Standard name
Human Ortholog
Description RNA-binding subunit of the TRAMP nuclear RNA surveillance complex; involved in nuclear RNA processing and degradation; involved in TRAMP complex assembly as a bridge between Mtr4p and Trf4p; stimulates the poly(A) polymerase activity of Pap2p in vitro; has 5 zinc knuckle motifs; AIR2 has a paralog, AIR1, that arose from the whole genome duplication; Air2p and Air1p have nonredundant roles in regulation of substrate specificity of the exosome
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0.05 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 0 0.06 0 0.05 0.05 0 0 0.07 0 0 0 0 0 0.08 0.15 0 0.07 0.11 0 0 0 0 0 0
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0.1 0.07 0 0.05 0 0.25 0.32 0.26 0.52 0.34 0.55 0.36 0 0 0 0 0 0.05 0 0 0 0 0 0
Nucleus 0.95 0.89 0.96 0.93 0.94 0.91 0.89 0.84 0.78 0.84 0.84 0.83 0.95 0.91 0.81 0.93 0.85 0.79 0.9 0.9 0.89 0.77 0.62 0.52
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 0 0.07 0.05 0 0 0 0 0.06 0 0 0 0 0.06 0.08 0.11
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vac/Vac Membrane 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.06 0.06 0 0 0.07 0.1 0.21 0.24
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 1 0 0 1 1 4 1 4 3 5 2 0 1 0 0 0 0 3 1 0 3 2 3
Bud Neck 0 0 0 0 0 0 1 2 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 3
Bud Site 0 0 0 0 0 2 4 5 19 9 13 11 0 0 0 1 0 0 – – – – – –
Cell Periphery 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 6 7 0 9 16 6 14 24 16 19 11 8 7 19 37 4 7 14 0 0 0 3 0 3
Endoplasmic Reticulum 0 0 0 0 1 0 1 0 0 0 0 0 0 1 0 1 2 2 0 0 0 0 1 1
Endosome 0 0 0 0 1 1 0 1 0 0 0 0 0 1 1 0 0 0 1 2 0 2 4 3
Golgi 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 1 3 0 0 0 0 0
Mitochondria 31 8 2 9 4 62 110 96 213 175 213 144 3 2 1 3 4 6 5 0 0 0 4 8
Nucleus 294 105 55 153 284 230 305 304 323 434 325 336 205 220 198 100 88 99 281 102 77 147 178 167
Nuclear Periphery 4 1 0 0 3 2 3 6 3 4 7 3 2 2 3 2 0 0 0 0 0 0 1 6
Nucleolus 2 2 0 3 0 1 5 10 13 12 26 21 5 1 4 4 6 2 4 0 0 11 22 35
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 2 0 0 0 6 2 1 1 4 0 2 1 0 0 0 2 0 1 2 6 5
Vac/Vac Membrane 2 2 0 0 1 3 2 2 1 7 4 6 2 1 5 2 6 8 6 3 5 18 59 76
Unique Cell Count 310 118 57 164 303 253 342 364 412 515 386 403 215 243 245 107 103 126 314 114 87 192 286 321
Labelled Cell Count 340 126 57 176 312 308 449 457 594 664 605 535 224 250 251 117 113 132 314 114 87 192 286 321


Nucleus

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 5.2 6.0 5.3 5.7 5.8 4.7 4.4 5.0 4.2 4.5 4.1 4.5 6.3 6.6 6.3 8.3 9.0 9.2 5.6 6.1 6.5
Std Deviation (1e-4) 0.7 1.1 0.6 1.6 1.5 1.2 1.1 1.6 0.9 1.2 1.0 0.9 1.1 1.4 1.4 1.7 2.0 2.0 1.3 1.6 1.2
Intensity Change (Log2) – – – 0.12 0.14 -0.17 -0.28 -0.08 -0.35 -0.23 -0.36 -0.23 0.26 0.33 0.24 0.64 0.76 0.79 0.09 0.22 0.3

WT3RAP60RAP140RAP220RAP300RAP380RAP460RAP540RAP620RAP7000510WT3HU80HU120HU1600510WT3rpd3Δ_1rpd3Δ_2rpd3Δ_30510WT1AF100AF140AF1800510
rapamycinhydroxy-urearpd3 knockoutalpha-factorMultiple Condition Time-Course Intensity PlotsGFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)

Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cell Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 0 0 0 0 0 0 0 0 0 0 0 3.1 0 0 0
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0 0 0 0 3.8 0 0 0 0 0 0 0 0 0 0
Nucleus -0.9 -0.8 -1.4 -1.7 -2.6 -3.2 -2.5 -2.5 -2.6 -0.4 -1.5 -2.9 -0.8 -2.2 -3.1
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vacuole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 2.7817 2.9134 2.6315 2.5495 2.9027 2.5433 2.0906 2.4186 2.1561 1.593 1.6601 1.9728 1.1219 1.1046 0.801 0.952 0.5929 0.7886
Actin 0.0271 0.0001 0.0143 0.016 0.0116 0.0012 0.0109 0 0.0046 0 0.0045 0.0002 0.0636 0.0002 0.0057 0.016 0.0269 0.0017
Bud 0.0005 0 0.0002 0.0017 0.0013 0.0002 0.0001 0 0.0001 0 0.0002 0.0001 0.0013 0.0003 0.0003 0.0083 0.0002 0.0002
Bud Neck 0.0012 0.0002 0.0007 0.0009 0.001 0.0021 0.0011 0.0001 0.0007 0.0001 0.0032 0.0012 0.0039 0.0002 0.0005 0.0013 0.0008 0.0012
Bud Periphery 0.0006 0.0001 0.0004 0.0025 0.0073 0.0007 0.0002 0 0.0002 0 0.0008 0.0003 0.0025 0.0005 0.0005 0.0401 0.0003 0.0005
Bud Site 0.0013 0.0002 0.001 0.0117 0.0009 0.0003 0.0006 0 0.0003 0 0.0009 0.0001 0.0124 0.0004 0.0124 0.0065 0.0009 0.0002
Cell Periphery 0.0003 0 0.0002 0.0004 0.0005 0.0002 0.0001 0 0.0001 0 0.0002 0.0001 0.0008 0.0001 0.0003 0.0018 0.0001 0.0001
Cytoplasm 0.0096 0.0051 0.0072 0.0021 0.002 0.0008 0.0023 0.0001 0.0007 0.0001 0.0015 0.0001 0.001 0.001 0.0008 0.0016 0.0661 0.0001
Cytoplasmic Foci 0.0129 0.0004 0.0054 0.0105 0.0095 0.001 0.009 0 0.0001 0 0.0008 0 0.0046 0 0.0019 0.0063 0.0224 0.0001
Eisosomes 0.0006 0 0.0002 0.0002 0.0001 0 0.0002 0 0.0001 0 0.0001 0 0.0004 0 0 0.0001 0.0001 0.0001
Endoplasmic Reticulum 0.0027 0.0003 0.0019 0.0029 0.0045 0.0006 0.0008 0 0.0004 0 0.0012 0.0001 0.0014 0.0001 0.0006 0.0016 0.0019 0.0003
Endosome 0.0168 0.0004 0.0087 0.0357 0.0277 0.0066 0.0082 0 0.001 0 0.0141 0.001 0.017 0.0006 0.009 0.0187 0.0243 0.0022
Golgi 0.0075 0 0.0039 0.0091 0.02 0.0016 0.0021 0 0.0006 0 0.0011 0.0001 0.0141 0.0002 0.0049 0.0152 0.006 0.0031
Lipid Particles 0.0191 0 0.0125 0.0222 0.0918 0.0067 0.0069 0 0.0006 0 0.0023 0.0001 0.0076 0.0002 0.0012 0.0056 0.0277 0.0006
Mitochondria 0.024 0.0005 0.0125 0.0736 0.0164 0.0108 0.0012 0.0002 0.0009 0.0001 0.0054 0.0013 0.0306 0.0106 0.0147 0.0138 0.0061 0.0224
None 0.013 0.0017 0.0116 0.0021 0.0043 0.0006 0.0044 0 0.0003 0 0.0014 0.0003 0.001 0.0007 0.0002 0.0006 0.0032 0.0001
Nuclear Periphery 0.0139 0.0055 0.0074 0.0157 0.0584 0.0072 0.0105 0.0065 0.006 0.0007 0.0406 0.0031 0.0079 0.0069 0.0051 0.012 0.0144 0.0016
Nucleolus 0.0512 0.0728 0.122 0.0699 0.0267 0.1192 0.0527 0.0544 0.1005 0.0361 0.0372 0.1199 0.0347 0.039 0.091 0.1395 0.0205 0.1154
Nucleus 0.7593 0.9071 0.7776 0.6937 0.6609 0.8318 0.8731 0.9348 0.8789 0.9301 0.8327 0.8695 0.7754 0.9353 0.8437 0.6897 0.7439 0.848
Peroxisomes 0.0165 0 0.0058 0.0109 0.0265 0.0006 0.0033 0 0.0001 0 0.0007 0 0.0097 0.0001 0.0014 0.0032 0.0173 0.0003
Punctate Nuclear 0.0166 0.005 0.004 0.0036 0.0075 0.0045 0.0106 0.0033 0.0024 0.0327 0.0431 0.0015 0.0013 0.0008 0.0019 0.0013 0.0105 0.0006
Vacuole 0.0033 0.0003 0.0015 0.0075 0.0102 0.0019 0.0009 0.0001 0.0008 0 0.0054 0.0006 0.0055 0.0016 0.0021 0.0127 0.0038 0.0005
Vacuole Periphery 0.0019 0.0001 0.0011 0.0071 0.0109 0.0011 0.0006 0.0002 0.0004 0 0.0024 0.0005 0.0033 0.0013 0.0016 0.0039 0.0024 0.0008

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 7.9957 7.6242 16.2652 10.6315 11.0579 9.5895 15.8994 10.4058 11.0332 13.7729
Translational Efficiency 2.6283 2.5856 0.9898 1.1932 1.6585 2.7033 1.4672 1.8302 1.6504 1.4297

Hit Data

Dataset Hit
Protein Concentration ✘
Protein Localization ✘
Gene Expression ✘
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
1545 226 1891 1556 1474 1481 312 1395 3019 1707 2203 2951

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 761.92 961.83 934.49 995.45 737.05 864.08 1089.94 951.76 749.78 877.02 956.51 974.80
Standard Deviation 110.24 140.81 129.45 156.14 113.20 123.07 133.44 154.81 112.38 129.86 140.87 157.03
Intensity Change Log 2 — 0.336142 0.294540 0.385709 — 0.229402 0.564414 0.368835 — 0.284644 0.433544 0.377437

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.000227 0.001048 0.000460 0.000924 0.000206 0.000410 0.001048 0.000952 0.000217 0.000494 0.000543 0.000937
Bud Neck 0.002434 0.011136 0.020543 0.032408 0.004845 0.006631 0.011745 0.034305 0.003611 0.007227 0.019297 0.033305
Bud Site 0.000710 0.004379 0.001443 0.006365 0.001251 0.001347 0.000960 0.009161 0.000974 0.001749 0.001374 0.007687
Cell Periphery 0.000106 0.000096 0.000077 0.000098 0.000156 0.000124 0.000050 0.000210 0.000131 0.000121 0.000073 0.000151
Cytoplasm 0.013599 0.003626 0.002987 0.007225 0.009487 0.004103 0.001373 0.026965 0.011591 0.004040 0.002759 0.016556
Cytoplasmic Foci 0.001855 0.002564 0.000026 0.001319 0.001253 0.002167 0.000073 0.004749 0.001561 0.002220 0.000033 0.002940
Eisosomes 0.000017 0.000038 0.000024 0.000028 0.000016 0.000023 0.000038 0.000040 0.000017 0.000025 0.000026 0.000034
Endoplasmic Reticulum 0.004098 0.006483 0.004913 0.006780 0.004810 0.006856 0.007829 0.006137 0.004446 0.006806 0.005326 0.006476
Endosome 0.000903 0.000799 0.000198 0.001964 0.000621 0.001333 0.000285 0.004766 0.000765 0.001263 0.000210 0.003289
Golgi 0.000143 0.001025 0.000039 0.004323 0.000183 0.001005 0.000069 0.003510 0.000162 0.001007 0.000043 0.003939
Lipid Particles 0.000496 0.000303 0.000050 0.000207 0.000596 0.001610 0.000185 0.000715 0.000545 0.001437 0.000069 0.000447
Mitochondria 0.001376 0.002250 0.001436 0.003877 0.000876 0.003601 0.001045 0.004889 0.001132 0.003422 0.001381 0.004356
Mitotic Spindle 0.001234 0.001087 0.000727 0.009047 0.001217 0.002595 0.000202 0.022207 0.001226 0.002396 0.000652 0.015268
None 0.007548 0.002253 0.001711 0.002666 0.006647 0.002367 0.001557 0.009648 0.007108 0.002352 0.001689 0.005967
Nuclear Periphery 0.000818 0.000417 0.000980 0.002412 0.000966 0.001135 0.000471 0.002090 0.000891 0.001040 0.000908 0.002260
Nuclear Periphery Foci 0.000450 0.000468 0.000243 0.000944 0.000685 0.001022 0.000201 0.001004 0.000564 0.000949 0.000237 0.000972
Nucleolus 0.022963 0.027669 0.006618 0.023236 0.019594 0.019783 0.015877 0.027855 0.021318 0.020827 0.007929 0.025420
Nucleus 0.938110 0.931030 0.956037 0.885457 0.944632 0.938946 0.953516 0.823695 0.941294 0.937898 0.955680 0.856261
Peroxisomes 0.000455 0.001481 0.000094 0.000679 0.000236 0.000989 0.000395 0.001467 0.000348 0.001054 0.000137 0.001052
Vacuole 0.002148 0.001559 0.001253 0.007487 0.001445 0.002955 0.002950 0.011274 0.001805 0.002771 0.001493 0.009277
Vacuole Periphery 0.000309 0.000288 0.000141 0.002552 0.000280 0.000998 0.000132 0.004362 0.000295 0.000904 0.000139 0.003408

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin -2.30 -7.72 -6.11 0.06 -4.04 -2.95 -13.22 -15.00 -8.08 0.10 -3.57 -14.78 -11.63 -5.63 -6.45
Bud Neck -4.22 -17.84 -19.58 -8.82 -7.21 -2.29 -4.41 -17.58 -16.31 -9.83 -5.45 -17.14 -26.24 -21.41 -10.54
Bud Site -2.05 -2.60 -4.96 -0.47 -4.10 -0.32 -0.16 -5.87 -6.04 -6.23 -2.09 -1.80 -7.63 -6.23 -6.94
Cell Periphery 0.11 2.37 0.79 0.32 -1.73 0.78 4.12 -0.55 -1.30 -6.79 0.27 4.23 -0.00 -0.28 -5.68
Cytoplasm 4.03 6.64 2.30 -2.39 -5.35 3.04 5.13 -6.18 -8.42 -9.71 5.34 8.26 -3.46 -8.31 -10.92
Cytoplasmic Foci -0.46 4.01 2.12 1.35 -3.22 -1.06 3.18 -1.99 -0.79 -4.41 -0.71 5.25 -0.05 0.68 -5.50
Eisosomes -2.38 -4.78 -7.88 1.04 -3.92 -3.71 -8.44 -14.10 -9.80 -1.12 -4.16 -8.79 -15.84 -6.18 -7.62
Endoplasmic Reticulum -3.58 -3.28 -6.91 -0.52 -4.72 -3.59 -5.54 -5.30 -0.36 1.98 -4.98 -4.33 -8.61 -0.31 -4.71
Endosome 0.11 2.59 -1.53 -1.49 -4.39 -2.42 0.95 -3.95 -2.54 -4.21 -1.85 3.39 -4.14 -2.29 -6.03
Golgi -0.96 2.77 -2.93 -1.48 -3.06 -2.20 0.97 -3.09 -1.47 -3.30 -2.47 2.24 -4.08 -2.23 -4.32
Lipid Particles 2.02 6.60 3.27 0.80 -2.81 -1.47 1.36 -0.06 1.49 -2.02 -1.54 3.92 1.03 1.82 -3.97
Mitochondria -0.74 -0.32 -3.63 -1.47 -4.33 -2.73 -1.48 -6.57 -0.40 -5.60 -2.52 -1.11 -6.70 -0.55 -6.12
Mitotic Spindle 0.14 0.77 -4.91 -4.98 -5.39 -1.68 1.64 -7.24 -6.38 -7.70 -1.63 1.11 -8.71 -7.30 -9.20
None 4.44 6.45 4.75 -0.67 -2.44 3.79 4.70 -0.69 -4.48 -5.35 6.11 7.72 2.22 -4.06 -5.77
Nuclear Periphery 2.70 -0.94 -4.94 -6.28 -3.69 -0.92 1.85 -6.26 -4.51 -7.19 -0.97 -0.57 -7.47 -5.57 -5.25
Nuclear Periphery Foci -0.01 1.11 -1.24 -0.83 -1.86 -0.98 1.17 -1.34 -0.29 -2.92 -1.41 1.53 -1.79 0.05 -3.14
Nucleolus -0.99 8.35 -0.07 0.95 -8.49 -0.13 1.08 -4.09 -4.04 -4.09 0.33 9.35 -2.97 -3.09 -11.31
Nucleus 0.96 -3.31 10.15 4.99 14.08 1.36 -0.34 17.24 15.66 16.04 1.04 -3.04 19.44 16.12 22.72
Peroxisomes -1.39 3.22 0.17 1.42 -2.01 -2.54 -2.85 -3.01 -0.09 -2.44 -2.32 3.43 -1.95 0.93 -3.73
Vacuole -0.05 0.34 -6.12 -5.93 -6.93 -1.85 -2.08 -8.30 -7.53 -5.16 -1.61 -0.86 -10.31 -9.16 -10.07
Vacuole Periphery 0.07 2.45 -3.37 -3.32 -3.77 -2.54 1.61 -3.35 -2.15 -3.57 -2.54 2.79 -4.69 -2.73 -5.11
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description RNA-binding subunit of the TRAMP nuclear RNA surveillance complex; involved in nuclear RNA processing and degradation; involved in TRAMP complex assembly as a bridge between Mtr4p and Trf4p; stimulates the poly(A) polymerase activity of Pap2p in vitro; has 5 zinc knuckle motifs; AIR2 has a paralog, AIR1, that arose from the whole genome duplication; Air2p and Air1p have nonredundant roles in regulation of substrate specificity of the exosome
Localization
Cell Percentages nucleus (96%)
Cell Cycle Regulation No
Subcompartmental Group nucleus-4

Air2

Air2


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Air2-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available