Standard name
Human Ortholog
Description Eisosome core component; eisosomes are large immobile cell cortex structures associated with endocytosis; detected in phosphorylated state in mitochondria; phosphorylated on Thr233 upon Pkc1p hyperactivation in a Slt2p MAPK-dependent fashion; null mutant shows activation of Pkc1p/Ypk1p stress resistance pathways; member of BAR domain family; protein increases in abundance and relocalizes from plasma membrane to cytoplasm upon DNA replication stress
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0.38 0.44 0.49 0.58 0.32 0.44 0.3 0.33 0.4 0.37 0.34 0.39 0.59 0.44 0.43 0.22 0.35 0.35 0.87 0.8 0.75 0.82 0.82 0.8
Bud 0.07 0 0.06 0.05 0.06 0.05 0.1 0.06 0.05 0.05 0.05 0 0.07 0 0 0 0.05 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0.1 0.15 0.2 0.18 0.19 0.18 0.12 0.1 0.08 0.1 0.08 0.16 0.35 0.51 0.43 0.35 0.36 0.39 0 0.07 0.06 0.07 0.06 0.1
Cytoplasm 0 0 0 0 0 0 0.05 0 0 0 0 0 0 0.06 0.05 0 0 0 0 0 0 0 0 0
Endoplasmic Reticulum 0 0.13 0.09 0 0.12 0.1 0.18 0.22 0.19 0.15 0.18 0.19 0.26 0.17 0.21 0.06 0.06 0.12 0 0 0 0 0 0
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0.29 0.4 0.78 0.72 0.79 0.76 0.64 0.7 0.59 0.72 0.42 0.62 0.64 0.43 0.54 0.71 0.52 0.39 0 0.05 0.06 0.05 0.05 0
Mitochondria 0.91 0.44 0.36 0.46 0.15 0.25 0.33 0.31 0.64 0.45 0.75 0.48 0.05 0 0 0.13 0.15 0.15 0 0 0 0 0 0
Nucleus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0.06 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.06 0 0.07 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vac/Vac Membrane 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 76 33 115 136 97 103 95 113 81 78 75 80 98 84 96 54 77 63 169 80 185 105 184 210
Bud 13 0 13 11 18 12 32 22 11 11 11 7 12 7 3 3 10 1 0 0 0 0 1 1
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 19 11 46 41 58 42 37 35 16 21 18 32 58 96 96 85 79 70 1 6 16 8 13 27
Cytoplasm 2 1 5 4 12 10 15 13 5 7 5 6 1 11 11 7 8 7 0 0 0 0 1 0
Endoplasmic Reticulum 6 10 22 8 36 23 58 75 39 32 40 38 44 32 47 14 12 21 1 3 3 0 0 1
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 0 0 0 0 1 0 0 2
Golgi 57 30 182 167 241 178 203 240 120 152 92 126 107 82 122 173 114 71 7 5 14 5 12 5
Mitochondria 181 33 83 107 45 58 105 108 131 95 164 97 9 2 2 31 33 27 1 2 6 0 1 2
Nucleus 0 0 0 0 0 0 1 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1
Nuclear Periphery 2 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 1 0 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 3 0 3 13 1 4 1 0 0 0 3 1 0 0 0 0 0 0 11 0 17 5 7 6
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vac/Vac Membrane 0 1 1 0 0 0 0 0 0 0 0 0 1 3 0 2 1 1 0 0 0 0 0 0
Unique Cell Count 199 75 233 233 306 234 315 345 205 212 220 204 167 190 224 244 218 181 195 100 248 129 226 264
Labelled Cell Count 360 119 470 487 509 430 548 606 404 396 408 387 330 317 377 372 334 261 195 100 248 129 226 264


Punctate Nuclear

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 34.4 65.4 40.4 36.0 40.7 41.5 42.1 41.6 39.0 41.6 40.3 42.1 50.7 56.3 58.3 87.2 87.7 87.6 42.8 42.5 47.7
Std Deviation (1e-4) 8.7 18.6 11.5 8.6 9.5 10.8 10.7 10.7 9.1 11.4 11.5 12.4 13.9 18.7 18.7 25.5 22.6 24.6 10.7 12.9 13.8
Intensity Change (Log2) – – – -0.16 0.01 0.04 0.06 0.04 -0.05 0.04 -0.0 0.06 0.33 0.48 0.53 1.11 1.12 1.12 0.08 0.07 0.24


Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches 2.0 -4.2 -1.2 -4.6 -4.0 -2.1 -2.7 -3.3 -2.1 1.8 -1.1 -1.4 -6.2 -3.0 -3.0
Bud -0.4 0.1 -0.2 1.9 0.4 -0.1 -0.2 -0.3 -1.1 0.7 -0.9 -2.5 -2.6 -0.5 -2.8
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cell Periphery -0.6 -0.2 -0.5 -2.6 -3.3 -3.6 -2.9 -3.5 -1.1 3.4 6.7 5.3 3.7 3.9 4.3
Cytoplasm 0 1.2 1.3 1.6 1.1 0 0.8 0 0.5 0 2.0 1.6 0.5 1.0 1.0
Endoplasmic Reticulum -2.6 0.9 0.1 2.9 3.9 2.9 1.8 2.7 2.8 4.5 2.3 3.4 -1.5 -1.6 0.7
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi -1.6 0.2 -0.5 -3.5 -2.3 -4.4 -1.6 -7.9 -3.7 -3.1 -7.4 -5.4 -1.8 -5.8 -8.1
Mitochondria 2.3 -5.7 -2.6 -0.6 -1.1 5.9 2.0 8.3 2.5 -7.1 -8.8 -9.5 -5.9 -5.0 -4.7
Nucleus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 2.5 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vacuole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 80.6482 92.4254 77.0699 72.2295 75.2991 81.1389 63.5185 76.3191 63.9234 72.0678 68.6963 72.8106 95.9958 112.9234 94.1288 88.3433 92.714 100.0399
Actin 0.0128 0.0056 0.0019 0.0017 0.0063 0.0108 0.0856 0.0308 0.0479 0.0014 0.0019 0.0016 0.0221 0.0082 0.0133 0.0002 0.0001 0.0011
Bud 0.0001 0 0 0 0 0 0.0002 0 0.0001 0 0 0 0 0 0.0001 0 0 0
Bud Neck 0.0001 0.0001 0.0001 0.0001 0.0004 0 0.0008 0.0004 0.0006 0.0001 0 0 0.0002 0.0002 0.0008 0.0001 0 0.0001
Bud Periphery 0.0002 0 0 0 0 0 0.0002 0 0.0001 0 0 0 0.0001 0 0.0001 0 0 0
Bud Site 0.0002 0 0 0.0001 0 0 0.0016 0.0001 0.0003 0 0 0 0.0005 0 0.0011 0 0 0
Cell Periphery 0.0003 0.0001 0.0003 0.0003 0.0004 0.0001 0.0002 0.0001 0.0001 0 0 0 0.0004 0.0001 0.0002 0.0001 0.0001 0.0001
Cytoplasm 0.0001 0 0.0001 0.0006 0 0 0.0009 0 0.0022 0 0 0 0.0001 0 0.0007 0 0 0
Cytoplasmic Foci 0.0008 0 0.0048 0.0006 0 0 0.0086 0 0.0019 0 0 0 0.0009 0 0.0019 0 0 0
Eisosomes 0.9705 0.993 0.977 0.9651 0.991 0.9874 0.8474 0.9673 0.915 0.9984 0.998 0.998 0.9585 0.988 0.9664 0.9994 0.9997 0.9982
Endoplasmic Reticulum 0.0001 0 0 0.0009 0.0001 0 0.0012 0 0.0024 0 0 0 0.0001 0 0.0007 0 0 0
Endosome 0.0006 0 0 0.0096 0 0 0.0052 0 0.0058 0 0 0 0.0007 0 0.0024 0 0 0
Golgi 0.0009 0.001 0.0007 0.0013 0.0008 0.0016 0.0039 0.0001 0.0027 0 0.0001 0 0.002 0.0016 0.0016 0.0001 0.0001 0.0005
Lipid Particles 0.0023 0 0.0014 0.001 0 0 0.009 0 0.0019 0 0 0 0.0012 0 0.0015 0 0 0
Mitochondria 0.0051 0.0001 0.0053 0.001 0.0007 0 0.0018 0.001 0.005 0 0 0.0003 0.0095 0.0017 0.004 0 0 0
None 0.001 0 0.0024 0.0009 0 0 0.0131 0 0.0028 0 0 0 0.0008 0 0.0019 0 0 0
Nuclear Periphery 0.0003 0 0.0001 0.0109 0 0 0.009 0 0.0055 0 0 0 0.0001 0 0.0009 0 0 0
Nucleolus 0.002 0 0.004 0.0003 0 0 0.0007 0 0.0003 0 0 0 0.0011 0 0.0002 0 0 0
Nucleus 0.0005 0 0.0002 0.0026 0 0 0.001 0 0.0016 0 0 0 0.0002 0 0.0003 0 0 0
Peroxisomes 0.001 0 0.0008 0.0002 0.0002 0 0.005 0.0002 0.0008 0 0 0 0.0014 0.0001 0.0006 0 0 0
Punctate Nuclear 0.0004 0 0.0004 0.0014 0 0 0.0041 0 0.0016 0 0 0 0 0 0.0008 0 0 0
Vacuole 0.0002 0 0.0001 0.0006 0 0 0.0002 0 0.0005 0 0 0 0.0001 0 0.0003 0 0 0
Vacuole Periphery 0.0004 0 0.0002 0.0008 0 0 0.0003 0 0.0006 0 0 0 0.0001 0 0.0002 0 0 0

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 201.7499 188.5719 353.0504 506.7351 482.4809 281.1043 181.6205 245.1632 483.6457 458.8326
Translational Efficiency 1.4489 1.3298 1.1309 1.7725 1.5422 1.2248 1.6323 1.5805 1.4385 1.5388

Hit Data

Dataset Hit
Protein Concentration ✘
Protein Localization ✘
Gene Expression ✔
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
1512 934 2300 1337 1657 2072 139 1595 3169 3006 2439 2932

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 2320.51 2947.27 4520.85 5997.34 2598.46 3062.92 5520.33 5560.40 2465.84 3026.99 4577.81 5759.65
Standard Deviation 557.33 782.29 1171.60 1587.95 550.24 605.28 1183.18 1464.74 570.78 667.49 1194.95 1537.64
Intensity Change Log 2 — 0.344937 0.962152 1.369881 — 0.237251 1.087098 1.097532 — 0.289054 1.029501 1.232431

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.080396 0.062097 0.066755 0.047257 0.097982 0.051752 0.095133 0.068505 0.089591 0.054966 0.068372 0.058816
Bud Neck 0.000367 0.001136 0.001871 0.002078 0.000377 0.000654 0.008324 0.002533 0.000372 0.000804 0.002239 0.002326
Bud Site 0.000090 0.000128 0.000144 0.001925 0.000077 0.000188 0.000428 0.002643 0.000083 0.000169 0.000160 0.002316
Cell Periphery 0.000021 0.000058 0.000744 0.009283 0.000017 0.000087 0.000552 0.008767 0.000019 0.000078 0.000733 0.009002
Cytoplasm 0.000062 0.000014 0.000002 0.000298 0.000021 0.000010 0.000003 0.000171 0.000040 0.000011 0.000002 0.000229
Cytoplasmic Foci 0.009930 0.002193 0.000046 0.003078 0.004409 0.002039 0.000245 0.001107 0.007043 0.002087 0.000057 0.002006
Eisosomes 0.893286* 0.923162* 0.908471* 0.925155* 0.890088* 0.942784* 0.874302* 0.833072* 0.891614* 0.936687* 0.906524* 0.875062*
Endoplasmic Reticulum 0.000074 0.000228 0.003623 0.001912 0.000148 0.000156 0.007689 0.015993 0.000113 0.000178 0.003855 0.009572
Endosome 0.000037 0.000084 0.000444 0.000450 0.000028 0.000056 0.000615 0.001545 0.000032 0.000065 0.000454 0.001046
Golgi 0.001289 0.001410 0.013567 0.002720 0.001007 0.000351 0.007587 0.049339 0.001141 0.000680 0.013227 0.028081
Lipid Particles 0.002600 0.006481 0.002890 0.001360 0.000684 0.000509 0.002851 0.011838 0.001598 0.002365 0.002888 0.007060
Mitochondria 0.002356 0.001146 0.000723 0.002746 0.001936 0.000794 0.000675 0.001914 0.002136 0.000903 0.000720 0.002293
Mitotic Spindle 0.000147 0.000116 0.000034 0.000167 0.000087 0.000079 0.000051 0.000359 0.000116 0.000090 0.000035 0.000272
None 0.000517 0.000388 0.000244 0.000207 0.000295 0.000214 0.000090 0.000381 0.000401 0.000268 0.000236 0.000302
Nuclear Periphery 0.000014 0.000028 0.000187 0.000273 0.000010 0.000012 0.000385 0.000495 0.000012 0.000017 0.000198 0.000394
Nuclear Periphery Foci 0.000001 0.000002 0.000003 0.000014 0.000000 0.000002 0.000009 0.000042 0.000001 0.000002 0.000004 0.000029
Nucleolus 0.000058 0.000058 0.000005 0.000061 0.000021 0.000019 0.000010 0.000042 0.000039 0.000031 0.000005 0.000051
Nucleus 0.000028 0.000041 0.000027 0.000281 0.000020 0.000027 0.000058 0.000139 0.000024 0.000031 0.000029 0.000204
Peroxisomes 0.008668 0.001106 0.000021 0.000067 0.002756 0.000209 0.000020 0.000045 0.005577 0.000488 0.000021 0.000055
Vacuole 0.000037 0.000083 0.000136 0.000572 0.000024 0.000048 0.000894 0.000820 0.000030 0.000059 0.000180 0.000707
Vacuole Periphery 0.000022 0.000041 0.000060 0.000096 0.000014 0.000010 0.000079 0.000247 0.000018 0.000020 0.000061 0.000178

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin 2.94 2.50 5.61 2.41 3.71 8.38 0.16 4.69 -3.21 1.48 8.53 4.66 7.08 -1.08 2.09
Bud Neck -4.83 -11.37 -9.91 -4.19 -1.11 -3.67 -6.86 -10.90 -9.13 4.90 -6.05 -13.08 -14.65 -10.39 -0.62
Bud Site -1.78 -2.90 -3.88 -3.82 -3.79 -2.11 -5.06 -3.18 -3.05 -2.78 -2.33 -4.63 -4.64 -4.48 -4.50
Cell Periphery -4.28 -11.42 -7.59 -7.56 -6.99 -7.53 -7.03 -8.14 -8.07 -7.62 -8.40 -11.94 -11.13 -11.05 -10.21
Cytoplasm 5.28 6.76 -1.98 -2.24 -2.30 2.09 8.55 -2.01 -2.10 -2.17 5.33 8.73 -2.77 -3.05 -3.14
Cytoplasmic Foci 9.05 12.94 4.07 -1.20 -2.91 4.29 7.93 3.57 0.91 -1.66 10.06 15.41 5.47 -0.56 -3.50
Eisosomes -4.20 -2.48 -4.21 0.04 -2.27 -9.08 0.80 7.19 15.17 2.09 -10.25 -2.96 3.31 12.29 5.80
Endoplasmic Reticulum -2.19 -9.04 -5.46 -4.91 3.31 -0.09 -2.28 -11.73 -11.72 -2.33 -1.03 -8.99 -12.42 -12.32 -6.59
Endosome -2.68 -13.35 -9.64 -8.16 -0.18 -1.42 -4.17 -13.22 -12.78 -5.20 -2.16 -14.42 -15.30 -14.48 -8.29
Golgi -0.29 -10.47 -2.24 -2.14 8.66 2.59 -2.20 -15.22 -15.43 -9.59 1.97 -11.07 -14.94 -15.22 -7.09
Lipid Particles -1.99 -0.39 1.35 2.58 1.87 0.50 -2.20 -7.05 -7.05 -4.85 -1.12 -2.55 -5.67 -4.25 -4.16
Mitochondria 3.62 5.21 -1.10 -4.17 -5.38 2.71 2.92 -0.07 -3.34 -3.56 4.58 5.19 -0.71 -5.54 -6.14
Mitotic Spindle 1.03 5.20 -0.74 -1.47 -3.86 0.57 2.30 -1.43 -1.47 -1.59 1.71 6.49 -1.52 -1.74 -2.19
None 1.88 8.14 5.13 2.04 0.25 4.61 11.16 -0.96 -1.61 -2.60 4.99 8.15 0.98 -0.85 -1.33
Nuclear Periphery -5.09 -15.00 -8.41 -7.93 -2.62 -1.73 -3.96 -10.92 -10.86 -1.07 -4.19 -15.34 -13.63 -13.43 -6.41
Nuclear Periphery Foci -1.90 -4.37 -2.10 -1.95 -1.77 -1.12 -4.66 -2.93 -2.81 -2.39 -1.31 -6.02 -3.45 -3.29 -3.15
Nucleolus -0.01 9.66 -0.50 -0.48 -2.40 0.12 4.47 -1.42 -1.33 -1.94 0.84 11.73 -1.26 -1.54 -3.23
Nucleus -2.62 0.54 -1.74 -1.68 -1.75 -1.63 -6.89 -2.34 -2.22 -1.72 -2.16 -2.70 -2.45 -2.38 -2.41
Peroxisomes 5.57 7.68 7.63 1.36 -2.15 5.02 5.43 5.37 3.01 -2.64 7.87 9.25 9.19 1.80 -3.22
Vacuole -4.24 -6.55 -3.50 -3.22 -2.89 -1.17 -6.24 -5.02 -4.84 0.10 -1.96 -9.05 -6.10 -5.81 -4.80
Vacuole Periphery -1.70 -4.14 -4.92 -3.17 -2.29 0.79 -4.34 -7.30 -7.37 -4.85 -0.40 -5.36 -8.59 -8.32 -5.88
Standard name
Human Ortholog
Description Eisosome core component; eisosomes are large immobile cell cortex structures associated with endocytosis; detected in phosphorylated state in mitochondria; phosphorylated on Thr233 upon Pkc1p hyperactivation in a Slt2p MAPK-dependent fashion; null mutant shows activation of Pkc1p/Ypk1p stress resistance pathways; member of BAR domain family; protein increases in abundance and relocalizes from plasma membrane to cytoplasm upon DNA replication stress
Localization
Cell Percentages actin (14%)
Cell Cycle Regulation No
Subcompartmental Group N/A

Pil1

Pil1


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Pil1-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available