Standard name
Human Ortholog
Description D-2-hydroxyglutarate dehydrogenase, and minor D-lactate dehydrogenase; mitochondrial matrix protein that oxidizes D-2-hydroxyglutarate (D-2HG), an oncometabolite, to alpha-ketoglutarate with a minor role in lactate catabolism; located in the mitochondrial matrix
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.05
Bud 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.09 0.07 0 0 0 0 0 0
Cytoplasm 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.18 0.05 0.12 0 0 0 0 0 0
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.06 0 0 0 0 0 0
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.08 0.06 0.08 0 0 0 0 0 0
Golgi 0 0 0.09 0.05 0.05 0 0 0 0 0 0 0 0 0 0.11 0.16 0.31 0.24 0 0.1 0.1 0.08 0.1 0.12
Mitochondria 0.9 0.9 0.84 0.92 0.89 0.87 0.86 0.85 0.95 0.9 0.9 0.89 0.92 0.9 0.89 0.11 0.11 0.11 0.82 0.76 0.69 0.71 0.71 0.63
Nucleus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0.07 0 0 0.12 0.09 0.12 0.09 0.11 0.14 0.07 0 0 0 0.11 0.09 0.05 0 0 0 0 0 0
Nucleolus 0.13 0.05 0.1 0.06 0.08 0.12 0.17 0.14 0.1 0.08 0.11 0.12 0.06 0 0 0.13 0.12 0.12 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.15 0.1 0.06 0 0 0.06 0.13 0.05 0.07
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.05 0 0 0 0 0 0
Vac/Vac Membrane 0.1 0.13 0 0 0.05 0 0 0 0 0 0 0.05 0.06 0.05 0.06 0.13 0.17 0.2 0 0.06 0 0 0 0
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 2 2 1 0 0 1 0 0 0 0 0 1 5 1 2 2 1 4 5 1 11 10
Bud 0 0 4 2 2 0 8 8 3 2 3 3 1 0 0 5 0 1 0 1 0 0 1 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 1
Bud Site 0 1 0 0 0 1 0 1 1 0 0 1 0 0 0 2 2 1 – – – – – –
Cell Periphery 1 5 0 0 1 1 1 0 1 1 0 0 1 3 3 5 10 6 0 0 0 0 0 0
Cytoplasm 2 0 4 2 3 2 4 3 2 6 2 5 2 7 5 25 6 10 0 0 1 0 0 0
Endoplasmic Reticulum 0 2 1 3 4 1 1 2 1 6 1 1 0 2 2 6 3 5 0 0 0 0 0 1
Endosome 1 2 2 4 1 3 4 3 0 2 0 1 0 4 7 11 7 7 7 4 5 2 10 4
Golgi 2 8 12 7 7 0 2 3 2 3 2 1 5 11 27 22 36 20 5 23 15 10 26 22
Mitochondria 162 197 114 132 128 181 226 273 209 238 100 136 103 262 215 16 13 9 150 174 102 89 189 118
Nucleus 0 0 2 0 0 1 1 1 1 1 1 0 0 0 0 1 3 1 0 0 0 0 0 0
Nuclear Periphery 4 5 9 2 4 24 23 38 19 30 15 10 4 10 9 16 10 4 2 0 2 0 1 3
Nucleolus 23 10 14 9 12 24 44 44 21 20 12 18 7 12 4 19 14 10 2 1 1 2 2 2
Peroxisomes 5 6 1 1 1 6 5 7 0 1 1 1 5 13 7 21 12 5 7 4 8 15 13 12
SpindlePole 0 0 2 1 1 2 3 4 1 0 1 2 0 0 0 4 3 4 1 0 1 1 1 1
Vac/Vac Membrane 18 28 2 2 7 6 4 14 6 8 3 8 7 16 15 19 20 17 2 13 1 0 4 4
Unique Cell Count 180 218 136 143 144 208 262 321 220 263 111 153 112 292 242 141 116 83 184 230 148 127 267 188
Labelled Cell Count 218 264 169 167 172 252 326 402 267 318 141 188 135 341 299 173 141 102 184 230 148 127 267 188


Mitochondria

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 14.1 13.3 12.3 13.3 13.8 12.4 11.0 10.7 11.7 10.7 9.8 10.8 16.2 15.9 15.5 10.8 12.9 13.7 14.1 15.8 16.1
Std Deviation (1e-4) 3.8 4.2 4.2 3.9 5.3 3.5 4.0 3.1 3.7 4.1 3.2 3.1 3.8 4.1 3.9 3.2 3.6 4.3 3.7 4.4 5.0
Intensity Change (Log2) – – – 0.11 0.17 0.0 -0.17 -0.2 -0.08 -0.2 -0.33 -0.2 0.39 0.37 0.33 -0.19 0.07 0.16 0.2 0.36 0.38


Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cell Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 0 0 0 0 0 0 0 0 0 0 0 0 4.0 0 2.7
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 2.5 0 0
Golgi -1.3 -1.3 0 0 0 -3.7 -3.8 -2.4 -3.3 -1.4 -2.2 0.7 1.7 4.5 3.1
Mitochondria 2.2 1.2 0.8 0.7 0.3 3.5 2.0 1.4 1.3 1.9 1.7 1.4 -12.1 -11.5 -10.6
Nucleus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery -2.2 -1.5 1.5 0.8 1.7 0.7 1.5 1.8 0 -1.1 -1.5 -1.3 1.4 0.6 0
Nucleolus -1.2 -0.6 0.4 1.7 1.0 -0.2 -0.9 0.1 0.4 -1.1 -2.5 -3.8 0.8 0.4 0.4
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 4.4 3.4 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vacuole 0 0 0 0 0 0 0 0 0 0 1.9 2.1 3.8 4.4 4.8

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 23.5353 22.6804 23.7014 19.731 17.6762 22.3758 16.9184 21.4437 18.9262 17.3409 17.3829 18.7664 20.6884 22.0993 21.8388 20.637 20.941 20.5093
Actin 0.304 0.0034 0.0066 0.0254 0.0001 0.0125 0.0055 0.0032 0.0105 0.0068 0.0007 0.0011 0.0256 0.0078 0.0066 0.0005 0.0034 0.002
Bud 0.0007 0.0002 0.0005 0 0 0.0001 0.0005 0 0.0001 0.0001 0 0 0.0003 0.0002 0.0001 0 0 0
Bud Neck 0.0005 0.0006 0.0005 0.0001 0 0.0001 0.0002 0 0 0 0 0 0.0003 0.0001 0 0 0 0
Bud Periphery 0.001 0.0004 0.0019 0.0001 0 0.0001 0.0012 0.0002 0.0001 0.0001 0.0001 0 0.0004 0.0003 0.0003 0 0.0001 0.0001
Bud Site 0.0053 0.0003 0.0008 0.0002 0 0.0001 0.0019 0.0001 0.0001 0.0001 0.0001 0 0.0018 0.0013 0.0003 0 0.0001 0.0001
Cell Periphery 0.0002 0.0014 0.0015 0.0001 0 0.0002 0.0006 0.0003 0.0002 0 0.0001 0.0001 0.0006 0.0001 0.0002 0 0.0001 0
Cytoplasm 0 0.1075 0 0 0 0 0.0034 0 0 0 0 0 0.0005 0 0.0001 0 0 0
Cytoplasmic Foci 0.0003 0.0017 0.0002 0.0001 0 0.0002 0.0117 0.0002 0.001 0.0021 0.0018 0.0002 0.0083 0.0004 0.0032 0.0003 0.0003 0.0012
Eisosomes 0.0091 0.0005 0.0003 0.0013 0.0001 0.0008 0.0004 0.0003 0.0003 0.0002 0.0001 0.0001 0.0008 0.0004 0.0003 0.0003 0.0003 0.0001
Endoplasmic Reticulum 0 0.0001 0.0001 0 0 0.0001 0.0016 0 0 0 0.0001 0 0.0007 0 0.0001 0 0 0.0001
Endosome 0.0001 0.0085 0.0025 0.0001 0 0.0009 0.0105 0.0005 0.0005 0.001 0.0023 0.0007 0.0128 0.0004 0.0017 0.0002 0.0002 0.0025
Golgi 0.001 0.008 0.0019 0.0003 0.0001 0.0069 0.0107 0.001 0.0023 0.0065 0.0025 0.0039 0.0088 0.0022 0.0036 0.0006 0.0014 0.0051
Lipid Particles 0.0016 0.0337 0.0024 0.0004 0.0013 0.0018 0.041 0.0122 0.013 0.0449 0.0704 0.0195 0.0323 0.0033 0.0097 0.0053 0.0037 0.0025
Mitochondria 0.6656 0.7841 0.947 0.9688 0.9973 0.9727 0.8604 0.9528 0.9409 0.9187 0.9117 0.9566 0.8645 0.9773 0.9525 0.9876 0.9807 0.9826
None 0.0001 0 0 0 0 0 0.0028 0 0 0 0.0001 0 0.0018 0 0.0003 0 0 0
Nuclear Periphery 0 0.0006 0.0001 0 0 0.0001 0.0136 0.0001 0 0 0.0004 0.0002 0.001 0 0.0002 0 0 0.0001
Nucleolus 0.0001 0.0011 0.0006 0 0 0 0.0025 0.0013 0.0006 0.0001 0.0001 0.0001 0.0172 0.0002 0.0014 0 0 0
Nucleus 0.0001 0.0032 0.0004 0 0 0 0.0057 0.0003 0.0002 0 0.0001 0 0.0017 0.0001 0.0003 0 0 0
Peroxisomes 0.0099 0.0051 0.0027 0.003 0.0005 0.0003 0.0118 0.0065 0.0145 0.0184 0.006 0.0013 0.0106 0.0037 0.0051 0.0042 0.0074 0.0026
Punctate Nuclear 0 0 0 0 0 0 0.0022 0 0 0 0.0001 0 0.0015 0 0.0001 0 0 0.0001
Vacuole 0.0001 0.019 0.015 0 0.0001 0.0003 0.0054 0.0044 0.0035 0.0002 0.0006 0.0005 0.0031 0.0005 0.003 0.0001 0.0002 0.0001
Vacuole Periphery 0.0002 0.0204 0.0148 0.0002 0.0003 0.0026 0.0064 0.0165 0.0122 0.0006 0.0026 0.0158 0.0053 0.0019 0.011 0.0007 0.0019 0.0007

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 36.7109 24.1486 33.0817 31.1457 27.8399 34.6137 28.6425 33.8042 35.4013 30.3439
Translational Efficiency 1.1767 1.3031 1.0533 1.175 1.0498 1.0761 1.2118 1.0465 1.0165 1.0892

Hit Data

Dataset Hit
Protein Concentration ✘
Protein Localization ✘
Gene Expression ✘
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
705 1159 1264 764 1736 1852 231 754 2441 3011 1495 1518

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 764.30 665.07 1035.43 1095.89 860.01 905.70 1153.32 1119.35 832.37 813.08 1053.65 1107.54
Standard Deviation 92.38 124.73 160.96 160.81 109.09 137.29 127.54 172.84 113.18 176.89 161.96 167.31
Intensity Change Log 2 — -0.200633 0.438019 0.519892 — 0.074680 0.423368 0.380236 — -0.048355 0.430280 0.447636

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.000091 0.000713 0.000380 0.000910 0.000209 0.000283 0.000749 0.000944 0.000175 0.000449 0.000437 0.000927
Bud Neck 0.000635 0.003916 0.013427 0.023722 0.002560 0.006450 0.004215 0.016005 0.002004 0.005474 0.012004 0.019889
Bud Site 0.000110 0.003562 0.000760 0.003543 0.000287 0.000906 0.000780 0.004329 0.000236 0.001928 0.000763 0.003934
Cell Periphery 0.000138 0.000955 0.000071 0.000125 0.000132 0.000268 0.000065 0.000133 0.000134 0.000533 0.000070 0.000129
Cytoplasm 0.000422 0.014600 0.001016 0.002287 0.000299 0.000817 0.000650 0.004897 0.000334 0.006122 0.000959 0.003583
Cytoplasmic Foci 0.000401 0.001542 0.000008 0.000991 0.000038 0.000818 0.000132 0.000643 0.000143 0.001097 0.000027 0.000819
Eisosomes 0.000013 0.000033 0.000022 0.000032 0.000025 0.000033 0.000039 0.000031 0.000022 0.000033 0.000025 0.000032
Endoplasmic Reticulum 0.002962 0.008008 0.002818 0.003892 0.007251 0.010998 0.005541 0.004056 0.006012 0.009847 0.003238 0.003973
Endosome 0.000121 0.000930 0.000074 0.002357 0.000142 0.001360 0.000159 0.001600 0.000136 0.001195 0.000087 0.001981
Golgi 0.000456 0.000565 0.000026 0.002726 0.000047 0.000556 0.000085 0.000461 0.000165 0.000560 0.000035 0.001601
Lipid Particles 0.000350 0.000560 0.000021 0.000087 0.000080 0.000155 0.004183 0.000690 0.000158 0.000311 0.000664 0.000387
Mitochondria 0.001185 0.001160 0.000920 0.002486 0.000291 0.002764 0.000748 0.007375 0.000550 0.002146 0.000893 0.004915
Mitotic Spindle 0.000014 0.000355 0.000106 0.012592 0.000620 0.001394 0.000075 0.017033 0.000445 0.000994 0.000101 0.014797
None 0.004673 0.050114 0.001141 0.004407 0.001455 0.001324 0.001210 0.004871 0.002384 0.020104 0.001152 0.004638
Nuclear Periphery 0.000086 0.000264 0.000263 0.001455 0.000267 0.000832 0.000211 0.000955 0.000215 0.000613 0.000255 0.001207
Nuclear Periphery Foci 0.000017 0.000965 0.000022 0.001440 0.000198 0.000363 0.000857 0.000644 0.000145 0.000595 0.000151 0.001045
Nucleolus 0.010421 0.018514 0.002520 0.006023 0.005536 0.005365 0.002933 0.002498 0.006947 0.010426 0.002584 0.004272
Nucleus 0.977307* 0.890041* 0.975690* 0.925629* 0.979933* 0.961275* 0.974999* 0.927817* 0.979174* 0.933856* 0.975583* 0.926716*
Peroxisomes 0.000375 0.000703 0.000071 0.000306 0.000127 0.000561 0.000242 0.000146 0.000199 0.000616 0.000098 0.000226
Vacuole 0.000173 0.001939 0.000572 0.003847 0.000426 0.002554 0.002065 0.003859 0.000353 0.002318 0.000802 0.003853
Vacuole Periphery 0.000050 0.000560 0.000072 0.001143 0.000078 0.000924 0.000061 0.001012 0.000070 0.000784 0.000071 0.001078

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin -8.64 -12.65 -13.77 -4.96 -9.71 -1.28 -8.29 -8.08 -7.91 -2.57 -6.23 -8.12 -13.57 -10.15 -10.03
Bud Neck -7.03 -12.24 -12.30 -10.40 -4.84 -5.26 -4.12 -12.24 -9.24 -10.20 -6.94 -11.17 -16.79 -13.54 -6.87
Bud Site -3.81 -6.37 -5.53 -0.04 -4.34 -3.64 -3.02 -4.43 -3.68 -3.64 -4.59 -5.42 -6.79 -2.96 -5.60
Cell Periphery -4.11 1.14 0.30 4.38 -2.96 -2.63 2.04 0.61 3.37 -2.07 -4.84 2.35 0.64 5.28 -3.41
Cytoplasm -7.39 -2.86 -6.90 6.13 -5.08 -2.31 -1.57 -6.14 -5.44 -5.13 -7.58 -3.90 -8.38 2.50 -6.75
Cytoplasmic Foci -2.22 1.04 -0.29 2.14 -1.76 -2.15 -0.92 -1.62 1.01 -1.19 -3.34 1.09 -1.49 2.09 -2.37
Eisosomes -4.05 -4.97 -11.83 -1.31 -8.44 -2.38 -4.84 -3.47 -0.95 2.25 -3.94 -2.07 -7.35 -1.80 -7.00
Endoplasmic Reticulum -8.50 0.16 -4.76 5.23 -7.08 -5.43 1.80 5.42 9.81 2.89 -7.73 8.14 3.18 11.06 -6.20
Endosome -3.70 0.77 -1.87 -0.58 -1.93 -3.08 -0.73 -1.97 0.61 -1.88 -4.14 1.96 -2.63 0.05 -2.74
Golgi -0.24 0.97 -0.96 -0.89 -1.52 -2.24 -0.73 -1.94 0.90 -1.65 -1.85 1.00 -1.46 -0.63 -1.79
Lipid Particles -0.62 1.03 0.53 1.33 -6.35 -1.08 -1.02 -1.26 -1.04 0.90 -1.06 -0.75 -0.91 0.07 0.43
Mitochondria 0.02 0.17 -1.33 -4.76 -5.08 -3.54 -9.07 -2.88 -1.30 -2.55 -3.06 -1.32 -3.68 -1.79 -3.34
Mitotic Spindle -1.83 -1.55 -4.23 -4.10 -4.13 -0.98 -0.79 -3.92 -3.72 -2.38 -1.06 -0.38 -5.62 -5.41 -5.43
None -10.11 2.29 0.28 10.74 -4.46 0.23 0.40 -3.37 -4.18 -4.12 -9.92 2.06 -2.58 8.94 -6.19
Nuclear Periphery -6.48 -7.38 -4.74 -4.11 -4.03 -2.86 -0.52 -5.58 -1.38 -5.32 -3.26 -2.59 -6.59 -3.46 -6.12
Nuclear Periphery Foci -5.14 -1.43 -2.02 -0.27 -2.00 -0.45 -0.70 -1.11 -0.69 0.33 -2.71 0.37 -2.06 -0.73 -2.23
Nucleolus -4.38 5.32 2.26 6.78 -2.58 0.35 2.30 0.19 -0.08 -1.72 -4.12 5.52 1.18 4.75 -3.30
Nucleus 12.95 1.08 8.77 -3.47 8.86 6.10 1.87 9.45 6.12 5.70 14.10 2.84 13.26 2.61 11.65
Peroxisomes -1.05 1.27 0.32 1.61 -2.72 -2.08 -2.12 -1.50 1.82 1.20 -2.45 1.29 -0.52 2.34 -3.13
Vacuole -5.24 -3.12 -4.74 -3.79 -4.50 -5.12 -3.78 -5.37 -2.93 -2.18 -6.87 -3.92 -6.53 -4.63 -5.89
Vacuole Periphery -1.88 -1.72 -2.57 -0.37 -2.46 -4.03 0.74 -2.18 0.76 -2.21 -4.30 -0.49 -3.31 0.42 -3.29
Standard name
Human Ortholog
Description D-2-hydroxyglutarate dehydrogenase, and minor D-lactate dehydrogenase; mitochondrial matrix protein that oxidizes D-2-hydroxyglutarate (D-2HG), an oncometabolite, to alpha-ketoglutarate with a minor role in lactate catabolism; located in the mitochondrial matrix
Localization
Cell Percentages nucleus (99%)
Cell Cycle Regulation No
Subcompartmental Group nucleus-4

Dld2

Dld2


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Dld2-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available