Standard name
Human Ortholog
Description Ubiquitin-conjugating enzyme that regulates gluconeogenesis; negatively regulates gluconeogenesis by mediating the glucose-induced ubiquitination of fructose-1,6-bisphosphatase (FBPase); cytoplasmic enzyme that catalyzes the ubiquitination of histones in vitro
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 0.52 0.81 0.82 0.28 0.21 0.45 0.28 0.26 0.27 0.3 0.26 0.28 0.46 0.43 0.34 0.73 0.61 0.59 0.69 0.6 0.71 0.54 0.52 0.49
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.05 0.06 0 0 0 0 0 0
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0.05 0.05 0 0 0 0 0 0 0.13 0.08 0.18 0.11 0 0 0 0 0 0 0 0 0 0 0 0
Nucleus 0 0.06 0.09 0.5 0.29 0.37 0.21 0.2 0.25 0.27 0.27 0.26 0.22 0.37 0.17 0.29 0.16 0.16 0.18 0.2 0.17 0.26 0.29 0.27
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vac/Vac Membrane 0.47 0.2 0.34 0.32 0.59 0.31 0.6 0.59 0.46 0.45 0.48 0.5 0.56 0.41 0.6 0.45 0.55 0.59 0.08 0.12 0.07 0.11 0.08 0.09
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 1 0 0 0 1 1 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 1 0 2 0 0 3 3 2 6 4 1 0 0 0 0 0 0 0 1 0 1 5 9
Bud Neck 0 0 0 0 0 0 0 0 0 0 1 0 0 0 0 0 0 0 0 1 0 0 5 3
Bud Site 0 0 0 0 0 0 0 0 1 0 1 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 2 0 0 2 0 1 1 0 0 2 1 0 0 0 0 0 1 0 0 0 0 0 0
Cytoplasm 44 117 185 54 55 120 118 98 106 149 95 109 73 85 85 104 100 83 92 97 184 44 121 138
Endoplasmic Reticulum 0 1 0 0 0 2 0 0 1 0 1 2 0 1 0 6 8 8 1 0 0 0 0 2
Endosome 3 0 0 2 8 1 8 7 2 8 4 4 4 2 7 0 0 1 0 1 1 1 5 9
Golgi 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 1 3 2 1 0 0 0 0 1
Mitochondria 4 7 0 2 0 6 10 13 52 39 66 44 1 1 2 0 3 2 0 1 1 0 1 1
Nucleus 3 9 20 98 75 97 88 74 99 133 97 102 35 72 44 42 27 23 24 32 43 21 68 75
Nuclear Periphery 2 0 1 0 0 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 1
Nucleolus 0 0 0 0 1 0 0 1 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 1 0 0 0 0 0 0 0 0 0 2 0 1 2 1 3 7
Vac/Vac Membrane 40 29 76 63 154 83 251 221 182 222 174 195 89 81 152 64 91 83 10 19 18 8 19 24
Unique Cell Count 85 144 226 195 259 264 421 375 398 491 364 390 160 196 252 143 165 140 134 162 259 83 234 282
Labelled Cell Count 96 166 282 223 295 309 479 420 447 559 445 458 202 242 290 217 232 205 134 162 259 83 234 282


Cytoplasm, Nucleus

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 6.5 5.4 7.2 6.8 8.6 8.2 8.3 8.6 7.8 8.5 7.8 8.5 7.8 8.2 8.4 9.9 11.4 12.4 9.0 8.6 8.8
Std Deviation (1e-4) 1.2 0.7 1.3 1.2 1.2 1.3 1.5 1.6 1.8 2.0 1.8 2.2 1.2 1.2 1.2 1.9 2.0 2.7 3.1 2.5 2.1
Intensity Change (Log2) – – – -0.08 0.26 0.19 0.21 0.27 0.12 0.25 0.13 0.24 0.12 0.19 0.23 0.47 0.66 0.79 0.33 0.26 0.3

WT3RAP60RAP140RAP220RAP300RAP380RAP460RAP540RAP620RAP700051015WT3HU80HU120HU160051015WT3rpd3Δ_1rpd3Δ_2rpd3Δ_3051015WT1AF100AF140AF180051015
rapamycinhydroxy-urearpd3 knockoutalpha-factorMultiple Condition Time-Course Intensity PlotsGFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)

Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cell Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm -11.2 -13.3 -8.3 -13.1 -13.3 -13.3 -12.8 -13.2 -12.9 -7.4 -8.2 -10.6 -2.1 -4.7 -4.7
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0 0 0 0 0 5.7 4.4 6.8 5.2 0 0 0 0 0 0
Nucleus 9.4 5.6 7.2 3.9 3.6 4.9 5.5 5.3 5.2 3.6 6.9 2.8 5.1 2.3 2.2
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vacuole -0.3 5.7 -0.5 6.3 6.0 3.0 2.9 3.4 3.9 4.3 1.6 5.8 2.1 4.2 4.8

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 1.7096 2.0284 1.7589 2.1922 1.0638 1.9657 4.0392 4.99 4.5895 4.1148 3.6582 4.5837 1.0288 1.6217 1.2358 0.9174 0.8832 1.2119
Actin 0.0843 0.0005 0.0129 0.0032 0.0333 0.001 0.012 0.0003 0.0044 0.0015 0.0012 0.0004 0.0194 0.0003 0.0109 0.0007 0.006 0.0061
Bud 0.0006 0.0002 0.0005 0.0003 0.0006 0.0003 0.0002 0.0008 0.0002 0.0004 0.0002 0.0004 0.0005 0.0003 0.0003 0.0012 0.0002 0.0002
Bud Neck 0.002 0.0005 0.0009 0.0008 0.001 0.0025 0.0061 0.0005 0.0014 0.001 0.0021 0.0028 0.0029 0.0003 0.0006 0.001 0.0008 0.0105
Bud Periphery 0.0012 0.0001 0.0005 0.0001 0.0011 0.0002 0.0002 0.0004 0.0002 0.0002 0.0001 0.0004 0.0006 0.0002 0.0002 0.0007 0.0005 0.0003
Bud Site 0.0028 0.0008 0.0009 0.0003 0.0007 0.0003 0.0025 0.0026 0.0013 0.0005 0.0002 0.0004 0.0068 0.0006 0.001 0.0019 0.0003 0.0003
Cell Periphery 0.0003 0.0001 0.0001 0.0001 0.0001 0 0.0004 0.0001 0.0001 0.0001 0 0 0.0002 0.0001 0 0.0002 0.0001 0
Cytoplasm 0.395 0.5685 0.5061 0.3563 0.36 0.4568 0.558 0.7216 0.5848 0.6428 0.5078 0.5442 0.489 0.77 0.6394 0.6538 0.5559 0.601
Cytoplasmic Foci 0.0158 0.0046 0.0099 0.0148 0.0185 0.0098 0.0152 0.0043 0.0108 0.0057 0.0111 0.0037 0.016 0.0072 0.0111 0.0036 0.0015 0.0051
Eisosomes 0.0008 0 0.0001 0.0006 0.0001 0 0.0001 0 0.0001 0 0 0 0.0002 0 0.0001 0 0.0003 0
Endoplasmic Reticulum 0.0078 0.0081 0.0056 0.0068 0.0036 0.0061 0.0044 0.0037 0.0048 0.0047 0.0046 0.0026 0.0063 0.0055 0.006 0.0079 0.0035 0.0031
Endosome 0.0163 0.0058 0.0088 0.0105 0.0422 0.0112 0.0092 0.0069 0.0073 0.0038 0.0064 0.0048 0.0305 0.0052 0.0064 0.0035 0.0042 0.0055
Golgi 0.0093 0.0002 0.0035 0.0047 0.0455 0.0007 0.0028 0.0001 0.0012 0.0005 0.0002 0.0003 0.0079 0.0001 0.0038 0.0001 0.002 0.0018
Lipid Particles 0.0185 0.0004 0.0074 0.0216 0.0189 0.0002 0.0081 0.0001 0.002 0.0001 0.0002 0.0001 0.0134 0.0002 0.0033 0.0001 0.0037 0.0013
Mitochondria 0.0181 0.0004 0.0074 0.0017 0.0093 0.0025 0.0007 0.0003 0.0007 0.0007 0.0005 0.0012 0.0027 0.0002 0.0013 0.0006 0.0577 0.0105
None 0.0336 0.1051 0.0496 0.0732 0.1778 0.0431 0.1178 0.0919 0.165 0.0783 0.2103 0.0902 0.102 0.081 0.0453 0.0446 0.0054 0.0207
Nuclear Periphery 0.0211 0.0189 0.0244 0.0277 0.0091 0.0189 0.0142 0.0056 0.0093 0.007 0.0092 0.0079 0.0162 0.0089 0.0116 0.0128 0.0118 0.0094
Nucleolus 0.0006 0.0004 0.0008 0.0018 0.0003 0.0006 0.0006 0.0003 0.0005 0.0004 0.0006 0.0012 0.0006 0.0001 0.0003 0.001 0.0003 0.0004
Nucleus 0.3357 0.2773 0.3383 0.4252 0.2528 0.4287 0.2208 0.1398 0.1937 0.2465 0.2241 0.3253 0.2614 0.1152 0.2463 0.2544 0.3378 0.316
Peroxisomes 0.011 0.0001 0.0084 0.0342 0.0191 0.0004 0.0064 0.0001 0.0026 0.0003 0.0003 0.0001 0.0078 0.0002 0.0054 0.0001 0.0006 0.0005
Punctate Nuclear 0.022 0.0044 0.0112 0.0113 0.0037 0.0133 0.0183 0.0167 0.0076 0.004 0.0194 0.011 0.013 0.0022 0.0053 0.0086 0.0039 0.0057
Vacuole 0.0022 0.0031 0.0022 0.0038 0.0014 0.0025 0.0016 0.0033 0.0017 0.0013 0.0012 0.0022 0.0018 0.0017 0.0013 0.0028 0.0012 0.0013
Vacuole Periphery 0.001 0.0004 0.0007 0.001 0.001 0.0007 0.0003 0.0005 0.0003 0.0002 0.0003 0.0006 0.0008 0.0003 0.0003 0.0004 0.0021 0.0004

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 4.1986 10.5093 14.4827 17.3517 14.1537 13.4282 11.385 15.8805 17.3811 13.6611
Translational Efficiency 4.2674 2.0523 1.6228 1.8788 1.2351 2.022 2.6105 2.0424 2.2352 1.9477

Hit Data

Dataset Hit
Protein Concentration ✘
Protein Localization ✘
Gene Expression ✘
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
179 459 1874 2091 1688 2177 321 1719 1867 2636 2195 3810

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 1017.44 864.36 1018.36 1000.83 823.91 884.57 1105.40 922.80 842.46 881.05 1031.09 965.62
Standard Deviation 210.28 124.79 137.79 139.88 128.10 106.68 136.40 120.79 149.41 110.32 140.99 137.22
Intensity Change Log 2 — -0.235240 0.001304 -0.023747 — 0.102490 0.424010 0.163531 — -0.074291 0.205857 0.063067

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.001185 0.000536 0.000426 0.002096 0.000245 0.000117 0.001515 0.000450 0.000335 0.000190 0.000585 0.001353
Bud Neck 0.014568 0.007325 0.003676 0.017495 0.001396 0.006394 0.008099 0.004498 0.002659 0.006556 0.004323 0.011631
Bud Site 0.009237 0.008503 0.004799 0.028902 0.001920 0.005439 0.005787 0.009102 0.002622 0.005973 0.004944 0.019968
Cell Periphery 0.000544 0.000172 0.000122 0.000177 0.000161 0.000072 0.000305 0.000165 0.000197 0.000089 0.000149 0.000172
Cytoplasm 0.172780 0.458687 0.266164 0.223526 0.374068 0.519747 0.144492 0.323803 0.354769 0.509115 0.248371 0.268769
Cytoplasmic Foci 0.015845 0.089267 0.001580 0.004499 0.008659 0.035089 0.002882 0.003865 0.009348 0.044523 0.001771 0.004213
Eisosomes 0.000060 0.000067 0.000014 0.000028 0.000013 0.000024 0.000066 0.000021 0.000018 0.000031 0.000021 0.000025
Endoplasmic Reticulum 0.018987 0.004000 0.002817 0.004859 0.002366 0.000550 0.014729 0.004327 0.003960 0.001150 0.004559 0.004619
Endosome 0.002116 0.007100 0.000724 0.005887 0.000649 0.001773 0.002965 0.001928 0.000790 0.002700 0.001052 0.004101
Golgi 0.000166 0.002541 0.000053 0.005459 0.000130 0.000622 0.000175 0.000361 0.000134 0.000956 0.000071 0.003159
Lipid Particles 0.002124 0.003822 0.000369 0.001195 0.000391 0.000945 0.001921 0.000561 0.000557 0.001446 0.000596 0.000909
Mitochondria 0.000891 0.002046 0.000701 0.009138 0.000300 0.001803 0.000760 0.000920 0.000356 0.001845 0.000709 0.005430
Mitotic Spindle 0.000465 0.005265 0.002241 0.083381 0.000407 0.005014 0.000811 0.008615 0.000413 0.005058 0.002032 0.049648
None 0.003401 0.004898 0.006376 0.010259 0.012010 0.004344 0.004809 0.006185 0.011184 0.004440 0.006147 0.008421
Nuclear Periphery 0.001142 0.000596 0.001512 0.002771 0.000317 0.000413 0.002002 0.001425 0.000396 0.000445 0.001584 0.002164
Nuclear Periphery Foci 0.003270 0.002794 0.000671 0.001109 0.001050 0.000330 0.004240 0.001101 0.001263 0.000759 0.001193 0.001106
Nucleolus 0.001287 0.001023 0.000276 0.000572 0.000733 0.000701 0.000853 0.000324 0.000787 0.000757 0.000361 0.000460
Nucleus 0.706837 0.328847 0.689811 0.550985 0.585605 0.396696 0.730794 0.592498 0.597229 0.384881 0.695805 0.569715
Peroxisomes 0.000545 0.004576 0.000116 0.001356 0.000340 0.001898 0.000313 0.000110 0.000359 0.002364 0.000145 0.000794
Vacuole 0.044292 0.067255 0.017462 0.043428 0.008870 0.017526 0.072267 0.039282 0.012266 0.026186 0.025476 0.041558
Vacuole Periphery 0.000258 0.000678 0.000091 0.002879 0.000369 0.000506 0.000215 0.000458 0.000359 0.000536 0.000109 0.001787

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin 4.22 3.74 1.73 -2.79 -2.41 4.15 -10.87 -5.64 -8.09 8.56 4.56 -2.51 -5.22 -7.31 -0.61
Bud Neck 2.80 3.96 0.47 -4.37 -9.57 -6.23 -3.11 -8.93 1.00 0.71 -5.10 -4.92 -12.70 -4.18 -7.37
Bud Site 0.72 3.26 -1.52 -1.95 -4.85 -3.83 -4.03 -4.95 -1.40 -0.95 -3.88 -2.60 -8.32 -3.80 -4.41
Cell Periphery 5.26 6.00 5.83 2.49 -1.32 2.17 -2.96 0.03 -7.40 5.18 2.89 1.25 1.32 -7.38 0.10
Cytoplasm -14.40 -4.12 -0.53 20.71 8.73 -15.77 24.78 11.97 30.75 -16.20 -17.86 17.33 18.63 45.30 -0.51
Cytoplasmic Foci -11.04 4.44 4.33 14.64 -1.20 -13.92 6.31 5.07 18.28 -1.95 -17.84 8.65 7.41 23.48 -3.70
Eisosomes -0.24 6.29 4.08 5.58 -11.01 -5.00 -12.64 -8.12 -2.97 9.73 -5.87 -4.96 -8.06 -0.78 -3.21
Endoplasmic Reticulum 5.65 5.78 5.16 -3.08 -6.09 11.80 -14.10 -11.10 -21.25 10.89 8.83 -4.24 -4.13 -24.64 0.76
Endosome -4.53 4.36 0.52 4.76 -4.02 -4.11 -8.70 -2.54 0.88 4.11 -6.45 -4.23 -4.49 2.72 -2.47
Golgi -1.62 3.49 -2.80 0.73 -3.07 -3.11 -2.28 -1.15 2.30 -0.47 -2.97 2.67 -3.03 0.32 -3.27
Lipid Particles -1.26 2.28 1.54 2.84 -5.14 -4.89 -6.79 -6.76 1.48 5.41 -4.29 -2.27 -3.72 2.54 -2.01
Mitochondria -1.06 1.12 -6.52 -2.11 -6.93 -3.64 -12.84 -11.77 2.01 -1.64 -3.88 -13.62 -8.87 -1.87 -7.07
Mitotic Spindle -1.61 -3.45 -11.25 -7.61 -10.39 -4.11 -3.12 -5.22 -1.87 -4.61 -4.43 -4.30 -12.40 -8.62 -10.83
None -1.76 -4.34 -7.95 -4.68 -5.23 7.19 7.84 5.90 -3.66 -4.84 6.93 5.81 3.55 -7.82 -4.97
Nuclear Periphery 5.90 -6.02 -19.95 -29.86 -18.61 -4.54 -17.21 -28.25 -26.60 4.91 -1.98 -30.65 -37.65 -37.54 -14.14
Nuclear Periphery Foci 0.44 2.83 2.78 5.08 -0.44 6.64 -6.30 -1.82 -9.83 5.82 3.46 -0.70 1.16 -3.64 2.34
Nucleolus 0.44 2.27 1.46 3.38 -5.80 -0.01 0.20 1.25 3.04 2.12 -0.03 1.58 1.01 2.99 -2.77
Nucleus 15.69 -0.97 2.28 -22.57 7.78 20.23 -8.24 -3.25 -25.45 6.41 24.29 -12.75 -4.19 -35.29 11.08
Peroxisomes -4.13 2.97 0.83 4.28 -2.12 -3.27 0.26 1.15 4.10 4.99 -4.60 1.15 0.49 5.20 -1.56
Vacuole -0.85 3.51 -1.90 -1.45 -14.58 -6.70 -11.62 -19.00 -15.30 5.22 -7.31 -11.60 -24.74 -18.38 -10.54
Vacuole Periphery -2.45 3.55 -2.15 -0.39 -2.82 -0.51 0.71 0.33 1.21 -0.83 -0.74 1.20 -0.83 -0.13 -3.18
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Ubiquitin-conjugating enzyme that regulates gluconeogenesis; negatively regulates gluconeogenesis by mediating the glucose-induced ubiquitination of fructose-1,6-bisphosphatase (FBPase); cytoplasmic enzyme that catalyzes the ubiquitination of histones in vitro
Localization
Cell Percentages cytoplasm (59%)
Cell Cycle Regulation No
Subcompartmental Group cytoplasm-9

Ubc8

Ubc8


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Ubc8-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
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