Standard name
Human Ortholog
Description Reticulon protein; involved in nuclear pore assembly and maintenance of tubular ER morphology; promotes membrane curvature; regulates the ER asymmetry-induced inheritance block during ER stress; role in ER-derived peroxisomal biogenesis; increases tubular ER when overexpressed; mutants have reduced phosphatidylserine transfer between the ER and mitochondria; interacts with exocyst subunit Sec6p, Yip3p, and Sbh1p; member of the RTNLA subfamily
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0.09 0.09 0.1 0.06 0.13 0.17 0.17 0.19 0.28 0.33 0.35 0.09 0.05 0.06 0.11 0 0 0.15 0.1 0.24 0.11 0.15 0.19
Bud 0.06 0 0.05 0 0 0 0.05 0.05 0.06 0.09 0.08 0.06 0 0 0 0.09 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0.11 0.26 0.28 0.25 0.16 0.09 0.11 0.11 0.12 0.13 0.12 0.15 0.4 0.45 0.45 0.37 0.3 0.33 0.09 0.15 0.21 0.16 0.13 0.13
Cytoplasm 0.1 0.11 0.06 0.08 0.07 0.08 0.06 0.06 0.11 0.05 0.07 0 0 0 0.05 0 0.18 0.07 0 0.1 0 0.07 0.06 0
Endoplasmic Reticulum 0.6 0.57 0.51 0.57 0.57 0.72 0.65 0.67 0.57 0.51 0.44 0.42 0.63 0.49 0.54 0.08 0.06 0.07 0.61 0.49 0.41 0.44 0.49 0.47
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0.2 0.05 0.25 0.19 0.29 0.18 0.29 0.28 0.28 0.4 0.33 0.43 0.09 0.1 0.11 0.33 0.36 0.54 0 0.05 0 0 0.08 0.08
Mitochondria 0 0 0 0 0 0 0 0 0.15 0.09 0.14 0.12 0 0 0 0.16 0.32 0.13 0 0.05 0.05 0.1 0.05 0
Nucleus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vac/Vac Membrane 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 2 18 9 10 9 28 49 49 35 73 77 112 11 9 11 10 4 2 33 32 27 8 26 34
Bud 7 8 5 3 5 5 15 15 12 22 20 18 1 5 5 9 2 1 0 4 0 2 1 2
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 1 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 12 54 27 26 23 20 32 32 22 33 28 48 47 82 79 35 39 20 20 47 23 11 23 23
Cytoplasm 11 23 6 8 10 17 17 17 21 12 16 14 4 6 8 3 23 4 5 30 3 5 10 3
Endoplasmic Reticulum 68 119 49 59 80 156 185 194 107 131 103 135 74 88 95 8 8 4 135 155 46 32 89 85
Endosome 0 0 0 0 1 0 0 0 0 0 0 0 0 0 1 0 0 0 0 1 0 0 3 1
Golgi 23 10 24 20 40 40 84 82 52 102 77 138 10 18 20 31 47 33 9 15 2 2 13 14
Mitochondria 0 0 0 0 0 0 1 1 28 22 34 39 0 0 1 15 42 8 7 15 5 7 9 6
Nucleus 0 0 0 0 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1
Nuclear Periphery 0 0 0 0 0 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 1 0 0 0 0 1 1 1 0 2 2 1 0 0 0 1 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vac/Vac Membrane 0 2 1 0 1 0 2 2 0 0 2 2 0 0 0 2 0 2 0 9 0 0 1 0
Unique Cell Count 113 210 96 103 140 217 285 288 187 257 236 318 117 181 177 95 131 61 222 318 113 74 181 179
Labelled Cell Count 124 234 121 126 169 267 386 393 278 399 359 507 147 208 220 114 165 74 222 318 113 74 181 179


Cell Periphery, Endoplasmic Reticulum

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 91.7 78.9 72.2 68.3 61.1 48.6 43.7 43.7 35.4 35.9 34.0 35.0 81.2 78.2 76.0 62.4 74.6 88.3 71.4 74.7 79.0
Std Deviation (1e-4) 22.0 20.7 19.7 16.0 14.8 12.3 9.9 9.9 9.0 8.9 7.3 7.3 19.5 20.8 19.6 20.1 29.1 29.1 22.7 23.6 23.8
Intensity Change (Log2) – – – -0.08 -0.24 -0.57 -0.72 -0.72 -1.03 -1.01 -1.09 -1.05 0.17 0.12 0.07 -0.21 0.05 0.29 -0.02 0.05 0.13


Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches 0.1 -0.8 0.9 1.8 1.8 2.1 3.8 4.4 4.9 0 -1.4 -1.0 0.3 -2.0 0
Bud 0 0 0 0 0 0.4 1.1 1.0 0.2 0 0 0 1.1 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cell Periphery -0.5 -2.2 -4.3 -4.0 -4.0 -3.4 -3.4 -3.6 -2.9 1.8 2.8 2.7 1.3 0.3 0.6
Cytoplasm 0.4 0.3 0.5 -0.1 -0.1 1.4 0 0.2 0 0 0 0 0 2.5 0
Endoplasmic Reticulum 0.9 0.9 3.6 2.4 2.9 1.0 0 -1.2 -1.5 1.8 -0.4 0.4 -6.4 -7.7 -5.7
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi -0.9 0.6 -1.3 0.8 0.7 0.5 2.6 1.4 3.2 -3.3 -3.3 -2.9 1.2 1.7 3.7
Mitochondria 0 0 0 0 0 4.0 3.0 3.9 3.6 0 0 0 4.1 6.1 0
Nucleus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vacuole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 80.7656 86.506 78.8437 78.6783 71.5718 81.9994 77.6579 86.5182 76.0469 82.307 63.1179 83.8709 90.1822 94.4281 93.1449 91.2368 87.6449 92.9237
Actin 0.0327 0.0071 0.0407 0.0265 0.0251 0.0117 0.0725 0.0082 0.042 0.0335 0.062 0.02 0.057 0.0089 0.0128 0.0013 0.0184 0.003
Bud 0.0015 0.0007 0.0018 0.0003 0.0007 0.0003 0.0038 0.0008 0.0023 0.0012 0.0041 0.0004 0.0005 0.0005 0.0007 0.0001 0.0011 0.0001
Bud Neck 0.0078 0.0044 0.0076 0.0029 0.003 0.0154 0.0113 0.0069 0.0086 0.0227 0.0575 0.0243 0.0057 0.0042 0.0065 0.0044 0.0081 0.0117
Bud Periphery 0.0051 0.0022 0.01 0.0021 0.0051 0.0017 0.0154 0.0034 0.0083 0.0086 0.0246 0.0031 0.0022 0.0035 0.0045 0.0009 0.0054 0.0014
Bud Site 0.0075 0.0309 0.0081 0.0007 0.0007 0.0019 0.0354 0.04 0.0187 0.0022 0.0094 0.0004 0.0024 0.0213 0.0036 0.0003 0.0018 0.0002
Cell Periphery 0.1265 0.2123 0.1944 0.1667 0.0792 0.0686 0.1758 0.2734 0.1716 0.2383 0.1882 0.1585 0.131 0.2554 0.1738 0.1561 0.0876 0.1551
Cytoplasm 0.0151 0.0008 0.0008 0.0003 0.0004 0.0002 0.011 0.0012 0.0114 0.0006 0.0029 0.001 0.0011 0.0013 0.0005 0.0002 0.0003 0.0003
Cytoplasmic Foci 0.0253 0.0004 0.0003 0.0011 0.0396 0.0018 0.0407 0.0002 0.0081 0.0002 0.0056 0.0046 0.001 0.0002 0.0003 0.0001 0.0001 0.0001
Eisosomes 0.5966 0.6251 0.5927 0.5648 0.7336 0.7738 0.4818 0.5659 0.5458 0.5846 0.4881 0.6313 0.6513 0.5494 0.6385 0.6591 0.7755 0.6895
Endoplasmic Reticulum 0.0266 0.0414 0.0771 0.1129 0.0168 0.0413 0.0319 0.0487 0.0637 0.0418 0.0138 0.093 0.044 0.0867 0.08 0.1256 0.0301 0.0868
Endosome 0.0063 0.0011 0.0008 0.0047 0.0003 0.0023 0.0088 0.0003 0.0078 0.0015 0.009 0.0013 0.005 0.0006 0.0011 0.0006 0.0005 0.0007
Golgi 0.017 0.0132 0.0075 0.017 0.0038 0.0367 0.0095 0.0018 0.0086 0.0106 0.0112 0.0253 0.0116 0.0044 0.0093 0.0133 0.0062 0.0196
Lipid Particles 0.014 0.0039 0.0034 0.0056 0.0026 0.0066 0.0145 0.0023 0.005 0.0046 0.0075 0.002 0.0058 0.0059 0.0046 0.0022 0.0018 0.0015
Mitochondria 0.0509 0.01 0.0143 0.0651 0.058 0.0179 0.0305 0.009 0.0543 0.013 0.0758 0.0072 0.0337 0.0131 0.0326 0.0051 0.0282 0.0089
None 0.0043 0.0007 0.0034 0.001 0.0061 0.0007 0.0094 0.0009 0.0072 0.0008 0.0097 0.0046 0.0024 0.0011 0.0013 0.0009 0.0013 0.0008
Nuclear Periphery 0.0182 0.0285 0.0228 0.0124 0.0051 0.0088 0.0209 0.024 0.0178 0.0174 0.0073 0.0138 0.0229 0.0275 0.0171 0.0224 0.0113 0.0144
Nucleolus 0.0045 0.0009 0.001 0.0006 0.0141 0.0008 0.0035 0.0009 0.0026 0.0008 0.0024 0.0003 0.0064 0.0007 0.0007 0.0003 0.0058 0.0002
Nucleus 0.0016 0.0008 0.0008 0.0004 0.0008 0.0005 0.0017 0.0008 0.0011 0.0008 0.0021 0.0005 0.0017 0.0007 0.0006 0.0003 0.0017 0.0003
Peroxisomes 0.0191 0.0004 0.0004 0.0017 0.0017 0.0035 0.0027 0.0003 0.0021 0.0003 0.004 0.0003 0.001 0.0003 0.0012 0.0002 0.0003 0.0001
Punctate Nuclear 0.0012 0.0002 0.0001 0.0001 0.001 0.0007 0.0029 0.0001 0.0003 0.0001 0.0011 0.0002 0.002 0.0001 0.0001 0 0.0001 0
Vacuole 0.0133 0.0129 0.0092 0.0099 0.0016 0.0027 0.0132 0.0098 0.0097 0.0122 0.0109 0.0053 0.0086 0.0123 0.008 0.0051 0.0108 0.0036
Vacuole Periphery 0.0049 0.0021 0.0028 0.0034 0.0007 0.0021 0.0029 0.0012 0.0031 0.0041 0.0027 0.0027 0.0029 0.0019 0.0024 0.0015 0.0035 0.0016

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 319.9624 328.7921 331.3484 369.9557 294.8221 265.7633 334.9683 309.2743 273.8126 336.5165
Translational Efficiency 1.5297 1.5218 1.559 1.1757 1.425 1.9642 1.5315 1.4305 1.8564 1.535

Hit Data

Dataset Hit
Protein Concentration ✘
Protein Localization ✘
Gene Expression ✘
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
1954 1643 2122 1651 2189 1659 1486 1872 4143 3302 3608 3523

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 4895.99 5799.89 6123.81 5858.50 5000.49 5533.78 6192.05 5955.24 4951.20 5666.19 6151.92 5909.90
Standard Deviation 1290.55 1438.75 1144.92 1284.84 1139.58 1298.07 1093.90 1358.59 1214.25 1376.32 1124.69 1325.42
Intensity Change Log 2 — 0.244425 0.322829 0.258931 — 0.146196 0.308348 0.252090 — 0.195628 0.315530 0.255478

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.003876 0.005625 0.004235 0.007003 0.003059 0.008160 0.003574 0.007002 0.003444 0.006899 0.003963 0.007002
Bud Neck 0.003643 0.005000 0.008549 0.004232 0.002991 0.004300 0.005252 0.003839 0.003299 0.004648 0.007191 0.004023
Bud Site 0.001565 0.002373 0.008548 0.013018 0.000889 0.003314 0.002982 0.015092 0.001208 0.002846 0.006256 0.014120
Cell Periphery 0.196096* 0.220898* 0.447085* 0.654395* 0.195013* 0.258420* 0.648243* 0.622134* 0.195524* 0.239750* 0.529934* 0.637252*
Cytoplasm 0.000036 0.000084 0.000348 0.001651 0.000020 0.000049 0.000043 0.001777 0.000028 0.000066 0.000222 0.001718
Cytoplasmic Foci 0.001018 0.000697 0.001339 0.002409 0.001515 0.000925 0.000398 0.003561 0.001280 0.000811 0.000952 0.003021
Eisosomes 0.187379* 0.249396* 0.055019 0.030750 0.182140* 0.179396* 0.082595 0.018566 0.184611* 0.214226* 0.066376 0.024276
Endoplasmic Reticulum 0.415010* 0.338348* 0.262945* 0.125142* 0.407222* 0.372863* 0.123496* 0.150748* 0.410895* 0.355689* 0.205512* 0.138748*
Endosome 0.012911 0.011326 0.011484 0.008500 0.012275 0.012837 0.005815 0.009317 0.012575 0.012085 0.009150 0.008934
Golgi 0.070534 0.066899 0.032627 0.033297 0.096373 0.068483 0.025831 0.043448 0.084186 0.067695 0.029828 0.038691
Lipid Particles 0.023055 0.012482 0.072203 0.042168 0.008583 0.008938 0.006728 0.046290 0.015409 0.010701 0.045236 0.044358
Mitochondria 0.008909 0.007838 0.002398 0.003245 0.015284 0.007307 0.003159 0.005336 0.012277 0.007571 0.002711 0.004356
Mitotic Spindle 0.002847 0.002875 0.002637 0.003245 0.002455 0.002925 0.003066 0.002931 0.002640 0.002900 0.002814 0.003078
None 0.001350 0.000982 0.000375 0.000388 0.001914 0.000953 0.000303 0.000778 0.001648 0.000968 0.000346 0.000595
Nuclear Periphery 0.042156 0.038766 0.031815 0.019949 0.039647 0.041950 0.035372 0.018597 0.040830 0.040366 0.033280 0.019231
Nuclear Periphery Foci 0.000707 0.000553 0.001317 0.000939 0.000568 0.000626 0.000577 0.000980 0.000634 0.000590 0.001012 0.000961
Nucleolus 0.000251 0.000247 0.000195 0.000240 0.000337 0.000230 0.000287 0.000216 0.000297 0.000238 0.000233 0.000227
Nucleus 0.000293 0.000350 0.000392 0.000583 0.000322 0.000302 0.000343 0.000555 0.000308 0.000326 0.000372 0.000568
Peroxisomes 0.000908 0.000595 0.001244 0.001176 0.000769 0.000603 0.000422 0.001626 0.000834 0.000599 0.000905 0.001415
Vacuole 0.015188 0.022830 0.043341 0.030806 0.010370 0.015717 0.036633 0.028184 0.012643 0.019256 0.040578 0.029412
Vacuole Periphery 0.012267 0.011838 0.011902 0.016864 0.018254 0.011701 0.014881 0.019024 0.015431 0.011769 0.013129 0.018012

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin -1.62 -0.49 -2.30 -0.99 -2.10 -3.40 -0.57 -3.59 0.56 -2.69 -3.74 -0.94 -4.10 -0.23 -3.39
Bud Neck -2.35 -6.89 -1.14 1.18 5.97 -3.08 -3.90 -2.19 0.73 2.09 -3.83 -8.32 -2.28 1.40 6.33
Bud Site -1.52 -6.60 -6.83 -5.98 -2.46 -3.18 -3.83 -8.53 -6.51 -6.99 -3.46 -7.67 -10.90 -8.87 -6.01
Cell Periphery -3.29 -31.00* -51.79* -46.34* -21.10 -8.44 -55.16* -51.40* -39.41* 2.78 -8.31 -55.64 -72.86 -60.43* -14.93
Cytoplasm -1.02 -4.75 -3.07 -2.93 -2.49 -1.75 -1.98 -5.96 -5.86 -5.89 -1.44 -5.01 -5.75 -5.56 -5.07
Cytoplasmic Foci 1.37 -1.33 -3.06 -3.45 -2.31 4.70 17.01 -4.56 -5.63 -6.82 3.87 2.28 -5.42 -6.47 -6.01
Eisosomes -6.85 20.75 25.25 29.89* 6.89 0.36 15.02 30.09 26.90 14.83 -4.94 26.15 39.11 39.99* 15.79
Endoplasmic Reticulum 7.99 17.28 36.42* 25.77 18.79 3.85 37.57* 34.03* 27.43 -4.12 8.44 34.09 49.68 37.36 12.85
Endosome 3.42 3.17 8.64 5.10 5.71 -1.38 20.93 6.85 7.45 -9.02 1.59 11.96 10.98 8.70 0.69
Golgi 1.17 15.03 13.98 12.42 -0.30 8.38 25.67 17.55 9.04 -8.59 7.17 28.59 22.28 14.93 -6.07
Lipid Particles 5.03 -12.49 -5.19 -8.80 6.38 -0.41 2.10 -13.03 -12.62 -13.43 4.21 -12.84 -12.51 -15.07 0.33
Mitochondria 0.98 9.31 7.17 5.01 -2.45 6.35 10.43 7.19 1.96 -2.79 5.59 13.76 9.61 4.69 -3.75
Mitotic Spindle -0.29 1.97 -1.90 -1.76 -2.67 -4.20 -6.10 -1.89 -0.09 0.43 -3.11 -2.38 -2.67 -1.30 -1.80
None 3.26 8.97 8.92 7.74 -0.38 8.67 17.05 3.27 0.50 -1.45 8.60 17.68 5.46 1.97 -1.43
Nuclear Periphery 2.09 6.97 16.66 14.01 10.09 -1.56 2.93 18.22 17.99 13.05 0.43 7.33 24.65 22.63 16.25
Nuclear Periphery Foci 3.63 -7.42 -2.06 -3.89 2.90 -2.49 -0.41 -9.96 -8.20 -9.04 2.09 -8.09 -5.66 -7.02 0.66
Nucleolus -0.06 4.18 -0.19 -0.12 -2.14 5.66 2.62 5.87 0.42 4.00 3.58 5.46 3.27 0.11 -0.40
Nucleus -1.47 -4.76 -4.06 -2.73 -2.85 0.60 -0.51 -2.45 -2.61 -2.24 -0.88 -2.77 -4.10 -3.63 -3.29
Peroxisomes 2.49 -2.03 -1.06 -2.23 0.23 1.59 4.46 -4.05 -4.62 -5.73 2.90 -0.70 -3.55 -4.81 -2.84
Vacuole -5.04 -15.37 -8.85 -4.30 5.88 -5.08 -16.59 -12.54 -8.10 4.29 -7.22 -22.70 -14.98 -8.46 7.61
Vacuole Periphery 0.57 0.51 -5.15 -5.72 -5.99 7.97 3.89 -0.83 -10.00 -5.28 6.46 4.09 -4.02 -10.98 -8.65
Standard name
Human Ortholog
Description Reticulon protein; involved in nuclear pore assembly and maintenance of tubular ER morphology; promotes membrane curvature; regulates the ER asymmetry-induced inheritance block during ER stress; role in ER-derived peroxisomal biogenesis; increases tubular ER when overexpressed; mutants have reduced phosphatidylserine transfer between the ER and mitochondria; interacts with exocyst subunit Sec6p, Yip3p, and Sbh1p; member of the RTNLA subfamily
Localization
Cell Percentages ER (5%), cytoplasm (2%), mixed (59%)
Cell Cycle Regulation No
Subcompartmental Group N/A

Rtn1

Rtn1


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Rtn1-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available