Standard name
Human Ortholog
Description Phosphoinositide binding protein; required for vesicle formation in autophagy and the cytoplasm-to-vacuole targeting (CVT) pathway; binds PtdIns(3,5)P2, PI3P and PI4P; WD-40 repeat containing protein and PROPPIN family member; relocalizes from the vacuole to cytoplasm upon DNA replication stress; mammalian homologs include: WIPI1, WIPI2, WIPI3 and WIPI4/WDR45; mutations in human WDR45 cause static encephalopathy of childhood with neurodegeneration in adulthood (SENDA)
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 0.88 0.89 0.83 0.81 0.75 0.8 0.68 0.67 0.72 0.68 0.63 0.64 0.89 0.91 0.91 0.81 0.74 0.82 0.37 0.42 0.36 0.41 0.32 0.19
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Endosome 0 0 0.12 0.1 0.14 0.08 0.11 0.1 0 0 0 0 0.06 0.07 0.07 0.06 0.07 0.06 0.31 0.26 0.28 0.29 0.29 0.28
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0 0 0 0.11 0.11 0.28 0.31 0.34 0.37 0.43 0.51 0.45 0 0 0 0 0 0 0 0 0 0 0 0
Nucleus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vac/Vac Membrane 0.07 0.12 0.05 0 0.07 0 0.05 0.05 0 0.05 0.05 0 0.08 0.05 0 0.16 0.32 0.2 0.24 0.25 0.2 0.23 0.33 0.39
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 2 4 0 1 0 1 1 1 1 1 3 0 0 0 1 2 1 1 3 2 0 0 2
Bud 5 2 4 5 3 2 4 9 12 9 6 9 2 0 2 0 0 0 3 4 1 0 1 8
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 4 0 1 5
Bud Site 0 0 0 0 0 0 0 0 1 1 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 1 1 0 2 6 2 10 5 12 11 0 0 1 2 2 0 0 0 0 0 0 0
Cytoplasm 216 446 221 177 232 258 281 191 234 217 194 206 383 421 537 333 174 165 100 215 106 83 119 71
Endoplasmic Reticulum 2 9 8 3 2 2 3 2 4 0 6 1 7 3 4 16 10 8 2 2 11 2 2 6
Endosome 11 20 31 21 43 27 45 28 13 11 5 12 27 30 40 23 17 12 82 134 83 60 105 106
Golgi 0 0 0 1 1 1 0 0 0 0 0 0 1 0 0 3 2 0 0 2 0 0 0 0
Mitochondria 6 1 1 23 34 91 130 95 119 136 155 143 0 0 0 5 1 1 0 6 3 1 2 4
Nucleus 1 1 1 1 0 1 2 5 2 4 1 0 0 0 2 1 0 2 2 2 0 1 3 2
Nuclear Periphery 0 0 1 0 0 0 0 0 1 2 2 0 0 0 0 0 0 0 3 5 10 2 2 3
Nucleolus 1 1 0 0 1 3 1 1 1 0 1 2 0 0 0 1 0 1 0 0 0 0 0 1
Peroxisomes 0 0 0 0 0 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 1 0 2 4 5 7 4 4 2 3 3 0 1 4 2 1 1 5 4 2 0 2 9
Vac/Vac Membrane 18 58 14 7 23 5 22 13 10 16 15 10 36 21 20 65 76 39 64 126 59 46 122 150
Unique Cell Count 246 502 266 219 310 324 415 283 326 317 306 320 430 461 588 409 234 200 270 518 294 204 369 381
Labelled Cell Count 260 541 286 241 344 397 502 351 412 405 401 400 456 476 610 452 285 230 270 518 294 204 369 381


Ambiguous

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 6.3 7.6 6.5 6.1 6.3 5.8 5.4 5.3 5.6 5.4 5.3 5.4 7.6 7.6 7.5 10.0 12.0 10.5 6.7 6.7 7.8
Std Deviation (1e-4) 0.9 1.0 1.0 1.1 1.2 1.3 1.2 1.2 1.4 1.4 1.2 1.4 1.1 1.2 1.3 2.5 2.7 2.3 1.2 1.4 1.6
Intensity Change (Log2) – – – -0.09 -0.04 -0.16 -0.27 -0.28 -0.22 -0.26 -0.31 -0.28 0.22 0.23 0.21 0.62 0.88 0.68 0.05 0.05 0.26


Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 1.3 1.6 1.1 0 1.1 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cell Periphery 0 0 0 0 0 0 0 2.8 2.6 0 0 0 0 0 0
Cytoplasm -0.6 -2.4 -1.1 -4.4 -4.2 -3.2 -4.1 -5.3 -5.1 2.3 3.3 3.5 -0.6 -2.4 -0.2
Endoplasmic Reticulum 0 0 0 0 0 -1.5 0 -0.8 0 -1.2 0 0 0.6 0.8 0.6
Endosome -0.7 0.8 -1.3 -0.3 -0.7 -3.5 -3.8 -4.9 -3.7 -2.5 -2.4 -2.4 -2.8 -1.7 -2.1
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 5.1 5.3 9.2 10.0 10.2 10.9 12.1 13.5 12.4 0 0 0 0 0 0
Nucleus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vacuole -1.1 1.1 -2.5 0 -0.4 -1.3 -0.1 -0.2 -1.3 1.5 -0.4 -1.3 4.2 7.9 4.8

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 4.0591 4.4859 3.7576 3.6891 3.7766 4.077 5.9278 5.8108 6.0049 5.8244 5.1594 5.9804 7.0791 8.0315 7.1119 7.216 7.0149 7.5256
Actin 0.0529 0.0004 0.0122 0.0401 0.0275 0.0048 0.0267 0.0003 0.0274 0.0085 0.0389 0.002 0.0189 0.0002 0.0185 0.0256 0.0031 0.0064
Bud 0.0014 0.0014 0.0014 0.001 0.0029 0.0005 0.0005 0.0058 0.0097 0.0011 0.0013 0.0022 0.0009 0.0004 0.0008 0.0014 0.0003 0.0006
Bud Neck 0.0147 0.0005 0.0053 0.0028 0.0044 0.0081 0.0009 0.0002 0.0011 0.0018 0.0015 0.0022 0.0177 0.0003 0.0005 0.0004 0.0005 0.0032
Bud Periphery 0.0015 0.0007 0.0009 0.0017 0.0028 0.0006 0.0005 0.0024 0.006 0.0009 0.0012 0.0029 0.0007 0.0003 0.0005 0.0008 0.0007 0.0002
Bud Site 0.0095 0.0065 0.0116 0.0013 0.0107 0.0008 0.0022 0.0039 0.0137 0.0015 0.0056 0.0007 0.0055 0.0017 0.0012 0.0008 0.0002 0.0009
Cell Periphery 0.0005 0.0002 0.0004 0.0006 0.0002 0.0001 0.0001 0.0003 0.0004 0.0002 0.0001 0.0001 0.0004 0.0002 0.0001 0.0001 0.0001 0.0001
Cytoplasm 0.5341 0.8652 0.7498 0.5829 0.5642 0.7031 0.6998 0.8359 0.7303 0.6298 0.6314 0.7716 0.6004 0.7622 0.7168 0.6748 0.6877 0.7608
Cytoplasmic Foci 0.0801 0.0313 0.0423 0.095 0.0876 0.0611 0.0605 0.0161 0.0347 0.0956 0.0856 0.0378 0.0656 0.046 0.0509 0.0723 0.0414 0.0466
Eisosomes 0.0004 0.0001 0.0002 0.0003 0.0003 0.0001 0.0002 0 0.0001 0.0001 0.0002 0 0.0002 0 0.0001 0 0 0
Endoplasmic Reticulum 0.0088 0.0065 0.0071 0.0061 0.0042 0.0055 0.0069 0.0048 0.0045 0.0028 0.0037 0.0049 0.0103 0.0095 0.012 0.0039 0.0035 0.0056
Endosome 0.1203 0.0341 0.0647 0.0987 0.1359 0.1049 0.0669 0.0318 0.0638 0.0786 0.104 0.0811 0.0985 0.0669 0.0811 0.0878 0.1138 0.0792
Golgi 0.016 0.0011 0.0072 0.0077 0.0153 0.0049 0.008 0.0007 0.0119 0.0094 0.0286 0.0062 0.0095 0.0015 0.0033 0.0033 0.0055 0.002
Lipid Particles 0.0161 0.0003 0.0022 0.0077 0.0143 0.0031 0.0068 0.0003 0.003 0.0044 0.0099 0.002 0.0059 0.0006 0.0012 0.0004 0.0012 0.001
Mitochondria 0.0079 0.0004 0.0044 0.0228 0.0046 0.0063 0.0027 0.0005 0.0037 0.0016 0.01 0.012 0.0027 0.0003 0.0015 0.0009 0.0142 0.0008
None 0.0669 0.0241 0.056 0.048 0.0267 0.0447 0.0744 0.0699 0.0681 0.1079 0.0217 0.0485 0.1042 0.0678 0.063 0.0491 0.0721 0.0554
Nuclear Periphery 0.0082 0.0032 0.0044 0.0073 0.0213 0.0079 0.0113 0.0024 0.0026 0.0025 0.0034 0.0023 0.0111 0.0066 0.0067 0.0033 0.0105 0.0046
Nucleolus 0.0024 0.0003 0.0003 0.0002 0.0015 0.0002 0.0003 0.0004 0.0002 0.0003 0.0009 0.0002 0.0018 0.0002 0.0002 0.0002 0.0001 0.0002
Nucleus 0.0037 0.0054 0.006 0.0047 0.0247 0.0071 0.0081 0.0056 0.0026 0.0035 0.006 0.0041 0.0064 0.0064 0.0043 0.0128 0.003 0.0057
Peroxisomes 0.0141 0.0004 0.0066 0.0175 0.0034 0.0025 0.0078 0.0001 0.0064 0.0257 0.0149 0.0013 0.0057 0.0003 0.0029 0.004 0.0005 0.0008
Punctate Nuclear 0.0044 0.0024 0.002 0.003 0.0119 0.0039 0.0035 0.0029 0.0012 0.0075 0.021 0.0025 0.0133 0.0007 0.0017 0.0024 0.0006 0.0022
Vacuole 0.0317 0.0138 0.0132 0.0344 0.0289 0.0231 0.0095 0.0133 0.0072 0.0138 0.0078 0.0118 0.0171 0.025 0.0277 0.0478 0.0268 0.0195
Vacuole Periphery 0.0042 0.0017 0.0018 0.0163 0.0068 0.0066 0.0023 0.0022 0.0013 0.0025 0.0024 0.0036 0.0032 0.0028 0.005 0.0078 0.0143 0.0042

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 13.9486 13.1254 14.1225 19.7207 9.5184 13.9408 16.423 17.9142 18.3515 18.9687
Translational Efficiency 1.0607 0.8643 0.9167 0.73 1.4893 1.0214 0.7579 0.5994 0.7404 0.6959

Hit Data

Dataset Hit
Protein Concentration ✘
Protein Localization ✘
Gene Expression ✘
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
2583 1083 2352 1775 378 1870 115 1353 2961 2953 2467 3128

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 761.80 862.49 976.03 1109.48 797.74 832.01 1151.55 1097.93 766.39 843.19 984.21 1104.48
Standard Deviation 87.55 129.44 121.59 154.35 97.65 112.10 153.99 178.02 89.71 119.66 128.72 165.10
Intensity Change Log 2 — 0.179095 0.357513 0.542399 — 0.060682 0.529587 0.460796 — 0.119739 0.448093 0.501234

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.000134 0.000162 0.000126 0.000198 0.000655 0.000215 0.000195 0.001998 0.000200 0.000195 0.000129 0.000977
Bud Neck 0.020412 0.010210 0.024638 0.022210 0.006555 0.011578 0.008758 0.017172 0.018643 0.011076 0.023898 0.020031
Bud Site 0.017338 0.020410 0.011571 0.051327 0.009853 0.018026 0.019781 0.059433 0.016382 0.018900 0.011954 0.054833
Cell Periphery 0.000097 0.000054 0.000038 0.000055 0.000121 0.000068 0.000065 0.000545 0.000100 0.000063 0.000039 0.000267
Cytoplasm 0.388908* 0.371460* 0.442348* 0.449830* 0.506225* 0.270328* 0.231036* 0.478988* 0.403884* 0.307418* 0.432497* 0.462442*
Cytoplasmic Foci 0.213342* 0.198947* 0.026529 0.031327 0.215062* 0.238100* 0.042396 0.055116 0.213561* 0.223741* 0.027269 0.041617
Eisosomes 0.000054 0.000021 0.000013 0.000008 0.000064 0.000030 0.000025 0.000016 0.000055 0.000027 0.000014 0.000012
Endoplasmic Reticulum 0.003413 0.001748 0.001743 0.000491 0.001267 0.001466 0.001630 0.000723 0.003139 0.001569 0.001738 0.000591
Endosome 0.071467 0.088662 0.040689 0.024819 0.052240 0.145437 0.084133 0.031359 0.069013 0.124615 0.042715 0.027648
Golgi 0.007406 0.004150 0.000538 0.007418 0.001997 0.010326 0.000392 0.010725 0.006716 0.008061 0.000531 0.008849
Lipid Particles 0.006245 0.003318 0.001387 0.000882 0.004088 0.005009 0.001909 0.001228 0.005970 0.004389 0.001412 0.001032
Mitochondria 0.005884 0.001900 0.001280 0.003060 0.000421 0.007989 0.000217 0.002911 0.005186 0.005755 0.001231 0.002996
Mitotic Spindle 0.002043 0.018850 0.013471 0.062313 0.004468 0.024861 0.001934 0.024892 0.002353 0.022657 0.012933 0.046127
None 0.001037 0.001328 0.002775 0.001435 0.001161 0.000672 0.000319 0.004596 0.001053 0.000913 0.002660 0.002802
Nuclear Periphery 0.000193 0.000628 0.003335 0.000822 0.000309 0.000619 0.001098 0.000671 0.000208 0.000622 0.003231 0.000757
Nuclear Periphery Foci 0.000445 0.001954 0.003006 0.001401 0.002913 0.001471 0.005492 0.003120 0.000760 0.001648 0.003122 0.002145
Nucleolus 0.000936 0.001387 0.005189 0.002679 0.001003 0.001754 0.002618 0.000947 0.000944 0.001620 0.005069 0.001930
Nucleus 0.027375 0.020561 0.163608* 0.033547 0.048666 0.014115 0.041041 0.044911 0.030093 0.016479 0.157894* 0.038463
Peroxisomes 0.003008 0.004819 0.001916 0.003116 0.004352 0.006539 0.003679 0.003696 0.003180 0.005909 0.001998 0.003367
Vacuole 0.218087* 0.235024* 0.252331* 0.290888* 0.136474 0.225246* 0.549620* 0.244244* 0.207669* 0.228832* 0.266189* 0.270713*
Vacuole Periphery 0.012176 0.014407 0.003468 0.012174 0.002108 0.016152 0.003664 0.012706 0.010891 0.015512 0.003478 0.012404

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin -1.42 -0.12 -0.61 0.77 -0.51 1.35 1.32 -0.61 -1.90 -1.87 0.08 1.29 -1.71 -1.77 -2.10
Bud Neck 6.71 -4.94 0.90 -5.84 5.78 -3.23 -0.48 -3.71 -1.25 -3.50 6.26 -5.74 1.52 -5.37 7.39
Bud Site -1.33 6.19 -5.42 -3.82 -9.54 -3.92 -1.78 -10.17 -8.20 -6.42 -1.67 5.64 -9.81 -8.60 -14.33
Cell Periphery 9.18 14.57 12.32 2.88 -1.32 2.53 4.02 -5.69 -6.66 -7.28 3.09 15.57 -4.36 -5.50 -8.06
Cytoplasm 1.55 -1.37 -7.97 -7.43 -6.62 14.00 10.39 1.32 -20.34 -11.05 12.83 1.55 -8.87 -21.20 -10.06
Cytoplasmic Foci 2.72 49.18 48.41 28.76 0.94 -2.40 16.11 16.97 38.66 -1.04 -1.70 52.16 49.84 49.81 -3.49
Eisosomes 13.30 17.79 21.76 11.06 12.04 4.40 4.17 6.54 8.49 5.13 12.02 18.21 20.98 13.57 7.70
Endoplasmic Reticulum 4.69 4.37 9.17 7.99 16.97 -0.93 -1.67 4.85 6.21 4.76 5.27 4.08 9.30 10.33 15.88
Endosome -3.01 14.24 23.68 17.40 9.34 -14.24 -0.04 6.56 29.87 3.74 -14.73 13.72 24.34 34.62 9.69
Golgi 6.06 18.04 5.92 1.57 -3.10 -9.36 4.08 -2.41 4.67 -4.35 -1.74 18.33 5.00 5.74 -5.22
Lipid Particles 7.70 15.32 16.36 6.91 2.17 -1.64 3.99 4.49 7.75 0.53 4.29 15.83 16.39 10.17 1.02
Mitochondria 6.65 7.95 6.36 0.89 -0.27 -8.06 3.18 -2.98 6.64 -3.82 -0.54 7.81 6.66 6.53 -0.58
Mitotic Spindle -6.55 -9.37 -12.91 -6.50 -7.62 -6.15 0.61 -5.16 0.80 -6.80 -11.57 -9.06 -14.86 -4.77 -7.09
None -0.70 -7.70 -2.23 -0.61 6.23 2.81 4.84 -3.94 -5.40 -6.30 0.73 -7.85 -4.26 -5.14 2.33
Nuclear Periphery -6.46 -20.71 -14.48 -6.45 15.32 -4.49 -3.97 -4.03 -0.91 2.00 -9.00 -20.77 -13.89 -5.69 16.56
Nuclear Periphery Foci -5.62 -8.54 -4.86 1.68 5.55 3.85 -4.20 0.89 -1.30 4.19 -4.90 -8.43 -3.90 -0.41 4.94
Nucleolus -3.90 -13.21 -7.16 -4.33 9.00 -2.07 -1.12 0.47 4.07 1.53 -5.35 -13.17 -6.47 -0.97 10.82
Nucleus 3.15 -37.75 -12.34 -13.54 28.59 9.38 0.27 0.26 -14.28 -0.15 10.53 -36.58 -12.23 -20.92 29.88
Peroxisomes -3.64 6.92 4.52 5.78 -1.52 -2.37 1.48 2.32 8.50 0.49 -7.47 7.03 4.88 10.77 -2.03
Vacuole -2.94 -9.65 -15.18 -9.78 -6.28 -8.43 -18.45 -15.03 -9.56 11.40 -4.15 -13.59 -18.96 -14.56 -4.10
Vacuole Periphery -0.95 16.95 8.73 6.41 -4.10 -16.04 -0.40 -4.27 8.97 -3.89 -4.86 16.55 8.09 11.73 -5.72
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Phosphoinositide binding protein; required for vesicle formation in autophagy and the cytoplasm-to-vacuole targeting (CVT) pathway; binds PtdIns(3,5)P2, PI3P and PI4P; WD-40 repeat containing protein and PROPPIN family member; relocalizes from the vacuole to cytoplasm upon DNA replication stress; mammalian homologs include: WIPI1, WIPI2, WIPI3 and WIPI4/WDR45; mutations in human WDR45 cause static encephalopathy of childhood with neurodegeneration in adulthood (SENDA)
Localization
Cell Percentages cytoplasm (83%)
Cell Cycle Regulation No
Subcompartmental Group cytoplasm-9

Atg18

Atg18


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Atg18-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available