2UBP14 | |
| Actin | 0.000775 | 0.008136 | 0.006203 | 0.016177 | 0.001927 | 0.005921 | 0.005696 | 0.025225 | 0.001409 | 0.006754 | 0.005925 | 0.020029 |
| Bud Neck | 0.013573 | 0.020807 | 0.001210 | 0.005559 | 0.002579 | 0.016547 | 0.000314 | 0.004558 | 0.007518 | 0.018149 | 0.000719 | 0.005133 |
| Bud Site | 0.015964 | 0.046057 | 0.005752 | 0.004981 | 0.005636 | 0.034187 | 0.000430 | 0.004714 | 0.010275 | 0.038651 | 0.002837 | 0.004868 |
| Cell Periphery | 0.000516 | 0.000591 | 0.000206 | 0.000523 | 0.001064 | 0.001547 | 0.000082 | 0.000629 | 0.000818 | 0.001188 | 0.000138 | 0.000568 |
| Cytoplasm | 0.008163 | 0.007245 | 0.001578 | 0.000399 | 0.001261 | 0.005868 | 0.000172 | 0.000349 | 0.004361 | 0.006386 | 0.000808 | 0.000378 |
| Cytoplasmic Foci | 0.057313 | 0.059572 | 0.040349 | 0.020334 | 0.023898 | 0.039690 | 0.008903 | 0.017347 | 0.038909 | 0.047168 | 0.023121 | 0.019062 |
| Eisosomes | 0.000093 | 0.000151 | 0.000081 | 0.000899 | 0.000094 | 0.000145 | 0.000278 | 0.003619 | 0.000094 | 0.000147 | 0.000189 | 0.002057 |
| Endoplasmic Reticulum | 0.000629 | 0.000875 | 0.000769 | 0.004279 | 0.000379 | 0.000707 | 0.000156 | 0.003214 | 0.000491 | 0.000770 | 0.000433 | 0.003825 |
| Endosome | 0.127599 | 0.139071 | 0.035788 | 0.016311 | 0.047435 | 0.112669 | 0.004676 | 0.014588 | 0.083446 | 0.122600 | 0.018744 | 0.015578 |
| Golgi | 0.077027 | 0.068746 | 0.116101* | 0.277455* | 0.030824 | 0.050770 | 0.057957 | 0.290739* | 0.051579 | 0.057531 | 0.084248 | 0.283111* |
| Lipid Particles | 0.016231 | 0.006078 | 0.003200 | 0.018666 | 0.014204 | 0.010973 | 0.001690 | 0.005682 | 0.015114 | 0.009132 | 0.002373 | 0.013138 |
| Mitochondria | 0.533547* | 0.462149* | 0.704030* | 0.545178* | 0.809354* | 0.568685* | 0.902514* | 0.550691* | 0.685459* | 0.528612* | 0.812767* | 0.547525* |
| Mitotic Spindle | 0.019500 | 0.035609 | 0.019469 | 0.007417 | 0.004197 | 0.017536 | 0.000888 | 0.002365 | 0.011071 | 0.024334 | 0.009290 | 0.005266 |
| None | 0.001825 | 0.000952 | 0.000501 | 0.004308 | 0.000403 | 0.000521 | 0.001087 | 0.004858 | 0.001042 | 0.000683 | 0.000822 | 0.004542 |
| Nuclear Periphery | 0.000317 | 0.000756 | 0.001979 | 0.002787 | 0.000250 | 0.000277 | 0.000314 | 0.001236 | 0.000280 | 0.000457 | 0.001067 | 0.002127 |
| Nuclear Periphery Foci | 0.000883 | 0.001538 | 0.001143 | 0.001664 | 0.000569 | 0.000725 | 0.000147 | 0.000599 | 0.000710 | 0.001031 | 0.000597 | 0.001211 |
| Nucleolus | 0.001942 | 0.002716 | 0.000075 | 0.000280 | 0.000819 | 0.003469 | 0.000032 | 0.000468 | 0.001324 | 0.003185 | 0.000051 | 0.000360 |
| Nucleus | 0.003364 | 0.002975 | 0.000069 | 0.000197 | 0.000779 | 0.004303 | 0.000010 | 0.000331 | 0.001940 | 0.003804 | 0.000037 | 0.000254 |
| Peroxisomes | 0.083560 | 0.087066 | 0.007076 | 0.002571 | 0.041167 | 0.077221 | 0.002526 | 0.008150 | 0.060210 | 0.080924 | 0.004584 | 0.004946 |
| Vacuole | 0.021248 | 0.034850 | 0.020479 | 0.021723 | 0.007041 | 0.034274 | 0.002894 | 0.020006 | 0.013423 | 0.034491 | 0.010845 | 0.020992 |
| Vacuole Periphery | 0.015931 | 0.014062 | 0.033942 | 0.048293 | 0.006120 | 0.013966 | 0.009234 | 0.040630 | 0.010527 | 0.014002 | 0.020406 | 0.045030 |
Localization Changes (T-score)
| R1 | R2 | R1 & R2 | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UBP2_WT | UBP14_WT | UBP2UBP14_WT | UBP2UBP14_UBP2 | UBP2UBP14_UBP14 | UBP2_WT | UBP14_WT | UBP2UBP14_WT | UBP2UBP14_UBP2 | UBP2UBP14_UBP14 | UBP2_WT | UBP14_WT | UBP2UBP14_WT | UBP2UBP14_UBP2 | UBP2UBP14_UBP14 | |
| Actin | -2.77 | -6.64 | -4.58 | -1.86 | -2.88 | -2.47 | -3.58 | -4.99 | -3.96 | -4.14 | -3.80 | -6.59 | -6.70 | -4.30 | -4.98 |
| Bud Neck | -2.35 | 7.78 | 3.70 | 5.02 | -2.93 | -7.40 | 5.65 | -1.54 | 5.17 | -3.29 | -6.25 | 8.99 | 1.82 | 7.04 | -4.38 |
| Bud Site | -5.48 | 5.36 | 3.39 | 7.01 | 0.01 | -7.57 | 5.18 | 0.21 | 6.88 | -2.19 | -9.00 | 7.26 | 2.46 | 9.67 | -1.57 |
| Cell Periphery | -0.80 | 5.15 | -0.05 | 0.52 | -2.46 | -0.52 | 1.47 | 0.65 | 1.39 | -5.70 | -0.68 | 1.84 | 0.66 | 1.49 | -5.11 |
| Cytoplasm | 0.13 | 4.98 | 5.98 | 4.29 | 2.70 | -3.31 | 4.57 | 3.42 | 3.97 | -1.92 | -1.87 | 5.79 | 6.53 | 5.72 | 1.89 |
| Cytoplasmic Foci | -0.42 | 4.79 | 9.38 | 7.33 | 6.19 | -4.72 | 8.58 | 1.77 | 5.16 | -2.75 | -2.75 | 8.25 | 7.66 | 8.64 | 1.79 |
| Eisosomes | -5.22 | 2.15 | -7.78 | -7.19 | -7.90 | -2.96 | -6.39 | -3.11 | -3.06 | -2.95 | -4.97 | -5.92 | -4.02 | -3.91 | -3.82 |
| Endoplasmic Reticulum | -1.57 | -1.17 | -3.10 | -2.87 | -2.98 | -4.00 | 4.35 | -6.18 | -5.42 | -6.70 | -3.51 | 0.94 | -4.75 | -4.33 | -4.83 |
| Endosome | -1.11 | 16.95 | 20.10 | 14.18 | 7.84 | -9.47 | 13.84 | 7.99 | 14.50 | -3.57 | -6.69 | 20.98 | 20.01 | 20.35 | 1.75 |
| Golgi | 1.32 | -6.87 | -11.98 | -12.23 | -9.59 | -4.94 | -7.41 | -13.63 | -12.45 | -12.12 | -1.61 | -9.84 | -18.49 | -17.79 | -15.77 |
| Lipid Particles | 4.52 | 6.45 | -0.62 | -3.56 | -4.56 | 1.18 | 6.78 | 4.07 | 2.43 | -3.89 | 3.19 | 9.35 | 0.83 | -1.66 | -5.37 |
| Mitochondria | 3.43 | -12.63 | -0.52 | -3.14 | 7.41 | 14.84 | -10.12 | 10.95 | 0.68 | 15.57* | 11.81 | -14.96 | 8.33 | -1.06 | 17.10* |
| Mitotic Spindle | -3.17 | -0.04 | 3.26 | 5.05 | 3.46 | -6.01 | 4.68 | 1.38 | 6.31 | -1.32 | -5.46 | 1.32 | 2.77 | 6.67 | 2.02 |
| None | 0.82 | 2.31 | -3.48 | -4.55 | -9.33 | -1.88 | -10.42 | -8.20 | -7.97 | -6.94 | 0.82 | 0.86 | -8.31 | -9.66 | -11.29 |
| Nuclear Periphery | -0.81 | -3.23 | -5.37 | -2.96 | -1.22 | -0.39 | -0.62 | -5.03 | -4.88 | -4.36 | -0.84 | -3.29 | -6.71 | -4.99 | -3.00 |
| Nuclear Periphery Foci | -0.92 | -0.83 | -2.20 | -0.15 | -1.42 | -0.71 | 2.09 | -0.13 | 0.94 | -4.24 | -1.07 | 0.65 | -2.24 | -0.55 | -3.05 |
| Nucleolus | -0.65 | 4.45 | 3.96 | 2.43 | -2.47 | -2.60 | 2.65 | 0.79 | 2.92 | -1.37 | -2.39 | 5.12 | 3.47 | 3.88 | -2.12 |
| Nucleus | 0.20 | 3.58 | 3.43 | 3.33 | -1.47 | -2.63 | 2.91 | 1.21 | 2.93 | -1.30 | -1.99 | 4.31 | 3.70 | 3.95 | -1.87 |
| Peroxisomes | -0.39 | 15.32 | 15.86 | 10.74 | 2.82 | -5.58 | 11.96 | 6.38 | 9.98 | -1.60 | -3.86 | 19.22 | 16.13 | 15.38 | -0.32 |
| Vacuole | -3.45 | 0.33 | -0.15 | 2.69 | -0.36 | -8.20 | 4.84 | -2.60 | 2.24 | -3.43 | -8.16 | 2.37 | -2.58 | 3.49 | -3.49 |
| Vacuole Periphery | 0.90 | -7.93 | -6.72 | -7.05 | -2.89 | -4.91 | -3.63 | -6.38 | -4.77 | -5.79 | -2.66 | -8.62 | -9.66 | -8.45 | -6.80 |
| Standard name | |
|---|---|
| Human Ortholog | |
| Description | Dihydrolipoamide acetyltransferase component (E2) of the PDC; the pyruvate dehydrogenase complex (PDC) catalyzes the oxidative decarboxylation of pyruvate to acetyl-CoA |
| Localization | |
| Cell Percentages | mitochondrion (90%) |
| Cell Cycle Regulation | No |
| Subcompartmental Group | mito-2 |
Lat1
Lat1
Nearest neighbours ( genes)
correlation threshold
0.80
Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)
Endocytosis
| Temp | Actin Patch (Sac6-tdTomato) | Cortical Patch (Sla1-GFP) | Late Endosome (Snf7-GFP) | Vacuole (Vph1-GFP) |
|---|---|---|---|---|
| 37℃ | ||||
| RT |
Cell Cycle Omics
CYCLoPs (Lat1-GFP)
| Gene / Allele | Actin Patch (Sac6-tdTomato) | Cortical Patch (Sla1-GFP) | Late Endosome (Snf7-GFP) | Vacuole (Sac6-tdTomato) |
|---|
| Gene | Images |
|---|
| Gene | Images |
|---|
Images are not yet available
Images are not yet available
