Standard name
Human Ortholog
Description Mitochondrial ribosomal protein of the large subunit; not essential for mitochondrial translation
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0.06 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – 0.13 0.06 0 0 0 0 0 0
Cytoplasm 0 0.05 0 0 0.05 0.06 0.05 0.07 0.05 0 0.05 0 0 0 0 – 0.08 0.08 0 0 0 0.11 0.05 0.06
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – 0 0.08 0 0 0 0 0 0
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – 0 0.05 0 0 0 0 0 0
Golgi 0.07 0.08 0.3 0.23 0.37 0.1 0.06 0.14 0 0 0 0 0.23 0.27 0.43 – 0.17 0.25 0.05 0.09 0.07 0.05 0.08 0.11
Mitochondria 0.92 0.86 0.8 0.88 0.68 0.72 0.74 0.68 0.85 0.82 0.87 0.86 0.89 0.87 0.79 – 0 0.09 0.88 0.71 0.81 0.63 0.65 0.61
Nucleus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0
Nuclear Periphery 0.07 0.07 0.05 0 0 0.08 0.06 0.06 0.08 0.07 0.06 0.08 0 0.06 0 – 0.09 0.1 0 0 0 0 0 0
Nucleolus 0.09 0 0.05 0 0.07 0.12 0.12 0.09 0.16 0.12 0.11 0.09 0.05 0 0 – 0.13 0.22 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – 0.11 0.06 0 0 0.05 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0
Vac/Vac Membrane 0.07 0.12 0.09 0 0.13 0.1 0.11 0.12 0 0.07 0 0 0.07 0.06 0.1 – 0.25 0.14 0 0.07 0 0.06 0.07 0.05
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 6 5 2 0 1 2 0 1 3 2 6 6 4 – 1 1 1 4 5 1 12 13
Bud 0 0 2 4 2 3 2 3 3 3 4 4 1 2 2 – 1 1 0 2 1 2 23 14
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 1 0
Bud Site 0 0 0 0 0 0 0 1 0 2 0 2 0 0 0 – 0 0 – – – – – –
Cell Periphery 2 1 6 7 2 1 4 2 0 4 4 1 3 13 14 – 7 5 0 0 0 0 0 1
Cytoplasm 0 4 5 8 13 12 15 25 14 12 15 13 4 5 12 – 4 7 0 0 1 15 19 25
Endoplasmic Reticulum 1 2 1 0 1 0 2 1 2 3 0 2 0 3 8 – 0 7 0 0 0 2 1 1
Endosome 0 0 2 2 7 3 7 6 0 3 0 1 1 2 2 – 0 4 1 1 2 0 4 7
Golgi 10 6 67 52 91 22 18 53 1 11 3 3 34 99 186 – 9 22 7 8 18 7 30 48
Mitochondria 140 63 178 202 169 153 238 258 243 372 243 258 133 313 339 – 1 8 132 68 202 83 262 264
Nucleus 1 0 1 0 0 2 2 4 2 5 4 2 0 2 0 – 2 0 0 0 0 0 1 1
Nuclear Periphery 10 5 10 5 10 16 20 21 22 33 16 23 5 20 17 – 5 9 1 0 0 3 2 3
Nucleolus 14 2 11 10 17 26 40 35 47 54 30 28 8 10 4 – 7 19 1 1 1 1 1 5
Peroxisomes 2 0 3 4 0 3 4 2 0 4 3 4 2 9 10 – 6 5 3 0 12 1 6 6
SpindlePole 0 0 2 0 2 4 3 2 2 3 0 5 1 1 1 – 0 2 0 0 0 2 4 5
Vac/Vac Membrane 10 9 21 7 33 22 35 44 11 32 11 10 11 20 42 – 13 12 1 6 1 8 27 22
Unique Cell Count 153 73 222 229 247 213 321 377 287 454 278 299 149 361 429 53 87 150 97 252 134 405 432
Labelled Cell Count 190 92 315 306 349 267 391 459 347 542 336 358 209 505 641 56 102 150 97 252 134 405 432


Mitochondria

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 17.5 16.3 16.0 15.5 16.5 14.3 14.4 14.2 11.6 13.0 11.5 12.1 14.5 14.6 14.0 – 16.8 18.9 14.9 16.8 17.0
Std Deviation (1e-4) 4.1 4.6 3.4 3.3 4.0 3.7 3.9 3.6 3.0 4.0 3.2 3.4 3.2 3.0 2.8 – 5.0 5.3 6.3 6.0 6.3
Intensity Change (Log2) – – – -0.05 0.04 -0.17 -0.16 -0.18 -0.47 -0.3 -0.48 -0.4 -0.14 -0.14 -0.2 – 0.07 0.24 -0.11 0.06 0.08


Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches -0.4 0 0 0 0 0 0 0 0 0 0 0 – 0 0
Bud 0 0 0 0 0 0 0 0 0 0 0 0 – 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 – 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 – 0 0
Cell Periphery 0.2 0 0 0 0 0 0 0 0 0 0.6 0.4 – 0 0
Cytoplasm 0.8 1.7 1.8 1.5 2.4 1.5 0.3 1.8 1.3 0 0 0.4 – 0 0
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 0 0 0 0 – 0 0
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 – 0 0
Golgi -1.8 1.5 -5.1 -7.7 -4.8 -9.8 -10.6 -9.3 -9.7 -1.6 -0.7 3.3 – -1.9 -0.9
Mitochondria 2.3 -2.9 -2.0 -1.6 -3.1 1.3 0.6 2.2 1.9 2.3 2.1 -0.3 – -10.7 -11.5
Nucleus 0 0 0 0 0 0 0 0 0 0 0 0 – 0 0
Nuclear Periphery -1.4 -0.2 1.3 0.9 0.6 1.5 1.4 0.6 1.5 -0.6 0.5 -0.3 – 0 1.9
Nucleolus -0.3 0.9 2.7 2.9 1.9 4.0 2.9 2.4 1.9 0.2 -1.4 -3.2 – 0 4.5
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 – 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 – 0 0
Vacuole -2.8 1.3 0.3 0.5 0.8 -2.6 -1.1 -2.5 -2.9 -0.7 -1.8 0.1 – 3.0 1.1

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 15.3254 16.3313 15.5994 14.2958 10.7329 15.9725 12.79 15.1371 14.7634 12.3932 12.8058 14.5642 13.0578 15.0762 13.3644 13.2066 13.5693 14.528
Actin 0.0347 0.0115 0.0176 0.0005 0.0349 0.0001 0.0266 0.0042 0.012 0.0064 0.0004 0.0023 0.04 0.0004 0.0154 0.0311 0.0009 0.0121
Bud 0.0004 0.0001 0.0002 0.0001 0.0002 0 0.0005 0.0001 0.0003 0.0013 0.0006 0.0001 0.0003 0.0001 0.0001 0.0002 0.0002 0
Bud Neck 0.0022 0 0.0003 0 0.0001 0 0.0027 0 0.0058 0.0001 0.0001 0.0001 0.001 0 0.0001 0.0002 0 0.0002
Bud Periphery 0.0009 0.0002 0.0004 0.0002 0.0004 0 0.0014 0.0002 0.0006 0.005 0.0011 0.0001 0.0004 0.0002 0.0002 0.0005 0.0008 0.0001
Bud Site 0.0037 0.0003 0.0042 0.0001 0.0004 0 0.0045 0.0002 0.0014 0.0023 0.0002 0.0003 0.0022 0.0002 0.0002 0.0009 0 0.0001
Cell Periphery 0.0003 0.0001 0.0001 0 0.0002 0 0.0004 0.0001 0.0002 0.0023 0.0001 0.0001 0.0002 0.0005 0.0001 0.0001 0.0001 0.0001
Cytoplasm 0.0011 0 0.0002 0 0.0003 0 0.0005 0 0 0.0011 0.0002 0 0.0021 0 0.0001 0 0 0
Cytoplasmic Foci 0.015 0.0002 0.0039 0.0018 0.0172 0 0.0106 0.0003 0.0093 0.0011 0.0017 0.0018 0.0273 0.0003 0.0027 0.0003 0.0001 0.0021
Eisosomes 0.0012 0.0044 0.0003 0 0.0002 0.0001 0.0006 0.0004 0.0003 0.0002 0 0.0002 0.0005 0.0002 0.0001 0.0006 0.0002 0.0002
Endoplasmic Reticulum 0.0007 0 0.0003 0 0.0004 0 0.0007 0 0 0.0021 0.0002 0 0.0009 0 0.0002 0.0003 0 0.0001
Endosome 0.0065 0.0002 0.0031 0.0013 0.0068 0.0001 0.0178 0.0011 0.001 0.0087 0.0231 0.0032 0.0109 0.0094 0.0067 0.0009 0.006 0.0019
Golgi 0.0107 0.0006 0.0044 0.0019 0.0055 0.0006 0.0095 0.0116 0.0014 0.0016 0.0111 0.0126 0.0072 0.0056 0.0063 0.0018 0.0108 0.0048
Lipid Particles 0.0149 0.0012 0.0096 0.003 0.0511 0.0023 0.0336 0.0043 0.0029 0.0107 0.039 0.0092 0.037 0.0028 0.0216 0.0028 0.0005 0.008
Mitochondria 0.8784 0.9751 0.9349 0.9522 0.7909 0.9931 0.8319 0.9683 0.9534 0.8534 0.9041 0.9629 0.8371 0.9491 0.9413 0.9558 0.957 0.9548
None 0.0062 0 0.0008 0 0.0005 0 0.0035 0 0 0.0014 0.0001 0 0.0029 0 0.0001 0.0002 0 0.0001
Nuclear Periphery 0.0011 0 0.0039 0 0.0015 0.0001 0.0019 0 0.0001 0.0162 0.0005 0 0.0011 0 0.0001 0.0004 0.0001 0.0004
Nucleolus 0.0014 0 0.0002 0 0.0005 0 0.0012 0.0002 0.0004 0.0013 0.0002 0.0001 0.0011 0.0008 0.0002 0.0001 0 0
Nucleus 0.0007 0 0.0003 0 0.0005 0 0.0006 0.0001 0.0001 0.0089 0.0001 0 0.0006 0.0002 0 0.0001 0 0
Peroxisomes 0.0131 0.005 0.0128 0.0364 0.0514 0.0003 0.0346 0.0038 0.0028 0.0297 0.0011 0.0044 0.0086 0.0008 0.0025 0.001 0.0004 0.0041
Punctate Nuclear 0.0029 0 0.0009 0 0.0007 0 0.0012 0 0.0004 0.0028 0.0001 0.0002 0.0124 0 0.0001 0.0001 0 0.0001
Vacuole 0.001 0.0001 0.0003 0.0008 0.0111 0.0001 0.0037 0.0007 0.0012 0.0166 0.0077 0.0004 0.0014 0.0091 0.0005 0.0004 0.0014 0.0007
Vacuole Periphery 0.0029 0.0008 0.0013 0.0017 0.025 0.0031 0.0123 0.0045 0.0062 0.0268 0.0084 0.0019 0.0048 0.0203 0.0016 0.002 0.0216 0.01

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 36.7801 43.4254 28.5408 45.5754 31.4915 38.8405 43.5937 43.605 45.9649 53.3497
Translational Efficiency 1.2777 1.1513 1.7038 1.1835 1.4717 1.7378 1.4645 1.8568 1.6379 1.4716

Hit Data

Dataset Hit
Protein Concentration ✘
Protein Localization ✘
Gene Expression ✘
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
2176 193 2631 152 1483 1581 147 1637 3659 1774 2778 1789

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 1249.20 1466.87 1598.10 1977.42 1258.22 1463.86 1721.45 1810.02 1252.86 1464.19 1604.63 1824.24
Standard Deviation 240.63 306.84 311.16 329.94 262.35 301.16 308.05 335.09 249.70 301.79 312.22 337.90
Intensity Change Log 2 — 0.231737 0.355353 0.662615 — 0.218393 0.452240 0.524621 — 0.225056 0.404784 0.595019

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.000612 0.005638 0.001551 0.031871 0.002134 0.004777 0.011324 0.003155 0.001229 0.004871 0.002069 0.005595
Bud Neck 0.000171 0.001643 0.000825 0.004012 0.000652 0.001607 0.011200 0.001356 0.000366 0.001611 0.001374 0.001582
Bud Site 0.000210 0.000610 0.001489 0.004561 0.000456 0.001335 0.018933 0.002679 0.000309 0.001257 0.002412 0.002839
Cell Periphery 0.000037 0.000078 0.000131 0.000537 0.000145 0.000112 0.000285 0.000365 0.000080 0.000108 0.000139 0.000380
Cytoplasm 0.000356 0.000308 0.000269 0.000470 0.000144 0.000166 0.001406 0.000381 0.000270 0.000181 0.000329 0.000389
Cytoplasmic Foci 0.006560 0.029093 0.004670 0.020616 0.016045 0.013325 0.051405 0.008012 0.010404 0.015041 0.007143 0.009083
Eisosomes 0.000288 0.001009 0.000212 0.001374 0.000507 0.000784 0.000578 0.000465 0.000377 0.000808 0.000232 0.000542
Endoplasmic Reticulum 0.000042 0.000214 0.000059 0.000258 0.000124 0.000119 0.000232 0.000236 0.000075 0.000130 0.000068 0.000238
Endosome 0.000891 0.003826 0.001620 0.002803 0.001850 0.002828 0.015426 0.002081 0.001280 0.002937 0.002351 0.002142
Golgi 0.009382 0.027745 0.008515 0.034323 0.020898 0.025777 0.049580 0.027968 0.014050 0.025991 0.010688 0.028508
Lipid Particles 0.003930 0.012312 0.001592 0.003100 0.006586 0.005392 0.009499 0.002734 0.005007 0.006145 0.002011 0.002765
Mitochondria 0.965595* 0.883031* 0.961903* 0.848908* 0.930193* 0.924613* 0.725161* 0.916836* 0.951247* 0.920089* 0.949375* 0.911064*
Mitotic Spindle 0.000136 0.000824 0.000738 0.007708 0.001511 0.000619 0.009938 0.001395 0.000693 0.000641 0.001225 0.001931
None 0.001569 0.001897 0.001121 0.002638 0.002450 0.001510 0.002637 0.003012 0.001926 0.001552 0.001202 0.002980
Nuclear Periphery 0.000125 0.000183 0.000243 0.000740 0.000428 0.000163 0.004103 0.000793 0.000248 0.000165 0.000448 0.000788
Nuclear Periphery Foci 0.000092 0.000195 0.000126 0.000245 0.000223 0.000166 0.001633 0.000303 0.000145 0.000170 0.000206 0.000298
Nucleolus 0.000099 0.000406 0.000195 0.000462 0.000224 0.000453 0.001585 0.000445 0.000149 0.000448 0.000269 0.000446
Nucleus 0.000015 0.000063 0.000274 0.000065 0.000042 0.000086 0.000225 0.000051 0.000026 0.000084 0.000271 0.000052
Peroxisomes 0.005481 0.024593 0.003247 0.018930 0.007534 0.008737 0.030599 0.002331 0.006313 0.010462 0.004694 0.003742
Vacuole 0.001548 0.003791 0.004309 0.005675 0.002548 0.003871 0.027109 0.005715 0.001953 0.003863 0.005515 0.005711
Vacuole Periphery 0.002861 0.002541 0.006910 0.010704 0.005305 0.003558 0.027143 0.019688 0.003851 0.003447 0.007980 0.018925

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin -4.07 -4.25 -3.05 -2.54 -2.96 -2.96 -2.84 -1.40 1.82 2.52 -5.26 -2.48 -4.25 -0.61 -3.41
Bud Neck -3.26 -4.23 -4.15 -2.31 -3.39 -2.64 -5.63 -2.27 0.54 5.20 -3.98 -5.38 -4.34 0.05 -0.61
Bud Site -1.85 -3.29 -1.93 -1.76 -1.34 -2.01 -2.64 -3.30 -1.73 2.31 -2.46 -4.02 -3.95 -2.17 -0.49
Cell Periphery -2.76 -2.07 -1.45 -1.33 -1.17 0.32 -1.30 -1.44 -2.09 -0.63 -0.60 -1.00 -2.52 -2.37 -2.01
Cytoplasm 0.39 0.48 -0.06 -1.52 -1.69 -1.09 -4.01 -2.64 -2.40 3.13 0.68 -0.05 -0.29 -2.51 -0.53
Cytoplasmic Foci -3.82 2.26 -2.92 1.12 -3.32 1.59 -4.88 5.17 3.79 6.03 -3.42 3.54 1.18 4.03 -1.79
Eisosomes -4.72 3.25 -3.68 -1.10 -3.94 -3.01 -0.93 0.84 3.50 1.51 -5.45 6.36 -3.65 3.05 -7.21
Endoplasmic Reticulum -3.62 -1.02 -3.94 -0.61 -3.46 0.21 -2.77 -1.61 -1.70 -0.05 -3.28 0.30 -2.62 -1.71 -2.64
Endosome -3.36 -3.47 -3.15 0.97 -1.89 -2.01 -4.57 -0.61 1.57 4.50 -4.29 -3.95 -3.13 1.80 0.62
Golgi -3.72 0.67 -3.27 -0.73 -3.39 -1.61 -3.32 -2.32 -0.67 2.48 -5.09 2.49 -5.92 -0.82 -7.38
Lipid Particles -1.85 3.20 0.76 2.02 -1.69 1.05 -1.06 4.66 2.99 2.52 -1.11 5.08 3.83 3.61 -1.84
Mitochondria 5.06 1.11 5.85 1.34 5.66 0.89 7.76 2.17 1.23 -7.24 6.20 0.56 7.97 1.45 7.24
Mitotic Spindle -1.97 -3.76 -2.56 -2.31 -2.35 1.30 -3.47 0.12 -1.65 3.59 0.16 -1.62 -2.36 -2.58 -1.44
None -1.06 4.39 -2.85 -1.58 -4.12 5.92 -0.47 -2.86 -9.50 -0.95 3.46 7.78 -6.94 -9.48 -12.69
Nuclear Periphery -1.61 -2.53 -2.31 -2.09 -1.85 3.70 -1.97 -1.75 -3.16 1.77 2.27 -1.79 -2.93 -3.39 -1.61
Nuclear Periphery Foci -2.46 -0.97 -2.29 -0.67 -1.64 1.49 -2.14 -1.31 -2.26 2.01 -0.91 -1.25 -2.88 -2.31 -1.36
Nucleolus -1.39 -3.44 -2.34 -0.21 -1.70 -1.88 -3.40 -1.93 0.05 2.76 -2.82 -3.22 -2.98 0.00 -1.72
Nucleus -2.13 -1.06 -3.71 -0.09 0.87 -1.64 -4.75 -0.59 1.25 4.41 -2.49 -1.06 -2.17 1.24 0.96
Peroxisomes -2.93 2.36 -2.72 0.70 -3.20 -0.75 -3.34 4.49 5.14 4.13 -2.90 1.84 2.96 4.84 1.20
Vacuole -1.72 -4.90 -2.16 -0.83 -0.69 -1.53 -4.53 -3.52 -2.26 3.95 -3.15 -5.65 -5.69 -2.41 -0.23
Vacuole Periphery 0.57 -6.10 -2.21 -2.29 -1.06 2.46 -4.25 -8.82 -10.30 1.40 0.87 -5.99 -10.35 -10.57 -7.06
Standard name
Human Ortholog
Description Mitochondrial ribosomal protein of the large subunit; not essential for mitochondrial translation
Localization
Cell Percentages mitochondrion (100%)
Cell Cycle Regulation No
Subcompartmental Group mito-3

Mrpl13

Mrpl13


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Mrpl13-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available