Standard name
Human Ortholog
Description (SGD) Adenylate cyclase; required for cAMP production and cAMP-dependent protein kinase signaling; scaffold protein for Ras2-Ira interaction; the cAMP pathway controls a variety of cellular processes, including metabolism, cell cycle, stress response, stationary phase, and sporulation
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.05 0.06
Bud 0 – 0 0 0 0 0 0 0 0 0.05 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.05 0 0
Bud Site 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0.09 – 0.07 0.11 0.08 0 0 0 0 0 0.09 0.05 0.14 0.16 0.16 0.28 0.33 0.29 0.05 0 0.1 0.12 0.14 0.12
Cytoplasm 0.97 – 0.94 0.95 0.94 0.92 0.85 0.74 0.73 0.72 0.5 0.52 0.98 0.99 0.99 0.88 0.84 0.85 0.81 0.8 0.6 0.6 0.62 0.63
Endoplasmic Reticulum 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0.06 0.05 0.05 0 0 0 0 0 0
Endosome 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0 – 0.05 0.13 0.07 0.18 0.28 0.39 0.47 0.45 0.62 0.62 0 0 0 0 0 0 0 0.05 0.15 0.07 0 0
Nucleus 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vac/Vac Membrane 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 2 – 0 2 2 1 0 1 0 2 3 5 2 3 2 4 10 10 6 0 3 4 17 25
Bud 1 – 4 3 1 1 8 17 17 18 14 11 5 3 4 2 9 3 0 0 0 1 4 6
Bud Neck 0 – 1 0 0 1 4 1 2 1 0 0 0 0 1 0 1 0 5 0 3 6 10 15
Bud Site 0 – 0 0 0 0 0 0 0 2 0 1 0 0 0 0 0 0 – – – – – –
Cell Periphery 21 – 7 20 25 15 15 22 17 12 25 18 38 70 78 65 122 87 11 1 10 13 47 46
Cytoplasm 226 – 90 178 290 312 454 396 285 313 137 184 267 439 487 201 311 259 194 39 64 69 208 255
Endoplasmic Reticulum 0 – 0 0 1 1 3 5 1 5 4 13 0 1 0 13 17 16 6 1 1 4 10 10
Endosome 0 – 0 0 1 0 0 0 0 0 0 2 1 0 0 0 3 1 0 0 0 1 3 4
Golgi 0 – 0 0 0 0 0 0 0 0 0 0 0 1 2 0 1 3 1 0 0 0 3 2
Mitochondria 5 – 5 24 21 61 148 209 182 196 169 223 1 2 1 7 6 6 8 2 16 8 14 17
Nucleus 2 – 0 0 0 0 0 3 0 2 1 0 0 0 0 1 2 5 0 0 0 0 1 0
Nuclear Periphery 0 – 0 1 1 0 2 0 0 2 0 0 0 0 0 0 0 0 0 1 0 0 1 0
Nucleolus 0 – 0 0 0 0 2 0 0 1 0 3 0 0 0 1 0 2 0 0 0 0 0 0
Peroxisomes 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0 0 0 0 0
SpindlePole 0 – 0 0 0 2 1 4 1 2 3 2 0 0 0 0 0 1 0 0 0 0 0 1
Vac/Vac Membrane 0 – 0 0 2 0 3 3 1 0 1 3 1 0 0 6 10 10 3 0 1 3 8 10
Unique Cell Count 232 96 187 307 340 533 535 388 433 273 357 272 444 494 229 369 305 240 49 107 117 337 404
Labelled Cell Count 257 107 228 344 394 640 661 506 556 357 465 315 519 575 300 493 403 240 49 107 117 337 404


Ambiguous

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 4.9 – 3.7 3.9 4.5 3.7 3.5 3.6 3.2 3.6 3.3 3.4 5.6 5.8 5.7 8.3 8.0 7.8 5.0 6.0 6.1
Std Deviation (1e-4) 0.8 – 0.7 0.9 1.5 0.9 1.0 0.5 0.7 0.9 0.8 0.9 1.3 1.1 0.8 1.6 1.5 1.7 0.9 1.3 1.5
Intensity Change (Log2) – – – 0.08 0.28 -0.02 -0.07 -0.04 -0.21 -0.06 -0.17 -0.15 0.6 0.64 0.61 1.15 1.11 1.07 0.44 0.69 0.71


Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cell Periphery 0 0 0 0 0 0 0 0 0 1.7 2.2 2.2 4.2 5.0 4.3
Cytoplasm 0.5 0.3 -0.6 -2.3 -4.2 -4.3 -4.5 -7.5 -7.5 2.2 3.2 3.0 -1.6 -2.4 -2.2
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vacuole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 2.0451 1.1166 1.1155 0.585 0.5513 1.1964 1.3446 1.0518 0.8484 0.7561 1.3158 0.8523 2.4936 2.68 2.7053 2.1553 3.1602 2.5691
Actin 0.0896 0.0049 0.0308 0.0309 0.018 0.0332 0.0051 0.0033 0.0064 0.0019 0.1095 0.0103 0.0894 0.0055 0.0408 0.0016 0.0768 0.0136
Bud 0.0054 0.0082 0.0107 0.0003 0.0024 0.0061 0.0022 0.0036 0.0009 0.0005 0.0039 0.0013 0.002 0.0007 0.0052 0.0005 0.0006 0.0008
Bud Neck 0.026 0.0015 0.0038 0.0019 0.0158 0.0125 0.0038 0.0008 0.002 0.0021 0.0038 0.0046 0.0044 0.0005 0.0015 0.0002 0.0155 0.0023
Bud Periphery 0.0139 0.0071 0.0114 0.0005 0.0051 0.0063 0.0023 0.0041 0.0008 0.0005 0.0063 0.003 0.006 0.0014 0.0114 0.0015 0.0008 0.0014
Bud Site 0.0494 0.0695 0.0239 0.0007 0.0345 0.0045 0.0072 0.018 0.0111 0.0011 0.0288 0.0009 0.0036 0.0107 0.0032 0.0002 0.0086 0.0024
Cell Periphery 0.0122 0.0079 0.0052 0.0026 0.0027 0.0032 0.0024 0.0022 0.0013 0.0004 0.0018 0.0007 0.0019 0.0029 0.002 0.0011 0.0006 0.0015
Cytoplasm 0.2034 0.5887 0.6383 0.7824 0.6366 0.6394 0.4909 0.6157 0.6388 0.4817 0.5416 0.6229 0.287 0.6289 0.6213 0.5498 0.6631 0.7695
Cytoplasmic Foci 0.1132 0.0099 0.0123 0.0118 0.0054 0.0054 0.0923 0.0152 0.0197 0.0191 0.0409 0.0218 0.0814 0.0027 0.0111 0.0051 0.0329 0.0071
Eisosomes 0.0016 0.0006 0.0005 0.0002 0.0003 0.0004 0.0001 0.0004 0.0001 0.0001 0.0006 0.0001 0.0013 0.0001 0.0003 0.0002 0.0003 0.0001
Endoplasmic Reticulum 0.0057 0.0033 0.0034 0.0017 0.0039 0.0023 0.0088 0.0043 0.0029 0.0039 0.0048 0.0024 0.0115 0.0018 0.0021 0.0059 0.0016 0.0028
Endosome 0.064 0.0061 0.0063 0.0115 0.0016 0.0053 0.1332 0.0084 0.0203 0.0345 0.0189 0.0217 0.0403 0.0005 0.0014 0.0014 0.0084 0.0008
Golgi 0.0231 0.002 0.0025 0.0073 0.001 0.0021 0.025 0.0008 0.0125 0.0181 0.033 0.0079 0.0211 0.0004 0.0038 0.0006 0.0167 0.0019
Lipid Particles 0.0526 0.0012 0.0062 0.0142 0.0009 0.0031 0.0221 0.0009 0.0011 0.0016 0.0055 0.0096 0.0334 0.0002 0.003 0.0004 0.0148 0.0005
Mitochondria 0.005 0.0031 0.0009 0.0008 0.0002 0.0009 0.0062 0.0002 0.0074 0.0126 0.081 0.0062 0.0208 0.0001 0.0007 0.0001 0.0007 0.0006
None 0.1862 0.2785 0.2286 0.1186 0.2656 0.248 0.0784 0.3083 0.2549 0.4116 0.0815 0.2774 0.3148 0.3419 0.2765 0.4289 0.1362 0.19
Nuclear Periphery 0.0088 0.0004 0.0013 0.0025 0.0007 0.0076 0.0211 0.0006 0.0006 0.0007 0.0011 0.0005 0.0055 0.0002 0.0002 0.0006 0.0004 0.0002
Nucleolus 0.0048 0.0005 0.0007 0.0002 0.0004 0.0005 0.0017 0.0002 0.0001 0.0001 0.0007 0.0001 0.001 0.0001 0.0001 0.0001 0.0002 0
Nucleus 0.0078 0.0008 0.003 0.0004 0.0009 0.0053 0.0169 0.0008 0.0008 0.0009 0.0017 0.0006 0.0019 0.0003 0.0003 0.0004 0.0003 0.0003
Peroxisomes 0.0594 0.0011 0.0012 0.0049 0.0004 0.0066 0.0093 0.0006 0.0011 0.0025 0.0243 0.0043 0.0588 0.0001 0.0134 0.0001 0.0154 0.0036
Punctate Nuclear 0.0584 0.0009 0.007 0.0053 0.0022 0.0056 0.0162 0.0007 0.0004 0.0004 0.0031 0.0007 0.0067 0.0001 0.0008 0.0004 0.0056 0.0003
Vacuole 0.0084 0.0032 0.0019 0.001 0.0012 0.0015 0.0469 0.0106 0.0148 0.0051 0.0063 0.0025 0.0046 0.0008 0.0008 0.0009 0.0004 0.0003
Vacuole Periphery 0.0011 0.0003 0.0002 0.0003 0.0001 0.0003 0.0081 0.0003 0.0022 0.0007 0.001 0.0006 0.0026 0 0.0001 0.0001 0.0001 0

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 13.5181 11.1922 14.9251 27.2403 15.6447 17.2283 18.9428 26.6218 24.9903 24.7249
Translational Efficiency 0.4354 0.5189 0.5103 0.3434 0.4398 0.4042 0.3566 0.2954 0.3971 0.3253

Hit Data

Dataset Hit
Protein Concentration ✘
Protein Localization ✘
Gene Expression ✔
Translational Efficiency ✘

Micrographs

Select an organelle or subcellular structure:


Penetrance Data

Penetrance values (percentage of cells with morphologically abnormal structure) at each time point for each of the subcellular structures monitored.

TP0 TP3 TP6 TP9 TP12 TP15 TP18 TP21 TP24
Autophagosome (ATG8) 23.013416 76.657459 92.340426 86.568354 82.120109 73.892071 54.923761 59.880450 62.822505
Septin (CDC11) 14.148219 21.983914 46.835443 54.234592 61.685491 70.816327 73.415638 78.257081 81.429090
Spindle & SPB (DAD2) 18.835616 22.020725 35.476025 56.387363 49.926901 50.140252 74.053682 72.505762 76.876676
P-bodies (DCP2) 25.423729 46.808511 82.108317 93.416783 94.058442 83.706564 80.607375 56.486241 39.367986
Inner Nuclear Membrane (HEH2) 14.285714 20.602789 39.897885 55.206361 42.941983 55.205349 46.138415 46.493689 50.959488
Metacaspase (MCA1) 7.390983 22.322775 45.810859 60.886729 62.017027 55.796178 57.325887 52.748963 23.036649
Plasma Membrane (MID2) 27.172414 25.177936 38.902148 52.309099 57.892562 62.925852 57.473310 60.783451 56.851312
Necrosis Factor (NHP6A) 18.046133 17.719442 31.949458 51.905347 55.129376 78.010785 83.050847 85.819251 86.384319
Nucleolus (NOP10) 21.209302 22.161423 22.020310 35.763889 61.902817 63.614458 52.219680 37.296564 39.054966
Kinetochore (NUF2) 19.723866 27.951389 31.210191 26.666667 33.468973 37.129110 47.589952 51.407658 52.466598
Mitochondria (OM45) 22.656250 81.499203 97.853309 98.686205 97.839784 99.073171 99.020088 99.552239 99.916353
Eisosomes (PIL1) 14.923619 84.308943 96.413111 96.171754 91.006711 97.723368 97.111019 93.939394 88.851465
Proteasome (PRE2) 15.238880 15.364412 26.995646 33.678971 50.704793 58.266773 23.924573 36.677368 19.602873
DNA Damage Foci (RAD52) 11.844485 10.000000 12.962963 24.174095 38.808212 54.623547 47.395349 41.384538 36.306620
Actin Patches (SAC6) 19.852941 72.344498 88.166895 87.685542 78.358974 78.944844 76.677464 79.641765 82.469775
Golgi, Early (SEC21) 15.333333 40.973631 68.846550 57.000399 45.985401 50.000000 61.093696 81.681116 90.657045
Golgi, Late (SEC7) 19.979296 30.731103 53.085868 83.643815 88.245997 86.560458 86.086591 75.237372 59.712804
Endosomes (SNF7) 29.195089 28.194147 44.215484 52.712100 60.575114 60.640551 64.287575 55.982351 54.151808
Endoplasmic Reticulum (SPF1) 17.536814 45.421903 82.585752 85.660981 79.115922 83.448556 86.131883 94.082447 99.578059
Lipid Droplets (TGL3) 9.160794 12.142393 16.472065 33.786906 45.969635 63.093005 63.838310 63.543028 63.337738
Vacuole (VPH1) 36.467598 32.174616 65.240931 76.510417 87.122060 86.021505 74.855967 69.659319 60.297648

Micrographs

Cell Count

Number of cells analysed for each strain. R1, R2: biological replicates; R1 & R2: both replicates combined.

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
3 1330 335 1128 1490 257 21 700 1493 1587 356 1828

Protein Abundance

Mean and standard deviation of cell GFP intensity, and intensity change (log2) of each mutant relative to wild type.

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 888.70 763.82 1054.35 900.48 726.33 828.31 1249.41 968.31 726.66 774.26 1065.86 926.45
Standard Deviation 283.95 121.95 106.29 132.22 85.67 94.35 181.94 136.24 86.83 120.29 121.23 137.78
Intensity Change Log 2 — -0.218464 0.246585 0.018998 — 0.189546 0.782550 0.414844 — -0.020603 0.512429 0.210543

Localization Score (DeepLoc)

Localization score for each compartment. Values highlighted in green denote significant localization scores (marked * in the plot).

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.005996 0.010255 0.021083 0.009340 0.002208 0.004261 0.005388 0.003277 0.002216 0.009285 0.020157 0.007018
Bud Neck 0.004651 0.036772 0.006509 0.007206 0.040810 0.067896 0.006411 0.007362 0.040737 0.041812 0.006503 0.007265
Bud Site 0.040975 0.046054 0.087959 0.071921 0.014756 0.027739 0.291213* 0.047556 0.014809 0.043088 0.099949 0.062591
Cell Periphery 0.004636 0.003251 0.004642 0.001412 0.002126 0.003058 0.000972 0.001003 0.002131 0.003220 0.004425 0.001255
Cytoplasm 0.253109* 0.484134* 0.417830* 0.504104* 0.549200* 0.506504* 0.116606* 0.489551* 0.548605* 0.487757* 0.400061* 0.498531*
Cytoplasmic Foci 0.013193 0.231315* 0.171113 0.076507 0.197499* 0.206006* 0.028196 0.075286 0.197128* 0.227216* 0.162683 0.076040
Eisosomes 0.000530 0.008804 0.001246 0.001178 0.008603 0.007386 0.000069 0.000864 0.008587 0.008574 0.001177 0.001057
Endoplasmic Reticulum 0.002699 0.003596 0.015098 0.002223 0.001828 0.000701 0.005657 0.001967 0.001829 0.003128 0.014541 0.002125
Endosome 0.001413 0.024204 0.011423 0.007403 0.012367 0.027898 0.036598 0.015524 0.012345 0.024802 0.012908 0.010513
Golgi 0.002168 0.028136 0.002519 0.001442 0.019335 0.017879 0.000701 0.006229 0.019300 0.026475 0.002412 0.003275
Lipid Particles 0.002108 0.018334 0.008128 0.002041 0.014797 0.009053 0.022951 0.001908 0.014772 0.016831 0.009002 0.001990
Mitochondria 0.005931 0.006502 0.000100 0.000747 0.007848 0.004226 0.000144 0.007186 0.007844 0.006134 0.000102 0.003212
Mitotic Spindle 0.000288 0.000159 0.000365 0.004737 0.000271 0.000433 0.004860 0.023500 0.000271 0.000203 0.000630 0.011922
None 0.399374* 0.002375 0.000436 0.002637 0.001422 0.000147 0.000072 0.001458 0.002222 0.002014 0.000414 0.002186
Nuclear Periphery 0.000224 0.000207 0.000174 0.000101 0.000115 0.000116 0.001092 0.000333 0.000116 0.000192 0.000228 0.000190
Nuclear Periphery Foci 0.003398 0.000668 0.014129 0.001589 0.000326 0.000367 0.028079 0.001580 0.000333 0.000619 0.014952 0.001586
Nucleolus 0.097997 0.000548 0.000074 0.000118 0.000318 0.000164 0.000051 0.000832 0.000514 0.000486 0.000072 0.000391
Nucleus 0.109050 0.026247 0.038724 0.020963 0.068859 0.027346 0.004072 0.017685 0.068939 0.026425 0.036680 0.019708
Peroxisomes 0.003373 0.012510 0.001620 0.002845 0.008717 0.011297 0.001339 0.002566 0.008706 0.012313 0.001603 0.002738
Vacuole 0.048342 0.053460 0.196595 0.281132* 0.047088 0.076367 0.444482* 0.290951* 0.047090 0.057169 0.211218* 0.284892*
Vacuole Periphery 0.000543 0.002469 0.000235 0.000356 0.001508 0.001155 0.001046 0.003383 0.001506 0.002257 0.000283 0.001515

Localization Changes (T-score)

Change in localization of each mutant relative to its control (e.g. UBP2_WT: ubp2Δ vs wild type). Values highlighted in yellow (increase) or blue (decrease) denote significant changes (marked * in the plot).

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin N/A N/A N/A 1.78 2.90 -1.83 -1.02 -0.43 1.60 0.91 -7.98 -4.36 -4.49 3.31 3.42
Bud Neck N/A N/A N/A 15.02 0.31 -3.50 15.65 17.27 8.35 1.04 -0.39 16.91 17.66 17.06 0.92
Bud Site N/A N/A N/A -2.97 3.25 -2.70 -2.63 -5.56 -1.22 2.29 -11.51 -10.21 -11.59 -2.00 5.14
Cell Periphery N/A N/A N/A 7.63 8.52 -1.36 4.53 8.20 3.57 0.13 -4.11 -5.58 7.33 9.16 9.15
Cytoplasm N/A N/A N/A 1.77 -3.58 2.77 20.05 9.14 4.11 -13.79 7.33 11.14 10.62 3.90 -4.25
Cytoplasmic Foci N/A N/A N/A 28.75 13.32 -0.73 21.73 25.68 13.36 -4.68 -4.92 4.83 27.70 32.74 13.27
Eisosomes N/A N/A N/A 10.68 1.45 0.84 16.77 15.24 5.09 -2.74 0.01 14.46 15.08 11.97 2.42
Endoplasmic Reticulum N/A N/A N/A 2.85 8.64 3.44 -2.60 0.75 -1.51 2.76 -2.67 -8.92 0.27 2.86 8.98
Endosome N/A N/A N/A 11.65 5.22 -3.92 -2.53 1.78 4.43 2.92 -8.02 0.01 4.79 11.33 4.45
Golgi N/A N/A N/A 18.92 2.26 0.41 17.24 10.68 4.08 -2.59 -4.27 14.79 14.86 17.93 0.49
Lipid Particles N/A N/A N/A 10.66 9.48 1.77 -1.13 13.77 2.38 2.50 -1.24 4.60 13.81 10.84 8.58
Mitochondria N/A N/A N/A 8.52 -1.71 1.26 5.83 2.11 0.16 -2.62 1.14 5.86 4.21 4.94 -3.01
Mitotic Spindle N/A N/A N/A -3.35 -3.16 -0.81 -1.57 -3.96 -3.91 -1.95 0.61 -1.70 -5.01 -5.05 -4.73
None N/A N/A N/A 0.30 -2.02 7.88 8.46 0.93 -2.16 -2.41 0.30 2.92 0.71 0.49 -2.32
Nuclear Periphery N/A N/A N/A 1.27 3.78 0.01 -2.40 -1.89 -1.71 2.02 -1.50 -3.77 -2.07 -0.12 1.17
Nuclear Periphery Foci N/A N/A N/A -8.19 11.85 -0.07 -4.01 -9.29 -8.32 3.86 -4.11 -13.38 -13.63 -10.60 12.26
Nucleolus N/A N/A N/A 3.75 -1.81 2.13 3.08 -0.18 -0.84 -1.14 0.49 2.79 1.52 1.48 -1.28
Nucleus N/A N/A N/A 3.41 6.73 13.34 9.16 18.27 2.92 -1.59 17.12 9.86 20.07 4.45 6.63
Peroxisomes N/A N/A N/A 13.65 -2.06 -1.13 12.05 11.94 4.42 -1.76 -4.10 12.55 11.06 14.74 -2.15
Vacuole N/A N/A N/A -32.67 -9.59 -5.81 -7.88 -31.08 -26.51 2.71 -3.99 -16.22 -45.09 -43.11 -9.58
Vacuole Periphery N/A N/A N/A 6.83 -0.74 0.58 1.67 -0.36 -0.83 -1.62 -1.45 2.79 1.25 3.74 -2.34
Standard name
Human Ortholog
Description (SGD) Adenylate cyclase; required for cAMP production and cAMP-dependent protein kinase signaling; scaffold protein for Ras2-Ira interaction; the cAMP pathway controls a variety of cellular processes, including metabolism, cell cycle, stress response, stationary phase, and sporulation
Localization
Cell Percentages cytoplasm (60%)
Cell Cycle Regulation No
Subcompartmental Group cytoplasm-10

Cyr1

Cyr1


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Cyr1-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available