Standard name | |
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Human Ortholog | |
Description | Essential component of the TIM23 complex; acts as receptor for the translocase of the inner mitochondrial membrane (TIM23) complex guiding incoming precursors from the TOM complex; may control the gating of the Tim23p-Tim17p channel |
ensLOC | DeepLoc | |||||||||||||||||||||||
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Localization | WT1 | WT2 | WT3 | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 | WT1 | WT2 | WT3 | AF100 | AF140 | AF180 |
Cortical Patches | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 1 | 2 | 2 | 3 | – | – | – | 3 | 3 | 4 | 5 | 5 | 11 |
Bud | 0 | 0 | 4 | 2 | 1 | 1 | 3 | 8 | 4 | 8 | 9 | 0 | 2 | 1 | 0 | – | – | – | 1 | 0 | 0 | 1 | 1 | 2 |
Bud Neck | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | – | – | – | 1 | 0 | 0 | 0 | 0 | 0 |
Bud Site | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 2 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | – | – | – | – | – | – | – | – | – |
Cell Periphery | 1 | 6 | 2 | 3 | 0 | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 3 | 5 | 5 | – | – | – | 0 | 0 | 0 | 0 | 0 | 0 |
Cytoplasm | 5 | 0 | 3 | 5 | 2 | 5 | 3 | 9 | 6 | 6 | 5 | 2 | 9 | 6 | 3 | – | – | – | 1 | 0 | 0 | 0 | 0 | 0 |
Endoplasmic Reticulum | 0 | 2 | 0 | 0 | 1 | 1 | 0 | 1 | 2 | 2 | 0 | 0 | 5 | 5 | 1 | – | – | – | 0 | 0 | 0 | 0 | 1 | 1 |
Endosome | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 1 | – | – | – | 3 | 0 | 1 | 1 | 7 | 5 |
Golgi | 2 | 21 | 1 | 3 | 4 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 39 | 34 | 67 | – | – | – | 8 | 13 | 6 | 11 | 26 | 22 |
Mitochondria | 188 | 168 | 80 | 101 | 106 | 144 | 200 | 209 | 132 | 172 | 140 | 137 | 254 | 316 | 289 | – | – | – | 170 | 170 | 76 | 101 | 182 | 219 |
Nucleus | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 1 | 1 | 0 | 0 | – | – | – | 2 | 0 | 0 | 0 | 0 | 1 |
Nuclear Periphery | 4 | 3 | 3 | 0 | 5 | 7 | 15 | 18 | 10 | 19 | 10 | 13 | 2 | 5 | 7 | – | – | – | 0 | 1 | 0 | 1 | 2 | 3 |
Nucleolus | 21 | 6 | 8 | 4 | 13 | 24 | 28 | 40 | 26 | 20 | 10 | 19 | 7 | 10 | 3 | – | – | – | 3 | 1 | 2 | 1 | 4 | 2 |
Peroxisomes | 2 | 0 | 4 | 0 | 1 | 1 | 2 | 3 | 0 | 0 | 1 | 0 | 1 | 7 | 5 | – | – | – | 1 | 2 | 7 | 6 | 10 | 12 |
SpindlePole | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 2 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | – | – | – | 1 | 0 | 0 | 1 | 0 | 0 |
Vac/Vac Membrane | 26 | 29 | 3 | 2 | 7 | 6 | 10 | 5 | 0 | 6 | 1 | 4 | 31 | 30 | 38 | – | – | – | 6 | 17 | 0 | 2 | 8 | 22 |
Unique Cell Count | 207 | 185 | 92 | 110 | 117 | 167 | 224 | 239 | 143 | 184 | 147 | 145 | 285 | 352 | 334 | 207 | 213 | 101 | 140 | 257 | 312 | |||
Labelled Cell Count | 252 | 237 | 109 | 120 | 141 | 192 | 267 | 299 | 183 | 237 | 177 | 179 | 356 | 422 | 422 | 207 | 213 | 101 | 140 | 257 | 312 |
Screen | WT1 | WT2 | WT3 | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 | AF100 | AF140 | AF180 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Mean Cell GFP Intensity (1e-4) | 13.2 | 17.6 | 15.0 | 16.1 | 14.9 | 13.9 | 13.1 | 11.5 | 12.0 | 11.1 | 10.4 | 11.6 | 17.8 | 17.9 | 17.4 | – | – | – | 14.5 | 15.4 | 16.1 |
Std Deviation (1e-4) | 3.0 | 3.3 | 3.5 | 3.9 | 4.0 | 3.9 | 3.5 | 3.0 | 3.6 | 2.9 | 2.8 | 3.3 | 3.5 | 4.1 | 3.5 | – | – | – | 3.4 | 3.3 | 3.3 |
Intensity Change (Log2) | – | – | – | 0.11 | -0.01 | -0.1 | -0.19 | -0.38 | -0.31 | -0.43 | -0.53 | -0.37 | 0.25 | 0.26 | 0.22 | – | – | – | -0.05 | 0.05 | 0.11 |
Localization | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Cortical Patches | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | – | – | – |
Bud | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0.6 | 0 | 0 | 0 | 0 | – | – | – |
Bud Neck | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | – | – | – |
Bud Site | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | – | – | – |
Cell Periphery | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | – | – | – |
Cytoplasm | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | – | – | – |
Endoplasmic Reticulum | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | – | – | – |
Endosome | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | – | – | – |
Golgi | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 3.4 | 2.7 | 4.4 | – | – | – |
Mitochondria | 1.1 | 0.8 | -0.2 | 0.6 | 0.1 | 1.3 | 1.8 | 2.3 | 2.0 | 0.6 | 0.8 | -0.1 | – | – | – |
Nucleus | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | – | – | – |
Nuclear Periphery | 0 | 0 | 0 | 1.2 | 1.4 | 1.2 | 2.0 | 1.2 | 1.7 | 0 | 0 | 0 | – | – | – |
Nucleolus | -1.5 | 0.6 | 1.3 | 1.0 | 1.9 | 2.0 | 0.6 | -0.5 | 1.0 | 0 | 0 | 0 | – | – | – |
Peroxisomes | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | – | – | – |
SpindlePole | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | – | – | – |
Vacuole | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 2.2 | 1.7 | 2.3 | – | – | – |
R1 | R2 | R3 | ||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | |
Concentration | 15.8962 | 16.417 | 16.4297 | 15.2402 | 14.6916 | 16.9901 | 19.3456 | 18.7628 | 18.3358 | 19.0969 | 17.3087 | 18.7716 | 22.3302 | 21.5178 | 20.9603 | 19.1646 | 21.0447 | 21.1898 |
Actin | 0.0075 | 0.0036 | 0.0075 | 0.0065 | 0.0004 | 0.0002 | 0.0143 | 0.0048 | 0.0162 | 0.0046 | 0.0007 | 0.0067 | 0.0039 | 0.0016 | 0.0024 | 0.0208 | 0.0002 | 0.0004 |
Bud | 0.0004 | 0.0002 | 0.0004 | 0.0131 | 0.0001 | 0 | 0.0003 | 0.0002 | 0.0004 | 0.0001 | 0.0001 | 0 | 0.0001 | 0.0001 | 0.0017 | 0.0006 | 0 | 0 |
Bud Neck | 0.0017 | 0.0001 | 0.0005 | 0 | 0 | 0 | 0.0002 | 0.0001 | 0.0002 | 0.0001 | 0 | 0 | 0.0002 | 0.0001 | 0 | 0.0008 | 0 | 0 |
Bud Periphery | 0.0006 | 0.0004 | 0.0008 | 0.0178 | 0.0005 | 0 | 0.0005 | 0.0005 | 0.001 | 0.0004 | 0.0002 | 0.0001 | 0.0001 | 0.0002 | 0.0028 | 0.0009 | 0 | 0 |
Bud Site | 0.0121 | 0.0004 | 0.001 | 0.0032 | 0.0001 | 0 | 0.0012 | 0.0038 | 0.0026 | 0.0001 | 0.0001 | 0 | 0.0005 | 0.0003 | 0.0009 | 0.0101 | 0 | 0 |
Cell Periphery | 0.0011 | 0.0005 | 0.0007 | 0.0002 | 0.0004 | 0.0001 | 0.0003 | 0.0003 | 0.0009 | 0.0001 | 0.0001 | 0.0001 | 0.0003 | 0.0005 | 0.0002 | 0.0008 | 0 | 0.0001 |
Cytoplasm | 0.0013 | 0 | 0.0001 | 0 | 0.0001 | 0 | 0.0008 | 0 | 0.0007 | 0.0002 | 0.0074 | 0.0001 | 0.0014 | 0 | 0.0001 | 0.0021 | 0 | 0.0002 |
Cytoplasmic Foci | 0.0136 | 0.0008 | 0.0022 | 0.0002 | 0.0003 | 0 | 0.0139 | 0.0002 | 0.0029 | 0.0044 | 0.0019 | 0.0024 | 0.0035 | 0.0009 | 0.0054 | 0.0293 | 0.0076 | 0.0005 |
Eisosomes | 0.0006 | 0.0005 | 0.0007 | 0.0002 | 0.0001 | 0.0001 | 0.0005 | 0.001 | 0.0003 | 0.0004 | 0.0001 | 0.0001 | 0.0003 | 0.0001 | 0.0002 | 0.002 | 0 | 0.0001 |
Endoplasmic Reticulum | 0.0013 | 0 | 0.0004 | 0.0001 | 0.0001 | 0 | 0.0008 | 0.0002 | 0.0004 | 0.0006 | 0.0003 | 0.0002 | 0.0028 | 0 | 0.0001 | 0.0006 | 0 | 0.0001 |
Endosome | 0.012 | 0.0031 | 0.004 | 0.0046 | 0.0024 | 0.0003 | 0.0073 | 0.0014 | 0.003 | 0.0049 | 0.0062 | 0.0028 | 0.0079 | 0.0035 | 0.0019 | 0.0018 | 0.0002 | 0.0013 |
Golgi | 0.0132 | 0.0138 | 0.01 | 0.0017 | 0.0009 | 0.001 | 0.0058 | 0.0033 | 0.0058 | 0.0041 | 0.0006 | 0.0083 | 0.0017 | 0.0131 | 0.0014 | 0.0014 | 0.0003 | 0.0065 |
Lipid Particles | 0.0155 | 0.0046 | 0.0039 | 0.0021 | 0.0025 | 0.0018 | 0.017 | 0.0009 | 0.0074 | 0.0136 | 0.0003 | 0.0082 | 0.0043 | 0.0102 | 0.0092 | 0.018 | 0.0195 | 0.0013 |
Mitochondria | 0.8934 | 0.9513 | 0.9445 | 0.9358 | 0.9449 | 0.9908 | 0.9074 | 0.9702 | 0.9431 | 0.9463 | 0.9601 | 0.9624 | 0.9389 | 0.9482 | 0.9515 | 0.8727 | 0.9653 | 0.9789 |
None | 0.0013 | 0 | 0.0001 | 0.0001 | 0.0001 | 0 | 0.0049 | 0 | 0.0008 | 0.0003 | 0.0003 | 0.0001 | 0.0042 | 0 | 0.0004 | 0.0082 | 0 | 0.0001 |
Nuclear Periphery | 0.0041 | 0.0001 | 0.0045 | 0.0002 | 0.0002 | 0 | 0.0017 | 0.0013 | 0.0003 | 0.005 | 0.0034 | 0.0004 | 0.0077 | 0 | 0.0007 | 0.0013 | 0 | 0.0016 |
Nucleolus | 0.0025 | 0.0001 | 0.0002 | 0.0001 | 0.0021 | 0 | 0.0012 | 0.0001 | 0.0018 | 0.0001 | 0.0008 | 0.0001 | 0.002 | 0.0028 | 0.0003 | 0.0114 | 0.0044 | 0.0014 |
Nucleus | 0.001 | 0.0001 | 0.0003 | 0.0001 | 0.0016 | 0 | 0.0006 | 0.0001 | 0.0003 | 0.0002 | 0.0055 | 0 | 0.0017 | 0.0005 | 0.0002 | 0.003 | 0.0002 | 0.0022 |
Peroxisomes | 0.0066 | 0.009 | 0.0025 | 0.0014 | 0.0005 | 0.0002 | 0.0054 | 0.0021 | 0.0026 | 0.0023 | 0.0011 | 0.0013 | 0.0024 | 0.0017 | 0.0024 | 0.0043 | 0.0008 | 0.0005 |
Punctate Nuclear | 0.0006 | 0 | 0.0002 | 0 | 0 | 0 | 0.0048 | 0 | 0.0003 | 0.0061 | 0.0018 | 0.0002 | 0.0021 | 0 | 0.0024 | 0.0026 | 0.0005 | 0.0018 |
Vacuole | 0.0044 | 0.0026 | 0.0025 | 0.0023 | 0.0124 | 0.0003 | 0.0026 | 0.0017 | 0.0053 | 0.0016 | 0.0045 | 0.0004 | 0.0041 | 0.0056 | 0.0046 | 0.0031 | 0.0001 | 0.0004 |
Vacuole Periphery | 0.0052 | 0.0088 | 0.0131 | 0.0102 | 0.0302 | 0.0052 | 0.0086 | 0.0078 | 0.0039 | 0.0044 | 0.0044 | 0.0062 | 0.01 | 0.0106 | 0.0115 | 0.0041 | 0.0007 | 0.0027 |
R1 | R2 | |||||||||
---|---|---|---|---|---|---|---|---|---|---|
G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | |
Gene Expression | 58.987 | 57.9005 | 56.2632 | 67.1612 | 61.9832 | 77.0645 | 67.4291 | 64.9137 | 70.9608 | 72.5185 |
Translational Efficiency | 1.8692 | 1.6884 | 1.8273 | 1.541 | 1.5062 | 1.2727 | 1.2885 | 1.2817 | 1.23 | 1.2582 |
Dataset | Hit |
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Protein Concentration | ✘ |
Protein Localization | ✘ |
Gene Expression | ✘ |
Translational Efficiency | ✘ |
Temp | Actin Patch (Sac6-tdTomato) | Cortical Patch (Sla1-GFP) | Late Endosome (Snf7-GFP) | Vacuole (Vph1-GFP) |
---|---|---|---|---|
37℃ | ||||
RT |
Gene / Allele | Actin Patch (Sac6-tdTomato) | Cortical Patch (Sla1-GFP) | Late Endosome (Snf7-GFP) | Vacuole (Sac6-tdTomato) |
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Gene | Images |
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Gene | Images |
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