Standard name
Human Ortholog
Description AP4A phosphorylase; bifunctional diadenosine 5',5'''-P1,P4-tetraphosphate phosphorylase and ADP sulfurylase involved in catabolism of bis(5'-nucleosidyl) tetraphosphates; catalyzes phosphorolysis of dinucleoside oligophosphates, cleaving substrates' alpha/beta-anhydride bond and introducing Pi into the beta-position of the corresponding NDP formed; protein abundance increases under DNA replication stress; APA1 has a paralog, APA2, that arose from the whole genome duplication
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0.05 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 0 0 0 0 0 0 0.05 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 0.98 0.98 0.99 0.98 0.97 0.93 0.9 0.8 0.86 0.79 0.84 0.81 0.99 0.99 1.0 0.94 0.97 0.97 0.95 0.96 0.96 0.96 0.96 0.94
Endoplasmic Reticulum 0 0 0 0 0 0 0.06 0.11 0 0.07 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vac/Vac Membrane 0 0 0 0 0 0 0 0.07 0.06 0.1 0.05 0.07 0 0 0 0.05 0 0 0 0 0 0 0 0
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 1 1 5 3 4 10 11 0 0 0 1 0 0 0 0 0 0 0 0
Bud 2 0 1 0 0 0 0 0 1 2 0 0 0 0 0 1 0 0 1 1 0 0 3 8
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 1 0 1 2 5 7 8 14 5 9 8 11 0 3 0 15 1 5 0 0 0 0 0 0
Cytoplasm 393 237 268 275 354 330 329 340 239 286 208 179 258 341 454 357 195 299 378 223 250 238 347 385
Endoplasmic Reticulum 1 3 1 2 8 12 21 45 11 24 9 9 0 1 0 9 5 9 3 1 1 1 2 3
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 1 0 0 1 0 0
Golgi 0 0 0 0 0 1 0 3 5 3 1 2 0 0 0 2 0 1 0 0 0 0 0 0
Mitochondria 3 0 0 0 0 0 4 1 4 4 9 3 0 0 0 2 1 0 0 0 0 0 0 0
Nucleus 0 0 1 0 1 4 4 2 2 6 3 3 0 0 1 0 0 0 2 3 2 1 1 5
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vac/Vac Membrane 5 1 1 3 6 5 10 29 16 35 12 16 4 4 1 18 9 9 4 1 2 0 3 2
Unique Cell Count 401 241 270 281 365 354 367 426 278 360 248 222 260 345 455 378 201 309 400 233 261 248 363 411
Labelled Cell Count 405 241 273 282 374 360 377 439 286 373 260 234 262 349 456 405 212 323 400 233 261 248 363 411


Cytoplasm, Nucleus

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 38.6 49.9 35.0 33.6 31.6 28.6 26.9 26.8 24.0 24.2 22.1 23.4 39.1 41.8 42.7 48.8 47.3 44.3 43.5 45.3 51.3
Std Deviation (1e-4) 8.4 9.9 7.2 6.6 7.0 6.2 6.1 6.7 6.7 7.0 6.1 6.7 9.2 10.0 9.5 16.1 16.3 15.1 9.1 10.6 13.8
Intensity Change (Log2) – – – -0.06 -0.15 -0.29 -0.38 -0.39 -0.54 -0.54 -0.66 -0.59 0.16 0.25 0.29 0.48 0.43 0.34 0.31 0.37 0.55


Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cell Periphery 0 0 0 0 2.6 0 0 0 3.3 0 0 0 2.9 0 0
Cytoplasm -1.4 -2.0 -3.7 -4.9 -7.5 -5.9 -7.6 -6.4 -7.1 0 -0.5 1.1 -3.3 -1.9 -2.1
Endoplasmic Reticulum 0 0 2.6 3.7 5.3 2.9 4.0 0 0 0 0 0 0 0 0
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vacuole 0 0 0 0 4.1 3.6 5.0 3.2 4.1 0 0 0 3.3 0 0

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 22.4145 26.935 26.3434 24.4119 25.3525 26.73 28.9605 32.9176 31.3329 31.4705 29.1736 30.8119 29.0343 32.6417 31.7133 32.4848 29.0149 31.0628
Actin 0.0039 0.0002 0.0001 0.0001 0.0001 0.0004 0.0029 0.0001 0.0009 0 0.0017 0.001 0.0041 0.0003 0.0007 0 0.0001 0.0005
Bud 0.0004 0.0001 0.0001 0.0001 0 0.0001 0.0005 0 0.0001 0 0.0012 0.0001 0.0005 0.0002 0.0004 0 0 0.0005
Bud Neck 0.0013 0.0002 0.0002 0.0003 0.0003 0.0006 0.0006 0.0002 0.0003 0.0002 0.0013 0.0009 0.001 0.0002 0.0003 0.0002 0.0003 0.0008
Bud Periphery 0.0003 0 0 0 0 0.0001 0.0004 0 0.0001 0 0.0018 0.0001 0.0004 0 0.0002 0 0 0.0002
Bud Site 0.0006 0.0001 0 0.0001 0 0.0001 0.0005 0 0.0002 0 0.001 0 0.0011 0.0001 0.0001 0 0 0.0008
Cell Periphery 0.0002 0 0 0.0001 0 0.0002 0.0001 0 0.0001 0 0.0008 0 0.0001 0 0.0001 0 0 0
Cytoplasm 0.8382 0.9688 0.951 0.9091 0.9708 0.9195 0.9055 0.9826 0.9531 0.9649 0.8997 0.9282 0.9058 0.9753 0.9573 0.9718 0.9792 0.9371
Cytoplasmic Foci 0.0086 0.0012 0.0003 0.001 0.0005 0.0007 0.0073 0.0003 0.0022 0.0001 0.0025 0.0007 0.0026 0.0004 0.0006 0.0002 0.0002 0.0016
Eisosomes 0.0001 0 0 0 0 0 0 0 0 0 0.0001 0 0.0002 0 0 0 0 0
Endoplasmic Reticulum 0.0026 0.0006 0.0008 0.0006 0.0009 0.0024 0.0041 0.0004 0.0011 0.0002 0.0051 0.002 0.0014 0.0029 0.0009 0.0003 0.0003 0.001
Endosome 0.0116 0.0002 0.0001 0.0017 0.0002 0.0007 0.0042 0 0.0031 0 0.0045 0.0009 0.0023 0.0001 0.0002 0.0001 0.0001 0.0009
Golgi 0.0019 0 0 0.0001 0 0.0001 0.0004 0 0.0005 0 0.0008 0.0005 0.0009 0 0 0 0 0.0003
Lipid Particles 0.0062 0 0 0.0002 0 0.0002 0.0006 0 0.0009 0 0.0034 0.0016 0.0019 0 0 0 0 0.0012
Mitochondria 0.0065 0.0003 0.0005 0.0009 0 0.0007 0.0025 0 0.0007 0 0.0174 0.004 0.0046 0.0001 0.0002 0 0 0.0005
None 0.0026 0.0006 0.0006 0.001 0.0003 0.0009 0.0019 0.0002 0.0005 0.0001 0.0015 0.0006 0.0016 0.0003 0.0007 0.0002 0.0002 0.0006
Nuclear Periphery 0.0122 0.0028 0.0043 0.0084 0.0037 0.0073 0.0083 0.0012 0.003 0.0014 0.0053 0.0054 0.0075 0.0026 0.0036 0.0029 0.0022 0.0061
Nucleolus 0.0022 0.0017 0.0018 0.0034 0 0.0003 0.0003 0 0.0001 0 0.0014 0 0.0017 0 0 0 0 0.0005
Nucleus 0.0853 0.0222 0.0393 0.0659 0.022 0.0637 0.054 0.0141 0.0288 0.0329 0.0405 0.0523 0.056 0.0166 0.0327 0.0236 0.0169 0.0442
Peroxisomes 0.0011 0 0 0 0 0 0.0015 0 0.0003 0 0.0009 0.0003 0.001 0 0 0 0 0.0007
Punctate Nuclear 0.0099 0.0004 0.0002 0.0012 0.0006 0.0007 0.0013 0.0001 0.0009 0.0001 0.0005 0.0004 0.0038 0.0003 0.0014 0.0002 0.0002 0.0015
Vacuole 0.003 0.0006 0.0005 0.0035 0.0004 0.0011 0.0027 0.0005 0.0023 0.0001 0.0068 0.0009 0.001 0.0004 0.0004 0.0004 0.0003 0.0007
Vacuole Periphery 0.0012 0.0001 0.0002 0.0023 0.0001 0.0003 0.0006 0.0001 0.0008 0 0.0016 0.0002 0.0004 0 0.0001 0.0001 0.0001 0.0002

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 138.7822 164.396 134.1121 146.2851 134.7678 110.736 170.8666 153.9968 142.4016 142.1624
Translational Efficiency 2.5867 2.537 2.5175 1.9569 2.5689 3.3629 2.2777 2.4731 2.3795 2.3459

Hit Data

Dataset Hit
Protein Concentration ✔
Protein Localization ✘
Gene Expression ✔
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
1651 606 309 1879 1419 1907 151 958 3070 2513 460 2837

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 2449.72 2986.82 2486.53 4253.85 2418.67 3002.74 3187.26 4424.32 2435.37 2998.90 2716.55 4311.41
Standard Deviation 497.12 764.48 470.86 1073.44 465.16 585.72 648.26 1269.12 482.86 633.50 628.61 1146.11
Intensity Change Log 2 — 0.285993 0.021517 0.796152 — 0.312066 0.398103 0.871242 — 0.299005 0.220868 0.833946

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.000125 0.000147 0.000242 0.000177 0.000171 0.000106 0.000779 0.000401 0.000146 0.000116 0.000418 0.000253
Bud Neck 0.000343 0.000775 0.002023 0.001346 0.000476 0.000511 0.007726 0.003593 0.000405 0.000575 0.003895 0.002105
Bud Site 0.000797 0.001232 0.002116 0.004554 0.000969 0.001180 0.005140 0.015475 0.000876 0.001193 0.003108 0.008242
Cell Periphery 0.000176 0.000459 0.000742 0.000328 0.000211 0.000126 0.001680 0.000708 0.000192 0.000206 0.001050 0.000456
Cytoplasm 0.754149* 0.701909* 0.559449* 0.698600* 0.747145* 0.726563* 0.414875* 0.678438* 0.750912* 0.720618* 0.511991* 0.691792*
Cytoplasmic Foci 0.002874 0.009928 0.017154 0.004438 0.003553 0.003543 0.034334 0.013647 0.003188 0.005083 0.022793 0.007548
Eisosomes 0.000001 0.000001 0.000003 0.000001 0.000001 0.000001 0.000013 0.000008 0.000001 0.000001 0.000006 0.000004
Endoplasmic Reticulum 0.000061 0.000047 0.000087 0.000247 0.000121 0.000065 0.000604 0.004104 0.000089 0.000061 0.000257 0.001549
Endosome 0.000051 0.000067 0.000111 0.000296 0.000104 0.000176 0.001206 0.004501 0.000075 0.000149 0.000471 0.001716
Golgi 0.000493 0.000717 0.000448 0.000450 0.000944 0.000658 0.001149 0.004747 0.000701 0.000672 0.000678 0.001901
Lipid Particles 0.000243 0.000432 0.000942 0.000550 0.000255 0.000236 0.003993 0.002059 0.000249 0.000283 0.001944 0.001060
Mitochondria 0.000155 0.000122 0.000206 0.000209 0.000370 0.000170 0.000276 0.002653 0.000254 0.000159 0.000229 0.001034
Mitotic Spindle 0.000444 0.001361 0.000942 0.006644 0.001868 0.002360 0.001025 0.032656 0.001103 0.002119 0.000969 0.015428
None 0.011536 0.016859 0.009353 0.010245 0.011670 0.018410 0.010558 0.011230 0.011598 0.018036 0.009749 0.010578
Nuclear Periphery 0.000062 0.000124 0.000326 0.000166 0.000136 0.000082 0.000973 0.001109 0.000096 0.000092 0.000539 0.000485
Nuclear Periphery Foci 0.001125 0.001613 0.001624 0.000597 0.001115 0.000754 0.004307 0.004629 0.001121 0.000962 0.002505 0.001958
Nucleolus 0.000064 0.000134 0.000119 0.000131 0.000098 0.000108 0.000225 0.000614 0.000080 0.000115 0.000153 0.000294
Nucleus 0.224333* 0.256966* 0.391166* 0.262690* 0.226036* 0.241588* 0.394921* 0.185814* 0.225120* 0.245296* 0.392399* 0.236730*
Peroxisomes 0.000007 0.000012 0.000019 0.000077 0.000013 0.000019 0.000078 0.000445 0.000010 0.000017 0.000038 0.000201
Vacuole 0.002747 0.005703 0.012851 0.008035 0.002379 0.002811 0.115894 0.024476 0.002577 0.003508 0.046676 0.013587
Vacuole Periphery 0.000214 0.001393 0.000077 0.000219 0.002364 0.000532 0.000244 0.008692 0.001208 0.000739 0.000132 0.003080

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin -2.22 -6.11 -0.74 1.73 5.90 1.06 -8.38 -0.60 -1.62 7.73 0.36 -9.71 -0.83 -1.37 9.35
Bud Neck -5.70 -8.94 -6.81 -0.96 5.52 -1.99 -11.20 -10.55 -9.39 8.90 -4.71 -13.03 -11.54 -7.88 9.56
Bud Site -3.43 -8.38 -4.31 -2.63 1.56 -1.14 -6.79 -4.78 -4.49 2.67 -2.31 -9.67 -6.42 -5.45 2.97
Cell Periphery -5.84 -9.19 -5.36 2.05 6.20 1.32 -8.44 -5.49 -6.23 6.14 -2.41 -11.85 -7.56 -5.90 8.37
Cytoplasm 7.54 18.76 12.17 1.00 -12.61 4.27 26.08 9.59 6.86 -19.80 7.91 27.51 15.41 7.47 -19.82
Cytoplasmic Foci -7.90 -10.27 -7.24 4.71 8.46 -1.51 -9.29 -11.52 -10.95 6.69 -6.69 -13.54 -13.00 -5.77 10.46
Eisosomes -4.64 -7.68 -8.79 -0.85 5.71 -1.31 -10.85 -7.44 -7.14 8.67 -3.52 -12.36 -11.06 -8.72 9.61
Endoplasmic Reticulum 0.47 -4.36 -0.35 -0.44 0.94 1.81 -3.93 -0.90 -1.00 -0.25 1.58 -4.79 -0.92 -1.06 -0.06
Endosome -1.69 -5.98 -0.98 -0.33 1.75 -1.18 -5.75 -2.28 -2.06 0.72 -1.88 -7.05 -2.42 -1.70 1.25
Golgi -0.99 -0.40 1.85 2.67 2.86 1.06 -1.53 0.03 -0.69 0.84 0.36 -0.73 1.39 0.62 2.07
Lipid Particles -4.33 -8.21 -5.19 -1.73 4.33 -0.74 -6.70 -7.78 -7.44 3.56 -2.24 -9.95 -9.14 -7.64 5.28
Mitochondria 0.95 -3.17 0.19 -0.99 3.84 1.50 -0.14 -0.57 -1.40 -0.56 1.43 -0.79 -0.24 -1.31 0.29
Mitotic Spindle -1.88 -3.04 -3.39 -1.75 -1.16 -0.35 -0.57 -3.14 -3.06 -2.90 -1.65 -1.99 -4.19 -2.97 -2.92
None -2.47 5.93 4.61 4.97 -2.39 -4.65 5.22 4.03 10.20 -2.17 -6.07 7.60 5.86 11.60 -3.20
Nuclear Periphery -6.66 -11.83 -13.11 -2.94 7.66 0.52 -11.29 -4.14 -4.89 7.08 -1.26 -14.17 -6.63 -6.81 9.30
Nuclear Periphery Foci -3.79 -5.19 2.68 5.72 6.73 0.65 -7.37 -2.57 -3.13 4.67 -0.28 -8.64 -1.04 -0.80 7.67
Nucleolus -2.26 -5.78 -3.43 0.51 1.63 -0.71 -6.83 -2.58 -2.36 1.23 -2.32 -7.58 -3.51 -1.72 1.81
Nucleus -4.35 -12.00 -5.50 0.45 9.29 -3.16 -7.59 7.23 11.20 10.58 -5.20 -14.20 -1.03 4.12 13.66
Peroxisomes -2.97 -6.79 -1.52 -1.17 -0.06 -1.17 -8.40 -2.44 -2.25 0.81 -2.16 -10.01 -2.66 -2.22 0.42
Vacuole -4.96 -8.88 -16.79 -10.19 2.59 -5.45 -11.00 -18.83 -18.11 4.92 -6.06 -12.85 -24.48 -22.30 4.99
Vacuole Periphery -0.88 1.23 0.90 0.99 -0.06 1.90 2.12 0.65 -1.35 -1.62 1.12 2.29 1.16 0.05 -1.61
Standard name
Human Ortholog
Description AP4A phosphorylase; bifunctional diadenosine 5',5'''-P1,P4-tetraphosphate phosphorylase and ADP sulfurylase involved in catabolism of bis(5'-nucleosidyl) tetraphosphates; catalyzes phosphorolysis of dinucleoside oligophosphates, cleaving substrates' alpha/beta-anhydride bond and introducing Pi into the beta-position of the corresponding NDP formed; protein abundance increases under DNA replication stress; APA1 has a paralog, APA2, that arose from the whole genome duplication
Localization
Cell Percentages cytoplasm (97%)
Cell Cycle Regulation No
Subcompartmental Group cytoplasm-7

Apa1

Apa1


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Apa1-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available