Standard name
Human Ortholog
Description Chaperone that facilitates the assembly of cytochrome c oxidase; integral to the mitochondrial inner membrane; interacts with a subcomplex of subunits VII, VIIa, and VIII (Cox7p, Cox9p, and Cox8p) but not with the holoenzyme
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0.05 0 0.06 0 0 0 0 0 0
Bud 0 0 0.08 0.06 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0.05 0.09 0.1 0 0 0 0 0 0
Cytoplasm 0.07 0.13 0.1 0.06 0.09 0 – 0 0 0 0 0 0 0.05 0.1 0.14 0.29 0.21 0 0 0 0 0 0
Endoplasmic Reticulum 0 0 0 0 0 0 – 0 0 0 0 0 0 0.05 0 0.08 0.11 0 0 0 0 0 0 0
Endosome 0 0.08 0 0 0.15 0 – 0 0 0 0 0 0 0.05 0.16 0.11 0.11 0 0.07 0.06 0.07 0.06 0.07 0.07
Golgi 0 0.07 0 0 0 0 – 0 0 0 0 0 0.21 0.17 0.12 0.35 0.17 0.26 0 0 0 0.05 0.12 0.07
Mitochondria 0.81 0.63 0.92 0.93 0.78 0.94 – 0.9 0.94 0.94 0.96 0.96 0.77 0.74 0.61 0.11 0.17 0.17 0.73 0.72 0.77 0.74 0.64 0.6
Nucleus 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 – 0 0 0.05 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 – 0.05 0 0.06 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0.07 0 – 0 0 0 0 0 0 0 0.08 0 0 0 0 0 0 0 0.05 0
SpindlePole 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vac/Vac Membrane 0.16 0.28 0.05 0 0.12 0.08 – 0.06 0.06 0 0 0 0.15 0.15 0.12 0.19 0.23 0.28 0.07 0.07 0 0 0.05 0.13
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 7 2 1 0 0 0 – 0 0 0 0 0 3 3 0 2 1 4 8 7 1 1 5 8
Bud 7 1 23 15 6 13 – 32 19 11 9 17 1 1 1 1 0 2 3 2 0 0 0 3
Bud Neck 0 0 1 0 0 0 – 0 0 0 0 0 1 0 0 0 0 0 4 2 2 0 2 2
Bud Site 0 0 4 0 0 3 – 10 9 10 5 15 0 0 0 0 0 1 – – – – – –
Cell Periphery 11 9 3 4 2 2 – 4 6 2 2 3 4 5 5 2 3 7 0 0 1 0 1 0
Cytoplasm 29 31 26 16 23 15 – 30 14 12 10 9 7 9 13 5 10 15 6 4 2 0 1 2
Endoplasmic Reticulum 11 5 4 2 1 2 – 2 2 6 1 0 8 9 3 3 4 2 1 3 1 1 0 1
Endosome 16 18 1 1 39 4 – 8 1 1 0 0 7 9 20 4 4 3 32 18 18 6 15 17
Golgi 6 15 0 2 0 0 – 0 0 0 0 0 38 30 15 13 6 19 11 11 5 5 25 16
Mitochondria 329 146 249 252 200 383 – 834 518 489 352 445 141 134 78 4 6 12 337 215 208 77 143 148
Nucleus 4 3 2 1 4 12 – 22 7 3 7 12 0 0 0 0 0 1 1 1 0 0 1 1
Nuclear Periphery 1 3 0 0 2 12 – 15 21 25 12 17 4 0 0 0 0 0 4 1 1 0 1 0
Nucleolus 2 1 0 1 4 9 – 45 24 31 15 20 1 1 0 1 1 0 1 0 1 1 1 1
Peroxisomes 1 5 1 4 17 2 – 24 0 3 0 2 1 0 10 1 0 2 8 2 8 4 11 7
SpindlePole 3 4 7 2 8 8 – 27 10 8 4 14 1 5 0 0 1 1 3 2 1 1 1 0
Vac/Vac Membrane 65 65 14 5 32 33 – 57 33 16 16 15 28 27 15 7 8 20 30 21 11 2 10 31
Unique Cell Count 404 230 272 271 257 409 924 549 521 366 463 183 181 128 37 35 72 462 299 270 105 226 246
Labelled Cell Count 492 308 336 305 338 498 1110 664 617 433 569 245 233 160 43 44 89 462 299 270 105 226 246


Mitochondria

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 5.0 6.4 4.1 4.5 5.3 4.4 – 4.5 4.0 4.2 4.2 4.0 6.5 6.5 6.2 7.8 8.4 7.9 6.0 6.5 6.9
Std Deviation (1e-4) 0.8 1.4 1.2 2.0 1.7 1.6 – 1.4 1.2 1.0 1.2 1.0 1.2 1.2 1.0 1.4 2.0 1.7 1.5 1.2 1.6
Intensity Change (Log2) – – – 0.14 0.39 0.11 – 0.13 -0.01 0.05 0.04 -0.02 0.69 0.68 0.61 0.94 1.05 0.96 0.57 0.68 0.76

WT3RAP60RAP140RAP220RAP380RAP460RAP540RAP620RAP7000510WT3HU80HU120HU1600510WT3rpd3Δ_1rpd3Δ_2rpd3Δ_30510WT1AF100AF140AF1800510
rapamycinhydroxy-urearpd3 knockoutalpha-factorMultiple Condition Time-Course Intensity PlotsGFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)

Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0
Bud 0 -3.1 0 – 0 0 0 0 0 -3.7 -3.7 -3.0 0 0 -1.7
Bud Neck 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0
Cell Periphery 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm -1.6 -0.2 -3.2 – -4.3 -4.4 -4.5 -3.7 -4.7 -2.3 -1.8 0.2 0 0 2.6
Endoplasmic Reticulum 0 0 0 – 0 0 0 0 0 0 2.2 0 0 0 0
Endosome 0 6.4 0 – 0 0 0 0 0 0 0 6.4 0 0 0
Golgi 0 0 0 – 0 0 0 0 0 7.9 6.9 0 0 0 0
Mitochondria 0 -4.4 0 – 0 0 0 0 0 -4.3 -5.1 -7.4 -12.0 -11.0 -13.2
Nucleus 0 0 2.0 – 1.7 0 0 0 1.8 0 0 0 0 0 0
Nuclear Periphery 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 4.0 0 – 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0.4 0 – 0 0 0 0 0 0 0 0 0 0 0
Vacuole -2.1 3.0 1.5 – 0.6 0.5 -1.5 -0.5 -1.3 3.7 3.6 2.4 0 0 5.7

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 2.7206 2.0402 1.8023 1.9345 1.3275 1.6852 2.0537 1.5204 1.7902 1.552 1.9004 1.5531 2.8046 2.3531 2.2806 2.5106 1.6555 2.7666
Actin 0.0699 0.0131 0.0221 0.0183 0.07 0.0088 0.0524 0.0154 0.0294 0.0296 0.0563 0.0175 0.0457 0.0302 0.0347 0.0727 0.0309 0.0462
Bud 0.001 0.0025 0.0015 0.0162 0.0017 0.0006 0.0012 0.0069 0.0024 0.0059 0.0018 0.0015 0.0011 0.0035 0.0017 0.0105 0.0022 0.001
Bud Neck 0.0016 0.0029 0.0013 0.003 0.001 0.0067 0.0022 0.0012 0.0023 0.0006 0.0013 0.0161 0.0025 0.0015 0.0021 0.0011 0.0008 0.0024
Bud Periphery 0.0017 0.0035 0.0027 0.0367 0.0044 0.0011 0.0025 0.01 0.0049 0.0241 0.0025 0.0038 0.0033 0.0047 0.0033 0.0243 0.0044 0.0028
Bud Site 0.0018 0.0244 0.0061 0.018 0.0022 0.0015 0.006 0.0319 0.0121 0.0042 0.0038 0.0019 0.0026 0.0499 0.0222 0.0029 0.002 0.0024
Cell Periphery 0.0007 0.0018 0.0007 0.0013 0.0028 0.0005 0.0015 0.0014 0.0006 0.0008 0.0004 0.0006 0.0017 0.0028 0.0011 0.0014 0.0007 0.0007
Cytoplasm 0.024 0.0373 0.016 0.0221 0.0081 0.0065 0.0189 0.0624 0.0165 0.0202 0.0066 0.0167 0.0109 0.0345 0.0275 0.0308 0.0031 0.0066
Cytoplasmic Foci 0.0551 0.061 0.0757 0.0892 0.0711 0.0461 0.0678 0.0673 0.0603 0.0451 0.0446 0.0415 0.0476 0.0719 0.0405 0.0264 0.0159 0.0302
Eisosomes 0.0007 0.0005 0.0008 0.0002 0.0005 0.0003 0.0017 0.0004 0.0004 0.0004 0.0003 0.0004 0.0046 0.0015 0.0009 0.0006 0.0004 0.0006
Endoplasmic Reticulum 0.0097 0.0098 0.0024 0.0013 0.0032 0.0053 0.0235 0.005 0.0023 0.0152 0.0056 0.0021 0.0148 0.005 0.0037 0.0006 0.0024 0.0186
Endosome 0.1401 0.1628 0.1252 0.1022 0.138 0.1266 0.1961 0.1633 0.1329 0.1046 0.1497 0.1106 0.1047 0.1926 0.1117 0.027 0.098 0.1266
Golgi 0.0944 0.1219 0.1236 0.0339 0.0678 0.087 0.1014 0.1217 0.1017 0.077 0.1162 0.0937 0.0755 0.1157 0.088 0.0316 0.0999 0.13
Lipid Particles 0.0681 0.0259 0.0233 0.0275 0.011 0.0205 0.0659 0.0226 0.0202 0.0152 0.024 0.0415 0.049 0.0201 0.0136 0.0111 0.0022 0.0275
Mitochondria 0.411 0.4646 0.4999 0.5542 0.5413 0.6298 0.3466 0.4387 0.5633 0.6025 0.4835 0.5952 0.4848 0.3842 0.5749 0.716 0.7128 0.5508
None 0.0195 0.0126 0.017 0.0038 0.0013 0.0013 0.0085 0.0149 0.0144 0.0068 0.0746 0.0051 0.035 0.0223 0.0414 0.0006 0.0008 0.0025
Nuclear Periphery 0.0244 0.005 0.0084 0.0012 0.0012 0.0066 0.0255 0.0014 0.0013 0.002 0.0017 0.0024 0.0218 0.0031 0.0005 0.0002 0.0004 0.0141
Nucleolus 0.0011 0.0016 0.0008 0.001 0.0003 0.0003 0.001 0.0006 0.0004 0.001 0.0005 0.0054 0.0016 0.0009 0.0003 0.0001 0.0001 0.0016
Nucleus 0.0119 0.002 0.0012 0.0037 0.0005 0.0011 0.0067 0.001 0.0008 0.0013 0.0007 0.0022 0.0233 0.0062 0.0004 0.0002 0.0003 0.0034
Peroxisomes 0.0352 0.0227 0.0538 0.0286 0.056 0.0373 0.0427 0.0157 0.0179 0.0274 0.0165 0.0268 0.0495 0.0214 0.0175 0.0374 0.0107 0.0164
Punctate Nuclear 0.0072 0.0016 0.0041 0.0057 0.0009 0.0009 0.0063 0.0005 0.001 0.0009 0.002 0.0008 0.0079 0.0011 0.0004 0.0003 0.0001 0.0023
Vacuole 0.0119 0.0158 0.0075 0.0237 0.0094 0.0049 0.0119 0.0119 0.0089 0.0103 0.0038 0.0083 0.0065 0.0177 0.0072 0.0021 0.0055 0.0065
Vacuole Periphery 0.009 0.0068 0.006 0.0082 0.0073 0.0061 0.0096 0.006 0.006 0.0049 0.0037 0.0058 0.0056 0.0092 0.0064 0.0021 0.0065 0.0068

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 21.3456 17.6139 28.3189 20.2098 8.5155 26.257 23.0038 27.0453 27.1891 27.0616
Translational Efficiency 1.7887 1.3904 1.1753 1.9172 4.6763 1.6272 1.409 1.4294 1.6625 1.6534

Hit Data

Dataset Hit
Protein Concentration ✘
Protein Localization ✔
Gene Expression ✘
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
1199 1685 496 1207 1130 1702 1635 236 2329 3387 2131 1443

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 668.04 769.91 859.81 946.15 755.71 808.23 924.24 929.67 710.58 789.17 909.24 943.45
Standard Deviation 106.94 119.63 121.18 143.56 89.57 110.16 103.83 162.42 108.17 116.55 111.49 146.93
Intensity Change Log 2 — 0.204755 0.364083 0.502134 — 0.096933 0.290435 0.298886 — 0.148529 0.325460 0.397826

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.000904 0.001110 0.010029 0.011440 0.000817 0.001001 0.002248 0.012107 0.000862 0.001055 0.004059 0.011549
Bud Neck 0.018291 0.006928 0.025448 0.010753 0.010669 0.007749 0.010860 0.042304 0.014593 0.007341 0.014255 0.015913
Bud Site 0.017272 0.016129 0.113653 0.066580 0.012740 0.015424 0.047265 0.054120 0.015073 0.015775 0.062717 0.064543
Cell Periphery 0.000658 0.000649 0.000334 0.000831 0.000966 0.000404 0.000186 0.001264 0.000808 0.000526 0.000220 0.000902
Cytoplasm 0.022314 0.007303 0.106877 0.017040 0.010948 0.007079 0.021826 0.034319 0.016799 0.007191 0.041622 0.019866
Cytoplasmic Foci 0.075721 0.043446 0.131158 0.073963 0.064358 0.052360 0.038894 0.130670 0.070208 0.047925 0.060369 0.083237
Eisosomes 0.000283 0.000091 0.000164 0.000136 0.000160 0.000099 0.000057 0.000251 0.000224 0.000095 0.000082 0.000155
Endoplasmic Reticulum 0.001855 0.000599 0.012540 0.002477 0.001213 0.000374 0.001047 0.001500 0.001544 0.000486 0.003722 0.002317
Endosome 0.078980 0.085008 0.063973 0.094281 0.076315 0.084995 0.065069 0.107950 0.077687 0.085002 0.064814 0.096517
Golgi 0.099353 0.129525 0.043111 0.140655 0.119609 0.131459 0.058351 0.113799 0.109181 0.130497 0.054804 0.136263
Lipid Particles 0.017008 0.003140 0.008236 0.004231 0.007612 0.002088 0.000293 0.033295 0.012449 0.002611 0.002142 0.008984
Mitochondria 0.580903 0.629686 0.100680 0.372577 0.616506 0.617111 0.541993 0.245689 0.598177 0.623367 0.439275 0.351824
Mitotic Spindle 0.004225 0.010837 0.101106 0.056035 0.005976 0.010403 0.060603 0.050628 0.005075 0.010619 0.070030 0.055151
None 0.004413 0.000520 0.000968 0.000720 0.000436 0.000385 0.000330 0.003076 0.002483 0.000452 0.000479 0.001105
Nuclear Periphery 0.000414 0.000092 0.001364 0.000388 0.000221 0.000072 0.000222 0.000713 0.000320 0.000082 0.000488 0.000441
Nuclear Periphery Foci 0.000643 0.000251 0.003375 0.000746 0.000197 0.000125 0.000140 0.001366 0.000427 0.000188 0.000893 0.000847
Nucleolus 0.002350 0.001254 0.004697 0.001670 0.001164 0.000489 0.000477 0.007145 0.001775 0.000870 0.001459 0.002566
Nucleus 0.007319 0.003445 0.076395 0.004336 0.002799 0.000859 0.002441 0.018292 0.005126 0.002146 0.019654 0.006618
Peroxisomes 0.030965 0.023625 0.060877 0.029537 0.032525 0.025791 0.015783 0.063543 0.031722 0.024714 0.026279 0.035099
Vacuole 0.018515 0.017860 0.115195 0.070068 0.013877 0.020748 0.096419 0.049843 0.016265 0.019311 0.100789 0.066760
Vacuole Periphery 0.017612 0.018501 0.019820 0.041537 0.020893 0.020983 0.035496 0.028126 0.019204 0.019749 0.031847 0.039343

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin -0.69 -5.10 -5.91 -5.84 -0.68 -0.72 -3.26 -2.92 -2.87 -2.53 -0.97 -5.79 -6.64 -6.52 -4.46
Bud Neck 4.85 -2.44 2.93 -2.47 5.56 1.64 -0.35 -3.68 -4.05 -3.64 4.89 -0.06 -0.67 -4.55 -0.68
Bud Site 0.42 -11.79 -11.22 -12.29 4.93 -1.34 -12.73 -4.93 -4.60 -0.70 -0.46 -16.27 -13.27 -13.38 -0.71
Cell Periphery 0.06 4.55 -1.08 -0.85 -3.57 3.93 5.61 -0.79 -2.55 -3.23 2.58 7.67 -0.59 -2.46 -5.27
Cytoplasm 5.62 -10.57 1.69 -5.17 11.43 2.37 -5.73 -3.85 -4.53 -1.85 6.06 -9.63 -1.62 -7.24 7.98
Cytoplasmic Foci 8.64 -7.48 0.46 -8.42 7.87 3.39 7.55 -6.43 -7.69 -9.02 8.61 3.51 -3.44 -10.36 -6.32
Eisosomes 2.87 1.72 2.17 -3.53 2.08 4.83 8.79 -3.24 -5.74 -7.40 3.67 4.01 1.88 -5.19 -6.26
Endoplasmic Reticulum 2.44 -6.64 -1.10 -5.55 6.43 3.28 0.43 -0.75 -3.93 -1.22 3.63 -4.58 -2.04 -6.69 3.06
Endosome -1.23 3.40 -2.94 -1.87 -5.99 -1.79 2.52 -3.49 -2.56 -5.00 -2.13 4.07 -4.40 -2.79 -8.00
Golgi -4.90 10.23 -5.59 -1.41 -14.57 -1.75 10.51 0.59 1.58 -4.65 -4.67 13.55 -4.23 -0.77 -14.54
Lipid Particles 5.96 3.32 5.28 -1.06 2.89 4.88 6.80 -3.51 -4.30 -4.54 7.46 7.92 1.70 -4.37 -4.69
Mitochondria -3.83 37.74 14.93 20.15 -21.59 -0.06 6.14 17.01 17.61 13.69 -2.82 15.52 21.82 25.69 6.98
Mitotic Spindle -4.70 -11.13 -13.82 -11.63 4.54 -3.13 -15.73 -5.67 -5.09 1.24 -5.58 -19.48 -14.80 -12.95 3.09
None 3.48 3.04 3.26 -1.11 1.28 0.24 1.37 -2.41 -2.44 -2.52 3.48 3.46 2.20 -2.73 -2.73
Nuclear Periphery 2.82 -5.46 0.17 -5.13 6.35 3.04 -0.25 -2.43 -3.25 -2.41 3.76 -2.78 -1.50 -6.37 1.23
Nuclear Periphery Foci 1.96 -5.56 -0.54 -3.43 5.49 2.35 1.38 -2.37 -2.52 -2.46 2.30 -3.44 -2.62 -4.76 0.52
Nucleolus 1.63 -2.00 0.85 -0.89 2.77 1.19 1.22 -2.75 -3.11 -3.12 2.05 0.65 -1.33 -3.23 -2.07
Nucleus 1.96 -10.17 1.54 -0.71 10.68 2.56 0.00 -3.93 -4.47 -3.95 2.77 -7.94 -1.21 -4.02 7.10
Peroxisomes 2.41 -4.86 0.40 -1.87 5.06 2.11 5.67 -4.06 -5.09 -6.51 3.18 2.38 -1.09 -3.68 -3.05
Vacuole 0.32 -14.71 -12.84 -13.49 6.81 -3.76 -20.39 -5.90 -4.78 6.80 -2.20 -24.49 -14.88 -14.18 7.82
Vacuole Periphery -0.60 -0.17 -9.13 -8.70 -7.15 -0.05 -6.11 -1.45 -1.46 1.53 -0.48 -6.77 -8.69 -8.56 -3.01
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Chaperone that facilitates the assembly of cytochrome c oxidase; integral to the mitochondrial inner membrane; interacts with a subcomplex of subunits VII, VIIa, and VIII (Cox7p, Cox9p, and Cox8p) but not with the holoenzyme
Localization
Cell Percentages mitochondrion (95%)
Cell Cycle Regulation No
Subcompartmental Group mito-2

Pet100

Pet100


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Pet100-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available