Standard name
Human Ortholog
Description Mitochondrial matrix cochaperone; nucleotide release factor for Ssc1p in protein translocation and folding; also acts as cochaperone for Ssq1p in folding of Fe-S cluster proteins; acts as oxidative sensor to regulate mitochondrial Ssc1p; in presence of oxidative stress, dimeric Mge1p becomes a monomer and unable to regulate Ssc1p function; homolog of E. coli GrpE and human Mge1 (GRPEL1), which also responds to oxidative stress
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0.05 0.05 0.06 0.06 0 0.08 0.06 0.06 0.08 0.08 0.07 0.05 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 0.97 0.98 0.96 0.97 0.93 0.8 0.81 0.79 0.7 0.73 0.67 0.63 0.98 0.99 0.99 0.87 0.88 0.93 0.91 0.96 0.95 0.92 0.91 0.93
Endoplasmic Reticulum 0 0 0 0 0.05 0 0 0 0 0 0.05 0 0 0 0 0 0 0 0 0 0 0 0 0
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0 0 0 0 0 0.26 0.07 0.14 0.24 0.31 0.28 0.29 0 0 0 0 0 0 0 0 0 0 0 0
Nucleus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vac/Vac Membrane 0 0 0 0 0 0 0.1 0.08 0.06 0.05 0.06 0.11 0 0 0 0.15 0.14 0.07 0 0 0 0 0 0
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 1 0 0 1 1 1 4 3 5 2 8 8 0 0 0 2 0 0 2 0 0 0 1 0
Bud 0 1 0 0 1 2 2 2 3 2 7 4 0 0 0 2 0 0 1 0 0 0 1 0
Bud Neck 0 0 0 0 0 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 1 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0 0 0 0 – – – – – –
Cell Periphery 1 14 4 5 11 1 17 16 10 14 30 27 9 6 7 5 4 2 0 0 0 1 2 1
Cytoplasm 182 256 76 77 181 79 174 224 119 127 245 246 184 261 368 194 124 183 198 252 95 194 290 339
Endoplasmic Reticulum 3 4 3 1 9 2 7 4 7 1 17 13 4 2 2 9 2 5 3 2 0 6 8 9
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0 1 1 0 1
Golgi 1 0 0 0 0 0 1 0 0 0 2 1 0 0 0 3 0 0 1 0 0 0 0 1
Mitochondria 2 0 0 0 0 26 16 39 41 54 103 111 3 0 1 4 2 4 3 0 0 2 6 1
Nucleus 1 1 0 1 2 0 3 1 0 1 4 5 0 0 0 3 2 8 0 0 0 0 0 0
Nuclear Periphery 1 1 0 0 0 0 0 0 1 1 0 0 0 0 0 0 0 0 1 0 0 0 1 0
Nucleolus 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vac/Vac Membrane 1 0 0 0 4 4 22 24 11 9 21 43 0 0 0 33 20 13 0 2 0 2 1 0
Unique Cell Count 187 261 79 79 194 99 214 283 170 174 363 389 188 263 371 223 141 197 218 262 101 212 319 363
Labelled Cell Count 193 277 83 85 209 115 246 313 197 212 437 460 200 269 378 255 155 215 218 262 101 212 319 363


Cytoplasm

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 8.6 9.5 8.8 8.4 9.5 5.8 8.2 7.8 7.2 7.3 7.3 7.4 9.4 10.0 10.0 12.4 12.0 12.5 8.1 8.6 9.6
Std Deviation (1e-4) 1.8 1.3 1.3 1.2 1.6 1.2 1.8 1.6 1.6 1.6 1.4 1.5 1.4 1.5 1.7 4.1 3.8 3.6 1.3 1.5 1.8
Intensity Change (Log2) – – – -0.07 0.11 -0.6 -0.1 -0.17 -0.29 -0.27 -0.28 -0.26 0.09 0.18 0.19 0.49 0.44 0.51 -0.12 -0.03 0.13


Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cell Periphery 0 0 0 0.8 0 0 0.9 1.0 0.6 0 0 0 0 0 0
Cytoplasm 0.5 -0.9 -3.2 -3.2 -3.6 -4.7 -4.3 -5.2 -5.8 0.8 2.0 2.1 -2.3 -2.0 -1.0
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0 0 4.9 0 3.5 4.8 5.6 5.4 5.4 0 0 0 0 0 0
Nucleus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vacuole 0 0 0 3.0 2.7 0 0 0 3.1 0 0 0 3.6 3.5 0

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 2.3682 3.5797 3.1111 2.9959 2.5889 2.98 4.1658 6.1213 5.8385 5.2309 5.4614 5.5903 5.9216 7.6581 7.0095 6.8446 6.3888 6.7624
Actin 0.0143 0.0105 0.016 0.0038 0.0135 0.0018 0.0225 0.0004 0.0042 0.0032 0.009 0.0026 0.0012 0.0002 0.0043 0.0003 0.0018 0.0011
Bud 0.0006 0.0007 0.0051 0.0005 0.0005 0.0002 0.0009 0.0021 0.0046 0.0011 0.0012 0.0004 0.0001 0.0003 0.0006 0.0005 0.0002 0.0001
Bud Neck 0.0018 0.0003 0.0012 0.0004 0.0012 0.0013 0.0032 0.0007 0.0005 0.0005 0.0003 0.0021 0.0002 0.0001 0.0005 0.0003 0.0005 0.0015
Bud Periphery 0.0006 0.0004 0.0055 0.0003 0.0002 0.0001 0.001 0.0005 0.0014 0.0011 0.0013 0.0005 0.0001 0.0001 0.0002 0.0001 0.0001 0
Bud Site 0.0024 0.0015 0.0044 0.0009 0.0006 0.0001 0.003 0.0161 0.0032 0.0005 0.0004 0.0004 0.0003 0.0009 0.001 0.0005 0.0002 0.0001
Cell Periphery 0.0003 0.0001 0.0002 0.0001 0 0.0001 0.0004 0.0001 0.0001 0.0001 0.0001 0.0001 0.0003 0.0001 0.0002 0.0001 0.0001 0.0001
Cytoplasm 0.7956 0.9039 0.8386 0.8741 0.7726 0.8953 0.7124 0.9394 0.9339 0.864 0.9157 0.9497 0.9078 0.9693 0.9359 0.8957 0.9177 0.9581
Cytoplasmic Foci 0.0406 0.0163 0.0295 0.032 0.0425 0.0205 0.0304 0.0205 0.0119 0.0172 0.0079 0.0112 0.0133 0.0108 0.0166 0.0238 0.0227 0.0081
Eisosomes 0.0001 0 0.0001 0 0 0 0.0003 0 0 0 0 0 0 0 0 0 0 0
Endoplasmic Reticulum 0.0111 0.0044 0.0048 0.0049 0.0042 0.0114 0.0243 0.001 0.0019 0.0028 0.0073 0.0032 0.0216 0.0017 0.004 0.0037 0.0065 0.0068
Endosome 0.0508 0.0186 0.0365 0.0465 0.0693 0.0303 0.0538 0.0103 0.0137 0.0548 0.0326 0.0122 0.0135 0.0046 0.0192 0.0591 0.0279 0.0137
Golgi 0.0087 0.0054 0.0085 0.0107 0.0075 0.0035 0.014 0.0008 0.005 0.0086 0.0078 0.004 0.0027 0.0017 0.0033 0.0023 0.0028 0.0012
Lipid Particles 0.0038 0.0004 0.007 0.0026 0.0227 0.0005 0.0151 0.0002 0.0006 0.0055 0.0005 0.0013 0.0016 0.0001 0.0002 0.0002 0.0013 0.0006
Mitochondria 0.011 0.003 0.0061 0.003 0.0021 0.0014 0.0197 0.0001 0.0092 0.02 0.0064 0.0015 0.0006 0.0002 0.0005 0.0003 0.0004 0.0005
None 0.0353 0.0276 0.0168 0.0059 0.0218 0.0274 0.0258 0.0048 0.0042 0.0036 0.0025 0.0035 0.0303 0.0073 0.0091 0.0038 0.0125 0.005
Nuclear Periphery 0.004 0.0006 0.0018 0.0016 0.001 0.0007 0.0208 0.0003 0.0005 0.0013 0.0028 0.0006 0.0011 0.0002 0.0005 0.001 0.0008 0.0006
Nucleolus 0.0008 0 0.0001 0 0.0001 0 0.0007 0 0 0.0001 0 0 0 0 0 0 0 0
Nucleus 0.0023 0.0008 0.0009 0.0012 0.0009 0.0008 0.0163 0.0009 0.0009 0.0016 0.0009 0.0008 0.0009 0.0005 0.0007 0.0011 0.001 0.0007
Peroxisomes 0.0082 0.0017 0.0107 0.0042 0.0267 0.001 0.0176 0.0002 0.0012 0.0014 0.0002 0.0024 0.0014 0.0006 0.0004 0.0001 0.0003 0.0001
Punctate Nuclear 0.002 0.0003 0.0012 0.0009 0.0038 0.0002 0.0027 0.0003 0.0003 0.0005 0.0002 0.001 0.0007 0.0001 0.0002 0.0007 0.0004 0.0003
Vacuole 0.0045 0.0029 0.004 0.005 0.007 0.0026 0.0091 0.0013 0.002 0.0094 0.0018 0.0019 0.0021 0.0012 0.0022 0.0051 0.0024 0.0011
Vacuole Periphery 0.0012 0.0006 0.0011 0.0015 0.0016 0.0007 0.006 0.0002 0.0005 0.0027 0.0011 0.0007 0.0003 0.0001 0.0004 0.0012 0.0004 0.0003

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 140.5355 122.0407 117.1946 120.8477 122.8619 121.9975 124.847 123.4555 131.9542 138.0746
Translational Efficiency 1.8166 1.8993 1.9138 1.693 1.8964 2.3176 2.0007 1.9156 2.0127 1.9799

Hit Data

Dataset Hit
Protein Concentration ✔
Protein Localization ✘
Gene Expression ✘
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
1910 657 179 1215 1035 2677 924 1381 2945 3334 1103 2596

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 789.62 950.78 1318.87 1067.88 888.19 977.90 1118.09 1098.00 824.26 972.56 1150.67 1083.90
Standard Deviation 114.91 146.28 186.23 161.29 105.74 126.43 158.58 158.57 121.28 131.03 179.38 160.56
Intensity Change Log 2 — 0.267953 0.740072 0.435519 — 0.138819 0.332096 0.305938 — 0.201034 0.538503 0.368374

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.000341 0.000772 0.001977 0.002356 0.000347 0.000692 0.000524 0.000352 0.000343 0.000707 0.000760 0.001290
Bud Neck 0.006824 0.003217 0.003843 0.003625 0.003623 0.004746 0.001675 0.002960 0.005699 0.004445 0.002027 0.003271
Bud Site 0.020646 0.039936 0.031454 0.055014 0.020114 0.032032 0.022192 0.033041 0.020459 0.033590 0.023695 0.043325
Cell Periphery 0.000118 0.000131 0.000290 0.000202 0.000191 0.000110 0.000131 0.000071 0.000144 0.000114 0.000156 0.000132
Cytoplasm 0.667388* 0.733880* 0.607493* 0.747288* 0.685459* 0.760551* 0.831158* 0.793432* 0.673739* 0.755295* 0.794860* 0.771835*
Cytoplasmic Foci 0.167085 0.139594 0.089642 0.059542 0.207553* 0.115828 0.056529 0.056776 0.181307* 0.120512 0.061903 0.058071
Eisosomes 0.000056 0.000027 0.000029 0.000021 0.000067 0.000035 0.000010 0.000010 0.000060 0.000034 0.000013 0.000015
Endoplasmic Reticulum 0.002486 0.000829 0.001655 0.000506 0.001730 0.000448 0.000205 0.000160 0.002220 0.000523 0.000440 0.000322
Endosome 0.012595 0.011232 0.012971 0.007595 0.009591 0.007201 0.001978 0.003165 0.011540 0.007995 0.003762 0.005239
Golgi 0.010319 0.004207 0.000990 0.007394 0.009986 0.011248 0.000355 0.000506 0.010202 0.009861 0.000458 0.003730
Lipid Particles 0.002240 0.000543 0.003423 0.000751 0.001721 0.000700 0.000524 0.000352 0.002058 0.000669 0.000994 0.000539
Mitochondria 0.002501 0.001265 0.000088 0.002273 0.001200 0.002097 0.000057 0.000064 0.002044 0.001933 0.000062 0.001098
Mitotic Spindle 0.000526 0.000530 0.008480 0.011135 0.001503 0.005375 0.004293 0.006390 0.000870 0.004420 0.004972 0.008611
None 0.001416 0.000401 0.001326 0.000583 0.000577 0.001747 0.002529 0.001759 0.001121 0.001481 0.002334 0.001209
Nuclear Periphery 0.000151 0.000027 0.000495 0.000055 0.000065 0.000030 0.000062 0.000041 0.000120 0.000029 0.000133 0.000047
Nuclear Periphery Foci 0.000304 0.000751 0.010231 0.001189 0.000534 0.000143 0.003338 0.001066 0.000385 0.000263 0.004457 0.001124
Nucleolus 0.000329 0.000102 0.000118 0.000087 0.000110 0.000192 0.000096 0.000124 0.000252 0.000174 0.000099 0.000107
Nucleus 0.023995 0.009441 0.053532 0.011013 0.017517 0.008690 0.021942 0.012292 0.021718 0.008838 0.027069 0.011693
Peroxisomes 0.002107 0.002234 0.001559 0.003034 0.001198 0.002221 0.000985 0.001328 0.001787 0.002223 0.001079 0.002126
Vacuole 0.073611 0.048773 0.169882 0.084021 0.034328 0.042389 0.051209 0.085836 0.059806 0.043647 0.070468 0.084987
Vacuole Periphery 0.004961 0.002109 0.000522 0.002315 0.002585 0.003524 0.000209 0.000273 0.004126 0.003245 0.000260 0.001229

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin -1.71 -2.35 -3.98 -2.16 -0.55 -1.72 -2.74 0.84 1.96 3.12 -2.14 -3.51 -3.70 -1.09 -0.85
Bud Neck 6.17 4.44 6.96 0.46 2.23 -2.57 5.34 2.99 5.54 -2.31 3.11 10.22 8.20 5.05 -2.04
Bud Site -5.89 -0.77 -5.35 0.56 -2.56 -6.13 -0.33 -2.28 2.21 -1.78 -8.51 -0.49 -5.43 0.96 -3.98
Cell Periphery -0.98 -6.48 -1.43 -0.75 4.37 6.03 1.93 9.53 7.01 2.80 4.19 -0.74 3.78 1.13 2.44
Cytoplasm -5.82 5.07 -3.38 2.70 -6.52 -9.12 -11.54 -8.04 0.00 3.90 -13.64 -10.54 -8.83 3.74 3.23
Cytoplasmic Foci 3.97 12.36 24.39 13.51 2.31 14.67 24.69 25.29 17.69 0.27 14.88 30.56 34.78 22.56 1.00
Eisosomes 4.13 6.58 9.33 1.00 2.26 4.42 8.50 8.76 7.55 1.73 6.07 13.63 13.48 6.26 -0.85
Endoplasmic Reticulum 2.95 2.03 4.22 1.55 4.34 4.51 5.35 5.68 4.35 3.16 5.01 5.37 5.88 2.81 2.50
Endosome 0.94 2.20 7.75 4.05 3.08 2.47 8.61 7.32 9.61 -3.04 5.44 14.80 12.06 7.52 -1.08
Golgi 8.13 16.42 5.27 0.35 -2.58 -1.01 9.74 9.61 13.77 -0.79 0.41 19.30 11.28 9.57 -2.94
Lipid Particles 7.96 -2.65 4.87 -3.20 5.27 7.19 7.19 9.93 5.10 6.24 9.43 5.24 8.77 -0.31 4.36
Mitochondria 1.62 9.44 1.64 0.10 -1.28 -1.73 2.91 2.92 6.02 0.18 0.30 9.21 3.46 2.84 -1.32
Mitotic Spindle -0.09 -3.43 -4.48 -4.47 0.98 -3.09 -2.16 -2.50 -0.42 -0.57 -4.26 -4.04 -5.11 -2.02 -0.66
None 4.03 0.62 2.82 -3.35 2.55 -5.16 -2.68 -2.72 0.65 0.99 -1.32 -1.64 0.15 1.44 1.70
Nuclear Periphery 3.04 -7.87 0.93 -9.12 9.78 2.31 -3.21 -0.70 -7.05 3.87 3.43 -3.49 1.01 -10.74 8.00
Nuclear Periphery Foci -2.50 -8.93 -10.86 -3.68 7.87 5.44 -11.77 -5.12 -8.98 8.24 2.38 -14.83 -10.80 -12.63 11.12
Nucleolus 3.48 3.06 3.05 -0.47 0.55 -2.85 0.85 -1.44 2.26 -2.77 1.81 3.50 2.98 1.92 -1.14
Nucleus 8.29 -6.80 3.55 -6.06 7.93 7.20 -7.19 0.89 -8.75 8.38 12.00 -7.85 4.00 -11.53 10.83
Peroxisomes -0.29 3.00 -0.15 0.09 -2.36 -5.70 1.86 1.06 6.12 -1.02 -2.43 4.83 1.04 2.84 -2.95
Vacuole 4.67 -9.10 -13.85 -15.83 3.74 -3.38 -10.11 -18.71 -17.61 -8.10 7.06 -8.45 -20.21 -25.54 -7.05
Vacuole Periphery 4.90 9.73 6.06 1.66 -1.84 -1.98 7.25 7.11 9.63 -1.07 2.04 12.02 9.13 7.48 -2.31
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Mitochondrial matrix cochaperone; nucleotide release factor for Ssc1p in protein translocation and folding; also acts as cochaperone for Ssq1p in folding of Fe-S cluster proteins; acts as oxidative sensor to regulate mitochondrial Ssc1p; in presence of oxidative stress, dimeric Mge1p becomes a monomer and unable to regulate Ssc1p function; homolog of E. coli GrpE and human Mge1 (GRPEL1), which also responds to oxidative stress
Localization
Cell Percentages cytoplasm (96%)
Cell Cycle Regulation No
Subcompartmental Group cytoplasm-4

Mge1

Mge1


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Mge1-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available