Standard name
Human Ortholog
Description Adaptor protein involved in vesicle-mediated vacuolar protein sorting; multivalent adaptor protein; facilitates vesicle-mediated vacuolar protein sorting by ensuring high-fidelity vesicle docking and fusion, which are essential for targeting of vesicles to the endosome; required for vacuole inheritance
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0.06 0.09 0.08 0.14 0.14 0.11 0.11 0.11 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 0 0.05 0.07 0.07 0.08 0.07 0.06 0.08 0.06 0.09 0.06 0 0.12 0.12 0.17 0.34 0.32 0.28 0 0 0 0 0 0
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.06 0.06 0 0 0 0 0 0
Endosome 0.63 0.5 0.39 0.37 0.4 0.12 0.07 0 0 0 0 0 0.45 0.45 0.38 0.47 0.45 0.46 0.82 0.76 0.71 0.76 0.75 0.78
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0.12 0.23 0 0.18 0.15 0.47 0.55 0.46 0.62 0.69 0.66 0.57 0 0 0 0.11 0.07 0 0 0 0 0 0.06 0.06
Nucleus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0.05 0.06 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0.16 0 0.1 0.22 0.21 0.26 0.19 0.18 0.16 0.15 0.16 0.26 0 0 0.11 0 0 0 0 0 0.06 0 0 0
SpindlePole 0.47 0.34 0.7 0.54 0.49 0.43 0.41 0.5 0.37 0.32 0.36 0.42 0.54 0.56 0.52 0.25 0.34 0.37 0.1 0.09 0.15 0.12 0.06 0
Vac/Vac Membrane 0 0.07 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.07 0.05 0 0 0 0 0 0
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 2 6 2 0 1 0 0 0 1 0 0 0 10 10 6 1 4 4 0 3 6 0 4 5
Bud 9 13 11 7 21 50 52 84 73 72 78 73 8 8 4 0 4 4 0 1 1 1 1 1
Bud Neck 0 1 16 4 1 0 6 9 4 3 5 1 18 18 9 0 2 0 1 4 1 1 2 2
Bud Site 0 0 3 0 0 5 6 13 13 23 28 24 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 1 0 0 0 1 0 0 0 2 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 20 20 39 21 25 38 36 47 32 60 40 25 54 54 65 49 66 48 5 2 2 2 10 4
Endoplasmic Reticulum 0 3 2 2 1 3 0 2 0 0 1 0 10 5 3 2 12 11 0 0 1 2 4 2
Endosome 307 185 211 108 134 72 48 26 13 6 6 27 209 206 143 68 92 79 455 355 431 275 444 425
Golgi 1 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 3 3 3 2 5 6
Mitochondria 60 84 16 53 51 276 358 286 323 457 463 393 1 1 0 16 15 6 9 17 10 11 34 32
Nucleus 2 2 0 2 0 3 3 4 1 2 0 1 0 0 3 0 0 0 0 1 0 0 0 0
Nuclear Periphery 1 3 2 0 1 3 1 0 1 2 1 3 2 2 1 2 0 0 1 1 0 1 0 1
Nucleolus 25 21 8 5 4 16 19 16 12 18 16 22 4 4 5 0 0 1 2 4 3 1 3 1
Peroxisomes 80 10 54 66 68 153 124 111 83 99 113 175 2 3 41 2 1 1 11 14 36 12 16 18
SpindlePole 229 126 380 159 163 249 270 308 191 215 253 290 249 260 196 37 71 63 55 40 92 43 34 23
Vac/Vac Membrane 21 24 4 4 3 5 4 2 1 0 1 3 9 6 16 6 14 9 4 12 3 5 21 12
Unique Cell Count 487 369 540 294 331 582 652 622 518 666 702 685 460 461 377 146 206 171 555 471 603 363 591 544
Labelled Cell Count 757 498 750 431 473 873 928 908 748 957 1007 1037 576 577 492 183 282 226 555 471 603 363 591 544


Endosome

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 4.8 4.9 4.4 4.0 3.8 3.1 3.0 3.3 3.0 2.7 2.8 2.9 5.8 5.8 5.8 5.9 6.3 6.6 5.7 5.9 6.0
Std Deviation (1e-4) 0.6 0.8 0.8 1.2 1.2 0.8 1.1 1.0 0.9 0.9 0.8 0.6 0.9 0.9 1.3 1.7 1.8 2.0 1.3 1.4 1.5
Intensity Change (Log2) – – – -0.13 -0.2 -0.47 -0.53 -0.41 -0.52 -0.69 -0.66 -0.6 0.42 0.42 0.41 0.43 0.53 0.6 0.38 0.43 0.47

WT3RAP60RAP140RAP220RAP300RAP380RAP460RAP540RAP620RAP70002468WT3HU80HU120HU16002468WT3rpd3Δ_1rpd3Δ_2rpd3Δ_302468WT1AF100AF140AF18002468
rapamycinhydroxy-urearpd3 knockoutalpha-factorMultiple Condition Time-Course Intensity PlotsGFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)

Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches 0 0 0 0 0 0 0 0 0 2.6 2.6 0 0 0 0
Bud 0 0 0 0 0 0 0 0 0 -0.3 -0.3 -1.1 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0.8 0.8 -0.5 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cell Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 0 0.2 -0.5 -1.2 0.2 -0.7 1.1 -1.1 -2.8 2.5 2.4 4.7 8.4 8.7 7.3
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 0 2.6 0 0 0 0 0
Endosome 0 0 0 0 0 0 0 0 0 2.0 1.8 -0.3 1.6 1.4 1.7
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0 0 0 0 0 0 0 0 0 -3.3 -3.4 -3.4 4.1 2.6 0.4
Nucleus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 -0.9 -0.9 -0.2 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 -6.6 -6.4 0.4 -3.4 -4.4 -4.0
SpindlePole 0 0 0 0 0 0 0 0 0 -5.3 -4.6 -5.7 -9.9 -9.0 -7.9
Vacuole 0 0 0 0 0 0 0 0 0 1.7 0 3.6 0 0 0

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration – – – – – – – – – – – – – – – – – –
Actin – – – – – – 0.0073 0.0006 0.0009 0.0008 0.0008 0.0025 0.001 0.0014 0.0009 0.0001 0.0019 0.0003
Bud – – – – – – 0.0002 0.0002 0.0005 0.0001 0 0.0001 0.0004 0.001 0.0033 0.0009 0.0002 0.0013
Bud Neck – – – – – – 0.0006 0.0007 0.0009 0.0003 0.0002 0.0007 0.0005 0.0005 0.0008 0.0003 0.0002 0.0007
Bud Periphery – – – – – – 0.0003 0.0003 0.0007 0.0001 0 0.0001 0.0005 0.0004 0.0018 0.0001 0.0001 0.0008
Bud Site – – – – – – 0.0007 0.0015 0.001 0.0002 0.0001 0.0002 0.0021 0.0046 0.0021 0.0006 0.0001 0.0014
Cell Periphery – – – – – – 0.0001 0.0003 0.0001 0 0 0.0001 0.0004 0.0001 0.0001 0.0002 0 0.0002
Cytoplasm – – – – – – 0.0051 0.0223 0.0048 0.002 0.0039 0.0129 0.0114 0.0123 0.0086 0.0039 0.0061 0.0114
Cytoplasmic Foci – – – – – – 0.2559 0.2791 0.2746 0.2139 0.2788 0.2934 0.2637 0.2882 0.2744 0.2919 0.3151 0.2847
Eisosomes – – – – – – 0.0002 0.0001 0.0002 0.0001 0 0 0.0001 0.0001 0.0001 0 0.0001 0
Endoplasmic Reticulum – – – – – – 0.0008 0.0013 0.0003 0.0002 0.0001 0.001 0.0011 0.0006 0.0004 0.0001 0.0003 0.0005
Endosome – – – – – – 0.2739 0.257 0.2366 0.242 0.2379 0.1996 0.2518 0.3248 0.2369 0.2169 0.2043 0.2086
Golgi – – – – – – 0.0292 0.0299 0.034 0.0349 0.0306 0.0249 0.0247 0.0277 0.0311 0.0289 0.033 0.0232
Lipid Particles – – – – – – 0.2242 0.1327 0.1692 0.2268 0.1373 0.2359 0.2007 0.1293 0.1641 0.1785 0.1308 0.2048
Mitochondria – – – – – – 0.0059 0.011 0.005 0.0384 0.005 0.0032 0.0038 0.004 0.0065 0.0067 0.0129 0.0023
None – – – – – – 0.01 0.0573 0.0429 0.0313 0.0219 0.036 0.0429 0.03 0.0451 0.0441 0.0415 0.0427
Nuclear Periphery – – – – – – 0.0009 0.0006 0.0003 0.0003 0.0002 0.0016 0.0009 0.0007 0.0006 0.0001 0.0003 0.0006
Nucleolus – – – – – – 0.0004 0.0012 0.0005 0.0001 0.0002 0.0008 0.0009 0.0022 0.0013 0.006 0.0003 0.0005
Nucleus – – – – – – 0.0004 0.0005 0.0004 0.0001 0.0002 0.0008 0.0009 0.0016 0.0008 0.001 0.0002 0.0005
Peroxisomes – – – – – – 0.1754 0.1862 0.2168 0.2054 0.2575 0.1663 0.1795 0.1559 0.2076 0.2143 0.2454 0.2019
Punctate Nuclear – – – – – – 0.0038 0.0071 0.0041 0.0013 0.0236 0.0161 0.007 0.005 0.0084 0.002 0.0047 0.0093
Vacuole – – – – – – 0.0041 0.0089 0.0054 0.0012 0.0012 0.0033 0.0048 0.0081 0.004 0.0026 0.0016 0.0034
Vacuole Periphery – – – – – – 0.0008 0.0011 0.0007 0.0006 0.0004 0.0007 0.0009 0.0014 0.0009 0.0007 0.001 0.0008

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 6.4151 6.3719 6.6196 4.5467 4.1588 6.4116 6.6037 7.3922 5.6745 6.6696
Translational Efficiency 0.5999 0.7213 0.5032 0.5418 0.8924 0.5702 0.9295 0.7344 0.9734 0.8069

Hit Data

Dataset Hit
Protein Concentration –
Protein Localization ✘
Gene Expression ✘
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
133 1409 373 1216 2336 1173 470 1023 2469 2582 843 2239

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 915.45 756.14 923.36 815.11 665.06 743.44 873.20 814.15 678.55 750.37 895.39 814.67
Standard Deviation 146.42 111.15 96.41 122.80 82.95 99.92 104.35 109.57 104.21 106.39 103.94 116.94
Intensity Change Log 2 — -0.275828 0.012412 -0.167486 — 0.160732 0.392828 0.291810 — -0.075832 0.184847 0.043827

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.004401 0.000289 0.001017 0.002685 0.000174 0.000163 0.000542 0.000632 0.000402 0.000232 0.000752 0.001747
Bud Neck 0.012740 0.005566 0.017426 0.010079 0.007864 0.008301 0.009848 0.014295 0.008127 0.006808 0.013201 0.012005
Bud Site 0.040089 0.002777 0.012207 0.026591 0.001252 0.001749 0.008487 0.018658 0.003344 0.002310 0.010133 0.022967
Cell Periphery 0.000127 0.000037 0.000061 0.000047 0.000057 0.000055 0.000034 0.000040 0.000061 0.000045 0.000046 0.000044
Cytoplasm 0.007677 0.006364 0.004906 0.011622 0.006809 0.007843 0.003954 0.017306 0.006856 0.007036 0.004375 0.014219
Cytoplasmic Foci 0.145410 0.191881 0.148027 0.218007 0.167100 0.146951 0.146239 0.166847 0.165931 0.171469 0.147030 0.194632
Eisosomes 0.000051 0.000042 0.000058 0.000029 0.000063 0.000067 0.000039 0.000040 0.000063 0.000053 0.000047 0.000034
Endoplasmic Reticulum 0.000925 0.000176 0.001465 0.000425 0.000324 0.000198 0.000760 0.000245 0.000357 0.000186 0.001072 0.000343
Endosome 0.507483 0.585964 0.489819 0.394088 0.569324 0.577225 0.492086 0.496104 0.565993 0.581994 0.491083 0.440699
Golgi 0.031368 0.064559 0.015590 0.017239 0.077848 0.060695 0.006881 0.015158 0.075344 0.062804 0.010735 0.016288
Lipid Particles 0.005508 0.037707 0.018884 0.014430 0.066408 0.066210 0.021513 0.016077 0.063127 0.050656 0.020350 0.015182
Mitochondria 0.007741 0.008461 0.001289 0.003156 0.015278 0.021492 0.000636 0.003353 0.014872 0.014381 0.000925 0.003246
Mitotic Spindle 0.046638 0.011111 0.042924 0.083073 0.002278 0.002667 0.107646 0.056788 0.004668 0.007275 0.079008 0.071063
None 0.000033 0.000282 0.000131 0.000098 0.000784 0.000333 0.000079 0.000473 0.000743 0.000305 0.000102 0.000269
Nuclear Periphery 0.000251 0.000133 0.001262 0.000404 0.000139 0.000211 0.001296 0.000330 0.000145 0.000169 0.001281 0.000370
Nuclear Periphery Foci 0.002822 0.001892 0.024194 0.008774 0.000666 0.001076 0.035923 0.007181 0.000782 0.001521 0.030733 0.008046
Nucleolus 0.001098 0.000929 0.010170 0.001414 0.000929 0.002520 0.005929 0.004395 0.000938 0.001651 0.007805 0.002776
Nucleus 0.000926 0.001791 0.016662 0.002469 0.003000 0.004537 0.004484 0.006474 0.002889 0.003038 0.009872 0.004299
Peroxisomes 0.104101 0.068689 0.119221 0.156586 0.070438 0.081964 0.109805 0.124466 0.072252 0.074720 0.113972 0.141910
Vacuole 0.072014 0.009652 0.072249 0.047317 0.007980 0.013177 0.043108 0.048484 0.011430 0.011254 0.056002 0.047851
Vacuole Periphery 0.008598 0.001697 0.002436 0.001466 0.001285 0.002567 0.000711 0.002653 0.001679 0.002092 0.001474 0.002009

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin 1.40 1.11 0.49 -4.39 -2.46 0.23 -3.45 -3.69 -3.86 0.14 0.98 -1.75 -4.06 -4.99 -2.61
Bud Neck 2.43 -1.41 0.03 -5.15 2.15 -0.38 -2.90 -4.27 -3.70 -0.94 1.17 -4.59 -4.82 -6.09 0.74
Bud Site 3.32 2.39 1.05 -9.65 -5.01 -1.41 -7.41 -7.92 -7.63 -3.00 1.39 -7.11 -11.16 -12.27 -5.94
Cell Periphery 3.15 1.99 2.63 -2.10 1.92 0.11 0.68 0.87 1.62 0.48 0.96 0.32 0.85 -0.36 1.53
Cytoplasm 0.81 0.67 -3.73 -5.42 -5.01 -0.75 -0.58 -5.61 -5.01 -4.55 -0.25 -0.38 -7.37 -7.34 -6.49
Cytoplasmic Foci -4.21 -0.15 -5.58 -2.57 -7.62 3.54 3.95 0.80 -2.33 -2.99 -1.44 4.29 -4.78 -3.40 -8.08
Eisosomes 1.18 -0.74 1.85 2.26 5.30 -0.65 1.37 2.51 3.40 1.24 1.49 0.60 4.05 4.06 4.50
Endoplasmic Reticulum 2.88 -1.45 1.32 -3.59 2.92 0.90 -3.96 -0.31 -2.99 4.40 1.36 -4.84 -1.02 -4.40 4.72
Endosome -3.76 0.25 4.28 19.47 6.74 -0.47 7.87 9.49 8.55 -0.70 -1.75 8.95 17.91 19.77 4.46
Golgi -5.34 2.09 2.07 17.40 -0.16 4.61 28.40 23.37 15.07 -5.52 4.13 26.17 24.25 23.01 -3.91
Lipid Particles -9.80 -3.74 -4.36 7.32 1.12 -0.18 10.57 13.91 10.58 2.16 2.95 11.57 14.71 12.78 2.42
Mitochondria -0.38 1.44 0.99 4.32 -2.05 -2.45 12.22 9.29 8.00 -4.30 0.29 12.06 9.45 9.01 -4.03
Mitotic Spindle 3.29 0.83 -1.98 -13.25 -5.09 -0.78 -10.81 -12.34 -12.22 3.98 -1.56 -11.92 -18.43 -17.83 0.31
None -2.42 -2.07 -2.55 1.21 -0.00 1.46 2.22 0.70 -1.13 -2.54 1.51 2.16 1.42 -0.24 -2.32
Nuclear Periphery 3.17 -2.99 -2.54 -6.37 2.30 -1.36 -5.03 -6.74 -5.40 3.50 -0.48 -6.11 -8.04 -8.35 4.11
Nuclear Periphery Foci 1.72 -4.42 -2.32 -5.82 3.39 -1.82 -7.83 -5.30 -4.81 6.04 -2.49 -9.65 -8.37 -7.55 6.82
Nucleolus 1.34 -3.71 0.01 -2.86 3.88 -2.11 -4.59 -4.32 -2.97 1.44 -1.19 -6.17 -4.48 -3.70 3.99
Nucleus -0.79 -3.80 -2.76 -2.03 3.08 -1.19 -3.01 -2.78 -1.63 0.47 -0.21 -4.36 -2.65 -2.55 3.03
Peroxisomes 2.03 -0.97 -2.85 -11.23 -2.86 -2.26 -3.91 -7.49 -4.89 -1.50 -0.75 -5.81 -12.14 -11.66 -3.39
Vacuole 5.27 0.64 1.03 -13.90 0.60 -3.16 -9.23 -12.34 -11.03 -1.20 0.60 -11.70 -16.95 -17.65 -0.51
Vacuole Periphery 1.77 1.56 1.86 0.97 2.49 -2.41 2.53 -1.52 0.16 -2.22 -1.26 0.43 -0.51 0.53 -0.89
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Adaptor protein involved in vesicle-mediated vacuolar protein sorting; multivalent adaptor protein; facilitates vesicle-mediated vacuolar protein sorting by ensuring high-fidelity vesicle docking and fusion, which are essential for targeting of vesicles to the endosome; required for vacuole inheritance
Localization
Cell Percentages endosome (42%)
Cell Cycle Regulation No
Subcompartmental Group N/A

Pep7

Pep7


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Pep7-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available