Standard name
Human Ortholog
Description (SGD) Essential DEAH-box ATP-dependent RNA helicase specific to U3 snoRNP; functions with methyltransferase Bud23p; required for 18S rRNA synthesis; unwinding activity is activated by Utp14p, and Utp14p acts with Bud23p to recruit the helicase to the assembling preribosome; subject to autoinhibition; predominantly nucleolar in distribution
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0.09 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 0 0 0 0 0 0 0 0 0 0 0 0 0.07 0.09 0.09 0.16 0.07 0.13 0 0 0 0 0 0
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.05 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0 0.06 0.19 0.28 0.23 0.46 0.47 0.5 0.62 0.63 0.61 0.59 0.06 0 0.1 0.05 0 0.07 0 0 0 0 0 0
Nucleus 0.5 0.51 0.49 0.38 0.55 0.54 0.5 0.46 0.5 0.48 0.47 0.47 0.39 0.39 0.38 0.4 0.44 0.34 0.3 0.4 0.38 0.44 0.32 0.17
Nuclear Periphery 0 0 0 0 0.05 0 0.05 0 0.06 0.05 0 0.05 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0.53 0.52 0.49 0.69 0.42 0.36 0.34 0.35 0.27 0.3 0.26 0.33 0.64 0.5 0.56 0.36 0.43 0.49 0.63 0.49 0.5 0.41 0.47 0.5
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0.05 0 0 0 0 0 0 0 0 0 0.05 0.05 0 0 0 0 0 0 0 0 0
Vac/Vac Membrane 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.07 0.06 0 0 0 0 0.1 0.11 0.17
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 1 0 1 3 4 8 5 11 5 13 0 0 0 0 0 0 3 0 2 0 3 1
Bud Neck 0 0 0 0 0 0 0 0 1 0 0 3 0 0 0 0 0 0 0 0 0 0 0 1
Bud Site 0 0 1 3 3 17 13 13 18 22 8 48 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 7 4 8 1 12 8 14 25 13 22 10 19 9 11 15 14 8 15 0 1 0 0 0 0
Endoplasmic Reticulum 0 0 0 0 0 1 0 0 0 0 0 0 0 0 0 1 2 4 0 0 0 0 0 2
Endosome 5 1 2 1 5 2 2 3 1 1 1 0 1 1 2 4 1 0 4 2 8 0 4 5
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 2 1 2 1 0 1 1 1 0
Mitochondria 1 15 65 66 69 207 256 335 256 364 175 310 8 4 16 4 5 8 1 3 2 1 2 4
Nucleus 169 119 164 92 167 243 270 305 203 273 135 244 52 46 63 35 51 40 118 100 138 56 53 31
Nuclear Periphery 2 3 2 1 14 19 29 20 24 29 9 24 0 1 2 0 0 0 2 1 4 0 0 2
Nucleolus 181 121 163 165 127 162 186 234 111 174 74 172 84 59 93 31 50 58 247 123 183 51 77 91
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 1 3 0 1 0 0 0 0 0 0 0
SpindlePole 5 2 3 12 3 9 23 25 14 16 5 22 1 6 9 1 2 2 1 1 4 0 2 4
Vac/Vac Membrane 4 2 4 0 9 3 7 6 0 5 4 12 0 0 2 6 7 5 4 9 15 12 18 31
Unique Cell Count 340 233 334 239 303 453 542 669 410 574 286 523 132 118 167 87 116 119 391 250 364 126 166 183
Labelled Cell Count 374 267 413 341 410 674 804 974 646 918 426 867 155 129 205 98 128 134 391 250 364 126 166 183


Nucleolus

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 12.2 9.0 6.4 6.0 5.7 4.7 4.5 4.4 3.9 3.9 3.7 3.7 9.6 9.3 7.7 14.6 16.5 16.7 10.2 10.9 11.1
Std Deviation (1e-4) 3.0 2.3 1.2 1.2 1.3 1.2 1.1 1.1 1.3 1.2 1.0 1.6 2.5 2.5 2.0 4.4 5.8 4.5 2.5 2.4 2.3
Intensity Change (Log2) – – – -0.09 -0.18 -0.45 -0.53 -0.55 -0.71 -0.71 -0.79 -0.78 0.58 0.53 0.26 1.18 1.36 1.37 0.67 0.76 0.79


Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cell Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 0 1.1 -0.6 0.2 1.1 0.6 1.2 0.8 1.0 0 0 3.3 0 0 4.4
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 2.3 1.0 0 0 0 0 0 0 0 -3.6 -4.2 -2.8 -3.3 -3.9 -3.2
Nucleus -2.5 1.5 1.3 0.2 -1.1 0.1 -0.4 -0.5 -0.7 -1.9 -1.9 -2.4 -1.5 -1.0 -2.9
Nuclear Periphery 0 3.2 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 4.8 -1.7 0 0 0 0 0 0 0 2.9 0.2 1.5 -2.2 -1.1 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 3.0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vacuole 0 1.6 0 0 0 0 0 0 1.2 0 0 0 0 0 0

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 6.5715 8.0144 6.8969 6.9105 7.2048 7.0087 8.3058 11.4888 10.3477 8.594 8.5487 9.7432 9.0054 10.0843 9.2297 8.5359 9.7342 9.3053
Actin 0 0 0 0 0.0002 0.0001 0.0281 0 0.0001 0.0115 0.004 0.0032 0.0642 0 0.0024 0.0011 0 0
Bud 0.0001 0.0001 0 0.0001 0.0002 0.0001 0.0004 0 0.0001 0.0002 0.0001 0.0001 0.0004 0 0.0001 0.0011 0 0
Bud Neck 0.0003 0.0003 0.0003 0.0005 0.0005 0.0011 0.0008 0.0002 0.0001 0.0003 0.0004 0.0005 0.0006 0.0004 0.0005 0.0015 0.0002 0.0004
Bud Periphery 0.0002 0.0001 0.0001 0.0002 0.0007 0.0002 0.001 0 0.0002 0.0003 0.0003 0.0002 0.0008 0.0001 0.0002 0.0002 0.0002 0.0001
Bud Site 0.0003 0.0008 0.0002 0.0002 0.0005 0.0002 0.0013 0.0001 0.0003 0.0005 0.0002 0.0001 0.0009 0.0002 0.0015 0.0006 0.0001 0.0001
Cell Periphery 0.0002 0.0001 0.0001 0.0002 0.0005 0.0001 0.0005 0.0001 0.0001 0.0001 0.0002 0.0001 0.0003 0.0001 0.0002 0 0.0001 0.0001
Cytoplasm 0.0002 0 0 0 0.0001 0.0001 0.0123 0 0.0007 0.0073 0.0001 0.0001 0.001 0.0001 0 0.0763 0 0
Cytoplasmic Foci 0.0001 0 0.0001 0 0.0001 0.0001 0.0292 0 0.0037 0.0279 0.0015 0.0005 0.0052 0.0001 0.0036 0.0134 0 0
Eisosomes 0 0 0 0 0.0001 0 0.0001 0 0 0.0002 0.0001 0 0.0005 0 0 0 0 0
Endoplasmic Reticulum 0 0 0 0 0.0001 0.0001 0.0053 0 0.0005 0.0055 0.0009 0.0003 0.0014 0 0 0.0007 0 0
Endosome 0.0001 0 0.0001 0.0001 0.0005 0.0006 0.0207 0 0.0009 0.0323 0.0083 0.0016 0.0104 0.0001 0.0011 0.0016 0 0
Golgi 0 0 0 0 0.0001 0.0001 0.0053 0 0.0001 0.0156 0.0039 0.0012 0.0057 0 0.0014 0.0003 0 0
Lipid Particles 0.0002 0.0001 0.0003 0.0003 0.002 0.0003 0.0209 0.0001 0.0018 0.0258 0.0165 0.0031 0.0264 0.0002 0.0071 0.0002 0 0.0011
Mitochondria 0.0003 0.0002 0.0002 0.0001 0.0034 0.0002 0.0038 0.0002 0.0013 0.0069 0.0044 0.001 0.0036 0.0002 0.0006 0.0003 0.0014 0.0001
None 0.0002 0 0 0 0.0003 0.0001 0.0057 0 0.0007 0.0138 0.0006 0.0001 0.0057 0 0.0001 0.0012 0 0
Nuclear Periphery 0.0012 0.0003 0.0002 0.0005 0.0104 0.0051 0.0159 0.0005 0.0022 0.0164 0.0268 0.0022 0.0077 0.0074 0.0005 0.0059 0.0007 0.0021
Nucleolus 0.6376 0.5989 0.685 0.7128 0.6535 0.6666 0.5379 0.6513 0.7454 0.5123 0.6402 0.6815 0.5558 0.6791 0.6639 0.5759 0.6967 0.733
Nucleus 0.3548 0.3976 0.3111 0.2823 0.319 0.3184 0.2468 0.3464 0.2365 0.2868 0.2738 0.3011 0.2845 0.2993 0.3107 0.2577 0.2944 0.2606
Peroxisomes 0 0 0 0 0.0001 0 0.0134 0 0.0002 0.0111 0.0028 0.0008 0.0043 0 0.0043 0.0005 0 0
Punctate Nuclear 0.0031 0.0009 0.0015 0.001 0.0025 0.0058 0.0447 0.0008 0.0031 0.0218 0.0123 0.0016 0.018 0.0119 0.0009 0.0609 0.0054 0.0018
Vacuole 0.0007 0.0003 0.0004 0.0013 0.0024 0.0005 0.0041 0.0002 0.001 0.0011 0.0009 0.0004 0.0014 0.0005 0.0006 0.0005 0.0002 0.0002
Vacuole Periphery 0.0004 0.0002 0.0002 0.0003 0.0028 0.0002 0.0019 0.0001 0.0008 0.0023 0.0016 0.0003 0.0011 0.0002 0.0003 0.0002 0.0003 0.0002

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 44.0898 39.9322 38.2899 30.6332 34.9755 26.6711 28.5774 24.5079 21.4293 33.7726
Translational Efficiency 1.7439 1.585 1.2567 1.3472 1.3165 1.6221 1.3237 1.0189 1.0292 1.0201

Hit Data

Dataset Hit
Protein Concentration ✘
Protein Localization ✘
Gene Expression ✔
Translational Efficiency ✘


Micrographs

Cell Count

Number of cells analysed for each strain. R1, R2: biological replicates; R1 & R2: both replicates combined.

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
1999 233 2636 1618 2448 1219 952 3162 4447 1452 3588 4780

Protein Abundance

Mean and standard deviation of cell GFP intensity, and intensity change (log2) of each mutant relative to wild type.

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 861.49 1114.69 1267.46 1183.44 979.17 1086.66 1043.73 1170.11 926.27 1091.16 1208.10 1174.62
Standard Deviation 122.49 214.02 194.27 268.11 174.49 184.93 159.99 225.37 164.11 190.17 210.42 240.77
Intensity Change Log 2 — 0.371737 0.557034 0.458081 — 0.150269 0.092117 0.257013 — 0.258165 0.328413 0.354615

Localization Score (DeepLoc)

Localization score for each compartment. Values highlighted in green denote significant localization scores (marked * in the plot).

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.000164 0.000344 0.000188 0.000316 0.000215 0.000416 0.000315 0.000265 0.000192 0.000404 0.000222 0.000282
Bud Neck 0.001471 0.002553 0.005224 0.004983 0.002329 0.004063 0.004046 0.004669 0.001943 0.003821 0.004911 0.004775
Bud Site 0.000163 0.000215 0.000346 0.000356 0.000421 0.000580 0.000356 0.000327 0.000305 0.000521 0.000348 0.000337
Cell Periphery 0.000019 0.000017 0.000009 0.000018 0.000051 0.000062 0.000011 0.000025 0.000037 0.000054 0.000009 0.000022
Cytoplasm 0.000045 0.000248 0.000049 0.000027 0.000612 0.000159 0.000084 0.000089 0.000357 0.000173 0.000058 0.000068
Cytoplasmic Foci 0.000175 0.000196 0.000021 0.000088 0.000130 0.000502 0.000032 0.000068 0.000150 0.000453 0.000024 0.000075
Eisosomes 0.000046 0.000047 0.000051 0.000069 0.000061 0.000088 0.000049 0.000088 0.000055 0.000081 0.000051 0.000082
Endoplasmic Reticulum 0.001046 0.000724 0.000305 0.000320 0.001171 0.001485 0.000754 0.000437 0.001115 0.001363 0.000424 0.000397
Endosome 0.000192 0.000076 0.000028 0.000117 0.000207 0.000779 0.000061 0.000089 0.000201 0.000667 0.000037 0.000098
Golgi 0.000278 0.000140 0.000143 0.000109 0.000108 0.000342 0.000177 0.000104 0.000184 0.000310 0.000152 0.000106
Lipid Particles 0.000137 0.000071 0.000005 0.000019 0.000057 0.000524 0.000028 0.000058 0.000093 0.000452 0.000011 0.000045
Mitochondria 0.000796 0.000612 0.000465 0.000842 0.000378 0.003637 0.000476 0.000536 0.000566 0.003152 0.000468 0.000640
Mitotic Spindle 0.000909 0.000415 0.001666 0.000923 0.000829 0.005937 0.002871 0.000845 0.000865 0.005051 0.001986 0.000872
None 0.000680 0.000560 0.000201 0.000305 0.002324 0.000581 0.000356 0.000434 0.001585 0.000577 0.000243 0.000390
Nuclear Periphery 0.000133 0.000090 0.000085 0.000146 0.000103 0.000533 0.000108 0.000093 0.000117 0.000462 0.000091 0.000111
Nuclear Periphery Foci 0.000521 0.000490 0.000102 0.000140 0.000536 0.001192 0.000482 0.000067 0.000529 0.001080 0.000203 0.000092
Nucleolus 0.399653* 0.443375* 0.504111* 0.505328* 0.362280* 0.378448* 0.507348* 0.371199* 0.379080* 0.388867* 0.504970* 0.416601*
Nucleus 0.592286* 0.544575* 0.484585* 0.480930* 0.626606* 0.595428* 0.478542* 0.618730* 0.611178* 0.587268* 0.482982* 0.572085*
Peroxisomes 0.000900 0.004245 0.002031 0.003349 0.000803 0.002286 0.003541 0.001449 0.000846 0.002600 0.002431 0.002092
Vacuole 0.000206 0.000643 0.000122 0.000630 0.000431 0.001233 0.000192 0.000138 0.000330 0.001138 0.000140 0.000304
Vacuole Periphery 0.000180 0.000363 0.000264 0.000981 0.000347 0.001726 0.000170 0.000290 0.000272 0.001507 0.000239 0.000524

Localization Changes (T-score)

Change in localization of each mutant relative to its control (e.g. UBP2_WT: ubp2Δ vs wild type). Values highlighted in yellow (increase) or blue (decrease) denote significant changes (marked * in the plot).

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin -4.93 -2.06 -6.82 0.38 -6.46 -5.59 -3.70 -3.20 4.31 2.23 -6.98 -3.19 -7.20 3.84 -3.89
Bud Neck -2.33 -11.74 -6.51 -3.62 0.46 -3.47 -5.54 -9.69 -1.07 -0.79 -4.43 -12.02 -11.64 -2.12 1.13
Bud Site -1.07 -4.40 -3.15 -1.97 -0.31 -0.93 0.32 1.02 2.01 1.66 -1.73 -1.23 -0.59 1.53 0.93
Cell Periphery -0.21 2.63 -0.01 0.21 -2.75 -0.53 4.82 2.51 1.92 -1.86 -1.16 5.57 2.11 2.04 -2.66
Cytoplasm -1.28 -0.13 0.88 1.32 0.82 2.00 2.25 2.39 1.34 0.45 1.00 2.39 2.39 2.01 -0.09
Cytoplasmic Foci -0.44 1.61 0.80 0.78 -2.20 -1.75 1.25 0.93 2.98 -0.68 -1.96 1.97 1.25 3.07 -1.57
Eisosomes -0.22 -1.62 -7.26 -4.37 -5.65 -4.60 4.38 -7.17 -0.01 -11.09 -5.60 1.90 -10.29 -0.04 -11.53
Endoplasmic Reticulum 2.00 9.93 9.33 2.87 -0.46 -1.70 3.27 9.12 6.14 4.42 -1.63 11.32 12.77 6.63 1.67
Endosome 1.03 2.31 0.77 -0.23 -1.39 -2.66 1.69 1.44 3.51 -0.44 -2.69 2.93 1.69 3.43 -1.90
Golgi 0.60 0.97 1.23 0.60 2.14 -2.43 -4.15 0.21 2.35 1.98 -1.29 0.43 1.21 2.46 1.93
Lipid Particles 0.40 2.05 1.72 1.00 -2.24 -2.15 1.14 0.20 2.17 -0.50 -1.97 2.57 1.14 2.28 -1.01
Mitochondria 0.65 1.13 -0.36 -2.78 -5.50 -3.11 -3.07 -1.80 2.95 -0.37 -2.92 0.52 -0.70 2.83 -2.38
Mitotic Spindle 0.95 -1.82 -0.90 -1.77 0.50 -3.31 -2.03 -0.10 3.38 2.11 -3.25 -2.83 -0.64 3.06 2.46
None 0.23 5.45 4.31 2.13 -4.48 3.02 3.44 3.23 0.81 -0.71 3.04 4.25 3.66 1.56 -2.01
Nuclear Periphery 0.59 1.41 -1.01 -1.38 -2.35 -3.69 -0.47 0.41 3.76 0.68 -3.54 0.91 -0.31 3.48 -1.23
Nuclear Periphery Foci -0.15 5.24 4.11 1.42 -1.28 -1.47 -0.22 2.80 2.91 1.88 -1.58 2.23 4.25 3.03 1.81
Nucleolus -2.31 -13.89 -11.83 -3.38 0.14 -1.75 -15.13 -1.15 0.86 14.47 -1.17 -21.91 -6.53 -3.41 15.07
Nucleus 2.60 14.48 12.65 3.49 0.19 3.36 15.64 0.99 -2.64 -15.14 2.97 22.57 6.91 1.84 -15.36
Peroxisomes -5.33 -9.39 -14.08 1.35 -6.71 -4.64 -11.01 -6.67 2.71 8.67 -6.14 -14.93 -14.28 1.78 3.81
Vacuole -0.94 0.95 -2.07 0.24 -2.39 -3.13 1.22 2.94 4.74 1.62 -3.53 2.34 -0.13 3.34 -1.85
Vacuole Periphery -1.37 -3.62 -2.94 -1.66 -2.61 -3.02 4.02 1.29 3.16 -5.74 -3.25 0.86 -2.62 2.51 -2.94
Standard name
Human Ortholog
Description (SGD) Essential DEAH-box ATP-dependent RNA helicase specific to U3 snoRNP; functions with methyltransferase Bud23p; required for 18S rRNA synthesis; unwinding activity is activated by Utp14p, and Utp14p acts with Bud23p to recruit the helicase to the assembling preribosome; subject to autoinhibition; predominantly nucleolar in distribution
Localization
Cell Percentages nucleolus (48%), nucleus (22%), mixed (30%)
Cell Cycle Regulation Yes
nucleolus - S/G2 (5.9e-05)
Subcompartmental Group N/A

Ecm16

Ecm16


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)