Standard name
Human Ortholog
Description Subunit of the endosomal Vps27p-Hse1p complex; complex is required for sorting of ubiquitinated membrane proteins into intralumenal vesicles prior to vacuolar degradation, as well as for recycling of Golgi proteins and formation of lumenal membranes

Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0.08 0 0 0 0 0 0 0 0 0 0 0.05 0 0.05 0.12 0.08 0.15 0 0 0 0 0 0
Bud 0 0 0 0 0.05 0.06 0.13 0.12 0.14 0.1 0.14 0.12 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cell Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 0 0 0 0 0.05 0 0 0.05 0 0 0 0.05 0.06 0.06 0.1 0.17 0.09 0.17 0 0 0 0 0 0
Endoplasmic Reticulum 0 0.07 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.05 0 0 0 0 0 0 0
Endosome 0.77 0.58 0.76 0.45 0.58 0.43 0.31 0.4 0.39 0.28 0.22 0.23 0.84 0.82 0.75 0.51 0.55 0.39 0.88 0.81 0.8 0.85 0.85 0.84
Golgi 0 0.07 0 0 0 0 0 0 0 0 0 0 0 0 0 0.17 0.14 0.21 0 0 0 0 0 0.06
Mitochondria 0.18 0.16 0.05 0.27 0.21 0.38 0.37 0.28 0.37 0.44 0.57 0.5 0 0 0 0 0.09 0.11 0 0 0 0 0 0
Nucleus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0.14 0.08 0.09 0.12 0.14 0.09 0.11 0.09 0.07 0.06 0.08 0.06 0 0 0 0 0 0.07 0 0 0 0 0 0
Peroxisomes 0 0 0.23 0.32 0.22 0.2 0.21 0.2 0.13 0.16 0.12 0.12 0.09 0 0 0 0 0 0 0 0.06 0 0 0
SpindlePole 0.11 0.07 0.31 0.24 0.25 0.16 0.24 0.22 0.23 0.17 0.16 0.14 0.15 0.21 0.16 0.12 0.14 0.11 0 0 0.07 0 0 0
Vac/Vac Membrane 0.15 0.21 0 0 0 0 0 0 0 0 0 0 0.11 0.17 0.18 0.19 0.24 0.12 0 0 0 0 0 0
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 9 17 1 1 6 2 18 12 18 22 9 17 16 11 28 17 13 20 3 6 5 1 1 6
Bud 8 2 17 5 16 23 63 57 68 64 72 63 3 7 4 2 3 4 2 1 1 0 1 0
Bud Neck 0 0 0 0 0 0 0 0 2 1 2 0 0 1 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 1 2 7 9 5 6 8 8 0 0 0 0 0 0
Cell Periphery 0 0 0 0 1 2 0 0 2 1 0 0 0 0 0 0 0 1 0 0 0 0 0 0
Cytoplasm 14 8 8 11 19 16 13 25 14 19 15 24 19 32 50 24 16 22 1 1 0 4 5 7
Endoplasmic Reticulum 4 15 0 1 0 1 2 4 1 8 3 13 3 3 8 4 8 3 0 0 0 1 0 1
Endosome 352 127 326 116 201 169 150 197 194 173 117 120 287 433 384 74 94 51 445 206 357 328 405 422
Golgi 6 15 4 2 3 0 0 2 4 7 1 3 3 9 6 25 24 27 12 10 13 7 14 27
Mitochondria 83 36 21 70 72 147 177 138 188 268 303 266 4 0 0 5 15 14 3 5 2 8 5 3
Nucleus 1 0 0 0 0 0 1 1 0 1 0 0 0 0 1 2 0 1 1 0 0 0 0 0
Nuclear Periphery 8 3 2 5 4 1 3 0 3 2 3 3 4 1 2 1 0 0 0 1 1 1 1 4
Nucleolus 66 18 38 32 47 35 53 43 37 39 41 34 11 11 11 4 7 9 1 0 0 2 3 3
Peroxisomes 6 0 97 83 77 77 101 97 67 98 63 66 30 14 13 0 3 0 9 4 28 4 12 6
SpindlePole 52 15 132 61 88 61 113 108 117 105 84 74 52 112 80 18 24 14 21 6 32 12 7 3
Vac/Vac Membrane 70 47 14 2 15 8 7 7 13 19 12 19 39 90 90 28 41 15 3 5 2 12 10 10
Unique Cell Count 460 220 429 259 348 391 478 492 502 610 530 528 341 527 510 145 171 130 508 255 449 387 474 504
Labelled Cell Count 679 303 660 389 550 544 708 700 733 833 733 710 471 724 677 204 248 181 508 255 449 387 474 504


Endosome

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 7.3 9.0 7.9 7.7 7.9 6.9 6.7 6.8 6.8 6.8 6.3 6.6 9.7 10.0 9.6 13.8 13.5 12.7 9.4 10.0 11.1
Std Deviation (1e-4) 1.1 1.5 1.2 1.6 1.8 1.2 1.1 1.3 1.2 1.3 1.1 1.3 1.4 1.3 1.2 3.4 2.6 3.4 1.6 1.5 1.9
Intensity Change (Log2) -0.03 -0.01 -0.19 -0.23 -0.22 -0.23 -0.21 -0.32 -0.26 0.29 0.34 0.27 0.8 0.78 0.69 0.26 0.34 0.49

WT3RAP60RAP140RAP220RAP300RAP380RAP460RAP540RAP620RAP700051015WT3HU80HU120HU160051015WT3rpd3Δ_1rpd3Δ_2rpd3Δ_3051015WT1AF100AF140AF180051015
rapamycinhydroxy-urearpd3 knockoutalpha-factorMultiple Condition Time-Course Intensity PlotsGFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)

Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches 0 0 0 3.7 2.8 3.6 3.6 0 3.4 4.2 2.6 4.6 0 0 0
Bud -1.5 0.4 1.3 4.9 4.2 5.1 3.9 5.1 4.4 -2.7 -2.6 -3.3 0 -1.4 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cell Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 1.8 2.7 1.9 0.9 2.6 0.9 1.2 1.0 2.3 2.8 3.2 5.0 6.7 4.2 6.7
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 3.3 0 0 0 0 0 0
Endosome -8.3 -5.4 -9.6 -13.4 -11.0 -11.4 -15.1 -16.7 -16.4 2.8 2.3 -0.2 -5.7 -5.1 -7.8
Golgi 0 0 0 0 0 0 0 0 0 0 1.0 0 7.8 6.9 8.7
Mitochondria 8.3 6.7 11.6 11.7 9.3 11.9 13.8 17.0 15.3 -2.9 -5.1 -5.1 -0.7 1.8 2.4
Nucleus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 1.5 2.1 0 1.1 -0.1 -0.8 -1.5 -0.6 -1.4 -3.2 -4.7 -4.6 -2.4 -2.0 -0.7
Peroxisomes 2.7 -0.2 -1.0 -0.5 -1.1 -3.7 -2.7 -4.4 -4.1 -5.1 -9.6 -9.5 -6.3 -6.2 -6.0
SpindlePole -2.0 -1.7 -5.1 -2.4 -3.0 -2.6 -5.1 -5.5 -6.3 -5.0 -3.4 -5.5 -4.3 -4.2 -4.5
Vacuole -2.1 0.8 -1.1 -1.8 -1.9 -0.6 -0.1 -0.9 0.3 4.5 6.8 7.0 6.4 7.9 3.7

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 5.579 6.5784 6.4226 5.8247 5.5563 6.5745 5.5385 6.3925 6.0945 5.7465 5.5333 6.288 5.2319 6.5389 5.8215 5.8429 5.5509 5.7975
Actin 0.0069 0.0003 0.0009 0 0.0008 0.0005 0.0123 0.001 0.0066 0 0.0008 0.0006 0.0127 0.0005 0.0009 0.0014 0 0.0002
Bud 0.0001 0.0001 0.0001 0 0.0001 0 0.0001 0.0002 0.0005 0 0 0 0.0001 0 0 0.0003 0 0.0001
Bud Neck 0.0002 0.0001 0.0003 0.0001 0.0002 0.0003 0.0003 0.0005 0.0005 0.0001 0.0001 0.0012 0.0004 0.0001 0.0002 0.0003 0.0001 0.0002
Bud Periphery 0 0 0.0001 0 0 0 0.0001 0.0001 0.0006 0 0.0001 0 0.0001 0 0 0.0003 0 0
Bud Site 0.0003 0.0002 0.0004 0.0001 0.0002 0.0002 0.0014 0.0016 0.0043 0.0001 0.0001 0.0001 0.0006 0.0001 0.0001 0.0027 0.0001 0.0001
Cell Periphery 0 0 0 0 0 0 0.0001 0.0001 0.0003 0 0 0 0.0001 0 0 0.0001 0 0
Cytoplasm 0.0073 0.0096 0.0082 0.0017 0.0023 0.0078 0.0059 0.0111 0.0055 0.0019 0.004 0.0017 0.0037 0.0048 0.0027 0.004 0.002 0.0031
Cytoplasmic Foci 0.2321 0.2351 0.2392 0.1906 0.2539 0.2347 0.2062 0.2651 0.222 0.2305 0.2052 0.2194 0.212 0.249 0.2491 0.1196 0.2721 0.2155
Eisosomes 0 0 0 0 0 0 0.0001 0 0.0001 0 0 0 0.0002 0 0 0 0 0
Endoplasmic Reticulum 0.0009 0.0007 0.0008 0.0002 0.0001 0.0005 0.0027 0.0009 0.0007 0.0001 0.0028 0.0003 0.0005 0.0003 0.0002 0.0009 0.0004 0.0003
Endosome 0.5293 0.5662 0.5422 0.6671 0.5559 0.4748 0.588 0.5699 0.5437 0.6611 0.5861 0.5179 0.5689 0.566 0.5541 0.7191 0.5767 0.5418
Golgi 0.0823 0.0874 0.1312 0.1245 0.114 0.1748 0.0962 0.092 0.1233 0.0734 0.1041 0.1758 0.1069 0.1155 0.138 0.1122 0.0986 0.174
Lipid Particles 0.0619 0.0789 0.0289 0.0069 0.0234 0.0451 0.0493 0.0176 0.0379 0.0175 0.0353 0.0377 0.0515 0.0397 0.0235 0.0181 0.0215 0.032
Mitochondria 0.0013 0.0006 0.0012 0.0004 0.0005 0.0025 0.0039 0.0007 0.0172 0.0003 0.002 0.0028 0.0017 0.0003 0.0006 0.0019 0.0002 0.0009
None 0.0031 0.0001 0.0004 0 0 0.0001 0.0015 0.0011 0.0003 0 0.0001 0 0.0041 0 0 0.0006 0.0001 0
Nuclear Periphery 0.0023 0.0004 0.0003 0.0001 0.0001 0.0002 0.0062 0.0005 0.0004 0.0001 0.0154 0.0006 0.0006 0.0004 0.0001 0.0017 0.004 0.0002
Nucleolus 0.0001 0 0.0001 0 0 0 0.0002 0.0001 0.0004 0 0.0001 0.0003 0.0003 0 0 0.0004 0 0
Nucleus 0.0001 0.0001 0.0001 0 0 0.0001 0.0017 0.0002 0.0004 0 0.0004 0.0001 0.0004 0 0 0.0015 0.0001 0
Peroxisomes 0.0602 0.0142 0.0377 0.005 0.046 0.046 0.0146 0.0239 0.0253 0.0117 0.0223 0.0363 0.0297 0.0144 0.0247 0.0037 0.0193 0.025
Punctate Nuclear 0.0062 0.0016 0.0007 0.0001 0.0003 0.0005 0.0029 0.0007 0.0004 0.0003 0.0011 0.0006 0.0012 0.0003 0.0003 0.0027 0.001 0.0002
Vacuole 0.0035 0.0032 0.0052 0.0018 0.001 0.0093 0.0039 0.0107 0.007 0.0018 0.0093 0.0026 0.0028 0.0057 0.0037 0.0057 0.0021 0.0042
Vacuole Periphery 0.0017 0.0013 0.0021 0.0012 0.0012 0.0024 0.0024 0.0022 0.0026 0.0011 0.0107 0.0015 0.0013 0.0028 0.0017 0.0028 0.0017 0.002

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 17.8623 24.6775 12.3874 22.6492 14.7377 25.9672 27.8869 23.0319 24.8206 24.8636
Translational Efficiency 1.732 1.4892 2.3913 1.3949 2.0602 1.5916 1.3381 1.7326 1.4695 1.3893

Hit Data

Dataset Hit
Protein Concentration
Protein Localization
Gene Expression
Translational Efficiency

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
680 449 256 1422 2359 1827 155 1018 3039 2276 411 2440

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 836.84 1040.60 1180.73 1209.73 923.88 1019.43 1318.87 1267.65 904.40 1023.61 1232.83 1233.89
Standard Deviation 116.72 149.24 164.17 186.17 123.79 136.72 166.24 218.51 127.51 139.53 178.02 202.32
Intensity Change Log 2 0.314392 0.496655 0.531661 0.141985 0.513525 0.456379 0.226500 0.505532 0.492650

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.002010 0.002081 0.002157 0.024149 0.000286 0.000852 0.001075 0.049452 0.000672 0.001095 0.001749 0.034706
Bud Neck 0.002305 0.001333 0.008099 0.002100 0.001044 0.001071 0.006951 0.004275 0.001326 0.001123 0.007666 0.003008
Bud Site 0.005684 0.012932 0.015201 0.022468 0.001813 0.004980 0.012083 0.049117 0.002679 0.006548 0.014025 0.033586
Cell Periphery 0.000149 0.000054 0.000101 0.000183 0.000029 0.000061 0.000053 0.000341 0.000056 0.000060 0.000083 0.000249
Cytoplasm 0.002973 0.010866 0.002587 0.009809 0.001466 0.002671 0.001901 0.012487 0.001803 0.004288 0.002328 0.010926
Cytoplasmic Foci 0.219366 0.193721 0.205158 0.151740 0.113158 0.150144 0.246323 0.195681 0.136923 0.158741 0.220683 0.170073
Eisosomes 0.000041 0.000017 0.000028 0.000084 0.000010 0.000013 0.000014 0.000114 0.000017 0.000014 0.000023 0.000096
Endoplasmic Reticulum 0.000181 0.000089 0.000263 0.000432 0.000087 0.000111 0.000269 0.000453 0.000108 0.000106 0.000265 0.000441
Endosome 0.524332 0.598805 0.521984 0.379449 0.740212 0.683986 0.470694 0.339898 0.691907 0.667182 0.502641 0.362948
Golgi 0.148928 0.120650 0.062574 0.289447 0.085492 0.087773 0.047945 0.215752 0.099686 0.094259 0.057057 0.258700
Lipid Particles 0.020302 0.007437 0.012679 0.008210 0.015100 0.012407 0.015175 0.010803 0.016264 0.011427 0.013621 0.009292
Mitochondria 0.004120 0.002752 0.001141 0.002696 0.002884 0.004050 0.000833 0.004607 0.003161 0.003794 0.001025 0.003494
Mitotic Spindle 0.002378 0.004830 0.019701 0.010248 0.000875 0.005637 0.033470 0.014269 0.001211 0.005478 0.024894 0.011925
None 0.000151 0.000018 0.000014 0.000041 0.000088 0.000020 0.000007 0.000223 0.000102 0.000020 0.000012 0.000117
Nuclear Periphery 0.000048 0.000032 0.000677 0.000197 0.000034 0.000067 0.000862 0.000134 0.000037 0.000060 0.000747 0.000171
Nuclear Periphery Foci 0.000761 0.001037 0.011285 0.002140 0.001165 0.001763 0.017963 0.001175 0.001075 0.001620 0.013804 0.001737
Nucleolus 0.000772 0.000020 0.000600 0.000020 0.000280 0.000089 0.000239 0.000055 0.000390 0.000076 0.000464 0.000035
Nucleus 0.001600 0.000016 0.000323 0.000057 0.000064 0.000039 0.000147 0.000085 0.000408 0.000035 0.000257 0.000069
Peroxisomes 0.055729 0.024085 0.052589 0.015606 0.021240 0.015198 0.034045 0.038611 0.028958 0.016951 0.045595 0.025204
Vacuole 0.005688 0.014124 0.072392 0.064747 0.010917 0.021795 0.098549 0.052009 0.009747 0.020282 0.082257 0.059433
Vacuole Periphery 0.002481 0.005101 0.010445 0.016174 0.003755 0.007271 0.011401 0.010460 0.003470 0.006843 0.010806 0.013790

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin -0.09 -0.17 -6.92 -6.85 -6.76 -1.66 -0.88 -9.77 -9.63 -9.47 -1.29 -1.76 -12.14 -11.93 -11.50
Bud Neck 1.03 -3.81 0.17 -1.59 4.50 -0.13 -2.41 -7.55 -8.05 1.05 0.68 -5.08 -5.37 -7.55 3.70
Bud Site -2.08 -3.92 -7.61 -2.65 -2.61 -4.05 -4.12 -12.30 -11.34 -7.99 -4.11 -6.86 -15.60 -12.74 -7.68
Cell Periphery 1.76 0.84 -0.63 -5.76 -2.88 -1.98 -2.12 -3.21 -2.85 -2.95 -0.23 -1.53 -4.38 -4.27 -3.76
Cytoplasm -2.64 0.33 -5.02 0.31 -5.12 -1.78 -1.37 -7.97 -6.73 -7.43 -3.09 -1.29 -9.57 -5.70 -8.45
Cytoplasmic Foci 2.43 1.09 8.60 4.71 4.68 -7.74 -7.95 -13.19 -6.78 2.85 -4.89 -8.71 -7.76 -2.44 5.16
Eisosomes 3.08 1.60 -1.21 -1.97 -1.64 -1.71 -1.46 -6.40 -6.15 -6.00 1.27 -1.87 -3.78 -3.93 -3.49
Endoplasmic Reticulum 1.66 -1.16 -3.16 -5.69 -1.92 -0.85 -2.36 -4.62 -4.43 -1.41 0.07 -3.25 -6.48 -6.95 -2.38
Endosome -4.68 0.26 12.20 16.03 8.54 7.37 13.68 44.46 35.95 6.15 3.53 14.91 48.59 42.12 10.60
Golgi 3.13 10.24 -15.56 -17.71 -25.36 -0.60 6.25 -16.91 -16.45 -18.32 1.55 8.79 -28.66 -29.25 -30.69
Lipid Particles 3.79 1.92 3.81 -0.50 1.58 1.34 -0.01 2.18 0.77 0.82 2.78 0.94 4.61 1.43 1.62
Mitochondria 0.96 3.19 1.49 0.05 -3.50 -1.46 2.73 -1.48 -0.42 -3.03 -0.88 4.58 -0.48 0.41 -4.32
Mitotic Spindle -1.23 -3.54 -4.44 -2.47 1.88 -5.38 -4.00 -7.40 -4.45 2.34 -5.10 -5.54 -9.89 -5.13 2.95
None 2.29 2.34 1.83 -1.17 -1.35 0.84 0.97 -0.62 -1.05 -1.11 1.31 1.41 -0.09 -1.20 -1.29
Nuclear Periphery 0.55 -4.30 -4.03 -5.84 3.25 -3.27 -3.73 -8.08 -4.53 3.29 -2.35 -5.77 -7.54 -6.10 4.65
Nuclear Periphery Foci -0.88 -3.10 -3.19 -1.37 2.69 -0.97 -2.59 -0.31 0.84 2.57 -1.17 -3.95 -1.94 -0.32 3.72
Nucleolus 1.68 0.67 1.68 0.15 1.52 0.73 -0.01 0.88 0.92 2.70 1.55 -0.04 1.74 1.48 1.87
Nucleus 1.46 1.20 1.43 -1.53 2.00 0.64 -1.38 -0.60 -1.46 1.14 1.51 0.56 1.38 -1.63 2.29
Peroxisomes 5.70 0.45 8.29 2.26 5.47 3.22 -2.49 -4.96 -6.88 -0.64 6.30 -3.51 1.72 -3.97 4.28
Vacuole -3.83 -9.86 -19.39 -14.38 1.03 -6.61 -7.90 -13.05 -9.12 4.02 -7.62 -12.17 -22.57 -16.28 3.60
Vacuole Periphery -2.17 -4.22 -11.96 -7.32 -2.76 -4.29 -3.77 -6.27 -2.61 0.43 -4.84 -5.23 -12.74 -7.30 -1.96
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Componentsactinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Subunit of the endosomal Vps27p-Hse1p complex; complex is required for sorting of ubiquitinated membrane proteins into intralumenal vesicles prior to vacuolar degradation, as well as for recycling of Golgi proteins and formation of lumenal membranes
Localization
Cell Percentages endosome (88%)
Cell Cycle Regulation No
Subcompartmental Group N/A

Hse1

Hse1


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)

Molecular Function (Gene Ontology)

Cellular Component (Gene Ontology)


Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Hse1-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available