ORF
Human Ortholog
Description Protein of unknown function; predicted to contain a single transmembrane domain; mutant has increased aneuploidy tolerance; localized to both the mitochondrial outer membrane and the plasma membrane; protein abundance increases in response to DNA replication stress
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0.21 0.11 0.1 0.1 0.25 0.15 0.13 0.15 0.12 – 0.06 0.1 0.13 0.18 0.16 0.05 0.07 0.05 0 0.06 0 0.06 0 0
Bud 0.08 0.08 0 0 0.07 0 0.05 0.05 0.06 – 0.11 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0.08 0.07 0.05 0 0
Bud Site 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0.71 0.56 0.64 0.64 0.53 0.53 0.48 0.36 0.38 – 0.2 0.32 0.74 0.83 0.78 0.85 0.85 0.84 0.79 0.55 0.75 0.8 0.9 0.85
Cytoplasm 0.35 0.55 0.57 0.59 0.41 0.55 0.54 0.59 0.54 – 0.56 0.64 0.43 0.35 0.37 0.15 0.14 0.18 0.05 0.21 0.07 0 0 0
Endoplasmic Reticulum 0.05 0 0 0 0 0 0 0 0 – 0 0 0 0 0.06 0 0 0 0 0.05 0 0 0 0
Endosome 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0 0 0 0 0.05 0.15 0.14 0.1 0.3 – 0.34 0.18 0 0 0 0 0 0 0 0 0 0 0 0
Nucleus 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0.05 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vac/Vac Membrane 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 53 51 34 36 124 69 72 58 41 – 23 52 26 45 49 25 24 18 12 29 9 6 4 9
Bud 20 34 13 6 33 14 26 18 21 – 42 23 8 4 12 6 3 2 2 2 0 0 0 3
Bud Neck 0 0 1 1 3 1 4 2 1 – 0 2 0 0 0 0 0 0 11 44 30 4 5 7
Bud Site 0 0 2 1 0 0 0 0 0 – 2 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 181 253 230 236 269 249 262 139 132 – 74 169 149 205 239 436 276 321 245 288 342 84 222 263
Cytoplasm 88 247 202 217 207 256 292 230 191 – 211 333 87 87 114 76 46 68 16 107 31 4 2 7
Endoplasmic Reticulum 12 19 2 7 12 16 24 9 3 – 1 11 9 9 17 2 4 5 9 26 14 0 4 5
Endosome 0 0 1 1 1 0 0 0 0 – 0 0 0 0 1 0 0 0 1 3 1 0 0 2
Golgi 1 0 1 0 0 0 0 0 0 – 0 0 0 0 0 3 2 1 1 1 1 0 0 0
Mitochondria 2 4 2 10 23 69 78 37 105 – 127 92 1 1 0 9 2 3 4 9 10 1 3 3
Nucleus 0 1 4 2 2 2 3 5 4 – 6 4 2 2 2 22 5 19 0 0 0 0 0 0
Nuclear Periphery 2 0 0 0 1 0 0 2 0 – 7 1 0 0 0 0 0 0 0 0 0 0 0 1
Nucleolus 0 0 0 0 0 0 0 0 1 – 1 1 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 – 0 0 1 2 6 0 0 0 0 0 0 0 0 0
SpindlePole 4 2 5 6 9 3 3 4 1 – 5 7 0 0 0 1 2 4 0 0 0 0 0 0
Vac/Vac Membrane 0 0 6 2 6 0 2 4 0 – 9 10 0 0 2 8 1 5 1 5 7 0 1 1
Unique Cell Count 254 448 357 369 503 466 545 387 351 379 521 201 247 307 511 324 382 311 522 457 106 246 310
Labelled Cell Count 363 611 503 525 690 679 766 508 500 508 705 283 355 442 588 365 446 311 522 457 106 246 310


Endoplasmic Reticulum

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 7.9 8.2 7.6 7.1 7.4 6.0 6.0 6.4 5.3 – 5.0 5.8 8.3 8.3 8.2 15.2 15.2 14.6 7.4 7.2 7.7
Std Deviation (1e-4) 1.1 1.3 0.8 0.9 1.0 0.9 0.7 0.8 0.8 – 0.9 0.8 1.1 1.4 1.0 2.6 2.7 2.4 1.3 1.1 1.3
Intensity Change (Log2) – – – -0.08 -0.04 -0.33 -0.33 -0.24 -0.5 – -0.59 -0.38 0.12 0.14 0.11 1.01 1.01 0.95 -0.03 -0.07 0.03


Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches 0.1 5.6 2.3 1.7 2.3 0.9 – -1.8 0.2 1.2 3.1 2.5 -2.7 -1.0 -2.6
Bud -1.7 1.9 -0.5 0.8 0.7 1.5 – 3.8 0.6 0.2 -1.5 0.2 -2.4 -2.3 -3.0
Bud Neck 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0
Cell Periphery -0.1 -3.2 -3.2 -4.8 -7.8 -7.1 – -12.4 -9.4 2.4 5.0 3.8 7.2 6.2 6.1
Cytoplasm 0.6 -4.5 -0.5 -0.9 0.8 -0.6 – -0.2 2.2 -3.0 -5.2 -5.0 -13.0 -11.5 -10.9
Endoplasmic Reticulum 0 2.1 2.8 3.4 2.0 0 – 0 1.9 0 0 3.8 0 0 0
Endosome 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0
Mitochondria 2.3 3.5 7.2 7.1 5.5 10.9 – 11.8 8.0 0 0 0 0 0 0
Nucleus 0 0 0 0 0 0 – 0 0 0 0 0 2.7 0 3.0
Nuclear Periphery 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0
SpindlePole 0.2 0.4 0 0 0 0 – 0 0 0 0 0 0 0 0
Vacuole 0 0 0 0 0 0 – 0.7 0.3 0 0 0 -0.1 0 -0.4

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 3.4152 3.5633 3.3763 2.9743 2.733 3.5304 5.0699 5.4276 5.2286 4.4858 3.9967 5.0332 6.223 5.4919 5.4244 5.3459 5.1532 5.4263
Actin 0.0569 0.0134 0.0292 0.0073 0.066 0.0178 0.0144 0.0006 0.0046 0.0115 0.0342 0.0036 0.0094 0.0068 0.0028 0.0172 0.0002 0.0025
Bud 0.0011 0.0011 0.0026 0.0023 0.0008 0.0011 0.0007 0.0002 0.0007 0.0005 0.0021 0.0004 0.0003 0.0007 0.0005 0.0006 0.0004 0.0004
Bud Neck 0.0141 0.0044 0.0217 0.0141 0.0373 0.0426 0.0032 0.0021 0.0041 0.0067 0.0233 0.0245 0.0079 0.0041 0.0092 0.0106 0.0055 0.0269
Bud Periphery 0.0066 0.0066 0.0192 0.0283 0.0087 0.0121 0.0034 0.0013 0.0059 0.0055 0.0131 0.0079 0.0017 0.0032 0.0082 0.0087 0.0056 0.007
Bud Site 0.0179 0.0938 0.057 0.0032 0.0026 0.0033 0.0054 0.0643 0.0177 0.0064 0.0076 0.0008 0.0056 0.0868 0.0227 0.0027 0.0107 0.0012
Cell Periphery 0.5454 0.387 0.4248 0.572 0.5023 0.5281 0.6927 0.6616 0.7047 0.6846 0.5331 0.7538 0.6989 0.535 0.6486 0.6567 0.7683 0.7054
Cytoplasm 0.2181 0.4498 0.381 0.3461 0.2637 0.344 0.1864 0.2573 0.2283 0.1814 0.1616 0.1826 0.2199 0.3179 0.282 0.2491 0.1826 0.2349
Cytoplasmic Foci 0.0085 0.0018 0.0048 0.0003 0.0089 0.0024 0.0096 0.0001 0.0032 0.0098 0.0108 0.0009 0.0012 0.0008 0.0003 0.0012 0.0001 0.0009
Eisosomes 0.0059 0.0019 0.0032 0.0012 0.0023 0.001 0.0184 0.0014 0.001 0.015 0.0063 0.0011 0.0077 0.0014 0.0018 0.0015 0.0004 0.0005
Endoplasmic Reticulum 0.0241 0.0141 0.0178 0.0166 0.0295 0.018 0.0119 0.008 0.0153 0.0246 0.0253 0.0125 0.0232 0.0282 0.0159 0.0244 0.0205 0.0115
Endosome 0.022 0.0005 0.0014 0.0001 0.0241 0.0045 0.0181 0 0.0024 0.0025 0.0457 0.0003 0.001 0.0029 0 0.0008 0 0.0007
Golgi 0.0153 0.0011 0.0029 0.0004 0.0111 0.0067 0.0064 0.0001 0.0025 0.0043 0.0308 0.0008 0.0012 0.0012 0.0003 0.0019 0.0001 0.0004
Lipid Particles 0.0081 0.0018 0.0104 0.0011 0.0133 0.0034 0.0096 0.0005 0.002 0.0142 0.0069 0.0012 0.0024 0.004 0.0008 0.0033 0.0009 0.001
Mitochondria 0.0055 0.0001 0.0015 0 0.0025 0.002 0.0091 0 0.0014 0.0091 0.052 0.0047 0.0034 0.0001 0 0.0113 0 0.0004
None 0.0153 0.0178 0.0146 0.0016 0.0061 0.0043 0.0015 0.0003 0.0007 0.002 0.0012 0.0003 0.0052 0.0013 0.0038 0.0051 0.0005 0.0011
Nuclear Periphery 0.0133 0.001 0.0008 0.0006 0.0061 0.0026 0.002 0.0004 0.0005 0.0009 0.0022 0.0003 0.0009 0.0011 0.0005 0.0006 0.0005 0.0018
Nucleolus 0.0007 0.0002 0.0002 0.0001 0.0004 0.0004 0.0002 0 0.0001 0.0002 0.0002 0 0.0002 0.0001 0 0.0001 0 0.0001
Nucleus 0.0083 0.0006 0.0006 0.0004 0.0011 0.001 0.0004 0.0002 0.0002 0.0003 0.0007 0.0002 0.0004 0.0005 0.0002 0.0003 0.0002 0.0005
Peroxisomes 0.0034 0.0001 0.0016 0 0.0041 0.0003 0.0026 0 0.0024 0.0167 0.0269 0.0016 0.0062 0 0 0.0007 0 0
Punctate Nuclear 0.0046 0.0002 0.0002 0 0.0053 0.0012 0.0009 0 0.0002 0.0002 0.0003 0 0.0003 0.0001 0 0.0001 0 0.0002
Vacuole 0.004 0.0028 0.0042 0.004 0.0029 0.0029 0.0028 0.0014 0.0018 0.0034 0.0085 0.0024 0.0029 0.0037 0.0024 0.0028 0.0036 0.0028
Vacuole Periphery 0.001 0.0001 0.0001 0.0001 0.0007 0.0003 0.0004 0 0.0001 0.0002 0.0073 0.0001 0.0002 0.0001 0 0.0002 0 0.0001

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 26.4587 22.0131 22.5905 27.8424 22.0773 21.4694 27.8218 29.2455 29.4474 29.1363
Translational Efficiency 0.904 1.2233 1.2229 1.08 1.0835 1.0952 1.1656 1.0049 0.9161 0.8541

Hit Data

Dataset Hit
Protein Concentration ✘
Protein Localization ✘
Gene Expression ✘
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
1843 538 118 817 1840 1369 159 141 3683 1907 277 958

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 813.50 1015.98 1288.08 1305.70 918.04 991.22 1310.63 1359.22 865.73 998.21 1301.02 1313.58
Standard Deviation 93.10 143.19 146.56 218.00 122.09 140.58 166.12 192.11 120.49 141.76 158.48 215.22
Intensity Change Log 2 — 0.320658 0.663008 0.682609 — 0.110648 0.513632 0.566150 — 0.213129 0.585740 0.622037

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.007601 0.010187 0.054045 0.065553 0.007342 0.016529 0.062047 0.068590 0.007472 0.014740 0.058639 0.066000
Bud Neck 0.071903 0.036077 0.058226 0.063279 0.047017 0.059086 0.045262 0.044699 0.059470 0.052595 0.050784 0.060544
Bud Site 0.053082 0.113877* 0.205924* 0.234912* 0.063062 0.096167 0.192874* 0.272483* 0.058068 0.101164* 0.198433* 0.240442*
Cell Periphery 0.184592* 0.399865* 0.166223* 0.219159* 0.244223* 0.346218* 0.157769* 0.194333* 0.214383* 0.361353* 0.161370* 0.215505*
Cytoplasm 0.535663* 0.382786* 0.115300* 0.154104* 0.552256* 0.397859* 0.123301* 0.146152* 0.543953* 0.393607* 0.119893* 0.152934*
Cytoplasmic Foci 0.014954 0.005725 0.029093 0.004574 0.008543 0.011067 0.026722 0.005458 0.011751 0.009560 0.027732 0.004704
Eisosomes 0.050330 0.009590 0.009306 0.046872 0.025904 0.023309 0.023688 0.033167 0.038127 0.019439 0.017561 0.044855
Endoplasmic Reticulum 0.009040 0.013171 0.115303* 0.017544 0.009619 0.007600 0.051795 0.021321 0.009329 0.009171 0.078849 0.018100
Endosome 0.001474 0.001157 0.008244 0.002704 0.001138 0.002010 0.004312 0.000830 0.001306 0.001770 0.005987 0.002428
Golgi 0.005778 0.003562 0.005319 0.003680 0.004180 0.005532 0.001273 0.000339 0.004980 0.004976 0.002997 0.003189
Lipid Particles 0.005077 0.002029 0.021762 0.009009 0.003421 0.002369 0.009400 0.003807 0.004249 0.002273 0.014666 0.008244
Mitochondria 0.003585 0.001124 0.000270 0.000967 0.001518 0.001639 0.000124 0.000151 0.002552 0.001494 0.000186 0.000847
Mitotic Spindle 0.000283 0.000264 0.000441 0.002206 0.000284 0.000580 0.000271 0.000145 0.000283 0.000491 0.000343 0.001903
None 0.001896 0.000080 0.000049 0.000300 0.000507 0.000120 0.000130 0.002103 0.001202 0.000108 0.000095 0.000565
Nuclear Periphery 0.000148 0.000138 0.000328 0.000217 0.000146 0.000120 0.000277 0.000157 0.000147 0.000125 0.000299 0.000208
Nuclear Periphery Foci 0.000695 0.000917 0.009343 0.001052 0.000697 0.000609 0.007001 0.001573 0.000696 0.000696 0.007999 0.001129
Nucleolus 0.000165 0.000040 0.000039 0.000028 0.000072 0.000080 0.000046 0.000016 0.000119 0.000069 0.000043 0.000026
Nucleus 0.029791 0.003223 0.026065 0.054071 0.010801 0.006435 0.032422 0.037643 0.020304 0.005528 0.029714 0.051653
Peroxisomes 0.006860 0.003397 0.000728 0.000477 0.004260 0.003339 0.000499 0.000308 0.005561 0.003355 0.000597 0.000452
Vacuole 0.016753 0.012407 0.173754 0.117716 0.014727 0.018922 0.260704* 0.164162 0.015741 0.017084 0.223664* 0.124552
Vacuole Periphery 0.000330 0.000384 0.000239 0.001574 0.000282 0.000412 0.000084 0.002562 0.000306 0.000404 0.000150 0.001720

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin -2.59 -7.10 -17.90 -16.67 -2.10 -6.84 -6.31 -7.19 -6.02 -0.96 -7.24 -9.07 -19.38 -16.30 -2.09
Bud Neck 8.40 1.68 2.50 -5.89 -0.62 -3.35 1.11 1.68 4.09 0.20 2.38 2.36 0.31 -1.72 -2.04
Bud Site -7.65 -8.84 -22.18 -10.95 -1.71 -6.63 -7.20 -10.37 -8.46 -3.19 -10.44 -11.18 -24.19 -16.73 -3.51
Cell Periphery -15.08 1.62 -2.78 12.54 -2.85 -10.62 6.67 4.63 9.72 -1.01 -18.91 5.82 1.67 16.69 -4.32
Cytoplasm 11.89 28.58 48.64 17.42 -2.57 17.60 32.68 23.53 14.12 -1.38 21.48 43.47 57.93 29.81 -3.10
Cytoplasmic Foci 7.25 -3.65 7.71 0.61 5.93 -1.81 -4.88 1.43 2.48 5.16 1.95 -5.92 7.07 3.58 7.98
Eisosomes 21.82* 21.25 1.85 -13.66 -13.63 1.69 1.86 -0.36 -0.97 -1.40 14.41 11.96 -1.86 -9.99 -10.03
Endoplasmic Reticulum -1.98 -7.25 -5.81 -1.99 6.62 1.71 -6.49 -3.26 -3.86 4.04 0.15 -9.17 -6.77 -6.30 7.84
Endosome 1.00 -6.75 -1.29 -1.67 4.54 -2.59 -5.45 1.01 2.94 5.58 -1.82 -8.44 -1.40 -0.71 4.32
Golgi 2.09 0.95 1.84 0.10 1.15 -1.52 6.83 9.07 6.60 4.22 0.00 4.95 1.89 1.68 -0.17
Lipid Particles 5.90 -5.90 -3.27 -5.63 3.94 2.40 -6.06 -0.99 -2.65 4.85 5.72 -7.59 -3.92 -5.70 3.38
Mitochondria 5.35 9.05 5.72 0.48 -2.23 -0.43 9.19 9.05 6.22 -0.90 3.88 11.93 5.47 2.17 -2.53
Mitotic Spindle 0.34 -2.25 -1.75 -1.76 -1.61 -1.13 -1.10 2.20 1.59 1.50 -1.11 -1.41 -1.72 -1.44 -1.40
None 8.99 9.16 7.74 -4.79 -5.63 5.78 4.28 -0.77 -1.02 -0.99 10.17 9.88 2.77 -1.72 -1.68
Nuclear Periphery 0.52 -5.34 -5.75 -3.58 3.15 2.31 -4.51 -1.30 -2.68 3.73 2.27 -6.79 -6.08 -6.54 3.96
Nuclear Periphery Foci -0.83 -7.99 -4.41 -0.81 7.55 1.09 -7.86 -3.03 -3.23 6.20 -0.05 -11.17 -5.48 -4.09 10.28
Nucleolus 6.36 6.75 7.55 1.56 2.66 -0.31 1.83 15.84 1.93 2.12 1.83 6.13 9.91 1.81 2.11
Nucleus 20.46 0.62 -9.48 -19.64 -7.14 6.53 -6.74 -7.51 -8.50 -1.66 19.30 -4.42 -14.13 -20.41 -7.13
Peroxisomes 6.12 14.19 15.16 7.62 2.50 1.78 9.96 10.64 8.35 2.39 5.58 17.28 18.09 10.28 2.31
Vacuole 2.49 -9.17 -23.15 -23.02 3.40 -3.44 -13.72 -10.96 -10.71 3.32 -1.42 -16.11 -25.07 -24.45 7.53
Vacuole Periphery -0.59 1.61 -1.27 -1.21 -1.38 -1.62 5.08 -0.88 -0.81 -0.98 -1.53 4.49 -1.52 -1.39 -1.72
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
ORF
Human Ortholog
Description Protein of unknown function; predicted to contain a single transmembrane domain; mutant has increased aneuploidy tolerance; localized to both the mitochondrial outer membrane and the plasma membrane; protein abundance increases in response to DNA replication stress
Localization
Cell Percentages cell periphery (57%)
Cell Cycle Regulation No
Subcompartmental Group cell periphery-3

YGR266W

YGR266W


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Ygr266w-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available