| Standard name | |
|---|---|
| Human Ortholog | |
| Description (SGD) | Copper metallochaperone that transfers copper to Sco1p and Cox11p; eventual delivery to cytochrome c oxidase; contains twin cysteine-x9-cysteine motifs; interacts with the MICOS complex, and interaction is promoted by copper ions; human homolog COX17 partially complements yeast null mutant |
Micrographs
Sub-cellular Localization
Yeast GFP Assignment
Protein Abundance
Localization Change
External localization resources
| ensLOC | DeepLoc | |||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Localization | WT1 | WT2 | WT3 | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 | WT1 | WT2 | WT3 | AF100 | AF140 | AF180 |
| Cortical Patches | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 4 | 2 | 3 | 3 | 6 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Bud | 0 | 0 | 2 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 2 | 4 | 0 | 0 | 0 | 2 | 0 | 0 | 0 | 5 | 3 |
| Bud Neck | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Bud Site | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | – | – | – | – | – | – |
| Cell Periphery | 2 | 0 | 0 | 1 | 2 | 1 | 1 | 5 | 5 | 10 | 7 | 10 | 0 | 5 | 3 | 3 | 4 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
| Cytoplasm | 325 | 93 | 239 | 187 | 209 | 216 | 311 | 315 | 193 | 243 | 134 | 187 | 254 | 407 | 517 | 254 | 174 | 260 | 315 | 86 | 229 | 136 | 348 | 347 |
| Endoplasmic Reticulum | 1 | 0 | 0 | 0 | 0 | 2 | 15 | 25 | 8 | 17 | 11 | 8 | 1 | 1 | 5 | 5 | 6 | 14 | 0 | 0 | 0 | 0 | 1 | 2 |
| Endosome | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Golgi | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 2 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Mitochondria | 0 | 0 | 1 | 1 | 0 | 2 | 2 | 7 | 10 | 15 | 12 | 18 | 0 | 0 | 1 | 3 | 2 | 3 | 0 | 0 | 0 | 0 | 0 | 0 |
| Nucleus | 0 | 0 | 0 | 0 | 0 | 1 | 3 | 3 | 2 | 5 | 1 | 3 | 0 | 0 | 2 | 1 | 0 | 0 | 4 | 2 | 1 | 2 | 4 | 3 |
| Nuclear Periphery | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Nucleolus | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Peroxisomes | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| SpindlePole | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Vac/Vac Membrane | 0 | 0 | 1 | 0 | 4 | 1 | 2 | 15 | 9 | 6 | 2 | 7 | 0 | 2 | 2 | 1 | 0 | 4 | 0 | 1 | 1 | 3 | 2 | 1 |
| Unique Cell Count | 326 | 93 | 239 | 188 | 213 | 218 | 332 | 366 | 222 | 283 | 159 | 227 | 255 | 410 | 527 | 258 | 175 | 266 | 325 | 92 | 236 | 146 | 368 | 364 |
| Labelled Cell Count | 328 | 93 | 243 | 189 | 215 | 223 | 337 | 374 | 229 | 300 | 172 | 240 | 255 | 417 | 534 | 269 | 187 | 282 | 325 | 92 | 236 | 146 | 368 | 364 |
Yeast GFP Assignment
Protein Abundance
| Screen | WT1 | WT2 | WT3 | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 | AF100 | AF140 | AF180 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Mean Cell GFP Intensity (1e-4) | 43.2 | 45.5 | 24.7 | 32.2 | 35.1 | 28.3 | 25.9 | 26.3 | 24.4 | 23.0 | 22.7 | 23.3 | 43.9 | 44.6 | 44.1 | 62.7 | 61.5 | 65.4 | 33.8 | 42.4 | 44.2 |
| Std Deviation (1e-4) | 8.7 | 8.6 | 6.0 | 7.3 | 6.9 | 5.7 | 5.6 | 6.4 | 5.8 | 5.3 | 5.0 | 5.3 | 10.4 | 10.2 | 9.6 | 24.2 | 21.7 | 20.3 | 9.3 | 11.2 | 11.0 |
| Intensity Change (Log2) | – | – | – | 0.38 | 0.51 | 0.2 | 0.07 | 0.09 | -0.02 | -0.1 | -0.12 | -0.08 | 0.83 | 0.85 | 0.84 | 1.34 | 1.32 | 1.41 | 0.45 | 0.78 | 0.84 |
Localization Change
| Localization | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Cortical Patches | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Bud | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Bud Neck | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Bud Site | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Cell Periphery | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Cytoplasm | -1.1 | -2.1 | -1.5 | -4.0 | -6.0 | -5.8 | -6.0 | -6.3 | -6.8 | -1.0 | -1.3 | -2.1 | -1.9 | -1.2 | -2.3 |
| Endoplasmic Reticulum | 0 | 0 | 0 | 3.3 | 4.1 | 0 | 3.9 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 3.6 |
| Endosome | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Golgi | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Mitochondria | 0 | 0 | 0 | 0 | 0 | 2.9 | 3.2 | 3.9 | 4.1 | 0 | 0 | 0 | 0 | 0 | 0 |
| Nucleus | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Nuclear Periphery | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Nucleolus | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Peroxisomes | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| SpindlePole | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Vacuole | 0 | 0 | 0 | 0 | 2.8 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
External localization resources
Images
Protein Concentration and Protein Localization Data
| R1 | R2 | R3 | ||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | |
| Concentration | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
| Actin | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
| Bud | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
| Bud Neck | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
| Bud Periphery | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
| Bud Site | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
| Cell Periphery | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
| Cytoplasm | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
| Cytoplasmic Foci | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
| Eisosomes | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
| Endoplasmic Reticulum | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
| Endosome | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
| Golgi | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
| Lipid Particles | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
| Mitochondria | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
| None | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
| Nuclear Periphery | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
| Nucleolus | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
| Nucleus | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
| Peroxisomes | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
| Punctate Nuclear | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
| Vacuole | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
| Vacuole Periphery | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
Sequencing Data
| R1 | R2 | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | |
| Gene Expression | 47.2888 | 42.2733 | 48.7956 | 61.6029 | 88.5617 | 68.2682 | 68.8628 | 94.5582 | 116.2856 | 87.435 |
| Translational Efficiency | 2.8112 | 3.6338 | 2.9196 | 2.6751 | 1.7208 | 3.7428 | 3.3826 | 2.7254 | 2.6345 | 2.683 |
Hit Data
| Dataset | Hit |
|---|---|
| Protein Concentration | – |
| Protein Localization | – |
| Gene Expression | ✘ |
| Translational Efficiency | ✘ |
Micrographs
Cell Count
Number of cells analysed for each strain. R1, R2: biological replicates; R1 & R2: both replicates combined.
| R1 | R2 | R1 & R2 | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| WT | UBP2 | UBP14 | UBP2UBP14 | WT | UBP2 | UBP14 | UBP2UBP14 | WT | UBP2 | UBP14 | UBP2UBP14 |
| 9 | 1201 | 432 | 1182 | 1853 | 1307 | 2656 | 221 | 1862 | 2508 | 3088 | 1403 |
Protein Abundance
Mean and standard deviation of cell GFP intensity, and intensity change (log2) of each mutant relative to wild type.
| R1 | R2 | R1 & R2 | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| WT | UBP2 | UBP14 | UBP2UBP14 | WT | UBP2 | UBP14 | UBP2UBP14 | WT | UBP2 | UBP14 | UBP2UBP14 | |
| Mean | 5138.05 | 2678.90 | 3075.18 | 3923.68 | 2465.23 | 2679.96 | 3398.75 | 4264.83 | 2478.15 | 2679.45 | 3353.48 | 3977.42 |
| Standard Deviation | 1477.92 | 533.73 | 657.41 | 1079.97 | 523.73 | 533.92 | 585.93 | 1214.02 | 563.81 | 533.83 | 606.91 | 1109.16 |
| Intensity Change Log 2 | — | -0.939580 | -0.740550 | -0.389014 | — | 0.120489 | 0.463282 | 0.790766 | — | -0.504696 | -0.231980 | 0.106979 |
Localization Score (DeepLoc)
Localization score for each compartment. Values highlighted in green denote significant localization scores (marked * in the plot).
| R1 | R2 | R1 & R2 | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| WT | UBP2 | UBP14 | UBP2UBP14 | WT | UBP2 | UBP14 | UBP2UBP14 | WT | UBP2 | UBP14 | UBP2UBP14 | |
| Actin | 0.000924 | 0.000121 | 0.000138 | 0.001393 | 0.000163 | 0.000173 | 0.000037 | 0.001932 | 0.000167 | 0.000148 | 0.000051 | 0.001478 |
| Bud Neck | 0.002227 | 0.000378 | 0.000966 | 0.008808 | 0.000546 | 0.000715 | 0.000300 | 0.007699 | 0.000554 | 0.000554 | 0.000393 | 0.008633 |
| Bud Site | 0.003993 | 0.000525 | 0.000527 | 0.021608 | 0.001173 | 0.002231 | 0.000910 | 0.006600 | 0.001187 | 0.001414 | 0.000857 | 0.019244 |
| Cell Periphery | 0.000803 | 0.000145 | 0.000437 | 0.000642 | 0.000144 | 0.000121 | 0.000043 | 0.000720 | 0.000147 | 0.000133 | 0.000098 | 0.000654 |
| Cytoplasm | 0.405624* | 0.640173* | 0.428126* | 0.577023* | 0.746326* | 0.684267* | 0.738024* | 0.528957* | 0.744679* | 0.663152* | 0.694671* | 0.569451* |
| Cytoplasmic Foci | 0.004092 | 0.004557 | 0.008268 | 0.017420 | 0.004490 | 0.005829 | 0.001928 | 0.044806 | 0.004488 | 0.005220 | 0.002815 | 0.021733 |
| Eisosomes | 0.000030 | 0.000001 | 0.000001 | 0.000018 | 0.000001 | 0.000002 | 0.000001 | 0.000017 | 0.000001 | 0.000001 | 0.000001 | 0.000018 |
| Endoplasmic Reticulum | 0.009195 | 0.000076 | 0.000044 | 0.000440 | 0.000209 | 0.000215 | 0.000013 | 0.000534 | 0.000253 | 0.000148 | 0.000017 | 0.000454 |
| Endosome | 0.002192 | 0.000059 | 0.000051 | 0.009301 | 0.000225 | 0.000967 | 0.000015 | 0.056524 | 0.000235 | 0.000532 | 0.000020 | 0.016740 |
| Golgi | 0.003420 | 0.000443 | 0.000344 | 0.016568 | 0.000658 | 0.000948 | 0.000053 | 0.036388 | 0.000671 | 0.000706 | 0.000094 | 0.019690 |
| Lipid Particles | 0.001845 | 0.000195 | 0.000333 | 0.003655 | 0.000365 | 0.000516 | 0.000077 | 0.007901 | 0.000372 | 0.000362 | 0.000113 | 0.004324 |
| Mitochondria | 0.000603 | 0.000112 | 0.000290 | 0.010064 | 0.000206 | 0.000190 | 0.000115 | 0.023235 | 0.000208 | 0.000152 | 0.000139 | 0.012139 |
| Mitotic Spindle | 0.000196 | 0.000447 | 0.000267 | 0.045759 | 0.001769 | 0.005972 | 0.001891 | 0.060707 | 0.001762 | 0.003326 | 0.001664 | 0.048113 |
| None | 0.006584 | 0.017269 | 0.008625 | 0.017919 | 0.009690 | 0.015521 | 0.015019 | 0.009260 | 0.009675 | 0.016358 | 0.014124 | 0.016555 |
| Nuclear Periphery | 0.001527 | 0.000078 | 0.000268 | 0.000715 | 0.000254 | 0.000130 | 0.000087 | 0.001777 | 0.000261 | 0.000105 | 0.000113 | 0.000882 |
| Nuclear Periphery Foci | 0.016596 | 0.001094 | 0.000549 | 0.003806 | 0.002373 | 0.001628 | 0.000164 | 0.003497 | 0.002441 | 0.001372 | 0.000218 | 0.003758 |
| Nucleolus | 0.001412 | 0.000065 | 0.000074 | 0.001048 | 0.000158 | 0.000164 | 0.000075 | 0.000230 | 0.000164 | 0.000116 | 0.000075 | 0.000920 |
| Nucleus | 0.444885* | 0.331417* | 0.545728* | 0.230630* | 0.226698* | 0.274501* | 0.237836* | 0.132887* | 0.227753* | 0.301756* | 0.280909* | 0.215234* |
| Peroxisomes | 0.000184 | 0.000006 | 0.000007 | 0.002453 | 0.000018 | 0.000065 | 0.000014 | 0.001492 | 0.000019 | 0.000037 | 0.000013 | 0.002301 |
| Vacuole | 0.089566 | 0.002660 | 0.004872 | 0.029105 | 0.004066 | 0.005153 | 0.003377 | 0.051126 | 0.004480 | 0.003959 | 0.003586 | 0.032574 |
| Vacuole Periphery | 0.004106 | 0.000181 | 0.000086 | 0.001626 | 0.000466 | 0.000695 | 0.000020 | 0.023710 | 0.000483 | 0.000449 | 0.000029 | 0.005105 |
Localization Changes (T-score)
Change in localization of each mutant relative to its control (e.g. UBP2_WT: ubp2Δ vs wild type). Values highlighted in yellow (increase) or blue (decrease) denote significant changes (marked * in the plot).
| R1 | R2 | R1 & R2 | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UBP2_ |
UBP14_ |
UBP2UBP14_ |
UBP2UBP14_ |
UBP2UBP14_ |
UBP2_ |
UBP14_ |
UBP2UBP14_ |
UBP2UBP14_ |
UBP2UBP14_ |
UBP2_ |
UBP14_ |
UBP2UBP14_ |
UBP2UBP14_ |
UBP2UBP14_ |
|
| Actin | N/A | N/A | N/A | -2.24 | -0.76 | -0.13 | 3.24 | -0.28 | -0.23 | -1.56 | 0.90 | 2.77 | -1.53 | -1.94 | -2.77 |
| Bud Neck | N/A | N/A | N/A | -10.10 | -5.18 | -1.74 | 1.92 | -4.03 | -3.84 | -4.17 | -0.05 | -0.44 | -10.10 | -10.14 | -10.11 |
| Bud Site | N/A | N/A | N/A | -6.89 | -6.30 | -1.96 | 0.72 | -6.19 | -5.14 | -6.51 | -0.53 | 0.71 | -7.04 | -6.99 | -7.47 |
| Cell Periphery | N/A | N/A | N/A | -9.66 | 3.37 | 0.33 | 6.39 | -6.26 | -6.32 | -7.25 | 0.13 | -0.55 | -11.61 | -12.03 | -11.36 |
| Cytoplasm | N/A | N/A | N/A | 8.85 | -14.01 | 10.57 | 6.45 | 7.89 | 3.86 | 5.87 | 14.57 | 13.06 | 22.47 | 11.76 | 12.56 |
| Cytoplasmic Foci | N/A | N/A | N/A | -7.75 | 1.36 | -2.92 | 3.62 | -7.99 | -7.37 | -8.44 | -2.36 | -0.38 | -12.50 | -10.54 | -12.20 |
| Eisosomes | N/A | N/A | N/A | -6.09 | -3.00 | -1.13 | 1.40 | -6.69 | -5.20 | -7.26 | 0.01 | 0.48 | -6.29 | -6.18 | -6.69 |
| Endoplasmic Reticulum | N/A | N/A | N/A | -0.67 | -0.65 | 0.37 | 4.04 | 3.25 | 1.81 | -1.44 | 1.68 | 3.85 | 2.83 | 1.21 | -3.80 |
| Endosome | N/A | N/A | N/A | -2.92 | -2.83 | -2.01 | 2.68 | -1.62 | -1.35 | -1.74 | -1.20 | 2.63 | -2.87 | -2.43 | -3.38 |
| Golgi | N/A | N/A | N/A | -1.76 | -1.64 | -0.44 | 3.88 | -0.85 | -0.78 | -1.18 | 0.28 | 3.49 | -1.68 | -1.76 | -2.38 |
| Lipid Particles | N/A | N/A | N/A | -10.39 | -6.23 | -0.63 | 2.79 | -4.98 | -4.55 | -5.37 | 0.30 | 1.62 | -10.57 | -10.02 | -11.41 |
| Mitochondria | N/A | N/A | N/A | -1.39 | -1.09 | 0.67 | 2.58 | -1.10 | -1.13 | -1.18 | 1.78 | 1.42 | -1.49 | -1.57 | -1.55 |
| Mitotic Spindle | N/A | N/A | N/A | -5.34 | -5.44 | -2.37 | -1.47 | -1.51 | -0.45 | -1.24 | -1.46 | -1.04 | -4.92 | -4.07 | -4.60 |
| None | N/A | N/A | N/A | 7.96 | -0.53 | -4.76 | -7.55 | 1.07 | 4.09 | 4.80 | -8.09 | -6.49 | 1.27 | 8.15 | 6.60 |
| Nuclear Periphery | N/A | N/A | N/A | -15.89 | -2.15 | 0.78 | 0.66 | -3.51 | -5.98 | -6.00 | 1.26 | 0.15 | -4.52 | -15.55 | -12.82 |
| Nuclear Periphery Foci | N/A | N/A | N/A | -2.03 | -3.50 | 1.80 | 7.80 | 1.00 | -0.72 | -6.77 | 2.95 | 7.54 | 2.17 | -1.20 | -9.97 |
| Nucleolus | N/A | N/A | N/A | -4.65 | -4.01 | 0.38 | 1.42 | 0.15 | -0.24 | -1.41 | 1.18 | 1.49 | -1.73 | -3.64 | -4.27 |
| Nucleus | N/A | N/A | N/A | 11.17 | 27.73 | -8.42 | -5.71 | 11.76 | 16.69 | 15.30 | -13.55 | -12.40 | 1.26 | 13.33 | 12.32 |
| Peroxisomes | N/A | N/A | N/A | -1.33 | -1.29 | -1.45 | 1.12 | -1.59 | -0.98 | -1.77 | -0.68 | 1.16 | -1.33 | -1.29 | -1.39 |
| Vacuole | N/A | N/A | N/A | -24.33 | -20.37 | -4.67 | -7.32 | -12.72 | -12.27 | -12.21 | -1.94 | -6.97 | -26.71 | -26.36 | -25.23 |
| Vacuole Periphery | N/A | N/A | N/A | -1.20 | -2.14 | -0.28 | 2.61 | -0.77 | -0.69 | -1.10 | 0.50 | 2.60 | -0.06 | -0.48 | -2.06 |
| Standard name | |
|---|---|
| Human Ortholog | |
| Description (SGD) | Copper metallochaperone that transfers copper to Sco1p and Cox11p; eventual delivery to cytochrome c oxidase; contains twin cysteine-x9-cysteine motifs; interacts with the MICOS complex, and interaction is promoted by copper ions; human homolog COX17 partially complements yeast null mutant |
| Localization | |
| Cell Percentages | cytoplasm (95%) |
| Cell Cycle Regulation | No |
| Subcompartmental Group | cytoplasm-7 |
Cox17
Cox17
Nearest neighbours ( genes)
correlation threshold
0.80
Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)
Endocytosis
| Temp | Actin Patch (Sac6-tdTomato) | Cortical Patch (Sla1-GFP) | Late Endosome (Snf7-GFP) | Vacuole (Vph1-GFP) |
|---|---|---|---|---|
| 37℃ | ||||
| RT |
Cell Cycle Omics
CYCLoPs (Cox17-GFP)
| Gene / Allele | Actin Patch (Sac6-tdTomato) | Cortical Patch (Sla1-GFP) | Late Endosome (Snf7-GFP) | Vacuole (Sac6-tdTomato) |
|---|
| Gene | Images |
|---|
| Gene | Images |
|---|
Images are not yet available
Images are not yet available
