Standard name
Human Ortholog
Description Inositol hexakisphosphate and inositol heptakisphosphate kinase; generation of high energy inositol pyrophosphates by Kcs1p is required for many processes such as vacuolar biogenesis, stress response, RNA polymerase I-mediated rRNA transcription and telomere maintenance; inositol hexakisphosphate is also known as IP6; inositol heptakisphosphate is also known as IP7
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.1 0.07 0 0 0 0 0 0 0
Cytoplasm 0.98 0.98 0.99 0.97 0.99 0.95 0.93 0.86 0.79 0.8 0.71 0.73 1.0 0.98 0.98 0.89 0.91 0.89 0.94 0.94 0.91 0.93 0.9 0.9
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.05 0 0.05 0 0 0 0 0 0
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0 0 0 0.08 0 0.16 0.21 0.26 0.45 0.38 0.44 0.51 0 0 0 0.05 0 0 0 0 0 0 0 0
Nucleus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vac/Vac Membrane 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.07 0.07 0 0 0 0 0 0
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 1 0 2 1 0 0 0 0 0 0 0 0 0 0 0 3 0
Bud 0 0 3 1 4 2 4 12 12 7 5 11 1 1 17 0 0 0 0 0 0 0 1 1
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1
Bud Site 0 0 0 0 0 0 0 0 0 1 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 3 4 2 2 7 6 11 14 3 11 8 11 8 14 25 12 8 6 0 0 0 0 0 0
Cytoplasm 168 150 224 296 421 370 603 695 306 386 192 329 320 524 569 112 107 145 162 145 220 149 306 358
Endoplasmic Reticulum 1 1 0 3 2 3 5 3 6 8 5 0 1 2 2 6 3 8 0 0 2 1 6 15
Endosome 0 0 0 0 0 0 1 2 0 0 0 0 0 1 0 3 1 0 0 0 1 0 3 6
Golgi 2 0 0 0 0 0 0 1 0 0 0 0 0 3 2 0 0 0 2 1 0 1 1 3
Mitochondria 1 0 7 25 14 63 137 208 172 185 120 233 0 2 22 6 4 6 1 0 5 2 2 3
Nucleus 0 1 0 0 2 2 0 4 0 3 1 0 0 2 0 5 4 4 0 0 0 0 1 0
Nuclear Periphery 0 0 0 0 0 0 2 0 0 1 1 1 0 0 0 0 0 0 1 0 0 0 0 0
Nucleolus 0 0 0 1 0 0 0 0 1 0 0 0 0 0 1 0 1 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1
SpindlePole 0 0 0 0 0 0 1 0 0 1 0 0 0 0 1 0 0 0 0 0 0 0 2 0
Vac/Vac Membrane 0 0 0 0 1 0 0 8 0 2 1 2 0 2 1 2 8 11 0 3 6 1 7 4
Unique Cell Count 172 153 227 306 426 388 649 804 386 483 272 453 321 532 581 126 118 163 173 154 241 161 342 400
Labelled Cell Count 175 156 236 328 451 446 764 948 500 607 334 587 330 551 640 146 136 180 173 154 241 161 342 400


Cytoplasm

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 8.7 6.9 5.2 5.1 5.3 4.7 4.5 4.5 4.0 3.9 4.0 3.8 7.7 7.5 6.3 9.4 10.2 10.3 7.7 7.2 8.2
Std Deviation (1e-4) 1.0 1.0 0.6 0.7 0.9 0.6 0.8 0.8 0.7 0.7 0.6 0.6 0.9 1.2 1.0 1.6 1.7 1.8 1.1 1.3 1.3
Intensity Change (Log2) – – – -0.02 0.02 -0.16 -0.22 -0.21 -0.39 -0.41 -0.4 -0.46 0.56 0.53 0.26 0.85 0.97 0.98 0.56 0.46 0.66


Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0 0 0 0 1.3 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cell Periphery 0 0 0 0 0 0 0 0 0 0 0 2.4 0 0 0
Cytoplasm -1.4 0.2 -2.2 -3.3 -5.2 -6.8 -6.7 -8.4 -8.2 1.4 -0.2 -0.7 -4.1 -3.6 -4.2
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 2.4 0.1 0 0 0 0 0 0 0 0 0 0.5 0 0 0.3
Nucleus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vacuole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 3.9879 4.6943 4.205 4.0386 4.2173 4.4613 4.5916 6.0143 5.8379 5.5647 5.0937 5.2076 2.4342 3.5236 2.8031 3.1119 2.4783 2.8463
Actin 0.0912 0.0005 0.0096 0.0004 0.0061 0.0018 0.0435 0.0015 0.0017 0.0142 0.0134 0.0031 0.0076 0.0016 0.0023 0.0001 0.0007 0.0012
Bud 0.0026 0.001 0.0007 0.0004 0.0019 0.0004 0.0014 0.0004 0.0005 0.0006 0.0015 0.0002 0.0015 0.0007 0.0004 0.0003 0.0003 0.0001
Bud Neck 0.0473 0.0006 0.0005 0.0033 0.0008 0.002 0.0016 0.0002 0.0007 0.0013 0.0012 0.0007 0.0003 0.0003 0.0002 0.0004 0.0004 0.0004
Bud Periphery 0.0031 0.0004 0.0006 0.0004 0.0067 0.0003 0.0012 0.0002 0.0004 0.0005 0.0021 0.0002 0.0039 0.0003 0.0002 0.0001 0.0001 0.0001
Bud Site 0.0189 0.0113 0.0019 0.0026 0.0049 0.0009 0.0045 0.0083 0.0032 0.0035 0.0026 0.0001 0.0022 0.0045 0.001 0.0002 0.0002 0.0001
Cell Periphery 0.0014 0.0005 0.0006 0.0001 0.0014 0.0001 0.0003 0.0002 0.0002 0.0001 0.0001 0.0001 0.0008 0.0002 0.0002 0.0001 0.0001 0.0001
Cytoplasm 0.5976 0.9384 0.8981 0.8572 0.8296 0.9518 0.7415 0.9466 0.9164 0.8818 0.7595 0.9344 0.7841 0.9417 0.9387 0.867 0.898 0.9273
Cytoplasmic Foci 0.0416 0.0072 0.0164 0.0341 0.0076 0.0084 0.0443 0.0136 0.021 0.0187 0.0381 0.013 0.0333 0.0178 0.0112 0.0158 0.0204 0.0112
Eisosomes 0.0006 0 0 0 0.0002 0 0.0007 0 0 0.0001 0 0 0.0001 0 0 0 0 0
Endoplasmic Reticulum 0.0112 0.0018 0.0066 0.0032 0.0044 0.0033 0.0086 0.0018 0.0062 0.0017 0.0026 0.0137 0.0081 0.0009 0.0037 0.0014 0.008 0.0026
Endosome 0.0514 0.0053 0.0149 0.0324 0.0288 0.0082 0.0473 0.0051 0.0151 0.0195 0.0467 0.012 0.016 0.0045 0.0069 0.022 0.0391 0.0084
Golgi 0.0204 0.0011 0.004 0.0046 0.015 0.0015 0.0099 0.0007 0.005 0.0055 0.0089 0.0028 0.0036 0.0008 0.001 0.0008 0.0022 0.0022
Lipid Particles 0.0161 0.0002 0.0028 0.0004 0.0221 0.0005 0.0063 0.0004 0.0009 0.0026 0.0088 0.0014 0.0072 0.0002 0.0008 0 0.0004 0.0012
Mitochondria 0.0069 0.0062 0.0015 0.0004 0.0372 0.009 0.0072 0.0008 0.0016 0.0013 0.0149 0.0078 0.0015 0.0002 0.0002 0.0004 0.0004 0.0111
None 0.0285 0.017 0.0166 0.0432 0.0172 0.008 0.0495 0.0155 0.0123 0.0094 0.0031 0.0043 0.0411 0.0222 0.0166 0.084 0.0252 0.0276
Nuclear Periphery 0.0216 0.0003 0.0028 0.001 0.0041 0.0003 0.0069 0.0003 0.0009 0.0027 0.0215 0.0023 0.0116 0.0002 0.0005 0.0004 0.0011 0.0002
Nucleolus 0.0017 0.0001 0.0001 0.0001 0.0003 0 0.0028 0 0.0004 0.0004 0.0014 0 0.0009 0 0 0 0 0
Nucleus 0.0045 0.0038 0.0022 0.0009 0.0014 0.0006 0.0039 0.0005 0.0015 0.0019 0.0267 0.0011 0.0368 0.0005 0.0006 0.0006 0.0006 0.0003
Peroxisomes 0.0089 0.001 0.0127 0.0025 0.0028 0.0007 0.0064 0.0004 0.0018 0.0016 0.008 0.0003 0.0185 0.0006 0.0129 0.0002 0.0002 0.0046
Punctate Nuclear 0.0116 0.0002 0.0018 0.0003 0.0009 0.0004 0.0038 0.0017 0.0011 0.028 0.0252 0.0006 0.017 0.0006 0.0003 0.0001 0.0004 0.0001
Vacuole 0.0099 0.0027 0.0046 0.011 0.0045 0.0015 0.0067 0.0014 0.0081 0.004 0.0095 0.0013 0.0033 0.0021 0.002 0.0049 0.0017 0.001
Vacuole Periphery 0.003 0.0002 0.0008 0.0015 0.0021 0.0003 0.0018 0.0002 0.001 0.0009 0.0044 0.0007 0.0008 0.0002 0.0003 0.001 0.0005 0.0002

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 29.0462 22.2115 18.339 22.6684 24.5014 22.3846 24.514 25.1915 22.5664 30.5127
Translational Efficiency 0.8632 0.9475 0.9005 0.6105 0.7498 0.849 0.6851 0.5693 0.5324 0.6206

Hit Data

Dataset Hit
Protein Concentration ✘
Protein Localization ✘
Gene Expression ✘
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
846 1334 126 1132 1913 1665 253 1592 2759 2999 379 2724

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 795.90 912.98 1372.05 1098.60 821.46 822.13 1217.47 1121.06 813.62 862.54 1268.86 1111.73
Standard Deviation 96.67 120.87 136.76 133.30 120.17 164.09 127.76 126.81 114.10 153.25 149.72 130.02
Intensity Change Log 2 — 0.197996 0.785674 0.465007 — 0.001176 0.567624 0.448601 — 0.101386 0.679044 0.456698

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.000194 0.000201 0.000690 0.001523 0.000170 0.000114 0.000390 0.000451 0.000177 0.000153 0.000490 0.000897
Bud Neck 0.008090 0.004616 0.001324 0.002134 0.002608 0.013026 0.002873 0.001739 0.004289 0.009285 0.002358 0.001903
Bud Site 0.018611 0.024601 0.014068 0.035987 0.014294 0.016820 0.022853 0.022873 0.015618 0.020281 0.019933 0.028323
Cell Periphery 0.000247 0.000097 0.000250 0.000123 0.000108 0.000475 0.000171 0.000096 0.000150 0.000307 0.000198 0.000107
Cytoplasm 0.662113* 0.685242* 0.820132* 0.787036* 0.733811* 0.498323* 0.539655* 0.815018* 0.711826* 0.581467* 0.632900* 0.803390*
Cytoplasmic Foci 0.197257* 0.184084* 0.073420 0.060287 0.149694 0.136541 0.124992 0.058650 0.164278 0.157689 0.107847 0.059330
Eisosomes 0.000107 0.000027 0.000009 0.000011 0.000024 0.000184 0.000042 0.000010 0.000049 0.000114 0.000031 0.000010
Endoplasmic Reticulum 0.001284 0.000865 0.002479 0.000147 0.001430 0.001732 0.001138 0.000135 0.001385 0.001346 0.001584 0.000140
Endosome 0.019439 0.017441 0.007298 0.003923 0.009771 0.028488 0.018432 0.003306 0.012735 0.023574 0.014730 0.003562
Golgi 0.006627 0.006903 0.003065 0.003852 0.008454 0.005970 0.000527 0.003207 0.007894 0.006385 0.001371 0.003475
Lipid Particles 0.002520 0.001123 0.002151 0.000633 0.001531 0.004571 0.002383 0.000562 0.001835 0.003037 0.002306 0.000591
Mitochondria 0.001646 0.001421 0.000011 0.000697 0.002399 0.002243 0.000028 0.001023 0.002168 0.001877 0.000022 0.000887
Mitotic Spindle 0.001294 0.001674 0.002035 0.015869 0.002196 0.007640 0.000472 0.006856 0.001919 0.004986 0.000992 0.010602
None 0.001850 0.001143 0.000225 0.000480 0.002436 0.004907 0.000189 0.000862 0.002256 0.003233 0.000201 0.000704
Nuclear Periphery 0.000066 0.000042 0.000066 0.000098 0.000060 0.000302 0.000191 0.000062 0.000062 0.000186 0.000149 0.000077
Nuclear Periphery Foci 0.000757 0.000432 0.011102 0.001243 0.000575 0.000212 0.011356 0.000917 0.000631 0.000310 0.011272 0.001052
Nucleolus 0.000441 0.000162 0.000027 0.000118 0.000393 0.000926 0.000097 0.000111 0.000407 0.000586 0.000074 0.000114
Nucleus 0.012297 0.006771 0.008368 0.008940 0.013706 0.071778 0.011307 0.005091 0.013274 0.042862 0.010330 0.006691
Peroxisomes 0.001383 0.002091 0.000216 0.002699 0.001033 0.003031 0.000578 0.001647 0.001141 0.002613 0.000458 0.002084
Vacuole 0.060479 0.057999 0.052398 0.072689 0.050984 0.198227 0.261836* 0.075487 0.053896 0.135851 0.192207 0.074325
Vacuole Periphery 0.003298 0.003065 0.000665 0.001511 0.004324 0.004490 0.000491 0.001897 0.004009 0.003857 0.000549 0.001737

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin -0.12 -4.89 -3.03 -3.05 -0.95 2.07 -5.00 -3.04 -4.00 -0.11 1.08 -6.88 -3.98 -4.26 -1.16
Bud Neck 3.97 8.55 7.51 4.96 -1.66 -10.59 0.16 3.51 11.41 1.16 -7.85 3.81 7.89 12.36 0.72
Bud Site -3.29 1.94 -3.25 -1.02 -4.40 -1.69 -2.01 -3.52 -1.81 0.35 -4.02 -1.40 -5.09 -1.84 -1.50
Cell Periphery 9.59 -0.14 5.46 -1.03 3.32 -5.43 -4.12 3.49 5.79 5.97 -4.10 -2.59 5.22 5.42 5.55
Cytoplasm -2.31 -8.40 -8.96 -7.05 3.30 27.44 10.83 -8.29 -34.62 -14.29 19.41 5.40 -10.93 -29.56 -9.90
Cytoplasmic Foci 1.85 15.54 23.84 23.39 2.52 2.56 4.57 22.20 18.85 9.61 1.58 11.12 31.31 29.67 9.49
Eisosomes 7.68 9.32 9.31 9.86 -0.56 -11.52 -5.61 9.14 12.57 11.05 -7.59 5.04 11.50 13.22 9.84
Endoplasmic Reticulum 1.14 -0.91 4.90 2.60 1.92 -0.86 1.66 5.15 7.23 8.64 0.18 -0.13 6.63 6.89 3.34
Endosome 1.21 6.94 11.88 13.46 3.95 -12.44 -3.51 12.53 17.70 8.17 -10.23 0.01 16.97 22.00 8.90
Golgi -0.38 5.10 5.16 5.30 0.83 3.17 17.00 6.36 3.44 -2.19 2.85 16.29 8.28 5.76 -1.56
Lipid Particles 5.31 0.56 7.55 3.13 3.12 -5.68 -2.18 8.22 7.58 6.15 -3.81 -1.25 11.02 8.01 6.54
Mitochondria 0.24 2.18 1.60 1.65 -2.53 0.27 4.68 3.00 3.69 -3.14 0.57 5.11 3.51 3.60 -3.93
Mitotic Spindle -0.24 -0.50 -3.48 -3.52 -3.26 -2.93 2.01 -2.33 0.94 -3.93 -2.67 1.32 -4.07 -1.52 -5.14
None 1.38 5.12 4.18 1.51 -4.13 -2.34 10.78 3.64 3.64 -1.12 -1.62 11.78 5.38 3.87 -1.57
Nuclear Periphery 1.16 -0.36 -1.63 -2.91 -1.62 -5.11 -8.22 -0.22 4.81 6.07 -4.52 -7.20 -1.36 3.62 4.60
Nuclear Periphery Foci 3.28 -7.10 -5.18 -9.07 6.67 3.55 -12.12 -3.45 -9.78 11.64 4.06 -13.84 -5.72 -13.14 13.14
Nucleolus 1.54 2.25 1.79 2.61 -7.46 -1.29 2.04 1.95 5.17 -1.61 -0.30 2.68 2.43 5.37 -4.52
Nucleus 4.89 2.87 0.08 -4.62 -2.70 -16.74 1.62 8.36 19.12 6.75 -14.25 2.91 5.44 16.58 2.65
Peroxisomes -3.01 7.96 -1.00 0.81 -4.58 -3.78 4.56 -1.11 2.92 -3.12 -4.71 8.04 -1.67 3.00 -5.26
Vacuole 0.60 0.26 -11.52 -12.25 -6.11 -24.71 -15.21 -13.15 14.42 11.42 -21.25 -12.77 -17.75 5.30 7.57
Vacuole Periphery 0.38 4.48 3.66 5.22 -0.70 -0.24 9.92 4.61 4.41 -1.92 0.38 10.72 6.21 6.09 -2.11
Standard name
Human Ortholog
Description Inositol hexakisphosphate and inositol heptakisphosphate kinase; generation of high energy inositol pyrophosphates by Kcs1p is required for many processes such as vacuolar biogenesis, stress response, RNA polymerase I-mediated rRNA transcription and telomere maintenance; inositol hexakisphosphate is also known as IP6; inositol heptakisphosphate is also known as IP7
Localization
Cell Percentages cytoplasm (98%)
Cell Cycle Regulation No
Subcompartmental Group cytoplasm-4

Kcs1

Kcs1


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Kcs1-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available