Standard name
Human Ortholog
Description Cytoplasmic aspartyl aminopeptidase with possible vacuole function; Cvt pathway cargo protein; cleaves unblocked N-terminal acidic amino acids from peptide substrates; forms a 12-subunit homo-oligomer; M18 metalloprotease family

Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cell Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 0.88 0.96 0.84 0.98 0.84 0.88 0.84 0.73 0.71 0.69 0.67 0.62 0.95 0.99 0.99 0.92 0.92 0.97 0.75 0.76 0.6 0.89 0.88 0.81
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 0 0 0.06 0 0 0 0 0 0 0 0 0 0 0 0 0
Endosome 0 0 0.07 0 0 0 0 0 0 0 0 0 0 0 0 0.05 0 0 0 0 0.07 0 0 0
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0.12 0.05 0.11 0.07 0.06 0.1 0.08 0.23 0.23 0.26 0.32 0.41 0 0 0 0 0 0 0.08 0.06 0.15 0 0 0
Nucleus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vac/Vac Membrane 0 0 0.05 0 0.06 0 0.06 0.1 0 0 0 0 0 0 0 0 0.08 0 0 0 0 0 0 0
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 0 3 1 0 0 0 0 0 1 0 0 4 2 2 0 2 2
Bud 5 0 3 1 0 0 0 1 2 2 1 2 0 0 0 0 0 0 8 3 1 0 5 5
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 1 1 0 1
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cell Periphery 0 0 1 1 4 3 3 5 4 6 1 4 0 1 0 6 3 3 0 0 0 0 0 0
Cytoplasm 257 73 74 95 107 110 134 156 94 121 64 78 143 195 195 180 197 141 228 73 68 92 198 167
Endoplasmic Reticulum 2 1 1 0 3 5 6 1 4 7 6 4 2 0 0 4 7 5 1 0 2 0 2 3
Endosome 5 0 6 0 5 0 1 3 0 1 0 0 0 0 0 9 4 2 13 1 7 1 3 3
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0 3 0 1 0 0 0 1 2
Mitochondria 35 4 10 7 8 13 13 48 31 45 31 51 3 1 1 1 0 0 25 5 17 2 3 5
Nucleus 1 0 0 2 1 1 2 2 1 2 0 1 2 1 0 1 3 1 0 0 0 1 0 0
Nuclear Periphery 1 0 0 0 0 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 1 1 3 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 2 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0 0 0
SpindlePole 1 0 1 0 0 0 0 0 1 0 0 0 0 0 0 0 2 0 9 1 4 1 2 4
Vac/Vac Membrane 6 0 4 0 8 3 10 21 2 7 1 5 3 2 1 6 17 4 3 1 1 1 3 5
Unique Cell Count 291 76 88 97 128 125 159 213 133 176 96 125 151 197 197 195 214 145 304 96 115 104 227 207
Labelled Cell Count 313 78 102 106 136 135 170 238 145 193 105 145 153 201 197 208 236 156 304 96 115 104 227 207


Cytoplasm

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 4.5 4.8 5.3 5.7 7.8 7.3 7.5 7.6 7.8 7.5 7.2 7.2 6.7 6.6 6.9 13.8 15.5 17.0 4.9 6.5 7.7
Std Deviation (1e-4) 1.3 1.4 1.7 1.7 2.2 1.6 1.7 1.8 1.7 1.7 2.0 1.8 2.0 1.9 1.8 3.0 3.4 4.3 1.5 2.9 2.3
Intensity Change (Log2) 0.1 0.56 0.45 0.48 0.5 0.54 0.48 0.44 0.43 0.32 0.3 0.37 1.37 1.54 1.67 -0.13 0.29 0.52

WT3RAP60RAP140RAP220RAP300RAP380RAP460RAP540RAP620RAP70005101520WT3HU80HU120HU16005101520WT3rpd3Δ_1rpd3Δ_2rpd3Δ_305101520WT1AF100AF140AF18005101520
rapamycinhydroxy-urearpd3 knockoutalpha-factorMultiple Condition Time-Course Intensity PlotsGFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)

Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Actin
Bud 0
Bud Neck 0
Bud Site 0
Cell Periphery 0
Cyto
Endoplasmic Reticulum 0
Endosome 0
Golgi 0
Mitochondria 0
Nuclear Periphery 0
Nuc
Nucleolus 0
Peroxisomes 0
SpindlePole 0
Vac
Cortical Patches 0
Cytoplasm 0
Nucleus 0
Vacuole 1.1

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 1.2342 1.4817 1.213 0.8463 0.7915 1.411 2.0512 2.2214 2.3353 1.8662 3.3014 2.1522 2.7467 2.3157 2.5623 2.8592 2.5342 3.1478
Actin 0.0147 0.0012 0.015 0.0204 0.0012 0.0055 0.0241 0.0172 0.0253 0.0455 0.0014 0.0144 0.04 0.0019 0.021 0.0074 0.0522 0.0101
Bud 0.0007 0.0016 0.0014 0.0011 0.0008 0.0018 0.0006 0.0048 0.0015 0.0005 0.0021 0.0008 0.0025 0.001 0.0024 0.004 0.0006 0.002
Bud Neck 0.0031 0.0006 0.0019 0.0056 0.0009 0.0043 0.0009 0.0011 0.0015 0.0002 0.0004 0.0056 0.0049 0.0003 0.0079 0.0006 0.0026 0.0048
Bud Periphery 0.0013 0.002 0.0023 0.0012 0.0006 0.0061 0.0005 0.007 0.0036 0.0003 0.0065 0.0023 0.0058 0.0009 0.0026 0.0069 0.0009 0.0052
Bud Site 0.0058 0.0055 0.0048 0.0023 0.0003 0.0015 0.0021 0.0204 0.0087 0.0007 0.0007 0.0004 0.0035 0.0053 0.0026 0.0014 0.0017 0.0004
Cell Periphery 0.0007 0.0004 0.0003 0.0002 0.0001 0.0002 0.0003 0.0011 0.001 0.0001 0.0003 0.0002 0.0009 0.0003 0.0004 0.0003 0.0003 0.0001
Cytoplasm 0.3617 0.5157 0.4097 0.4923 0.5785 0.4903 0.3299 0.3683 0.3298 0.309 0.3646 0.3819 0.3559 0.491 0.4967 0.4395 0.5017 0.4197
Cytoplasmic Foci 0.0665 0.0459 0.0595 0.0451 0.0881 0.0653 0.0713 0.0566 0.0669 0.063 0.0325 0.0706 0.0377 0.0389 0.0504 0.0648 0.0438 0.0568
Eisosomes 0.0005 0.0001 0.0003 0.0001 0.0001 0.0001 0.0005 0.0008 0.0007 0.0001 0.0002 0.0002 0.0011 0.0001 0.0003 0.0002 0.0005 0.0002
Endoplasmic Reticulum 0.011 0.0041 0.0063 0.0079 0.0042 0.0039 0.0036 0.0038 0.0042 0.0025 0.0029 0.0037 0.0083 0.0035 0.0045 0.0039 0.0096 0.0029
Endosome 0.0368 0.0269 0.0264 0.0369 0.053 0.0276 0.0337 0.0228 0.0297 0.0111 0.0629 0.0231 0.0212 0.0302 0.0259 0.0436 0.0223 0.0143
Golgi 0.0043 0.0019 0.005 0.002 0.0038 0.0029 0.017 0.0073 0.0095 0.005 0.0076 0.002 0.0063 0.0058 0.0059 0.0172 0.01 0.0021
Lipid Particles 0.0072 0.0008 0.0056 0.001 0.0004 0.0035 0.0086 0.0021 0.0101 0.0013 0.002 0.0041 0.0094 0.0012 0.0039 0.0175 0.019 0.001
Mitochondria 0.0054 0.0033 0.007 0.0021 0.0083 0.0047 0.0164 0.0033 0.0043 0.0014 0.0935 0.0009 0.0059 0.0025 0.0075 0.0359 0.0074 0.0018
None 0.4276 0.3684 0.4237 0.3551 0.2454 0.3546 0.4621 0.4681 0.4788 0.5345 0.357 0.4749 0.4555 0.4089 0.3475 0.2904 0.3014 0.4683
Nuclear Periphery 0.0139 0.0018 0.0032 0.0039 0.0015 0.006 0.001 0.0008 0.0032 0.0011 0.0081 0.0006 0.0128 0.0008 0.0021 0.0012 0.0025 0.001
Nucleolus 0.0018 0.0008 0.0008 0.0003 0.0001 0.0006 0.0003 0.0003 0.0005 0.0001 0.0003 0.0001 0.0006 0.0002 0.0008 0.0002 0.0008 0.0001
Nucleus 0.0115 0.005 0.0059 0.0076 0.003 0.0072 0.0017 0.0015 0.0015 0.0011 0.0016 0.0008 0.0099 0.0016 0.002 0.0013 0.0017 0.002
Peroxisomes 0.0079 0.0014 0.0086 0.0039 0.0044 0.0056 0.0146 0.0096 0.0115 0.019 0.0045 0.01 0.0071 0.0016 0.0082 0.0593 0.0112 0.0043
Punctate Nuclear 0.0082 0.0051 0.0052 0.0041 0.0011 0.0043 0.0068 0.001 0.0045 0.002 0.0015 0.002 0.0059 0.0008 0.0044 0.0009 0.0067 0.0017
Vacuole 0.0073 0.0064 0.0058 0.0053 0.003 0.0033 0.0032 0.0018 0.0024 0.0011 0.0246 0.0012 0.0035 0.0027 0.0023 0.0025 0.0023 0.0011
Vacuole Periphery 0.0022 0.001 0.0012 0.0014 0.0011 0.0008 0.0007 0.0002 0.0008 0.0003 0.0247 0.0003 0.0014 0.0007 0.0006 0.0011 0.0009 0.0003

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 41.1998 18.0802 30.3109 36.375 39.3345 50.161 24.036 26.7331 37.8083 37.1171
Translational Efficiency 1.2434 1.5749 1.1048 1.2954 1.246 0.985 1.1179 1.2542 1.105 1.0827

Hit Data

Dataset Hit
Protein Concentration
Protein Localization
Gene Expression
Translational Efficiency

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
316 391 87 1149 1900 2133 277 2164 2216 2524 364 3313

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 863.21 835.44 1147.01 888.23 851.60 748.11 1250.62 924.91 853.26 761.64 1225.86 912.19
Standard Deviation 142.28 166.67 214.82 181.52 136.37 103.52 224.68 177.04 137.29 119.82 226.71 179.46
Intensity Change Log 2 -0.047175 0.410094 0.041222 -0.186926 0.554396 0.119137 -0.114886 0.483560 0.080442

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.000258 0.000503 0.001130 0.000895 0.000115 0.000397 0.000748 0.000853 0.000135 0.000413 0.000839 0.000867
Bud Neck 0.004917 0.004777 0.003479 0.005943 0.005239 0.037236 0.003367 0.011047 0.005193 0.032207 0.003394 0.009277
Bud Site 0.009499 0.010980 0.015200 0.023659 0.003951 0.016585 0.012788 0.037216 0.004742 0.015717 0.013364 0.032514
Cell Periphery 0.000150 0.000136 0.000285 0.000158 0.000111 0.000129 0.000174 0.000136 0.000117 0.000130 0.000201 0.000144
Cytoplasm 0.656737 0.666503 0.381390 0.526224 0.675971 0.440998 0.476739 0.587638 0.673228 0.475932 0.453949 0.566339
Cytoplasmic Foci 0.176778 0.080481 0.081557 0.023463 0.132832 0.208215 0.058322 0.022828 0.139099 0.188428 0.063875 0.023048
Eisosomes 0.000060 0.000037 0.000095 0.000040 0.000044 0.000119 0.000050 0.000033 0.000046 0.000106 0.000060 0.000036
Endoplasmic Reticulum 0.000940 0.001419 0.006335 0.002198 0.002216 0.000707 0.004041 0.000884 0.002034 0.000818 0.004589 0.001340
Endosome 0.014898 0.008101 0.029078 0.005306 0.010502 0.024467 0.015981 0.009037 0.011129 0.021931 0.019112 0.007743
Golgi 0.001644 0.002559 0.009179 0.001509 0.001391 0.005358 0.000424 0.005702 0.001427 0.004925 0.002516 0.004248
Lipid Particles 0.002986 0.001976 0.006571 0.001415 0.003297 0.006775 0.003601 0.000890 0.003253 0.006032 0.004311 0.001072
Mitochondria 0.003200 0.000665 0.000615 0.001357 0.001099 0.011586 0.000196 0.003377 0.001399 0.009894 0.000296 0.002676
Mitotic Spindle 0.000395 0.007626 0.004754 0.028265 0.001179 0.011766 0.007810 0.047882 0.001067 0.011125 0.007080 0.041079
None 0.002422 0.011915 0.001331 0.007863 0.007241 0.003642 0.002125 0.006115 0.006554 0.004923 0.001936 0.006721
Nuclear Periphery 0.000171 0.000317 0.001698 0.001243 0.000294 0.000537 0.001167 0.001062 0.000276 0.000503 0.001294 0.001125
Nuclear Periphery Foci 0.003122 0.004801 0.020608 0.002002 0.001362 0.000337 0.014895 0.000661 0.001613 0.001029 0.016260 0.001126
Nucleolus 0.000421 0.002240 0.000535 0.000373 0.000813 0.002143 0.000250 0.000518 0.000757 0.002158 0.000318 0.000468
Nucleus 0.070542 0.144558 0.260849 0.236359 0.100538 0.138282 0.152290 0.156831 0.096260 0.139254 0.178236 0.184412
Peroxisomes 0.002559 0.003131 0.007842 0.000960 0.001649 0.015970 0.004550 0.001644 0.001778 0.013981 0.005337 0.001407
Vacuole 0.047720 0.046632 0.166791 0.126451 0.049165 0.072402 0.240132 0.103812 0.048959 0.068410 0.222603 0.111664
Vacuole Periphery 0.000583 0.000643 0.000678 0.004316 0.000992 0.002346 0.000351 0.001833 0.000934 0.002082 0.000429 0.002694

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin -2.06 -4.89 -3.06 -1.12 1.93 -3.37 -2.60 -2.73 -0.64 1.24 -3.85 -3.55 -4.29 -1.35 1.53
Bud Neck 0.01 0.20 -0.78 -0.70 -0.93 -16.10 -0.48 -5.09 13.56 -2.35 -15.73 -0.34 -4.63 13.86 -2.24
Bud Site -0.65 -1.07 -2.62 -1.74 -0.27 -10.08 -5.19 -9.66 -1.98 -2.70 -9.68 -5.10 -10.95 -2.04 -2.30
Cell Periphery 0.70 -5.70 1.01 0.11 6.46 -1.85 -4.94 1.96 3.06 5.75 -1.59 -7.47 0.90 2.16 7.78
Cytoplasm 0.35 10.18 14.55 14.62 -2.73 27.60 16.61 21.41 -6.17 -6.01 25.04 19.68 28.40 0.85 -5.99
Cytoplasmic Foci 7.88 7.68 15.04 9.18 3.28 -12.34 10.81 28.17 39.61 4.44 -8.81 12.84 31.90 39.86 5.46
Eisosomes 2.86 -3.92 1.22 -2.78 4.77 -10.07 -2.77 3.10 11.16 4.54 -9.44 -4.97 1.72 10.23 5.93
Endoplasmic Reticulum -2.96 -7.19 -10.48 -6.91 4.93 3.22 -2.88 2.06 -3.40 6.29 2.95 -5.31 0.15 -7.12 7.25
Endosome 2.33 -1.06 4.38 3.06 3.34 -10.03 -1.38 6.03 15.06 4.67 -8.42 -1.99 8.07 16.05 5.77
Golgi -0.59 -0.72 2.00 1.59 0.99 -7.72 6.75 -1.11 3.79 -2.58 -7.33 0.00 -0.39 5.14 -0.17
Lipid Particles 1.43 -2.90 1.80 0.46 3.94 -5.75 -1.37 7.48 10.49 7.27 -5.33 -2.93 7.04 10.13 7.50
Mitochondria 1.21 1.30 1.10 -0.91 -1.94 -10.16 3.77 -1.66 9.12 -4.44 -9.17 3.14 -0.25 9.45 -5.00
Mitotic Spindle -2.87 -1.47 -7.51 -3.43 -1.14 -6.65 -2.65 -11.39 -6.76 -5.37 -7.19 -2.97 -13.40 -7.32 -4.95
None -4.08 3.36 -3.62 2.90 -6.03 4.48 8.03 2.39 -2.65 -7.25 2.07 8.51 1.99 -0.46 -9.00
Nuclear Periphery -5.22 -9.75 -18.67 -16.59 0.43 -2.32 -13.09 -24.10 -10.88 -3.68 -2.64 -15.89 -29.80 -13.80 -3.02
Nuclear Periphery Foci -0.30 -2.73 1.19 1.86 3.02 7.36 -6.28 2.81 -5.05 6.45 1.99 -6.45 1.22 -1.44 6.59
Nucleolus -1.78 -1.14 0.55 1.82 1.71 -4.30 3.80 1.19 4.61 -2.20 -4.62 3.41 2.08 5.10 -1.39
Nucleus -7.27 -6.94 -20.95 -9.45 -0.34 -7.90 -4.47 -20.95 -12.24 -5.62 -10.01 -7.32 -28.99 -16.78 -5.12
Peroxisomes -0.82 -0.79 3.40 2.92 1.55 -12.17 -1.46 1.95 12.97 2.17 -12.09 -1.73 3.11 13.30 2.69
Vacuole -1.14 -8.58 -22.09 -20.26 0.19 -7.83 -18.14 -26.00 -20.51 9.02 -7.71 -19.85 -34.44 -28.35 7.80
Vacuole Periphery -0.23 0.13 -1.55 -1.47 -1.58 -5.18 8.37 1.03 5.08 -2.84 -5.14 7.49 -0.40 3.33 -2.94
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Componentsactinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Cytoplasmic aspartyl aminopeptidase with possible vacuole function; Cvt pathway cargo protein; cleaves unblocked N-terminal acidic amino acids from peptide substrates; forms a 12-subunit homo-oligomer; M18 metalloprotease family
Localization
Cell Percentages cytoplasm (89%)
Cell Cycle Regulation No
Subcompartmental Group cytoplasm-9

Ape4

Ape4


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)

Molecular Function (Gene Ontology)

Cellular Component (Gene Ontology)


Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Ape4-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available