Standard name
Human Ortholog
Description Mitogen-activated serine/threonine protein kinase involved in mating; phosphoactivated by Ste7p; substrates include Ste12p, Far1p, Bni1p, Sst2p; inhibits invasive growth during mating by phosphorylating Tec1p, promoting its; inhibits recruitment of Ste5p, Cdc42p-mediated asymmetry and mating morphogenesis
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.07 0.07 0 0.07 0.08 0.05
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 0.23 0.21 0.18 0.23 0.25 0.26 0.27 0.29 0.31 0.27 0.22 0.27 0.4 0.44 0.47 0.31 0.3 0.42 0.06 0.07 0.21 0.21 0.16 0.1
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Endosome 0 0 0 0 0.05 0.07 0 0.05 0 0.05 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.05
Mitochondria 0 0 0 0 0 0.07 0.27 0.09 0.26 0.19 0.44 0.25 0 0 0 0 0 0 0 0 0 0 0 0
Nucleus 0.2 0.23 0.29 0.5 0.23 0.28 0.26 0.3 0.29 0.32 0.31 0.34 0.16 0.2 0.18 0.11 0.09 0.08 0.66 0.68 0.47 0.42 0.41 0.35
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vac/Vac Membrane 0.67 0.75 0.6 0.38 0.58 0.48 0.31 0.34 0.27 0.25 0.19 0.27 0.54 0.55 0.5 0.7 0.71 0.58 0.11 0.12 0.14 0.18 0.24 0.29
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 2 1 0 0 0 2 0 0 0
Bud 0 0 0 0 0 3 6 4 4 11 3 2 0 0 0 1 0 0 10 19 9 7 15 9
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 1 1 1 1
Bud Site 0 0 0 0 0 0 3 0 3 0 1 2 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0 1 0 0 1 0 0 1 0 0 0 0 0 1 2 2 0 0 0 0 0 0
Cytoplasm 26 47 36 38 65 75 72 87 102 88 40 54 40 69 67 92 72 98 8 18 50 23 30 19
Endoplasmic Reticulum 0 0 0 0 1 1 0 0 1 1 0 0 1 0 0 11 5 8 1 0 3 1 3 3
Endosome 0 1 2 0 13 21 6 16 4 15 0 0 1 2 1 10 8 2 1 3 7 1 3 5
Golgi 0 4 0 0 1 0 0 0 0 0 0 0 3 3 1 5 2 4 0 0 1 0 3 9
Mitochondria 4 1 1 1 1 20 73 27 85 64 79 49 1 0 0 3 4 2 1 0 7 1 0 0
Nucleus 23 50 59 84 59 81 69 91 97 106 56 67 16 31 26 34 23 18 93 179 114 45 78 66
Nuclear Periphery 0 0 0 0 0 1 0 0 0 0 0 1 0 0 0 0 0 0 1 0 1 0 0 1
Nucleolus 0 1 0 1 1 0 5 1 2 4 0 1 1 0 0 1 1 2 2 2 3 2 2 3
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 1 0 0 0 0 2 0 0 0 0 0 1 1 0 1 3 4 2 2 5
Vac/Vac Membrane 76 165 121 64 152 138 84 103 88 83 35 53 55 86 71 209 173 136 15 32 34 19 44 55
Unique Cell Count 113 220 201 168 261 285 269 299 329 330 180 198 101 156 143 297 244 234 143 264 245 110 189 189
Labelled Cell Count 129 269 219 189 294 340 319 329 386 375 214 229 118 191 166 370 292 272 143 264 245 110 189 189


Cytoplasm, Nucleus

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 12.1 16.6 10.3 10.5 9.4 7.7 6.5 7.4 6.1 6.5 5.6 6.1 13.6 14.0 13.0 11.6 11.5 10.8 22.5 30.4 40.0
Std Deviation (1e-4) 3.0 3.8 2.0 1.9 1.6 1.9 1.5 1.6 1.4 1.5 1.3 1.2 3.2 3.0 2.6 2.1 2.2 2.0 8.1 10.8 13.9
Intensity Change (Log2) – – – 0.03 -0.13 -0.41 -0.66 -0.47 -0.75 -0.67 -0.88 -0.76 0.41 0.44 0.34 0.18 0.16 0.08 1.13 1.56 1.96

WT3RAP60RAP140RAP220RAP300RAP380RAP460RAP540RAP620RAP70002040WT3HU80HU120HU16002040WT3rpd3Δ_1rpd3Δ_2rpd3Δ_302040WT1AF100AF140AF18002040
rapamycinhydroxy-urearpd3 knockoutalpha-factorMultiple Condition Time-Course Intensity PlotsGFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)

Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cell Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 1.1 1.8 2.2 2.3 2.8 3.3 2.3 1.1 2.2 4.1 5.4 5.8 3.3 2.8 5.4
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Endosome 0 2.4 3.3 0 2.6 0 2.3 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0 0 3.5 7.8 4.1 7.7 6.4 10.4 7.3 0 0 0 0 0 0
Nucleus 4.1 -1.6 -0.2 -0.9 0.3 0 0.7 0.4 1.0 -2.6 -2.0 -2.4 -5.0 -5.4 -5.9
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vacuole -4.2 -0.4 -2.6 -6.3 -5.7 -7.6 -8.1 -8.1 -6.7 -1.0 -1.0 -1.9 2.4 2.4 -0.4

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 6.7127 10.1855 8.24 8.5165 7.4308 8.5179 7.4669 9.154 8.1443 7.7605 6.7706 7.6637 5.3523 7.1821 6.934 4.9172 4.0845 6.6238
Actin 0.0095 0.0011 0.0022 0.0028 0.0044 0.0016 0.0025 0.0001 0.0003 0 0.0042 0 0.0686 0.0019 0.034 0.0018 0.0172 0.0005
Bud 0.0011 0.0001 0.0012 0.0003 0.0009 0.0002 0.0003 0.0001 0.0001 0 0.0009 0 0.0027 0.0004 0.0003 0.003 0.0009 0.0002
Bud Neck 0.0047 0.0003 0.0005 0.0015 0.0186 0.0029 0.0011 0.0003 0.0003 0.0002 0.0017 0.0016 0.0027 0.0003 0.0004 0.0072 0.0011 0.0017
Bud Periphery 0.0023 0 0.0005 0.0004 0.0031 0.0002 0.0006 0.0001 0.0002 0 0.0005 0 0.0027 0.0004 0.0002 0.0041 0.0014 0.0001
Bud Site 0.0022 0.0014 0.001 0.0006 0.0016 0.0003 0.0007 0.0003 0.0003 0 0.0011 0 0.0228 0.0008 0.0006 0.0009 0.0026 0.0002
Cell Periphery 0.0006 0 0.0001 0.0001 0.0007 0.0001 0.0001 0 0 0 0.0001 0 0.0007 0.0001 0.0001 0.0002 0.0003 0
Cytoplasm 0.041 0.0263 0.0297 0.0058 0.0355 0.0226 0.0261 0.0284 0.0106 0.0032 0.0119 0.0095 0.0405 0.035 0.0387 0.0423 0.0124 0.0359
Cytoplasmic Foci 0.0178 0.0033 0.0076 0.0042 0.0291 0.0075 0.0053 0.0002 0.0009 0 0.0007 0.0001 0.0528 0.0036 0.0092 0.004 0.0242 0.0213
Eisosomes 0.0001 0 0 0 0 0 0 0 0 0 0.0001 0 0.0004 0 0.0001 0 0.0003 0
Endoplasmic Reticulum 0.0127 0.0013 0.0019 0.0003 0.0095 0.0018 0.0015 0.0005 0.0005 0 0.0024 0.0002 0.0096 0.0019 0.0034 0.0049 0.0037 0.0009
Endosome 0.031 0.0042 0.0108 0.0167 0.0332 0.0092 0.004 0.0002 0.0022 0 0.0157 0.0003 0.0489 0.0086 0.0201 0.0813 0.0842 0.0019
Golgi 0.0122 0.0005 0.0051 0.0168 0.0029 0.0065 0.0007 0 0.0007 0 0.0017 0 0.0149 0.0075 0.0156 0.0102 0.0362 0.0006
Lipid Particles 0.0077 0.0016 0.0024 0.0014 0.0096 0.0053 0.0017 0 0.0004 0 0.0019 0 0.0303 0.0005 0.0023 0.002 0.0356 0.0026
Mitochondria 0.0165 0.0003 0.0073 0.0157 0.0028 0.0027 0.0042 0.0001 0.0024 0 0.0014 0.0001 0.0184 0.0029 0.0391 0.0129 0.1599 0.0007
None 0.0111 0.0027 0.0121 0.0001 0.0039 0.0004 0.0007 0.0001 0.0005 0 0.0011 0.0001 0.0401 0.033 0.0003 0.001 0.0007 0.0023
Nuclear Periphery 0.0404 0.0145 0.0099 0.0041 0.0191 0.0081 0.0108 0.0077 0.0046 0.0021 0.0319 0.0065 0.0339 0.0131 0.0086 0.0107 0.0119 0.0118
Nucleolus 0.0028 0.0015 0.0017 0.0009 0.0037 0.0023 0.002 0.0011 0.0012 0.0006 0.002 0.0016 0.0081 0.0011 0.0005 0.0014 0.0012 0.0016
Nucleus 0.7524 0.9343 0.897 0.9215 0.7943 0.9172 0.9253 0.9506 0.9639 0.993 0.9128 0.972 0.5595 0.8844 0.8224 0.7923 0.586 0.9102
Peroxisomes 0.0072 0.0006 0.0017 0.0008 0.0039 0.0043 0.0067 0 0.0011 0 0.0003 0 0.0129 0.0003 0.002 0.0005 0.0063 0.0029
Punctate Nuclear 0.0161 0.0045 0.0048 0.0032 0.0159 0.0027 0.0029 0.0091 0.0088 0.0008 0.0053 0.0075 0.008 0.0022 0.0011 0.001 0.0084 0.0034
Vacuole 0.0086 0.0013 0.002 0.0023 0.0063 0.0035 0.0018 0.0009 0.0009 0 0.001 0.0004 0.0144 0.0015 0.0005 0.0106 0.0037 0.0009
Vacuole Periphery 0.0024 0.0002 0.0006 0.0005 0.0008 0.0007 0.0009 0.0001 0.0002 0 0.0012 0.0001 0.0069 0.0005 0.0004 0.0078 0.002 0.0003

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 15.5848 8.3591 14.4733 14.0482 21.5535 8.3073 14.7908 15.2119 11.9107 16.4056
Translational Efficiency 0.943 1.4279 0.8366 0.8677 0.9195 1.3604 0.6301 0.762 0.9311 1.0398

Hit Data

Dataset Hit
Protein Concentration ✘
Protein Localization ✘
Gene Expression ✘
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
1741 146 386 1248 1543 1798 287 978 3284 1944 673 2226

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 1069.20 1337.42 1512.88 1317.87 1088.24 1365.59 1386.91 1291.57 1078.15 1363.47 1459.16 1306.32
Standard Deviation 166.22 307.58 247.18 304.74 168.05 270.72 217.14 216.32 167.35 273.76 242.96 269.81
Intensity Change Log 2 — 0.322921 0.500766 0.301676 — 0.327528 0.349877 0.247129 — 0.325246 0.426628 0.274420

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.000340 0.001082 0.001317 0.001060 0.000736 0.000707 0.001547 0.001438 0.000526 0.000735 0.001415 0.001226
Bud Neck 0.004556 0.007901 0.016915 0.014509 0.005708 0.015530 0.008046 0.021626 0.005097 0.014957 0.013133 0.017636
Bud Site 0.001475 0.003818 0.005463 0.008770 0.002339 0.006123 0.004547 0.032686 0.001881 0.005950 0.005072 0.019277
Cell Periphery 0.000129 0.000304 0.000355 0.000388 0.000235 0.000243 0.000326 0.000345 0.000179 0.000247 0.000343 0.000369
Cytoplasm 0.116823 0.119945 0.042918 0.176725 0.095980 0.075555 0.049773 0.099470 0.107030 0.078889 0.045842 0.142783
Cytoplasmic Foci 0.001291 0.001895 0.000600 0.001775 0.001680 0.002159 0.002390 0.035606 0.001474 0.002139 0.001363 0.016638
Eisosomes 0.000012 0.000022 0.000038 0.000022 0.000017 0.000019 0.000081 0.000030 0.000014 0.000019 0.000056 0.000025
Endoplasmic Reticulum 0.004343 0.004902 0.004182 0.003659 0.006149 0.004018 0.010687 0.001891 0.005191 0.004084 0.006956 0.002882
Endosome 0.000277 0.000325 0.000566 0.001372 0.000607 0.001321 0.001303 0.044157 0.000432 0.001246 0.000880 0.020170
Golgi 0.000073 0.000142 0.000139 0.007719 0.000168 0.001176 0.000126 0.027484 0.000118 0.001098 0.000133 0.016403
Lipid Particles 0.000180 0.000256 0.000462 0.000421 0.000373 0.000510 0.001187 0.001180 0.000271 0.000491 0.000771 0.000754
Mitochondria 0.000534 0.000817 0.002252 0.004210 0.001088 0.001658 0.001394 0.016046 0.000794 0.001595 0.001886 0.009410
Mitotic Spindle 0.000279 0.004164 0.010539 0.031396 0.003276 0.016271 0.001449 0.325913 0.001687 0.015362 0.006663 0.160793
None 0.004798 0.005145 0.006709 0.014888 0.002890 0.006157 0.004711 0.018976 0.003902 0.006081 0.005857 0.016684
Nuclear Periphery 0.000812 0.000429 0.001406 0.001604 0.001371 0.001178 0.001265 0.001378 0.001075 0.001121 0.001346 0.001505
Nuclear Periphery Foci 0.000659 0.001603 0.000571 0.002983 0.000862 0.001854 0.001362 0.001400 0.000754 0.001835 0.000908 0.002288
Nucleolus 0.000355 0.000453 0.000638 0.000542 0.000491 0.000948 0.000850 0.003361 0.000419 0.000911 0.000728 0.001781
Nucleus 0.857180 0.838064 0.888771 0.708322 0.868832 0.856771 0.873969 0.321548 0.862655 0.855366 0.882459 0.538392
Peroxisomes 0.000052 0.000093 0.000113 0.000080 0.000192 0.000344 0.000235 0.009222 0.000118 0.000325 0.000165 0.004096
Vacuole 0.005745 0.008549 0.015931 0.015845 0.006877 0.007137 0.034615 0.030731 0.006277 0.007243 0.023899 0.022385
Vacuole Periphery 0.000086 0.000089 0.000116 0.003710 0.000130 0.000324 0.000137 0.005511 0.000107 0.000307 0.000125 0.004501

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin -5.06 -11.47 -14.83 -0.48 3.22 -0.16 -3.90 -2.50 -6.92 3.33 -1.62 -7.96 -5.75 -7.81 4.57
Bud Neck -2.63 -7.26 -13.17 -6.45 -0.51 -10.15 -3.76 -12.33 -5.56 -6.57 -11.29 -8.09 -17.98 -6.48 -4.05
Bud Site -3.21 -7.91 -9.73 -4.11 -1.45 -4.12 -4.60 -10.28 -8.42 -7.60 -5.47 -8.90 -13.51 -8.70 -6.98
Cell Periphery -3.10 -10.45 -11.97 -0.37 1.93 -0.04 -3.12 -1.57 -2.25 2.28 -2.79 -9.16 -7.97 -4.62 2.92
Cytoplasm 0.24 13.93 4.69 1.38 -8.36 5.10 9.52 4.14 -0.37 -5.77 7.51 16.74 6.12 -1.20 -10.15
Cytoplasmic Foci -0.78 1.65 -0.63 0.58 -1.95 0.76 0.82 -3.32 -3.85 -3.86 -0.14 1.62 -3.21 -2.90 -4.32
Eisosomes -3.80 -12.86 -15.66 -3.11 4.13 -2.13 -11.64 -13.75 -13.27 4.98 -6.02 -16.94 -20.47 -15.41 6.36
Endoplasmic Reticulum -1.22 -2.36 -1.04 0.73 1.43 5.06 -6.57 4.71 -0.35 9.25 3.66 -6.33 2.54 -1.27 7.97
Endosome -1.61 -5.75 -5.55 -3.09 -0.24 -1.82 -4.03 -4.42 -3.95 -3.58 -2.84 -6.30 -5.08 -3.55 -3.57
Golgi -2.91 -6.04 -1.95 -1.85 -1.77 -2.18 -0.37 -3.41 -2.30 -3.39 -2.40 -2.57 -3.52 -2.11 -3.37
Lipid Particles -2.06 -6.73 -9.66 -5.32 -1.22 -0.60 -6.45 -11.42 -6.56 -3.21 -1.37 -9.11 -14.62 -5.52 -3.01
Mitochondria -4.35 -20.10 -9.73 -8.06 -2.58 -1.30 -1.66 -3.45 -3.16 -2.98 -3.24 -6.48 -6.81 -5.33 -3.80
Mitotic Spindle -1.09 -3.04 -7.97 -3.48 -2.35 -4.59 -0.22 -16.32 -14.79 -16.30 -5.75 -2.94 -17.41 -13.63 -13.54
None -0.27 -0.61 -5.72 -4.40 -4.42 -4.05 -1.23 -10.40 -7.38 -9.12 -2.70 -1.21 -11.40 -7.75 -9.22
Nuclear Periphery 3.06 -9.54 -15.20 -15.37 -5.04 -0.58 -3.17 -16.61 -16.03 -13.04 -3.28 -9.25 -22.10 -17.55 -12.09
Nuclear Periphery Foci -1.89 -0.30 -3.79 -1.81 -3.67 -0.76 -1.38 -3.49 -2.04 -2.72 -1.24 -1.15 -5.08 -2.39 -4.59
Nucleolus -1.20 -4.65 -3.86 -3.66 -2.78 -2.09 -3.43 -7.77 -6.05 -7.08 -2.38 -5.64 -8.05 -5.24 -6.77
Nucleus 1.04 0.10 9.92 3.13 6.88 1.33 0.78 24.59 23.76 19.00 1.15 0.60 23.87 20.86 17.74
Peroxisomes -2.42 -7.00 -5.79 -1.02 1.25 -0.65 -0.42 -2.84 -2.71 -2.80 -1.66 -2.23 -3.01 -2.38 -2.74
Vacuole -1.77 -6.32 -12.48 -7.32 -0.60 -2.17 -6.50 -16.10 -15.50 -5.02 -3.11 -9.04 -19.92 -18.07 -4.26
Vacuole Periphery -0.61 -3.42 -1.73 -1.70 -1.56 -1.99 -1.07 -2.76 -1.99 -2.60 -2.55 -2.85 -2.49 -1.92 -2.28
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Mitogen-activated serine/threonine protein kinase involved in mating; phosphoactivated by Ste7p; substrates include Ste12p, Far1p, Bni1p, Sst2p; inhibits invasive growth during mating by phosphorylating Tec1p, promoting its; inhibits recruitment of Ste5p, Cdc42p-mediated asymmetry and mating morphogenesis
Localization
Cell Percentages nucleus (24%), cytoplasm (9%), mixed (66%)
Cell Cycle Regulation No
Subcompartmental Group N/A

Fus3

Fus3


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Fus3-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available