Standard name
Human Ortholog
Description Conserved zinc-finger domain protein involved in pre-mRNA splicing; critical for splicing of nearly all intron-containing genes; required for assembly of U4 snRNA into the U4/U6 particle
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0.11 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 0.07 0.06 0.06 0.13 0.16 0.1 0.11 0.07 0.07 0 0.05 0 0.24 0.23 0.3 0.14 0.17 0.14 0 0 0 0.09 0.09 0.09
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.06 0 0 0 0 0 0 0
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 0 0.06 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0.56 0.24 0.15 0.44 0.28 0.65 0.7 0.65 0.66 0.76 0.79 0.8 0 0 0 0.12 0.08 0.09 0 0 0 0 0 0.05
Nucleus 0.71 0.76 0.81 0.72 0.68 0.6 0.58 0.65 0.69 0.64 0.67 0.69 0.67 0.67 0.61 0.76 0.72 0.74 0.76 0.77 0.69 0.63 0.62 0.54
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.06 0 0.07
Vac/Vac Membrane 0.07 0.16 0 0.06 0.05 0 0 0 0 0 0 0 0.08 0 0.06 0.07 0.07 0.11 0.12 0.12 0.17 0.15 0.15 0.16
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 1 0 0 1 1 4 3 2 5 6 3 5 0 0 0 3 0 0 0 0 3 3 5 6
Bud Neck 0 0 0 0 0 0 0 0 1 0 0 0 0 0 0 0 1 0 0 0 0 0 2 3
Bud Site 2 0 0 3 3 6 8 12 8 17 10 30 0 0 0 1 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 0 0 0 0 0 0 0 2 1 0 0 0 0 0 0 0 0 0 0
Cytoplasm 11 6 11 14 29 19 29 19 27 17 11 10 39 56 87 36 65 37 3 3 3 18 26 27
Endoplasmic Reticulum 0 0 2 1 0 0 0 0 0 0 0 0 0 1 1 11 22 6 0 0 0 1 0 0
Endosome 0 0 5 1 1 1 0 0 0 0 0 0 7 14 8 1 5 3 3 0 4 2 3 3
Golgi 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 1 2 0 1 1 0 0 0
Mitochondria 93 25 31 48 51 120 187 176 260 292 182 220 2 4 2 30 30 25 1 1 4 4 7 14
Nucleus 118 81 162 78 126 110 155 176 272 245 153 191 107 163 175 197 273 196 128 90 152 127 176 161
Nuclear Periphery 0 0 0 0 0 2 2 0 1 1 1 3 0 0 1 0 2 0 0 1 2 0 0 0
Nucleolus 0 1 1 0 0 1 2 1 4 9 8 9 0 0 0 0 0 0 3 1 2 1 3 5
Peroxisomes 0 0 1 0 0 0 0 0 0 0 0 0 1 0 1 0 0 0 0 0 0 0 0 0
SpindlePole 1 0 3 0 2 0 0 0 0 2 0 2 3 5 2 4 6 0 5 1 5 11 11 20
Vac/Vac Membrane 11 17 6 7 9 4 9 5 12 12 5 3 12 9 17 17 26 28 19 13 38 30 42 48
Unique Cell Count 167 106 200 109 185 184 268 272 393 382 229 276 160 243 287 259 377 266 170 117 222 202 284 299
Labelled Cell Count 237 130 223 153 222 267 395 391 590 601 373 473 173 253 294 300 431 297 170 117 222 202 284 299


Cytoplasm, Nucleus

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 3.5 4.6 4.3 4.3 4.0 3.4 3.6 3.6 3.5 3.2 3.2 3.2 5.8 5.2 5.2 5.7 5.7 5.5 5.6 5.7 5.8
Std Deviation (1e-4) 0.6 0.8 1.0 2.2 1.1 1.4 1.5 1.9 1.4 1.1 1.3 1.2 1.6 1.1 1.2 1.3 1.5 1.0 1.1 1.2 1.4
Intensity Change (Log2) – – – -0.02 -0.11 -0.33 -0.26 -0.25 -0.3 -0.42 -0.45 -0.42 0.42 0.28 0.27 0.4 0.41 0.34 0.37 0.41 0.42

WT3RAP60RAP140RAP220RAP300RAP380RAP460RAP540RAP620RAP7000246WT3HU80HU120HU1600246WT3rpd3Δ_1rpd3Δ_2rpd3Δ_30246WT1AF100AF140AF1800246
rapamycinhydroxy-urearpd3 knockoutalpha-factorMultiple Condition Time-Course Intensity PlotsGFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)

Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Actin – – – – – – – – – – – – – – –
Bud – – – – – – – – – – – – 0 0 0
Bud Neck – – – – – – – – – – – – 0 0 0
Bud Site – – – – – – – – – – – – 0 0 0
Cell Periphery – – – – – – – – – – – – 0 0 0
Cyto – – – – – – – – – – – – – – –
Endoplasmic Reticulum – – – – – – – – – – – – 0 0 0
Endosome – – – – – – – – – – – – 0 0 0
Golgi – – – – – – – – – – – – 0 0 0
Mitochondria – – – – – – – – – – – – 0 0 0
Nuclear Periphery – – – – – – – – – – – – 0 0 0
Nuc – – – – – – – – – – – – – – –
Nucleolus – – – – – – – – – – – – 0 0 0
Peroxisomes – – – – – – – – – – – – 0 0 0
SpindlePole – – – – – – – – – – – – 0 0 0
Vac – – – – – – – – – – – – – – –
Cortical Patches – – – – – – – – – – – – 0 0 0
Cytoplasm – – – – – – – – – – – – 0 0 0
Nucleus – – – – – – – – – – – – 0 0 0
Vacuole – – – – – – – – – – – – 1.7 1.9 3.1

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 1.1207 1.8318 1.6506 1.1944 1.4663 1.563 0.6411 1.0314 0.8458 0.8713 0.686 0.7822 -0.4282 0.3548 -0.3053 0.298 -0.3983 -0.1787
Actin 0.0023 0 0.0113 0.0001 0.0001 0.0001 0.0077 0 0.0078 0.0024 0.0164 0.009 0.0003 0 0 0.0006 0.0001 0.0001
Bud 0.0001 0 0.0001 0.0002 0 0 0.0006 0 0.0006 0.0005 0.0004 0.0001 0.0001 0 0 0.0001 0 0
Bud Neck 0.0004 0.0003 0.0003 0.0004 0.0007 0.0012 0.0148 0.0001 0.0011 0.0029 0.0017 0.001 0.0035 0.0001 0.0001 0.0003 0.0003 0.0009
Bud Periphery 0.0002 0 0.0001 0.0001 0 0 0.0013 0 0.0014 0.0014 0.001 0.0002 0.0001 0 0 0.0003 0 0
Bud Site 0.0004 0.0002 0.0004 0.0001 0.0001 0.0001 0.0034 0.0001 0.0016 0.0069 0.0042 0.0001 0.0005 0 0 0.0003 0 0
Cell Periphery 0 0 0 0 0 0 0.0003 0 0.0001 0.0011 0.0002 0 0 0 0 0 0 0
Cytoplasm 0.0132 0.021 0.009 0.0041 0.0071 0.0036 0.0054 0.0104 0.0052 0.0005 0.0067 0.0045 0.0126 0.0021 0.0039 0.0038 0.0162 0.002
Cytoplasmic Foci 0.0034 0.0005 0.0009 0.0003 0.0004 0.0006 0.0101 0.0003 0.0039 0.0035 0.0044 0.001 0.0017 0.0001 0.0002 0.0012 0.0001 0.0001
Eisosomes 0.0001 0 0.0001 0 0 0 0.0001 0 0.0001 0.0002 0.0002 0.0001 0 0 0 0 0 0
Endoplasmic Reticulum 0.0005 0.0003 0.0005 0.0002 0.0007 0.0001 0.0014 0.0003 0.0008 0.0002 0.0007 0.0009 0.0007 0.0001 0.0001 0.0006 0.0017 0.0002
Endosome 0.0025 0.0004 0.0006 0.0003 0.001 0.0002 0.0091 0.0003 0.0038 0.0042 0.0084 0.003 0.0026 0.0001 0.0001 0.0017 0.0007 0.0003
Golgi 0.0008 0 0.0002 0 0 0 0.002 0 0.0013 0.0034 0.0048 0.001 0.0007 0 0 0.0001 0 0
Lipid Particles 0.0079 0 0.0002 0 0.0003 0.0002 0.003 0 0.0028 0.0097 0.0258 0.0007 0.0031 0 0 0.0002 0 0.0001
Mitochondria 0.0019 0.0003 0.0004 0.0002 0.0003 0.0001 0.0045 0.0002 0.0039 0.021 0.0117 0.0026 0.0007 0.0001 0.0001 0.0037 0.0001 0.0001
None 0.073 0.0355 0.0577 0.003 0.027 0.0329 0.0105 0.0194 0.0116 0.0003 0.0243 0.0046 0.0261 0.0154 0.006 0.0024 0.0019 0.0077
Nuclear Periphery 0.0081 0.0062 0.0127 0.0078 0.0093 0.0026 0.0109 0.0108 0.0097 0.0014 0.0268 0.0113 0.0086 0.0073 0.0022 0.0114 0.0182 0.0061
Nucleolus 0.0071 0.0106 0.0063 0.0085 0.0161 0.0131 0.0128 0.0057 0.0107 0.0111 0.0133 0.013 0.0079 0.0049 0.0055 0.0054 0.0045 0.0102
Nucleus 0.8471 0.8827 0.8844 0.9346 0.9157 0.9234 0.8573 0.9403 0.9106 0.9154 0.8117 0.93 0.9175 0.9615 0.9711 0.9379 0.9502 0.9619
Peroxisomes 0.0048 0 0.0007 0 0 0 0.0021 0 0.0027 0.006 0.0063 0.0004 0.0026 0 0 0.0001 0 0
Punctate Nuclear 0.025 0.0411 0.0137 0.0398 0.0201 0.0216 0.0342 0.0113 0.018 0.0047 0.0286 0.016 0.0101 0.0081 0.0106 0.0278 0.0052 0.0101
Vacuole 0.0007 0.0007 0.0003 0.0002 0.0007 0.0001 0.0068 0.0005 0.0017 0.0023 0.0012 0.0002 0.0006 0.0001 0.0001 0.001 0.0003 0.0001
Vacuole Periphery 0.0005 0.0001 0.0001 0.0001 0.0002 0 0.0016 0.0003 0.0007 0.0007 0.0012 0.0004 0.0001 0.0001 0 0.0009 0.0001 0.0001

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 22.9364 18.3069 24.4521 28.7017 31.3311 20.4676 24.9886 21.2382 22.4332 26.348
Translational Efficiency 0.7326 1.0075 0.8232 0.5655 0.4704 0.8758 0.7672 0.8934 0.7541 0.7029

Hit Data

Dataset Hit
Protein Concentration ✘
Protein Localization ✘
Gene Expression ✘
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
2061 927 135 1107 2295 2602 174 1442 4356 3529 309 2549

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 624.69 707.96 868.36 822.69 693.84 761.73 951.26 871.55 661.12 747.61 915.04 850.33
Standard Deviation 77.33 95.13 110.65 114.77 81.42 90.33 98.08 133.67 86.68 94.62 111.61 128.12
Intensity Change Log 2 — 0.180527 0.475153 0.397208 — 0.134677 0.455237 0.328980 — 0.156581 0.464707 0.361708

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.000058 0.000372 0.000412 0.001025 0.000038 0.000143 0.000578 0.001030 0.000047 0.000203 0.000506 0.001028
Bud Neck 0.003911 0.005581 0.002432 0.013407 0.003464 0.007658 0.003415 0.017526 0.003676 0.007112 0.002986 0.015737
Bud Site 0.002132 0.002164 0.000580 0.015115 0.000634 0.003180 0.001209 0.028472 0.001343 0.002913 0.000934 0.022671
Cell Periphery 0.000410 0.000189 0.000082 0.000152 0.000153 0.000134 0.000140 0.000187 0.000275 0.000149 0.000115 0.000172
Cytoplasm 0.116382 0.066986 0.023816 0.121015 0.106561 0.089203 0.019003 0.133507 0.111208 0.083367 0.021106 0.128082
Cytoplasmic Foci 0.020116 0.009992 0.002278 0.006264 0.007745 0.010081 0.002557 0.009267 0.013598 0.010058 0.002435 0.007963
Eisosomes 0.000042 0.000040 0.000045 0.000037 0.000015 0.000023 0.000066 0.000037 0.000027 0.000027 0.000057 0.000037
Endoplasmic Reticulum 0.001544 0.004494 0.004945 0.005585 0.001027 0.001945 0.007707 0.006159 0.001272 0.002615 0.006500 0.005910
Endosome 0.000857 0.001230 0.000519 0.008405 0.000473 0.001389 0.001052 0.011996 0.000655 0.001347 0.000819 0.010436
Golgi 0.000432 0.000268 0.000052 0.002687 0.000093 0.000592 0.000071 0.013847 0.000253 0.000506 0.000063 0.009001
Lipid Particles 0.003802 0.003891 0.000857 0.001873 0.001725 0.002442 0.001339 0.001357 0.002708 0.002823 0.001129 0.001581
Mitochondria 0.003214 0.005011 0.000455 0.003446 0.002490 0.004833 0.000714 0.005513 0.002833 0.004880 0.000601 0.004615
Mitotic Spindle 0.000274 0.002438 0.000046 0.030336 0.001381 0.005120 0.001625 0.067487 0.000858 0.004415 0.000935 0.051353
None 0.021559 0.014498 0.003443 0.013184 0.005081 0.005545 0.014068 0.011793 0.012877 0.007897 0.009426 0.012397
Nuclear Periphery 0.001672 0.001906 0.000662 0.002947 0.002419 0.002674 0.001334 0.003766 0.002066 0.002472 0.001041 0.003410
Nuclear Periphery Foci 0.000632 0.001407 0.000167 0.002825 0.000218 0.000345 0.000402 0.001387 0.000414 0.000624 0.000299 0.002011
Nucleolus 0.007182 0.009316 0.003061 0.002844 0.002686 0.004501 0.006535 0.001781 0.004813 0.005766 0.005017 0.002243
Nucleus 0.811585 0.862239 0.950445 0.725858 0.861395 0.854234 0.923240 0.640960 0.837828 0.856337 0.935126 0.677830
Peroxisomes 0.001338 0.002170 0.000220 0.001098 0.000671 0.001655 0.000344 0.001665 0.000987 0.001790 0.000290 0.001419
Vacuole 0.002541 0.005032 0.005392 0.035578 0.001501 0.003907 0.014446 0.038742 0.001993 0.004203 0.010490 0.037368
Vacuole Periphery 0.000316 0.000776 0.000088 0.006319 0.000229 0.000396 0.000154 0.003522 0.000270 0.000496 0.000125 0.004737

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin -9.90 -6.23 -5.30 -3.31 -2.45 -4.32 -7.90 -9.35 -8.21 -0.19 -8.27 -9.69 -9.89 -8.09 -1.81
Bud Neck -2.38 -0.44 -6.24 -4.10 -5.13 -5.62 -2.43 -10.86 -6.31 -7.47 -5.97 -2.14 -12.27 -7.01 -9.03
Bud Site -0.48 1.60 -4.88 -4.71 -5.72 -4.63 -3.07 -8.55 -7.06 -7.31 -3.32 -1.17 -9.74 -8.32 -9.21
Cell Periphery 3.45 5.31 4.73 3.44 -2.88 1.00 0.54 0.72 -0.67 0.06 3.97 4.73 4.53 1.54 -1.17
Cytoplasm 8.40 10.73 2.98 -4.40 -7.99 3.67 16.66 -0.96 -4.26 -15.86 7.60 18.66 1.29 -5.25 -16.06
Cytoplasmic Foci 5.14 11.24 10.81 4.94 -1.79 -2.10 6.03 3.45 5.72 -2.94 3.37 12.67 10.68 7.76 -3.41
Eisosomes -0.18 -1.06 -3.61 -4.12 -1.23 -6.52 -9.39 -19.74 -14.30 3.59 -0.48 -7.86 -12.84 -14.79 2.28
Endoplasmic Reticulum -9.77 -6.66 -14.71 -7.00 -3.43 -7.51 -8.22 -17.00 -14.60 1.84 -11.05 -9.95 -22.41 -17.28 0.17
Endosome -2.37 1.66 -4.19 -3.55 -4.48 -4.87 -3.11 -5.29 -4.06 -4.08 -4.73 -2.06 -6.72 -5.34 -5.95
Golgi 1.25 3.14 -1.69 -2.22 -2.85 -2.65 -0.48 -3.29 -2.87 -3.27 -1.66 2.74 -3.56 -3.18 -3.80
Lipid Particles -0.03 8.07 5.57 3.18 -2.77 -1.38 0.75 0.98 3.32 0.35 -0.15 5.46 4.46 4.42 -1.59
Mitochondria -1.24 5.87 1.41 1.89 -5.23 -2.56 2.57 -1.28 1.78 -6.18 -2.81 5.35 -0.31 2.83 -8.04
Mitotic Spindle -2.59 1.84 -7.22 -6.27 -7.28 -3.31 -1.31 -11.37 -10.25 -9.71 -4.34 -1.28 -13.43 -11.71 -11.95
None 3.29 10.80 7.39 3.23 -3.28 -0.60 -1.48 -3.27 -2.79 0.40 5.45 2.92 4.37 -0.50 -0.66
Nuclear Periphery -1.05 7.54 -9.22 -6.11 -13.70 -1.47 1.77 -9.72 -8.88 -10.09 -2.95 4.05 -12.98 -10.40 -14.64
Nuclear Periphery Foci -1.49 1.66 -2.51 -0.58 -4.02 -2.26 -1.65 -7.60 -6.69 -1.89 -1.24 -0.50 -5.26 -4.18 -4.02
Nucleolus -1.61 3.76 6.06 5.11 0.74 -3.88 -2.06 0.68 4.07 2.24 -1.87 0.37 5.58 6.44 2.32
Nucleus -5.31 -12.45 5.59 9.37 15.05 1.19 -3.48 19.76 19.08 17.00 -3.41 -10.36 18.24 20.46 22.37
Peroxisomes -1.84 7.97 3.64 3.42 -2.59 -3.06 1.74 -0.28 2.98 -2.40 -3.23 5.59 1.75 4.53 -3.41
Vacuole -2.82 -2.67 -14.36 -13.13 -12.48 -5.17 -5.37 -19.16 -18.50 -7.96 -5.32 -5.72 -23.88 -22.86 -12.67
Vacuole Periphery -1.68 3.08 -2.81 -2.16 -3.09 -2.16 1.12 -3.69 -3.07 -3.98 -2.47 2.98 -4.05 -3.42 -4.43
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Conserved zinc-finger domain protein involved in pre-mRNA splicing; critical for splicing of nearly all intron-containing genes; required for assembly of U4 snRNA into the U4/U6 particle
Localization
Cell Percentages nucleus (90%)
Cell Cycle Regulation No
Subcompartmental Group nucleus-3

Sad1

Sad1


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Sad1-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available