Standard name
Human Ortholog
Description Cytoplasmic type 2C protein phosphatase (PP2C); identified as a high-copy number suppressor of cnb1 mpk1 synthetic lethality; overexpression decreases high-osmolarity induced Hog1p phosphorylation and kinase activity
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0 0 0 0.05 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 0.97 0.97 0.99 0.96 0.96 0.83 0.73 0.77 0.71 0.67 0.69 0.62 1.0 0.99 1.0 0.97 0.97 0.95 0.92 0.94 0.91 0.93 0.95 0.96
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0 0 0 0.13 0.11 0.36 0.44 0.39 0.41 0.53 0.51 0.55 0 0 0 0 0 0 0 0 0 0 0 0
Nucleus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vac/Vac Membrane 0 0 0 0 0 0 0 0 0.05 0 0.06 0.09 0 0 0 0 0 0.05 0 0 0 0 0 0
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 4 0 0 0
Bud 0 0 1 1 1 8 18 3 17 25 24 28 0 0 0 0 1 0 0 0 2 1 2 1
Bud Neck 0 1 1 0 0 1 0 0 0 0 0 0 0 0 0 1 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 2 0 2 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 1 3 1 6 5 8 5 8 5 3 5 6 0 3 3 4 7 0 0 1 0 0 0
Cytoplasm 175 307 446 305 422 412 486 482 404 457 333 413 413 263 346 222 315 276 167 296 405 215 256 218
Endoplasmic Reticulum 0 4 1 2 0 2 3 0 3 4 1 3 0 0 0 5 9 2 0 0 3 1 0 0
Endosome 0 0 1 1 2 1 1 2 3 2 1 0 0 0 0 0 0 1 5 4 2 1 0 1
Golgi 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 1 1 3 0 0 0
Mitochondria 7 12 3 43 48 178 291 243 236 360 245 366 0 0 0 1 4 5 0 3 7 2 3 0
Nucleus 1 0 2 1 0 0 6 4 4 6 3 1 1 0 1 3 3 2 0 0 2 1 0 0
Nuclear Periphery 0 0 1 1 0 1 6 3 1 1 2 3 0 0 0 1 0 0 0 1 1 1 0 0
Nucleolus 0 0 0 1 0 0 0 0 0 3 1 1 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 1 1 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 1 0 1 2 0 0 0 0 0 0 1 1 4 1 0 0
Vac/Vac Membrane 0 1 2 0 4 3 26 24 27 17 30 60 0 2 0 5 6 14 1 1 1 1 3 2
Unique Cell Count 181 316 451 319 440 495 664 626 569 679 484 670 413 266 347 229 324 292 182 315 448 231 270 229
Labelled Cell Count 183 326 462 356 483 611 845 766 704 882 644 884 420 266 351 241 342 308 182 315 448 231 270 229


Cytoplasm

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 4.5 5.0 4.7 4.4 4.6 3.9 3.8 3.8 3.9 3.9 3.5 3.7 6.4 6.4 6.1 7.8 7.5 7.8 6.3 6.6 7.2
Std Deviation (1e-4) 0.7 0.7 1.2 1.3 1.3 0.8 1.0 0.8 1.0 0.9 0.9 0.7 0.8 0.9 0.9 1.4 1.3 1.4 1.1 1.2 1.3
Intensity Change (Log2) – – – -0.1 -0.02 -0.27 -0.29 -0.29 -0.25 -0.26 -0.4 -0.33 0.46 0.47 0.38 0.74 0.68 0.75 0.44 0.51 0.62

WT3RAP60RAP140RAP220RAP300RAP380RAP460RAP540RAP620RAP70002468WT3HU80HU120HU16002468WT3rpd3Δ_1rpd3Δ_2rpd3Δ_302468WT1AF100AF140AF18002468
rapamycinhydroxy-urearpd3 knockoutalpha-factorMultiple Condition Time-Course Intensity PlotsGFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)

Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cell Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm -2.9 -2.8 -8.3 -11.4 -10.3 -11.9 -13.0 -12.3 -14.5 2.1 0 1.3 -1.8 -1.7 -3.5
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vacuole 0 0 0 3.6 3.6 4.1 2.6 4.8 6.1 0 0 0 0 0 4.0

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 2.2359 3.086 2.6572 2.9007 2.9371 2.873 2.211 2.41 2.6473 2.3726 3.0471 2.3755 0.7048 1.4185 0.7515 1.6202 0.5765 0.93
Actin 0.0222 0.0014 0.0061 0.0012 0.0014 0.0007 0.0451 0.0056 0.0153 0.0022 0.021 0.0077 0.029 0.0117 0.005 0.0376 0.004 0.0134
Bud 0.0016 0.0004 0.0055 0.0002 0.0005 0.0071 0.0026 0.0021 0.0025 0.0016 0.0014 0.0018 0.001 0.0037 0.0028 0.0022 0.0006 0.0016
Bud Neck 0.001 0.0005 0.0016 0.0006 0.0005 0.0106 0.0035 0.0004 0.0087 0.001 0.0068 0.0014 0.0018 0.0006 0.0017 0.0025 0.0008 0.0061
Bud Periphery 0.0018 0.0003 0.002 0.0001 0.0005 0.0021 0.0023 0.0019 0.0087 0.0034 0.0023 0.003 0.0012 0.0026 0.0038 0.0033 0.0018 0.0022
Bud Site 0.0022 0.0037 0.0103 0.0003 0.0007 0.0005 0.0049 0.014 0.0111 0.0011 0.0035 0.0004 0.0029 0.0146 0.0135 0.0083 0.0007 0.0012
Cell Periphery 0.0002 0.0001 0.0004 0 0.0001 0.0002 0.0003 0.0003 0.0004 0.0001 0.0002 0.0002 0.0002 0.0004 0.0007 0.0003 0.0001 0.0001
Cytoplasm 0.5237 0.6807 0.5542 0.5435 0.6447 0.6754 0.5031 0.6851 0.6458 0.6157 0.5822 0.7647 0.5686 0.667 0.666 0.5597 0.6617 0.7554
Cytoplasmic Foci 0.016 0.0056 0.0125 0.0169 0.0071 0.0097 0.0192 0.0106 0.0107 0.023 0.0247 0.0174 0.0218 0.0116 0.0096 0.0275 0.02 0.016
Eisosomes 0.0007 0 0.0001 0 0 0 0.0004 0.0001 0.0002 0.0001 0.0001 0 0.0001 0.0001 0.0001 0.0002 0.0001 0.0001
Endoplasmic Reticulum 0.0049 0.0014 0.0031 0.0011 0.0023 0.0018 0.0063 0.0023 0.0077 0.0038 0.011 0.0036 0.0054 0.0017 0.003 0.0088 0.0026 0.0028
Endosome 0.0091 0.0015 0.0055 0.0036 0.0062 0.0026 0.0345 0.0035 0.0184 0.0196 0.0435 0.0069 0.024 0.0047 0.0037 0.0632 0.0185 0.0059
Golgi 0.0026 0.0003 0.0008 0.0009 0.0005 0.0003 0.0069 0.0009 0.0022 0.0009 0.0066 0.0006 0.0078 0.0016 0.0008 0.0236 0.0041 0.002
Lipid Particles 0.0049 0.0001 0.0017 0.0034 0.0002 0.001 0.0055 0.0008 0.0021 0.0008 0.0022 0.0003 0.0147 0.0006 0.0011 0.0089 0.0099 0.0023
Mitochondria 0.0009 0.0002 0.0009 0.0004 0.0011 0.0011 0.0057 0.0019 0.0022 0.001 0.0105 0.0012 0.0068 0.0013 0.0008 0.0137 0.0227 0.0008
None 0.3895 0.2972 0.3665 0.3867 0.3186 0.2768 0.3103 0.259 0.2384 0.2846 0.1973 0.1781 0.257 0.2645 0.2727 0.1651 0.223 0.1763
Nuclear Periphery 0.0038 0.0007 0.0024 0.0022 0.0024 0.0007 0.0136 0.0008 0.0071 0.0067 0.0396 0.0021 0.0158 0.0008 0.0015 0.0184 0.0056 0.0032
Nucleolus 0.0004 0.0001 0.0005 0.0005 0.0005 0.0004 0.0006 0.0003 0.0011 0.0015 0.0009 0.0001 0.0008 0.0002 0.0003 0.0036 0.0019 0.0001
Nucleus 0.0036 0.0035 0.0117 0.0019 0.008 0.003 0.0161 0.0035 0.008 0.0162 0.0146 0.0039 0.0108 0.0046 0.0044 0.0207 0.0037 0.0041
Peroxisomes 0.0034 0.0001 0.0047 0.002 0.0002 0.0018 0.0085 0.0016 0.001 0.0027 0.0053 0.0017 0.0212 0.0042 0.0038 0.016 0.006 0.0029
Punctate Nuclear 0.0059 0.0014 0.0077 0.0333 0.0027 0.0034 0.0048 0.0034 0.0045 0.0099 0.0059 0.003 0.0035 0.0012 0.0027 0.0091 0.0086 0.0024
Vacuole 0.001 0.0008 0.0013 0.001 0.0014 0.0008 0.0041 0.0019 0.0032 0.0034 0.0115 0.0016 0.0039 0.002 0.0016 0.0051 0.0025 0.0009
Vacuole Periphery 0.0003 0.0001 0.0002 0.0002 0.0004 0.0001 0.0017 0.0002 0.0008 0.0007 0.009 0.0004 0.0015 0.0002 0.0002 0.0025 0.0012 0.0004

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 20.0704 19.1934 20.4347 19.6669 13.3136 10.2629 17.719 19.0776 23.9298 19.3556
Translational Efficiency 0.6608 0.674 0.6505 0.7522 0.8424 1.0421 0.7141 0.635 0.6438 0.6914

Hit Data

Dataset Hit
Protein Concentration ✔
Protein Localization ✘
Gene Expression ✘
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
1747 204 1194 1267 1931 843 234 1590 3678 1047 1428 2857

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 739.60 860.60 866.82 865.69 709.78 792.08 988.77 935.61 723.94 805.43 886.80 904.60
Standard Deviation 78.05 92.38 105.09 118.39 82.12 90.61 102.84 124.93 81.58 94.92 114.04 126.92
Intensity Change Log 2 — 0.218598 0.228987 0.227105 — 0.158274 0.478263 0.398535 — 0.189372 0.356442 0.313603

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.000191 0.000294 0.000149 0.001378 0.000082 0.000535 0.000286 0.001263 0.000134 0.000488 0.000172 0.001314
Bud Neck 0.010619 0.019684 0.004531 0.003631 0.006647 0.014341 0.001282 0.006822 0.008534 0.015382 0.003999 0.005407
Bud Site 0.006169 0.016881 0.008476 0.033332 0.003113 0.014522 0.002850 0.038559 0.004565 0.014981 0.007554 0.036241
Cell Periphery 0.000109 0.000167 0.000153 0.000200 0.000109 0.000091 0.000172 0.000135 0.000109 0.000106 0.000156 0.000164
Cytoplasm 0.529029 0.410982 0.607089 0.584360 0.636634 0.537058 0.454195 0.537806 0.585523 0.512493 0.582035 0.558451
Cytoplasmic Foci 0.240475 0.262250 0.022274 0.032860 0.154064 0.231400 0.022416 0.026289 0.195108 0.237411 0.022298 0.029203
Eisosomes 0.000130 0.000113 0.000035 0.000053 0.000074 0.000110 0.000072 0.000037 0.000101 0.000111 0.000041 0.000044
Endoplasmic Reticulum 0.001201 0.001417 0.001321 0.002880 0.001197 0.000460 0.003936 0.001506 0.001199 0.000647 0.001749 0.002116
Endosome 0.013678 0.036801 0.003488 0.004401 0.006650 0.019594 0.004130 0.012788 0.009988 0.022947 0.003593 0.009069
Golgi 0.003298 0.007379 0.000167 0.005801 0.001251 0.006491 0.000082 0.009373 0.002223 0.006664 0.000153 0.007789
Lipid Particles 0.006687 0.006906 0.001059 0.001746 0.003931 0.002986 0.002083 0.002494 0.005240 0.003750 0.001226 0.002162
Mitochondria 0.003768 0.004070 0.000416 0.003337 0.002254 0.004018 0.000138 0.008149 0.002973 0.004028 0.000371 0.006015
Mitotic Spindle 0.002764 0.005181 0.003396 0.017381 0.001326 0.007121 0.000484 0.059481 0.002009 0.006743 0.002919 0.040811
None 0.001743 0.000991 0.006927 0.003999 0.003237 0.002145 0.003540 0.002666 0.002527 0.001920 0.006372 0.003257
Nuclear Periphery 0.000319 0.000429 0.000851 0.000629 0.000443 0.000172 0.001284 0.001737 0.000384 0.000222 0.000922 0.001246
Nuclear Periphery Foci 0.000463 0.001094 0.001318 0.004300 0.000831 0.000453 0.004978 0.002916 0.000656 0.000578 0.001918 0.003530
Nucleolus 0.000656 0.001083 0.000697 0.000221 0.000514 0.000589 0.000196 0.000641 0.000581 0.000685 0.000615 0.000455
Nucleus 0.098610 0.067791 0.270254 0.118076 0.131990 0.062934 0.291671 0.104192 0.116135 0.063881 0.273764 0.110349
Peroxisomes 0.004333 0.010009 0.000276 0.001950 0.001345 0.007438 0.000182 0.002056 0.002765 0.007939 0.000260 0.002009
Vacuole 0.074569 0.144052 0.066834 0.178767 0.043354 0.086101 0.205896 0.173771 0.058181 0.097392 0.089622 0.175987
Vacuole Periphery 0.001187 0.002428 0.000289 0.000699 0.000955 0.001440 0.000129 0.007318 0.001065 0.001633 0.000263 0.004382

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin -1.57 0.21 -4.48 -3.79 -4.68 -1.83 -6.15 -2.52 -0.08 -0.66 -1.75 -3.51 -4.49 -0.91 -3.78
Bud Neck -2.06 5.02 8.10 4.01 1.49 -4.98 6.08 2.98 6.95 -3.63 -4.54 4.96 7.77 8.35 0.44
Bud Site -3.49 -1.02 -5.49 -0.68 -4.47 -5.32 -1.96 -6.80 -0.81 -6.30 -5.60 -2.22 -8.63 -1.27 -5.87
Cell Periphery -2.42 -3.36 -3.76 0.52 -0.17 2.10 -4.88 3.41 0.17 5.95 0.34 -4.94 -1.49 -1.35 3.81
Cytoplasm 5.84 -2.26 5.26 -3.15 6.78 9.08 15.79 20.23 6.62 -4.98 7.53 7.42 17.80 4.56 6.19
Cytoplasmic Foci -1.31 42.67 41.37 17.08 -3.67 -9.44 34.00 36.47 29.53 1.00 -5.75 52.94 53.88 33.54 -0.89
Eisosomes 1.66 13.42 11.08 5.83 -5.25 -2.04 -2.95 11.34 3.93 8.08 -0.63 12.90 14.88 4.41 0.39
Endoplasmic Reticulum -0.58 -4.03 -6.58 -3.36 -3.58 4.50 -7.85 -1.59 -11.83 7.60 4.10 -7.82 -5.89 -11.77 3.31
Endosome -5.46 11.51 13.34 8.28 1.29 -7.50 4.10 2.74 8.38 -0.21 -7.86 11.21 10.91 11.82 -0.37
Golgi -1.16 8.12 1.13 1.47 -2.02 -3.38 6.73 -1.92 2.21 -3.59 -3.09 10.03 -0.31 2.74 -3.88
Lipid Particles -0.00 11.27 10.02 3.02 -3.71 2.16 3.45 5.06 3.19 2.49 3.13 12.73 10.39 4.63 -0.99
Mitochondria -0.07 3.92 2.33 1.30 -1.69 -1.22 3.97 -0.38 1.01 -4.49 -0.80 5.26 1.51 1.66 -4.22
Mitotic Spindle -0.59 -0.62 -3.56 -1.11 -3.24 -2.31 1.36 -7.68 -4.69 -8.08 -2.17 -1.23 -8.41 -4.20 -7.72
None 1.50 -3.73 -1.46 -3.33 2.87 1.49 0.86 0.41 -1.31 -0.61 1.02 -3.23 -1.16 -1.65 2.79
Nuclear Periphery -1.47 -14.58 -10.84 -5.37 3.59 1.41 -5.85 -4.28 -7.41 0.29 1.56 -7.79 -6.13 -9.67 -0.42
Nuclear Periphery Foci -4.02 -8.28 -5.93 -4.40 -3.36 1.87 -8.53 -3.40 -5.37 6.02 0.51 -9.10 -6.83 -7.34 -1.05
Nucleolus -1.83 0.13 5.71 4.70 2.50 -0.83 6.41 2.07 2.06 -1.46 -0.99 0.07 5.17 4.02 1.94
Nucleus 3.58 -25.42 -7.66 -7.72 19.29 16.36 -9.79 -1.94 -16.33 9.03 14.91 -25.87 -6.59 -19.14 21.74
Peroxisomes -1.89 8.05 5.91 3.30 -1.83 -4.35 7.89 3.45 4.85 -3.76 -3.95 9.87 6.79 5.75 -3.16
Vacuole -6.04 -4.48 -28.62 -10.89 -23.32 -10.73 -15.11 -36.92 -27.85 -0.52 -9.86 -13.75 -46.31 -32.06 -24.33
Vacuole Periphery -2.21 5.67 4.23 3.87 -0.44 -1.56 4.06 -2.25 -1.34 -4.17 -2.25 6.01 -0.86 0.82 -3.92
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Cytoplasmic type 2C protein phosphatase (PP2C); identified as a high-copy number suppressor of cnb1 mpk1 synthetic lethality; overexpression decreases high-osmolarity induced Hog1p phosphorylation and kinase activity
Localization
Cell Percentages cytoplasm (70%)
Cell Cycle Regulation No
Subcompartmental Group cytoplasm-9

Ptc4

Ptc4


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Ptc4-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available