Standard name
Human Ortholog
Description Tripartite DNA replication factor; single-stranded DNA-dependent ATPase, ATP-dependent nuclease, helicase; tracking protein for flap cleavage during Okazaki fragment maturation; involved in DNA repair/processing of meiotic DNA double strand breaks; component of telomeric chromatin with cell-cycle dependent localization; required for telomerase-dependent telomere synthesis; forms nuclear foci upon DNA replication stress; human homolog DNA2 complements yeast dna2 mutant
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 0.53 0.43 0.58 0.62 0.51 0.5 0.62 0.59 0.49 0.55 0.49 0.5 0.63 0.55 0.63 0.56 0.52 0.57 0.38 0.37 0.44 0.72 0.91 0.91
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.06 0.05 0.07 0 0 0 0 0 0
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.06 0.07 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0.11 0.4 0.35 0.54 0.32 0.48 0.44 0.5 0.66 0.61 0.66 0.66 0 0 0.15 0 0 0 0 0 0.08 0 0 0
Nucleus 0.37 0.19 0.15 0.18 0.21 0.24 0.15 0.14 0.11 0.13 0.1 0.1 0.27 0.26 0.09 0.24 0.21 0.17 0.36 0.36 0.24 0.11 0 0
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vac/Vac Membrane 0.16 0.17 0 0 0 0 0 0 0 0 0 0 0.11 0.16 0.22 0.23 0.28 0.29 0.1 0.14 0.14 0.09 0 0
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0 0 0 0 0 0 1
Bud 0 0 1 1 4 7 8 13 4 6 4 4 0 1 6 0 0 0 3 1 1 1 1 3
Bud Neck 0 0 0 0 1 0 3 1 0 1 0 1 0 0 0 1 0 0 0 0 0 1 1 0
Bud Site 0 0 0 0 0 3 6 6 3 2 2 1 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 1 1 1 0 0 1 0 1 1 2 5 2 3 0 0 0 0 0 0
Cytoplasm 10 47 80 35 106 93 166 207 94 148 90 127 172 145 193 426 277 359 28 43 66 117 349 298
Endoplasmic Reticulum 0 0 0 1 0 0 0 1 1 1 0 0 0 2 0 42 26 47 0 0 0 1 0 1
Endosome 0 0 0 0 6 0 0 0 0 0 2 2 2 7 1 22 34 43 1 2 2 0 3 1
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0 0 0 0 0 0
Mitochondria 2 44 48 30 67 90 117 176 128 166 121 166 6 3 45 8 13 11 1 2 11 1 5 8
Nucleus 7 21 21 10 43 44 39 48 22 35 18 26 75 70 29 181 112 110 27 42 36 17 5 0
Nuclear Periphery 0 0 0 0 0 1 2 1 2 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 1 2 0 2 0 0 5 1 1 1 0 0 0 0 3 3 4 0 0 1 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0 0 0 0 0
SpindlePole 0 0 2 0 5 1 3 6 3 2 2 3 1 0 1 7 5 4 3 4 4 4 5 4
Vac/Vac Membrane 3 19 5 0 8 6 3 5 1 4 4 3 31 43 66 172 152 180 7 16 20 15 7 2
Unique Cell Count 19 110 139 56 207 186 268 353 193 271 183 252 275 265 306 760 537 631 76 119 150 163 383 328
Labelled Cell Count 22 132 159 77 242 246 348 470 259 366 246 333 288 272 344 868 625 761 76 119 150 163 383 328


Nucleus

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 4.6 3.4 3.5 3.5 3.4 3.3 2.9 3.1 2.7 2.9 2.9 2.5 4.6 4.8 4.0 6.0 6.1 6.4 4.7 4.5 5.2
Std Deviation (1e-4) 0.6 0.5 1.0 2.0 0.9 1.1 1.0 1.4 1.0 1.6 1.2 0.8 0.7 0.8 0.9 1.3 1.3 1.5 0.9 0.8 1.1
Intensity Change (Log2) – – – 0.02 -0.01 -0.07 -0.23 -0.14 -0.35 -0.27 -0.27 -0.47 0.41 0.46 0.23 0.79 0.83 0.9 0.45 0.4 0.58

WT3RAP60RAP140RAP220RAP300RAP380RAP460RAP540RAP620RAP7000246WT3HU80HU120HU1600246WT3rpd3Δ_1rpd3Δ_2rpd3Δ_30246WT1AF100AF140AF1800246
rapamycinhydroxy-urearpd3 knockoutalpha-factorMultiple Condition Time-Course Intensity PlotsGFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)

Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Actin – – – – – – – – – – – – – – –
Bud – – – – – – – – – – – – 0 0 0
Bud Neck – – – – – – – – – – – – 0 0 0
Bud Site – – – – – – – – – – – – 0 0 0
Cell Periphery – – – – – – – – – – – – 0 0 0
Cyto – – – – – – – – – – – – – – –
Endoplasmic Reticulum – – – – – – – – – – – – 0 0 0
Endosome – – – – – – – – – – – – 0 0 0
Golgi – – – – – – – – – – – – 0 0 0
Mitochondria – – – – – – – – – – – – 0 0 0
Nuclear Periphery – – – – – – – – – – – – 0 0 0
Nuc – – – – – – – – – – – – – – –
Nucleolus – – – – – – – – – – – – 0 0 0
Peroxisomes – – – – – – – – – – – – 0 0 0
SpindlePole – – – – – – – – – – – – 0 0 0
Vac – – – – – – – – – – – – – – –
Cortical Patches – – – – – – – – – – – – 0 0 0
Cytoplasm – – – – – – – – – – – – 0 0 0
Nucleus – – – – – – – – – – – – 0 0 0
Vacuole – – – – – – – – – – – – 5.2 6.1 6.2

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 0.4164 1.1862 0.8814 0.6918 1.2919 0.8956 1.4485 1.6505 1.5637 1.47 1.327 1.5574 0.9674 1.3425 1.3263 1.3611 1.0345 1.202
Actin 0.0316 0.0008 0.0131 0.0002 0.0189 0.0004 0.0276 0.0002 0.0113 0.0051 0.001 0.0026 0.0022 0.0001 0.0252 0 0.0004 0.0005
Bud 0.0031 0.0008 0.0005 0.0001 0.0021 0.0003 0.0023 0.0052 0.0061 0.0005 0.0002 0.0013 0.0024 0.0001 0.0008 0 0.0001 0.0007
Bud Neck 0.0067 0.0017 0.0063 0.0012 0.0015 0.0103 0.0019 0.0007 0.0011 0.0021 0.0011 0.005 0.0008 0.0002 0.0028 0.0003 0.0005 0.0042
Bud Periphery 0.0063 0.001 0.0011 0.0001 0.0044 0.0004 0.0027 0.0018 0.0065 0.0007 0.0002 0.0016 0.0026 0 0.0013 0 0.0002 0.0009
Bud Site 0.0059 0.0138 0.0039 0.0004 0.0043 0.0005 0.0038 0.0075 0.0076 0.0008 0.0033 0.0005 0.0023 0.0006 0.0028 0.0002 0.0002 0.0026
Cell Periphery 0.0014 0.0005 0.0009 0.0001 0.0005 0.0003 0.0004 0.0002 0.0003 0.0001 0.0001 0.0004 0.0004 0.0001 0.0004 0 0.0001 0.0001
Cytoplasm 0.3133 0.2529 0.0944 0.0779 0.1038 0.2933 0.3085 0.2069 0.0418 0.0678 0.0561 0.3071 0.2206 0.1071 0.0507 0.0423 0.0354 0.1945
Cytoplasmic Foci 0.0322 0.0107 0.0163 0.0076 0.0132 0.005 0.043 0.0079 0.0064 0.0052 0.0352 0.0151 0.019 0.0012 0.0061 0.0126 0.0012 0.0065
Eisosomes 0.0005 0.0001 0.0006 0 0.0002 0 0.0003 0 0.0002 0 0 0 0.0001 0.0001 0.0007 0 0 0.0001
Endoplasmic Reticulum 0.0209 0.0077 0.0038 0.0024 0.0051 0.0039 0.0134 0.0026 0.0013 0.0016 0.002 0.0026 0.0094 0.0022 0.0088 0.0008 0.0036 0.0034
Endosome 0.0202 0.0031 0.0061 0.0081 0.02 0.0077 0.0525 0.003 0.0127 0.0153 0.0239 0.0124 0.0062 0.0013 0.0166 0.0081 0.0081 0.0028
Golgi 0.0044 0.0003 0.0027 0.0001 0.0073 0.0007 0.0171 0.0002 0.0066 0.0124 0.0071 0.006 0.0016 0 0.0063 0.0001 0.0001 0.0002
Lipid Particles 0.0104 0.0007 0.0078 0.0003 0.016 0.0101 0.0329 0.0002 0.0093 0.0063 0.0058 0.0009 0.0182 0.0002 0.0014 0.0005 0.0002 0.0004
Mitochondria 0.0137 0.0008 0.0125 0.0007 0.041 0.001 0.0216 0.0008 0.0105 0.0087 0.0073 0.0035 0.0029 0.0004 0.0075 0.0003 0.0009 0.0008
None 0.3286 0.2762 0.1047 0.0619 0.1078 0.1084 0.2505 0.1906 0.0664 0.0463 0.0647 0.1215 0.4776 0.2583 0.0885 0.0133 0.0393 0.3294
Nuclear Periphery 0.0261 0.02 0.0136 0.0127 0.0202 0.0081 0.0255 0.0084 0.0222 0.011 0.0208 0.0088 0.0135 0.0091 0.0308 0.0072 0.0116 0.0084
Nucleolus 0.0064 0.0039 0.0128 0.006 0.0086 0.0061 0.0021 0.0035 0.0055 0.0048 0.0044 0.0033 0.0029 0.0038 0.0053 0.004 0.0074 0.0096
Nucleus 0.1049 0.3466 0.6283 0.6802 0.5798 0.531 0.11 0.5397 0.7136 0.7258 0.7406 0.4592 0.1781 0.5997 0.6995 0.8366 0.8827 0.4014
Peroxisomes 0.0063 0.0006 0.0123 0.0001 0.0105 0.0007 0.0407 0.0005 0.0082 0.002 0.0029 0.0055 0.0094 0 0.0011 0.0001 0.0001 0.0003
Punctate Nuclear 0.031 0.0493 0.0528 0.1368 0.0258 0.0072 0.0316 0.0143 0.0569 0.0813 0.0118 0.0348 0.0165 0.0133 0.0374 0.0653 0.0041 0.0304
Vacuole 0.0219 0.0076 0.0045 0.0027 0.0064 0.0039 0.0087 0.0051 0.0043 0.0015 0.0098 0.0059 0.0116 0.0019 0.0046 0.0078 0.003 0.0023
Vacuole Periphery 0.004 0.0009 0.001 0.0004 0.0026 0.0004 0.0028 0.0006 0.0013 0.0007 0.0015 0.0021 0.0016 0.0002 0.0016 0.0005 0.001 0.0003

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 6.7619 9.7148 8.3302 11.1411 6.5754 8.4478 11.1869 11.123 11.766 11.504
Translational Efficiency 0.7979 0.5724 0.6476 0.521 0.7304 0.7555 0.5357 0.4818 0.4951 0.5244

Hit Data

Dataset Hit
Protein Concentration ✔
Protein Localization ✘
Gene Expression ✘
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
109 1535 194 920 1326 2090 651 42 1435 3625 845 962

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 580.62 734.17 1027.42 905.77 602.63 727.01 777.50 921.05 600.96 730.04 834.88 906.44
Standard Deviation 75.85 104.48 118.32 125.66 103.89 104.80 128.77 112.48 102.20 104.72 164.43 125.15
Intensity Change Log 2 — 0.338520 0.823360 0.641550 — 0.270703 0.367570 0.612007 — 0.304379 0.609180 0.626580

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.000069 0.000181 0.001153 0.002035 0.000388 0.000233 0.000432 0.000719 0.000364 0.000211 0.000597 0.001978
Bud Neck 0.014963 0.010821 0.004335 0.011164 0.008238 0.016705 0.003047 0.002245 0.008749 0.014214 0.003343 0.010775
Bud Site 0.003013 0.004679 0.004385 0.044202 0.002149 0.009835 0.002959 0.001797 0.002215 0.007652 0.003287 0.042351
Cell Periphery 0.000256 0.000137 0.000247 0.000289 0.000214 0.000246 0.000140 0.000173 0.000217 0.000200 0.000165 0.000284
Cytoplasm 0.261100 0.314612 0.121118 0.207942 0.340123 0.323962 0.170093 0.058106 0.334121 0.320003 0.158849 0.201400
Cytoplasmic Foci 0.065998 0.036843 0.015215 0.016795 0.059214 0.061175 0.003230 0.002406 0.059729 0.050872 0.005982 0.016166
Eisosomes 0.000081 0.000030 0.000117 0.000040 0.000082 0.000054 0.000029 0.000067 0.000082 0.000044 0.000049 0.000041
Endoplasmic Reticulum 0.001485 0.001465 0.012494 0.004865 0.000852 0.001641 0.004464 0.012086 0.000900 0.001567 0.006308 0.005181
Endosome 0.004454 0.003468 0.006440 0.011057 0.002909 0.008372 0.001084 0.001922 0.003026 0.006295 0.002314 0.010658
Golgi 0.000134 0.000927 0.000158 0.010632 0.000715 0.003398 0.000148 0.000073 0.000671 0.002352 0.000151 0.010171
Lipid Particles 0.005576 0.001754 0.004846 0.000892 0.004498 0.004955 0.000819 0.001404 0.004580 0.003599 0.001743 0.000914
Mitochondria 0.002094 0.003277 0.000731 0.007363 0.004335 0.013063 0.000826 0.000619 0.004165 0.008919 0.000804 0.007069
Mitotic Spindle 0.000146 0.011966 0.003266 0.175835 0.001310 0.009588 0.011259 0.001052 0.001221 0.010595 0.009424 0.168204
None 0.011877 0.011673 0.002568 0.009173 0.034334 0.008003 0.017213 0.002637 0.032628 0.009557 0.013851 0.008888
Nuclear Periphery 0.000803 0.000916 0.002470 0.005499 0.000841 0.001423 0.001097 0.001643 0.000839 0.001208 0.001412 0.005331
Nuclear Periphery Foci 0.000262 0.000786 0.003250 0.003801 0.000652 0.000659 0.001251 0.001264 0.000623 0.000712 0.001710 0.003691
Nucleolus 0.006432 0.004380 0.001199 0.001244 0.004830 0.003777 0.001571 0.000698 0.004952 0.004032 0.001485 0.001220
Nucleus 0.599731 0.571173 0.680633 0.427111 0.521838 0.503741 0.764803 0.854810 0.527755 0.532295 0.745479 0.445784
Peroxisomes 0.002588 0.002567 0.001262 0.001044 0.002391 0.005000 0.000730 0.000177 0.002406 0.003970 0.000852 0.001006
Vacuole 0.018223 0.017647 0.133801 0.054663 0.009701 0.022023 0.014664 0.055986 0.010348 0.020170 0.042016 0.054721
Vacuole Periphery 0.000713 0.000696 0.000312 0.004353 0.000384 0.002147 0.000140 0.000115 0.000409 0.001533 0.000180 0.004168

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin -3.37 -7.18 -6.79 -6.14 0.45 0.50 -1.39 -2.04 -4.43 -1.36 0.50 -2.13 -3.07 -6.27 -1.98
Bud Neck 0.50 1.51 -1.02 -4.22 -6.60 -4.72 1.49 2.10 7.07 0.58 -3.97 1.90 -5.41 -2.71 -7.38
Bud Site -1.48 -1.19 -6.51 -6.43 -5.94 -6.26 -2.91 -1.57 3.79 0.97 -6.87 -3.33 -7.57 -5.32 -6.18
Cell Periphery 2.19 0.33 1.37 -2.26 2.43 -0.69 2.02 0.45 0.98 -0.85 0.60 1.59 1.20 0.66 -0.46
Cytoplasm -1.81 5.82 4.12 15.08 -4.12 1.55 15.17 17.62 17.36 5.66 1.75 17.84 18.19 20.21 -0.51
Cytoplasmic Foci 2.75 5.48 5.82 11.14 1.22 -0.33 16.86 12.44 14.10 -0.28 2.52 17.30 16.14 20.51 -1.65
Eisosomes 3.86 -2.80 1.84 -8.53 7.45 1.33 1.81 -0.50 -2.09 -2.57 1.96 0.94 1.12 -4.87 0.63
Endoplasmic Reticulum -0.34 -11.65 -8.85 -13.54 6.80 -4.45 -11.21 -5.71 -5.39 -3.32 -5.62 -15.98 -16.56 -14.65 0.88
Endosome 0.52 -1.15 0.08 -0.85 2.11 -5.62 2.90 -0.17 2.81 -1.08 -4.81 0.98 -1.56 2.62 -2.52
Golgi -3.03 -0.50 -2.62 -1.70 -2.60 -4.00 2.05 3.54 5.14 1.54 -3.94 2.24 -1.93 0.01 -2.47
Lipid Particles 3.14 1.30 3.58 2.84 5.50 -0.28 7.10 4.16 4.46 -1.49 2.26 6.11 7.61 7.79 2.75
Mitochondria -1.54 2.60 -1.82 -0.49 -4.36 -5.22 3.55 3.58 8.63 0.01 -3.95 3.73 0.65 5.21 -4.01
Mitotic Spindle -6.14 -1.58 -14.69 -12.95 -12.91 -5.61 -4.73 -1.04 -0.46 0.35 -7.78 -4.91 -14.54 -13.33 -11.90
None 0.28 3.01 1.65 4.30 -6.86 8.73 5.33 6.75 0.42 2.27 8.22 6.48 9.20 3.56 2.88
Nuclear Periphery -1.24 -10.06 -9.72 -9.66 -4.77 -3.29 -5.26 -4.86 -3.03 -2.56 -3.57 -8.83 -10.12 -9.10 -7.42
Nuclear Periphery Foci -1.33 -4.99 -3.63 -2.53 -0.17 0.50 -2.94 -0.93 -1.37 2.36 -0.27 -3.50 -3.37 -3.33 0.70
Nucleolus 0.83 2.29 0.60 -0.46 -3.85 1.45 1.82 6.06 5.43 3.52 1.32 2.82 0.18 -0.82 -2.07
Nucleus 0.79 -1.17 3.22 5.48 5.94 1.35 -15.17 -5.99 -6.43 -0.52 -0.54 -14.25 1.76 2.43 14.12
Peroxisomes 0.78 1.87 2.36 4.69 0.69 -3.77 3.88 7.14 9.19 2.47 -2.60 4.27 6.30 9.47 1.30
Vacuole -0.25 -9.39 -10.69 -14.27 3.74 -7.45 -4.95 -3.24 -2.79 -2.76 -7.43 -10.05 -16.28 -14.63 -7.09
Vacuole Periphery 0.10 1.80 -1.09 -1.31 -2.59 -4.80 4.60 4.84 5.49 0.55 -5.04 4.53 -2.23 1.24 -2.97
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Tripartite DNA replication factor; single-stranded DNA-dependent ATPase, ATP-dependent nuclease, helicase; tracking protein for flap cleavage during Okazaki fragment maturation; involved in DNA repair/processing of meiotic DNA double strand breaks; component of telomeric chromatin with cell-cycle dependent localization; required for telomerase-dependent telomere synthesis; forms nuclear foci upon DNA replication stress; human homolog DNA2 complements yeast dna2 mutant
Localization
Cell Percentages nucleus (38%), cytoplasm (10%), mixed (41%)
Cell Cycle Regulation Yes
nucleus - S/G2 (0.00055)
Subcompartmental Group N/A

Dna2

Dna2


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Dna2-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available