Standard name
Human Ortholog
Description Nucleolar protein required for 60S ribosome subunit biogenesis; constituent of 66S pre-ribosomal particles; physically interacts with Nop8p and the exosome subunit Rrp43p
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 0 0 0 0 0 0.05 0 – 0 0 0 0 0 0.08 0.07 0 0 0 0 0 0 0 0 0
Endoplasmic Reticulum 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Endosome 0 0 0 0 0.05 0.09 0.18 – 0.12 0.14 0.14 0.09 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0 0 0 0.06 0 0.11 0 – 0.06 0.06 0.08 0.12 0.12 0.11 0.15 0.07 0.13 0.08 0 0 0 0.08 0.08 0.07
Nucleus 0.46 0.57 0.5 0 0.08 0.06 0.08 – 0.11 0.12 0.12 0.12 0.13 0.08 0.05 0.18 0.14 0.15 0.23 0.35 0.22 0.08 0.06 0.07
Nuclear Periphery 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0.53 0.49 0.47 0.95 0.86 0.73 0.84 – 0.82 0.83 0.81 0.77 0.89 0.84 0.87 0.8 0.84 0.84 0.64 0.57 0.65 0.68 0.66 0.64
Peroxisomes 0 0 0 0.06 0.06 0 0.11 – 0 0.07 0 0 0 0 0.05 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0.07 0.07 0.13 0.17 – 0.07 0.13 0.08 0.09 0 0 0 0 0 0 0 0 0 0 0 0
Vac/Vac Membrane 0.05 0.05 0.05 0 0 0.1 0 – 0 0 0 0 0 0 0 0.05 0 0.05 0.06 0.07 0.07 0.11 0.12 0.15
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1
Bud 0 0 0 0 0 0 0 – 0 0 0 0 0 0 1 0 0 0 0 0 0 0 2 3
Bud Neck 0 0 0 0 0 0 0 – 1 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0
Bud Site 0 0 0 0 0 2 0 – 1 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 3 1 6 3 11 20 12 – 9 6 4 5 2 21 19 2 1 5 0 0 0 1 0 2
Endoplasmic Reticulum 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 6 2 0 0 0 1 0 0 0
Endosome 0 0 0 9 23 37 108 – 64 69 37 15 2 3 1 0 0 0 3 0 0 2 4 4
Golgi 0 0 0 0 4 8 0 – 0 1 0 0 0 0 0 1 0 0 0 0 1 1 0 2
Mitochondria 5 4 2 16 14 43 9 – 32 28 21 19 21 29 43 23 34 23 0 0 0 12 23 24
Nucleus 102 126 101 10 33 23 51 – 61 61 31 20 23 21 14 59 39 43 59 97 54 12 18 26
Nuclear Periphery 0 0 3 0 0 4 4 – 7 4 6 0 0 0 0 0 2 0 7 1 10 2 3 5
Nucleolus 118 109 95 252 364 291 512 – 444 422 212 126 159 223 244 257 227 246 162 160 164 112 202 229
Peroxisomes 6 1 0 16 24 6 66 – 23 33 11 2 4 4 13 2 1 1 0 0 0 0 0 1
SpindlePole 0 0 0 18 29 50 105 – 40 66 21 14 0 4 5 0 0 1 2 1 0 0 8 4
Vac/Vac Membrane 11 12 10 0 12 41 15 – 5 7 5 6 1 2 1 17 9 14 15 18 16 18 36 52
Unique Cell Count 224 223 204 265 425 396 606 542 506 262 163 179 266 281 322 271 293 255 282 252 165 306 362
Labelled Cell Count 245 253 217 324 514 525 882 687 697 348 207 212 307 341 367 315 333 255 282 252 165 306 362


Nucleolus, Nucleus

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 32.7 31.4 24.3 24.6 23.3 17.9 16.7 – 15.0 14.9 13.2 13.6 31.0 28.3 31.9 47.1 48.9 48.5 28.7 28.5 30.3
Std Deviation (1e-4) 9.3 9.4 6.7 9.8 8.7 11.9 4.9 – 4.3 5.2 3.9 3.8 13.1 12.0 17.2 19.4 16.0 16.6 7.4 9.5 10.3
Intensity Change (Log2) – – – 0.02 -0.06 -0.44 -0.54 – -0.69 -0.7 -0.88 -0.83 0.36 0.22 0.39 0.96 1.01 1.0 0.24 0.23 0.32


Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Cell Periphery 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Cytoplasm 0 -0.3 1.2 0 – 0 0 0 0 0 2.3 1.9 0 0 0
Endoplasmic Reticulum 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Endosome 0 3.4 4.5 6.5 – 5.1 5.6 5.6 4.4 0 0 0 0 0 0
Golgi 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Mitochondria 2.8 1.7 4.4 0 – 2.9 2.7 3.5 4.4 4.4 4.3 5.4 3.2 4.7 3.4
Nucleus -11.6 -12.0 -12.5 -13.0 – -11.3 -10.8 -9.0 -7.5 -7.7 -10.2 -11.4 -7.6 -8.3 -8.4
Nuclear Periphery 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Nucleolus 11.9 10.3 6.5 10.8 – 9.6 10.0 7.8 6.0 8.7 8.6 9.5 7.9 8.6 8.8
Peroxisomes 3.6 3.5 0 4.9 – 3.0 3.7 0 0 0 0 3.1 0 0 0
SpindlePole 3.8 3.8 5.3 6.4 – 4.0 5.4 4.1 4.3 0 0 0 0 0 0
Vacuole 0 -1.3 2.3 -1.7 – 0 0 -1.8 -0.6 -2.5 -2.8 0 0.2 -0.9 -0.1

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 20.1456 25.0459 20.9899 18.9685 17.0904 21.0356 25.5295 28.6623 26.8735 24.829 19.6579 25.0908 29.5182 34.882 29.7996 27.4908 22.9511 30.8833
Actin 0.013 0 0.0059 0.0004 0 0.0002 0.0052 0 0.0014 0.0022 0.0088 0.0021 0.003 0 0.0206 0.0277 0.0842 0.0022
Bud 0.0002 0.0001 0.0003 0.0001 0.0001 0.0001 0.0003 0 0 0.0002 0.0003 0.0001 0.0001 0 0.0003 0.0001 0.0002 0.0001
Bud Neck 0.0002 0 0.0001 0.0001 0.0001 0.0002 0.0001 0 0.0001 0.0001 0.0002 0.0001 0.0001 0.0002 0.0003 0.0002 0.0002 0.0001
Bud Periphery 0.0002 0.0001 0.0003 0.0002 0.0002 0.0003 0.0005 0.0001 0 0.0003 0.001 0.0003 0.0002 0.0001 0.0005 0.0003 0.0003 0.0003
Bud Site 0.0008 0.0001 0.0013 0.0002 0.0001 0.0001 0.0013 0.0001 0.0001 0.0005 0.0006 0.0001 0.0003 0.0001 0.0005 0.0003 0.0003 0.0002
Cell Periphery 0.0006 0.0004 0.0003 0.0008 0.0006 0.0012 0.0006 0.0006 0.0003 0.0003 0.0012 0.0008 0.0011 0.0005 0.0006 0.0002 0.0006 0.0007
Cytoplasm 0.0081 0 0.0102 0.0013 0 0.0019 0.0042 0.0002 0.0016 0.0015 0.0021 0.0045 0.0022 0 0.002 0.0001 0.0005 0.0006
Cytoplasmic Foci 0.0112 0 0.0055 0.0276 0.0026 0.0012 0.0087 0.0001 0.0019 0.0052 0.0015 0.0061 0.0264 0 0.0007 0.0033 0.022 0.0099
Eisosomes 0.0002 0 0.0001 0.0001 0 0.0001 0.0002 0 0 0.0001 0.0008 0.0001 0.0001 0 0.0002 0.0002 0.0003 0.0001
Endoplasmic Reticulum 0.0043 0 0.0072 0.0002 0 0.0028 0.0011 0 0.0002 0.0014 0.0107 0.0015 0.0006 0 0.0149 0.0003 0.0007 0.0001
Endosome 0.0147 0 0.0114 0.0005 0 0.0031 0.0046 0.0004 0.0017 0.0207 0.0197 0.0061 0.0111 0 0.0112 0.0055 0.0065 0.0005
Golgi 0.0039 0 0.0028 0.0003 0 0.0002 0.001 0 0.0007 0.0059 0.0035 0.0026 0.003 0 0.0061 0.0176 0.0252 0.0017
Lipid Particles 0.0063 0.0001 0.0037 0.0087 0.002 0.0059 0.0038 0.0003 0.0022 0.0027 0.0125 0.0062 0.01 0.0001 0.0023 0.0085 0.0141 0.0112
Mitochondria 0.0157 0.0008 0.0166 0.0085 0.0395 0.0186 0.0188 0.0027 0.0015 0.0062 0.0472 0.0184 0.0034 0.0024 0.0139 0.0063 0.0243 0.0173
None 0.0027 0 0.0103 0.0052 0.0001 0.0004 0.003 0 0.0083 0.0005 0.0014 0.0019 0.0013 0 0.0002 0.0002 0.0009 0.0009
Nuclear Periphery 0.0092 0.0006 0.0101 0.0502 0.0001 0.0376 0.0042 0.0096 0.0016 0.0067 0.083 0.0356 0.0154 0.0002 0.0057 0.0026 0.0138 0.0233
Nucleolus 0.7963 0.7884 0.7818 0.8057 0.8527 0.6999 0.8036 0.8075 0.8453 0.7695 0.5976 0.7401 0.7691 0.8335 0.7878 0.7401 0.7027 0.7695
Nucleus 0.0945 0.2063 0.1245 0.0795 0.097 0.1847 0.1272 0.1582 0.1297 0.171 0.1521 0.1367 0.0959 0.1599 0.1211 0.1817 0.067 0.1319
Peroxisomes 0.0022 0 0.001 0.0013 0.0014 0.0001 0.0013 0 0.0012 0.0003 0.0016 0.0002 0.0254 0 0.0001 0.003 0.0014 0.0008
Punctate Nuclear 0.0055 0.0001 0.0038 0.0012 0.0002 0.0012 0.0043 0.0002 0.0006 0.0008 0.0015 0.0015 0.0181 0.0001 0.0002 0.0005 0.0009 0.0019
Vacuole 0.0015 0.0012 0.0011 0.0015 0.0011 0.0055 0.0016 0.0073 0.0005 0.0013 0.0052 0.0029 0.0016 0.0009 0.0031 0.0004 0.0021 0.0017
Vacuole Periphery 0.0085 0.0019 0.0016 0.0063 0.0022 0.0349 0.0043 0.0125 0.0011 0.0025 0.0476 0.032 0.0115 0.0017 0.0077 0.001 0.0318 0.0251

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 129.3368 86.7144 108.5836 85.8774 100.8765 62.6128 88.1335 80.7505 60.1699 92.2913
Translational Efficiency 1.8466 2.6585 1.5303 1.3158 1.621 2.7132 1.7712 1.6301 1.9062 1.9546

Hit Data

Dataset Hit
Protein Concentration ✔
Protein Localization ✔
Gene Expression ✘
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
1952 1135 3381 8 1227 2697 2422 71 3179 3832 5803 79

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 1644.61 1920.55 2973.92 2558.86 1761.41 2125.58 3046.82 3781.95 1689.69 2064.85 3004.35 3658.09
Standard Deviation 479.27 614.64 792.77 1971.15 419.21 529.28 882.71 963.16 460.55 563.76 832.27 1167.62
Intensity Change Log 2 — 0.223774 0.854620 0.637756 — 0.271126 0.790574 1.102400 — 0.248456 0.821854 0.896580

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.000981 0.001097 0.001574 0.000764 0.000778 0.000690 0.001832 0.001587 0.000902 0.000811 0.001682 0.001504
Bud Neck 0.001045 0.002252 0.001441 0.003262 0.000943 0.001529 0.003281 0.006720 0.001005 0.001743 0.002209 0.006370
Bud Site 0.000077 0.000292 0.000097 0.000252 0.000082 0.000175 0.000350 0.001094 0.000079 0.000210 0.000203 0.001008
Cell Periphery 0.000025 0.000062 0.000030 0.000110 0.000015 0.000025 0.000105 0.000080 0.000021 0.000036 0.000061 0.000083
Cytoplasm 0.000048 0.000216 0.000056 0.000061 0.000017 0.000150 0.000310 0.000399 0.000036 0.000170 0.000162 0.000365
Cytoplasmic Foci 0.000076 0.001583 0.000233 0.000477 0.000148 0.000568 0.001848 0.006671 0.000104 0.000869 0.000907 0.006044
Eisosomes 0.000093 0.000138 0.000141 0.000159 0.000121 0.000164 0.000166 0.000110 0.000104 0.000156 0.000151 0.000115
Endoplasmic Reticulum 0.000329 0.000237 0.000173 0.000029 0.000196 0.000171 0.000177 0.000098 0.000278 0.000191 0.000175 0.000091
Endosome 0.000013 0.000058 0.000009 0.000008 0.000010 0.000043 0.000019 0.000033 0.000012 0.000047 0.000013 0.000030
Golgi 0.000038 0.000194 0.000064 0.000113 0.000050 0.000064 0.000125 0.000611 0.000042 0.000103 0.000090 0.000560
Lipid Particles 0.000004 0.000157 0.000004 0.000008 0.000009 0.000031 0.000015 0.000053 0.000006 0.000068 0.000009 0.000048
Mitochondria 0.001691 0.002944 0.002207 0.002057 0.001558 0.001136 0.004496 0.011448 0.001640 0.001671 0.003163 0.010497
Mitotic Spindle 0.000068 0.000618 0.000349 0.000031 0.000685 0.000649 0.000394 0.020442 0.000306 0.000640 0.000368 0.018375
None 0.001098 0.001795 0.000406 0.377300* 0.000276 0.000372 0.001557 0.000902 0.000781 0.000793 0.000886 0.039018
Nuclear Periphery 0.002320 0.001703 0.008142 0.000182 0.004479 0.001132 0.006183 0.032410 0.003153 0.001301 0.007325 0.029146
Nuclear Periphery Foci 0.000375 0.000769 0.001205 0.000125 0.001404 0.000369 0.000904 0.008710 0.000772 0.000487 0.001080 0.007841
Nucleolus 0.456477* 0.537329* 0.510478* 0.464004* 0.625179* 0.504422* 0.514372* 0.641281* 0.521591* 0.514169* 0.512103* 0.623329*
Nucleus 0.527157* 0.425000* 0.453384* 0.133753* 0.349315* 0.478056* 0.430250* 0.188560* 0.458515* 0.462341* 0.443728* 0.183010*
Peroxisomes 0.004654 0.011311 0.009085 0.005860 0.010660 0.007721 0.010861 0.033500 0.006972 0.008784 0.009826 0.030701
Vacuole 0.000656 0.002054 0.000567 0.000967 0.000469 0.000359 0.002359 0.002901 0.000584 0.000861 0.001315 0.002705
Vacuole Periphery 0.002776 0.010190 0.010354 0.010478 0.003606 0.002174 0.020396 0.042392 0.003096 0.004548 0.014545 0.039160

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin NaN NaN NaN NaN NaN 2.35 -20.20 -2.77 -3.09 1.08 3.06 -22.95 -2.24 -2.60 0.91
Bud Neck NaN NaN NaN NaN NaN -3.22 -11.29 -6.58 -5.99 -4.13 -6.95 -12.94 -6.57 -5.67 -5.19
Bud Site NaN NaN NaN NaN NaN -2.96 -8.33 -3.73 -3.31 -2.82 -4.69 -8.55 -3.77 -3.19 -3.31
Cell Periphery NaN NaN NaN NaN NaN -2.04 -5.70 -3.57 -3.00 0.92 -3.91 -5.82 -3.59 -2.72 -1.27
Cytoplasm NaN NaN NaN NaN NaN -1.62 -4.38 -1.39 -0.91 -0.78 -1.98 -4.39 -1.35 -0.89 -1.06
Cytoplasmic Foci NaN NaN NaN NaN NaN -2.70 -4.19 -1.89 -1.77 -1.47 -3.43 -4.65 -1.90 -1.69 -1.69
Eisosomes NaN NaN NaN NaN NaN -4.80 -5.25 0.49 2.85 2.98 -8.24 -8.93 -0.81 2.25 1.99
Endoplasmic Reticulum NaN NaN NaN NaN NaN 1.02 0.92 4.15 4.04 4.64 4.55 7.46 9.98 5.42 5.81
Endosome NaN NaN NaN NaN NaN -1.33 -3.98 -4.07 0.48 -2.52 -1.93 -1.01 -3.63 0.99 -3.26
Golgi NaN NaN NaN NaN NaN -1.27 -10.82 -4.80 -4.59 -4.15 -3.06 -13.30 -4.87 -4.15 -4.42
Lipid Particles NaN NaN NaN NaN NaN -1.35 -2.75 -3.93 -0.37 -3.31 -2.18 -2.99 -4.20 1.00 -3.87
Mitochondria NaN NaN NaN NaN NaN 2.21 -12.15 -2.94 -3.07 -2.02 -0.31 -12.88 -2.91 -2.90 -2.39
Mitotic Spindle NaN NaN NaN NaN NaN -0.11 0.42 -1.35 -1.34 -1.36 -1.39 -0.44 -1.37 -1.34 -1.36
None NaN NaN NaN NaN NaN -2.53 -4.37 -4.82 -3.86 1.94 -0.15 -0.65 -1.77 -1.77 -1.76
Nuclear Periphery NaN NaN NaN NaN NaN 3.67 -1.50 -2.07 -2.35 -1.94 4.15 -6.53 -2.15 -2.32 -1.78
Nuclear Periphery Foci NaN NaN NaN NaN NaN 3.35 1.78 -1.97 -2.27 -2.13 1.65 -2.34 -2.14 -2.22 -2.04
Nucleolus NaN NaN NaN NaN NaN 12.38* 11.10 0.00 -3.33 -3.05 1.04 1.38 -2.44 -2.67 -2.73
Nucleus NaN NaN NaN NaN NaN -12.97 -7.98 4.54 8.69 7.15 -0.47 2.13 9.08 9.24 8.64
Peroxisomes NaN NaN NaN NaN NaN 4.87 -0.55 -3.17 -3.54 -3.12 -4.90 -7.68 -3.58 -3.33 -3.18
Vacuole NaN NaN NaN NaN NaN 0.61 -7.88 -4.07 -4.34 -0.87 -2.61 -6.80 -3.99 -3.40 -2.60
Vacuole Periphery NaN NaN NaN NaN NaN 2.25 -13.75 -2.64 -2.75 -1.42 -3.05 -19.85 -2.73 -2.61 -1.81
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Nucleolar protein required for 60S ribosome subunit biogenesis; constituent of 66S pre-ribosomal particles; physically interacts with Nop8p and the exosome subunit Rrp43p
Localization
Cell Percentages nucleus (43%), nucleolus (9%), mixed (46%)
Cell Cycle Regulation Yes
nucleus - MA (3e-05)
Subcompartmental Group N/A

Nip7

Nip7


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Nip7-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available