Standard name
Human Ortholog
Description Putative basic leucine zipper (bZIP) transcription factor; YAP7 has a paralog, YAP5, that arose from the whole genome duplication
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 0 0 0 0.05 0.1 0.07 0.14 0.17 0.13 0.14 0.15 0.1 0.11 0.13 0.19 0.19 0.15 0.12 0 0 0 0 0 0
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.05 0 0.06 0 0 0 0 0 0
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.05 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0 0.36 0 0 0 0.15 0.22 0.15 0.63 0.51 0.58 0.57 0 0 0 0.09 0.1 0 0 0 0 0 0 0.05
Nucleus 0.92 0.87 0.96 0.93 0.86 0.77 0.7 0.66 0.55 0.53 0.56 0.59 0.82 0.82 0.69 0.69 0.63 0.73 0.9 0.87 0.88 0.78 0.58 0.46
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.08 0.08
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vac/Vac Membrane 0.07 0 0 0 0 0.1 0.05 0.06 0.07 0.05 0 0 0 0 0.09 0.12 0.19 0.13 0.05 0.08 0.07 0.11 0.26 0.3
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 1 0 0 0 0 1 0 11 4 2 3 0 0 0 0 1 0 1 0 0 0 2 1
Bud Neck 0 0 0 0 1 0 1 6 2 1 3 4 0 0 0 0 0 0 0 0 0 1 0 0
Bud Site 0 0 0 0 0 2 1 1 12 4 4 7 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 2 2 4 9 17 26 40 70 38 47 35 23 13 27 40 18 20 12 0 0 0 2 2 5
Endoplasmic Reticulum 0 0 0 0 0 0 0 1 0 0 0 0 0 0 0 5 2 6 0 0 0 0 0 0
Endosome 0 0 0 0 3 7 1 3 2 1 2 0 1 0 11 3 2 3 0 0 0 1 1 8
Golgi 0 0 0 0 0 0 0 1 0 0 0 0 0 0 0 0 1 0 0 0 0 0 0 1
Mitochondria 1 48 0 3 2 53 62 64 190 170 137 138 1 1 1 9 14 3 0 2 0 1 5 12
Nucleus 96 117 157 154 150 268 195 278 166 177 133 143 101 166 143 66 84 71 92 122 145 103 143 123
Nuclear Periphery 1 0 0 1 0 0 0 2 1 2 0 0 0 0 0 0 2 0 0 0 1 0 0 2
Nucleolus 3 2 0 2 2 0 0 1 1 2 0 3 3 3 4 0 2 0 1 1 6 2 20 20
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 2 1 0 0 0 0 0 0 0 0
SpindlePole 0 0 1 1 3 4 7 11 2 6 2 4 2 7 9 1 0 0 0 0 0 2 3 5
Vac/Vac Membrane 7 5 3 4 7 34 15 27 21 17 10 9 5 8 18 12 25 13 5 10 10 14 62 81
Unique Cell Count 104 134 163 166 175 349 279 423 302 332 238 242 123 203 207 96 134 97 102 141 165 133 246 268
Labelled Cell Count 110 175 165 174 185 394 323 465 446 431 328 334 126 212 228 115 153 108 102 141 165 133 246 268


Nucleus

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 5.8 4.4 6.7 6.4 6.8 5.0 4.6 5.0 3.9 4.2 4.2 4.0 7.6 7.6 6.8 5.7 6.5 6.8 6.8 7.5 7.1
Std Deviation (1e-4) 0.8 0.7 1.0 1.4 2.6 1.4 1.4 1.5 1.3 1.5 1.5 0.9 2.3 2.1 1.9 1.6 1.8 1.6 1.4 2.1 1.8
Intensity Change (Log2) – – – -0.05 0.03 -0.42 -0.52 -0.4 -0.75 -0.65 -0.66 -0.74 0.19 0.19 0.03 -0.23 -0.03 0.03 0.02 0.18 0.08


Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Actin – – – – – – – – – – – – – – –
Bud – – – – – – – – – – – – 0 0 0
Bud Neck – – – – – – – – – – – – 0 0 0
Bud Site – – – – – – – – – – – – 0 0 0
Cell Periphery – – – – – – – – – – – – 0 0 0
Cyto – – – – – – – – – – – – – – –
Endoplasmic Reticulum – – – – – – – – – – – – 0 0 0
Endosome – – – – – – – – – – – – 0 0 0
Golgi – – – – – – – – – – – – 0 0 0
Mitochondria – – – – – – – – – – – – 0 0 0
Nuclear Periphery – – – – – – – – – – – – 0 0 0
Nuc – – – – – – – – – – – – – – –
Nucleolus – – – – – – – – – – – – 0 0 0
Peroxisomes – – – – – – – – – – – – 0 0 0
SpindlePole – – – – – – – – – – – – 0 0 0
Vac – – – – – – – – – – – – – – –
Cortical Patches – – – – – – – – – – – – 0 0 0
Cytoplasm – – – – – – – – – – – – 0 0 0
Nucleus – – – – – – – – – – – – 0 0 0
Vacuole – – – – – – – – – – – – 3.5 4.9 3.8

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 0.0446 0.2454 0.1263 0.4252 -0.0714 0.1989 3.1901 3.7578 3.5519 2.8383 3.3663 3.5026 0.629 1.2429 0.4007 0.7619 0.3309 0.5778
Actin 0.0001 0.0001 0.0001 0.0001 0 0 0.0248 0.0001 0.0047 0.0002 0.0025 0.008 0.0195 0.0034 0.006 0.0001 0 0
Bud 0.0001 0 0 0 0 0 0.0008 0 0.0003 0.0002 0.0002 0.0003 0.0015 0.0001 0.0001 0.0001 0 0
Bud Neck 0.0004 0.0003 0.0003 0.0005 0.0006 0.0014 0.0016 0.0006 0.0009 0.0012 0.0006 0.0022 0.0013 0.0006 0.0014 0.0005 0.0005 0.0023
Bud Periphery 0.0002 0 0 0 0 0 0.0009 0 0.0004 0.0002 0.0001 0.0008 0.0062 0.0001 0.0001 0.0001 0 0.0001
Bud Site 0.0001 0.0002 0.0001 0 0.0001 0.0001 0.0041 0.0009 0.003 0.0003 0.0004 0.0004 0.0027 0.0101 0.0005 0.0002 0 0.0001
Cell Periphery 0 0 0 0 0 0 0.0002 0.0001 0.0001 0.0001 0 0.0001 0.0002 0.0001 0 0 0 0
Cytoplasm 0.0027 0.0113 0.0065 0.0004 0.009 0.0019 0.0092 0.0015 0.0076 0.0302 0.0329 0.005 0.017 0.017 0.0177 0.0274 0.0007 0.0044
Cytoplasmic Foci 0.0001 0.0011 0.0002 0 0.0001 0 0.0302 0.0001 0.0036 0.0034 0.0057 0.0031 0.0044 0.0002 0.0014 0.0027 0 0.0001
Eisosomes 0 0 0 0 0 0 0.0002 0 0 0.0001 0 0.0002 0.0002 0.0001 0.0001 0 0 0
Endoplasmic Reticulum 0.0003 0.0038 0.0006 0.0001 0.0002 0.0003 0.0084 0.0003 0.0022 0.0017 0.0014 0.0019 0.0019 0.0021 0.001 0.001 0 0.0001
Endosome 0.0003 0.0144 0.0007 0 0.0005 0.0003 0.02 0.0007 0.0041 0.0305 0.0108 0.0061 0.0094 0.0008 0.0023 0.0004 0.0001 0.0002
Golgi 0 0.0003 0 0 0 0 0.0054 0 0.0067 0.0012 0.0028 0.0038 0.0028 0.0001 0.0003 0 0 0
Lipid Particles 0 0.0007 0.0001 0 0 0 0.0166 0.0003 0.0006 0.0002 0.0001 0.006 0.0037 0.0001 0.0004 0.0001 0 0
Mitochondria 0.002 0.0003 0.0003 0.0003 0.0002 0.0001 0.0143 0.0002 0.0028 0.0021 0.0007 0.0218 0.0055 0.0005 0.0005 0.0003 0.0002 0.0002
None 0.0045 0.0018 0.0229 0.0001 0.0053 0.0003 0.018 0.0005 0.0018 0.0203 0.0561 0.0142 0.0156 0.0137 0.008 0.0076 0.0001 0.0018
Nuclear Periphery 0.0086 0.0269 0.0382 0.0094 0.0119 0.0099 0.0214 0.0048 0.0097 0.0097 0.0046 0.0085 0.0098 0.0157 0.0168 0.0097 0.0019 0.0037
Nucleolus 0.0223 0.0141 0.0187 0.0075 0.0407 0.0333 0.0229 0.0266 0.0295 0.0158 0.0101 0.0169 0.0102 0.0114 0.0086 0.0154 0.0133 0.0144
Nucleus 0.9511 0.9135 0.9005 0.9807 0.9171 0.9389 0.757 0.9483 0.915 0.8568 0.8659 0.8753 0.8696 0.9179 0.9251 0.9263 0.9717 0.9681
Peroxisomes 0 0 0 0 0 0 0.0153 0 0.0021 0.0001 0.0003 0.0195 0.006 0.0001 0.0003 0 0 0
Punctate Nuclear 0.006 0.0093 0.0093 0.0008 0.0136 0.0131 0.0167 0.0137 0.0029 0.0178 0.0043 0.0039 0.0096 0.0052 0.0077 0.0075 0.0112 0.0042
Vacuole 0.0005 0.0013 0.0009 0.0001 0.0004 0.0003 0.0091 0.0011 0.0014 0.0061 0.0004 0.0014 0.0019 0.0007 0.0012 0.0004 0.0001 0.0003
Vacuole Periphery 0.0005 0.0004 0.0004 0.0001 0.0001 0.0001 0.003 0.0001 0.0004 0.0019 0.0002 0.0005 0.001 0.0003 0.0005 0.0001 0 0.0001

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 14.9513 14.7021 10.9096 19.88 23.262 17.9316 16.8923 22.3463 17.6159 19.2362
Translational Efficiency 1.2205 1.4316 1.5992 0.8605 0.7771 1.1854 0.867 0.9157 1.2268 0.9377

Hit Data

Dataset Hit
Protein Concentration ✘
Protein Localization ✘
Gene Expression ✘
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
1963 1667 2045 1663 1411 2045 124 1475 3374 3712 2169 3138

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 747.27 816.90 884.03 877.13 722.55 910.03 901.18 863.94 736.93 868.21 885.01 870.93
Standard Deviation 134.35 147.14 112.49 122.61 95.38 110.41 106.09 141.51 120.23 136.32 112.21 131.99
Intensity Change Log 2 — 0.128530 0.242466 0.231161 — 0.332817 0.318718 0.257834 — 0.232570 0.280454 0.244335

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.000085 0.000630 0.000547 0.000764 0.000277 0.000148 0.000310 0.000719 0.000165 0.000364 0.000533 0.000743
Bud Neck 0.001939 0.010795 0.018957 0.022693 0.001484 0.005299 0.001368 0.013648 0.001749 0.007767 0.017951 0.018442
Bud Site 0.000720 0.002792 0.002070 0.016189 0.000535 0.001015 0.000371 0.004903 0.000643 0.001813 0.001973 0.010884
Cell Periphery 0.000155 0.000152 0.000115 0.000212 0.000127 0.000067 0.000126 0.000190 0.000144 0.000105 0.000116 0.000202
Cytoplasm 0.018159 0.011875 0.006558 0.095075 0.047664 0.004853 0.035060 0.040377 0.030498 0.008006 0.008188 0.069364
Cytoplasmic Foci 0.003487 0.002036 0.000115 0.007711 0.002994 0.001386 0.004937 0.000526 0.003281 0.001678 0.000391 0.004333
Eisosomes 0.000017 0.000023 0.000023 0.000033 0.000020 0.000013 0.000053 0.000021 0.000018 0.000018 0.000024 0.000027
Endoplasmic Reticulum 0.002732 0.009181 0.008457 0.008796 0.003092 0.004859 0.003386 0.010465 0.002882 0.006800 0.008167 0.009581
Endosome 0.000517 0.001361 0.000450 0.007536 0.000388 0.001200 0.000402 0.000759 0.000463 0.001273 0.000448 0.004351
Golgi 0.000228 0.000620 0.000085 0.006163 0.000111 0.000894 0.000055 0.000916 0.000179 0.000771 0.000083 0.003697
Lipid Particles 0.000714 0.000664 0.000118 0.001296 0.000750 0.001337 0.001090 0.000299 0.000729 0.001035 0.000173 0.000827
Mitochondria 0.000800 0.002803 0.002490 0.010559 0.000613 0.004000 0.000376 0.001837 0.000722 0.003462 0.002369 0.006459
Mitotic Spindle 0.000736 0.002576 0.003074 0.053049 0.000066 0.002219 0.000056 0.002802 0.000456 0.002379 0.002901 0.029430
None 0.025857 0.005477 0.002065 0.007676 0.014838 0.001948 0.022009 0.008302 0.021249 0.003533 0.003205 0.007970
Nuclear Periphery 0.001110 0.002283 0.001381 0.005163 0.000576 0.001748 0.000450 0.002076 0.000887 0.001988 0.001328 0.003712
Nuclear Periphery Foci 0.000448 0.000771 0.000218 0.001748 0.000831 0.001044 0.000191 0.001031 0.000608 0.000922 0.000216 0.001411
Nucleolus 0.010433 0.012929 0.004344 0.004443 0.009461 0.008230 0.007705 0.004445 0.010026 0.010340 0.004536 0.004444
Nucleus 0.929955* 0.927785* 0.944080* 0.704867* 0.914232* 0.956237* 0.917340* 0.899394* 0.923380* 0.943460* 0.942551* 0.796304*
Peroxisomes 0.000418 0.001172 0.000099 0.000950 0.000634 0.000773 0.000335 0.000143 0.000508 0.000952 0.000112 0.000571
Vacuole 0.001335 0.003173 0.004396 0.037942 0.001142 0.001846 0.004293 0.006346 0.001254 0.002442 0.004390 0.023091
Vacuole Periphery 0.000155 0.000900 0.000359 0.007135 0.000163 0.000884 0.000085 0.000802 0.000158 0.000891 0.000344 0.004158

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin -5.07 -14.21 -10.02 -1.24 -2.21 3.04 -2.15 -9.02 -15.01 -1.75 -3.75 -11.50 -13.85 -6.75 -3.37
Bud Neck -8.78 -17.18 -13.35 -5.57 0.44 -5.96 -1.45 -12.91 -8.75 -10.06 -10.38 -17.51 -18.44 -10.24 0.77
Bud Site -3.87 -3.94 -7.82 -5.74 -6.23 -1.75 -0.84 -5.06 -4.47 -4.81 -4.06 -4.34 -9.27 -7.49 -6.58
Cell Periphery 0.27 2.18 0.47 0.25 -1.83 5.13 -0.31 -2.22 -5.56 -1.42 2.78 2.24 -0.77 -3.70 -3.14
Cytoplasm 3.14 6.60 -17.79 -19.63 -21.63 12.93 1.45 1.96 -12.22 -0.65 12.64 11.59 -12.34 -23.16 -22.18
Cytoplasmic Foci 1.93 5.73 -0.43 -2.42 -6.37 3.52 -0.76 5.75 2.38 2.47 3.66 7.46 2.05 -1.65 -5.90
Eisosomes -2.87 -3.36 -9.62 -7.58 -7.93 5.54 -5.59 -1.70 -9.00 5.25 1.13 -4.61 -9.02 -11.70 -4.22
Endoplasmic Reticulum -12.07 -15.45 -15.88 -1.52 -2.41 -5.50 -2.47 -16.51 -11.93 -5.15 -12.90 -16.36 -22.81 -9.53 -4.62
Endosome -2.61 0.52 -7.30 -4.77 -7.54 -3.45 -1.26 -3.79 1.71 -0.89 -4.12 0.02 -7.78 -3.87 -7.88
Golgi -1.57 1.18 -3.19 -2.57 -3.48 -2.44 1.66 -1.15 0.30 -1.23 -2.74 1.33 -3.29 -1.86 -3.59
Lipid Particles 0.37 4.41 -1.34 -1.70 -4.30 -0.94 -1.34 3.72 2.15 3.18 -0.84 5.88 0.31 0.99 -4.47
Mitochondria -5.11 -4.76 -6.60 -3.94 -4.12 -4.02 2.28 -8.41 2.21 -9.11 -5.50 -5.17 -7.93 -1.39 -3.26
Mitotic Spindle -1.99 -2.15 -10.58 -9.82 -9.84 -3.42 -0.78 -3.55 -1.55 -3.50 -3.34 -2.63 -10.98 -9.77 -9.31
None 7.74 9.26 7.30 -1.24 -6.42 8.97 -0.91 4.89 -5.93 2.16 10.78 10.95 8.58 -5.37 -5.73
Nuclear Periphery -3.24 -2.27 -14.39 -9.08 -12.97 -4.25 -0.47 -12.53 -3.01 -10.69 -4.85 -3.78 -17.34 -9.63 -12.94
Nuclear Periphery Foci -1.29 2.13 -4.24 -2.27 -5.27 -0.16 1.70 -1.07 -0.78 -2.47 -0.86 2.74 -3.16 -1.75 -5.15
Nucleolus -1.54 6.10 6.45 8.39 0.87 1.57 0.58 5.68 4.33 2.31 0.30 6.96 8.56 8.92 1.25
Nucleus 0.25 -2.26 23.80 24.00 26.95 -7.95 0.33 3.65 12.06 1.11 -5.48 -3.87 21.19 26.37 24.79
Peroxisomes -2.91 2.45 -0.39 2.84 -3.95 -0.24 0.85 1.69 2.97 3.67 -2.00 2.73 1.23 3.87 -3.92
Vacuole -2.94 -4.35 -17.93 -17.18 -16.05 -1.48 -2.16 -8.69 -7.71 0.33 -3.10 -4.92 -19.05 -18.22 -14.87
Vacuole Periphery -2.77 -2.06 -5.14 -3.49 -4.76 -3.38 2.30 -2.13 0.44 -2.32 -4.34 -2.08 -5.56 -2.97 -4.89
Standard name
Human Ortholog
Description Putative basic leucine zipper (bZIP) transcription factor; YAP7 has a paralog, YAP5, that arose from the whole genome duplication
Localization
Cell Percentages nucleus (96%)
Cell Cycle Regulation No
Subcompartmental Group nucleus-3

Yap7

Yap7


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Yap7-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available