Standard name
Human Ortholog
Description (SGD) Protein required for Stt4-containing PI kinase complex localization; required for Stt4-containing phosphoinositide (PI) kinase patch assembly at plasma membrane; recruited to plasma membrane via conserved basic patch near N-terminus; exhibits synthetic lethal genetic interactions with PHO85; mutations in human homolog EFR3A implicated in autism spectrum disorders
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0.22 0.33 0.26 0.33 0.31 0.34 0.16 0.24 0.24 0.19 0.21 0.2 0.4 0.3 0.13 0.22 0.3 0.2 0 0 0 0.09 0.05 0.05
Bud 0 0 0 0.05 0 0 0 0.06 0.08 0.05 0.07 0.05 0.09 0.05 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0.82 0.85 0.74 0.72 0.57 0.47 0.44 0.3 0.37 0.41 0.35 0.37 0.77 0.75 0.81 0.67 0.55 0.72 0.87 0.89 0.93 0.75 0.82 0.83
Cytoplasm 0 0 0 0.05 0.09 0.09 0.13 0.09 0.11 0.11 0.12 0.08 0.14 0.17 0.23 0.22 0.26 0.16 0 0 0 0 0 0
Endoplasmic Reticulum 0 0 0 0.05 0.07 0.09 0 0.11 0 0 0 0.05 0 0 0 0.05 0.06 0.06 0 0 0 0 0 0
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0.26 0.47 0.64 0.62 0.45 0.6 0.67 0.67 0.76 0.76 0.81 0.79 0 0 0 0.1 0.07 0.07 0 0 0 0.06 0 0
Nucleus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0.19 0.19 0.27 0.2 0.12 0.09 0.09 0.09 0 0.06 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vac/Vac Membrane 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 60 78 108 95 113 153 73 139 135 128 104 112 23 38 23 114 93 54 14 11 18 23 10 15
Bud 8 1 6 13 11 17 19 33 44 34 32 27 5 6 1 17 8 8 0 0 0 0 0 2
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 2 1 0 3 4 6
Bud Site 0 0 0 0 0 0 0 0 0 1 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 224 198 315 205 210 211 206 171 212 274 170 212 44 94 144 350 169 200 278 238 409 184 162 246
Cytoplasm 9 6 16 14 34 39 59 53 65 70 59 45 8 21 40 114 81 44 1 0 0 4 1 3
Endoplasmic Reticulum 11 4 18 15 27 42 20 65 17 25 21 30 0 5 6 27 19 16 4 4 2 5 3 7
Endosome 0 0 0 0 1 2 2 3 2 0 1 0 0 0 0 1 4 1 2 2 0 2 1 2
Golgi 1 0 1 1 2 0 1 2 0 0 0 0 0 0 0 1 1 3 2 1 1 1 1 0
Mitochondria 72 109 270 176 165 269 314 383 432 501 391 450 2 3 0 50 22 19 6 3 4 14 5 6
Nucleus 4 2 0 1 0 2 2 2 1 1 0 2 0 2 0 2 3 0 0 0 0 0 0 0
Nuclear Periphery 0 1 0 1 0 0 0 6 3 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 1 0 0 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 1 0
Peroxisomes 1 0 80 53 101 88 55 53 49 57 10 33 0 0 0 10 7 5 0 0 0 0 0 0
SpindlePole 2 0 0 0 4 1 1 1 3 4 0 3 0 4 0 10 9 8 0 0 0 0 0 0
Vac/Vac Membrane 0 0 0 2 10 3 16 7 10 14 5 6 0 0 0 1 4 0 2 0 0 3 1 2
Unique Cell Count 272 233 423 284 370 450 467 571 572 663 484 569 57 126 177 519 310 276 320 267 442 246 199 297
Labelled Cell Count 392 399 815 576 678 827 768 918 973 1110 793 921 82 173 214 697 421 358 320 267 442 246 199 297


Cell Periphery

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 8.8 8.9 8.7 8.4 7.8 6.8 6.7 6.6 6.2 5.9 5.8 6.0 8.3 9.0 9.2 6.5 7.0 8.5 9.2 9.6 10.3
Std Deviation (1e-4) 1.1 1.1 1.3 1.4 1.7 1.7 1.8 1.4 1.3 1.2 1.5 1.3 1.0 1.3 1.2 0.9 1.1 1.5 1.7 1.6 1.8
Intensity Change (Log2) – – – -0.06 -0.17 -0.37 -0.39 -0.41 -0.49 -0.57 -0.58 -0.55 -0.08 0.03 0.08 -0.44 -0.33 -0.05 0.08 0.13 0.23


Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches 2.3 1.6 2.7 -3.7 -0.4 -0.7 -2.4 -1.4 -2.2 2.4 1.0 -3.4 -1.3 1.3 -1.8
Bud 2.5 1.5 2.2 2.4 3.5 4.5 3.2 3.9 2.9 0 0 0 1.8 1.1 1.4
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cell Periphery -0.7 -5.3 -8.3 -9.2 -13.9 -11.7 -10.7 -11.9 -11.6 0.4 0 1.8 -2.4 -5.6 -0.6
Cytoplasm 0.7 3.1 3.0 4.7 3.4 4.3 4.0 4.6 2.7 0 5.1 7.2 8.0 8.8 5.6
Endoplasmic Reticulum 0.6 1.8 3.0 0 4.0 -1.1 -0.4 0.1 0.7 0 -0.1 -0.5 0.7 1.1 0.9
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria -0.5 -5.4 -1.2 1.1 1.1 4.0 4.2 5.7 5.3 -8.6 -12.1 -14.3 -17.5 -15.5 -14.9
Nucleus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes -0.1 2.8 0.2 -3.0 -4.4 -4.8 -5.0 -8.5 -6.4 -3.6 -5.3 -6.2 -8.8 -6.9 -6.8
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vacuole 0 0 0 3.8 0 0 3.0 0 0 0 0 0 0 0 0

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 4.2903 5.8936 5.4028 4.7628 4.2998 5.0717 5.7121 7.0482 6.6355 6.1817 5.7229 6.8065 6.1039 8.1524 7.1035 7.4745 7.1056 7.0491
Actin 0.0335 0.0155 0.0134 0.0052 0.0391 0.0059 0.0054 0.0003 0.0089 0.0493 0.0001 0.0079 0.0357 0.0014 0.0168 0.0373 0.0002 0.0026
Bud 0.0005 0.0017 0.0004 0.0003 0.0009 0.0002 0.0002 0.0001 0.0014 0.0003 0.0001 0.0002 0.0003 0.0001 0.0003 0.0002 0.0002 0.0002
Bud Neck 0.005 0.004 0.0042 0.0043 0.0143 0.003 0.0016 0.0019 0.0041 0.0129 0.0007 0.0033 0.011 0.002 0.0078 0.0013 0.0024 0.0037
Bud Periphery 0.0049 0.0045 0.0046 0.0058 0.0099 0.0046 0.0016 0.0016 0.0068 0.006 0.002 0.0037 0.0014 0.0005 0.0035 0.0059 0.0044 0.0038
Bud Site 0.0119 0.0846 0.0091 0.0035 0.0128 0.0007 0.0078 0.0395 0.0187 0.0098 0.0006 0.0018 0.009 0.0356 0.0181 0.0014 0.0013 0.0017
Cell Periphery 0.7368 0.7167 0.8431 0.8738 0.7256 0.9119 0.8012 0.8299 0.81 0.8396 0.9597 0.8936 0.8186 0.8802 0.8739 0.9028 0.9327 0.9352
Cytoplasm 0.0701 0.1211 0.0728 0.067 0.1134 0.0356 0.0406 0.0742 0.0505 0.036 0.0224 0.0461 0.0329 0.0536 0.0431 0.0133 0.042 0.0243
Cytoplasmic Foci 0.0041 0.0007 0.0004 0.0003 0.0038 0.0006 0.0138 0.0002 0.002 0.0001 0 0.0009 0.0076 0 0.0017 0.0024 0.0001 0.0002
Eisosomes 0.0752 0.0295 0.0274 0.0169 0.0262 0.0174 0.0626 0.0272 0.0365 0.0342 0.0083 0.0174 0.0555 0.0231 0.0203 0.0071 0.0102 0.0157
Endoplasmic Reticulum 0.0109 0.0136 0.0118 0.0175 0.0112 0.0075 0.0069 0.0014 0.0056 0.008 0.0043 0.0043 0.0021 0.0018 0.004 0.0087 0.0036 0.0027
Endosome 0.0042 0.0004 0.0017 0 0.0047 0.0001 0.0071 0 0.0069 0 0 0.0026 0.0038 0 0.0043 0.0011 0 0.0017
Golgi 0.0018 0.0009 0.0008 0.0003 0.005 0.0002 0.0024 0.0001 0.0038 0.0003 0 0.0033 0.0027 0 0.0011 0.0015 0.0001 0.0005
Lipid Particles 0.0044 0.0012 0.0008 0.0007 0.0078 0.0008 0.0118 0.0002 0.0018 0.0002 0.0001 0.0017 0.0037 0.0001 0.0006 0.0021 0.0002 0.0003
Mitochondria 0.0009 0.0014 0.0003 0.0001 0.0051 0.0001 0.0007 0 0.0155 0.0001 0 0.0042 0.0027 0 0.0002 0.0013 0 0.0007
None 0.0096 0.0007 0.0024 0.0007 0.0049 0.0089 0.003 0.022 0.0022 0.0005 0.0004 0.0022 0.0027 0.0004 0.0012 0.0014 0.0005 0.0006
Nuclear Periphery 0.0081 0.0007 0.003 0.0006 0.0022 0.0004 0.0058 0.0002 0.0107 0.0006 0.0004 0.0033 0.0022 0.0003 0.0007 0.0007 0.0003 0.004
Nucleolus 0.0002 0.0001 0.0001 0 0.0004 0 0.0002 0.0001 0.0007 0 0 0.0001 0.0005 0 0.0001 0.0001 0 0.0001
Nucleus 0.0051 0.0004 0.0006 0.0001 0.0006 0.0001 0.021 0.0001 0.0078 0.0001 0 0.0003 0.0005 0 0.0002 0.0001 0.0001 0.0004
Peroxisomes 0.0075 0.0001 0.0001 0 0.0028 0.0001 0.0021 0 0.0011 0.0005 0 0.0007 0.0032 0 0.0002 0.007 0 0
Punctate Nuclear 0.0013 0 0.0004 0 0.0055 0.0001 0.0015 0 0.0012 0 0 0.001 0.0026 0 0.0003 0.002 0 0.0002
Vacuole 0.0035 0.0021 0.0024 0.0026 0.0033 0.0018 0.0024 0.0009 0.0028 0.0014 0.0009 0.0014 0.0012 0.0009 0.0016 0.002 0.0018 0.0012
Vacuole Periphery 0.0004 0.0001 0.0002 0 0.0002 0 0.0002 0 0.001 0 0 0.0001 0.0002 0 0.0001 0.0001 0 0.0002

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 33.3511 24.7749 29.913 33.7822 25.5793 19.2484 31.5246 25.7903 24.4565 37.6848
Translational Efficiency 0.5781 0.5892 0.6102 0.5376 0.5719 0.9229 0.4892 0.6045 0.6809 0.5042

Hit Data

Dataset Hit
Protein Concentration ✘
Protein Localization ✘
Gene Expression ✘
Translational Efficiency ✘


Micrographs

Cell Count

Number of cells analysed for each strain. R1, R2: biological replicates; R1 & R2: both replicates combined.

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
183 1421 250 1376 1707 2009 1801 1438 1890 3430 2051 2814

Protein Abundance

Mean and standard deviation of cell GFP intensity, and intensity change (log2) of each mutant relative to wild type.

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 1066.79 998.73 1190.10 1139.02 873.16 966.08 1106.19 1135.25 891.91 979.61 1116.42 1137.09
Standard Deviation 145.08 141.87 121.27 146.81 126.14 126.37 135.76 143.49 140.31 133.98 136.86 145.14
Intensity Change Log 2 — -0.095110 0.157807 0.094517 — 0.145897 0.341281 0.378692 — 0.018370 0.243285 0.229384

Localization Score (DeepLoc)

Localization score for each compartment. Values highlighted in green denote significant localization scores (marked * in the plot).

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.029327 0.013933 0.052312 0.058825 0.005498 0.007635 0.013863 0.026912 0.007805 0.010244 0.018549 0.042517
Bud Neck 0.010944 0.007373 0.032019 0.016534 0.005689 0.005963 0.015405 0.011267 0.006198 0.006547 0.017430 0.013842
Bud Site 0.082042 0.031114 0.086903 0.105894* 0.012885 0.016494 0.040248 0.074519 0.019581 0.022551 0.045935 0.089861
Cell Periphery 0.724210* 0.870862* 0.383297* 0.665055* 0.828741* 0.864130* 0.830803* 0.783164* 0.818620* 0.866919* 0.776256* 0.725411*
Cytoplasm 0.091674 0.045595 0.199036* 0.101937* 0.072296 0.058262 0.068620 0.075412 0.074172 0.053014 0.084516 0.088383
Cytoplasmic Foci 0.005909 0.003028 0.035166 0.003930 0.007844 0.003802 0.001042 0.002222 0.007657 0.003482 0.005202 0.003057
Eisosomes 0.009604 0.005056 0.027650 0.017898 0.008423 0.008381 0.007373 0.008300 0.008538 0.007003 0.009845 0.012993
Endoplasmic Reticulum 0.011024 0.004999 0.047368 0.006243 0.008352 0.008555 0.009550 0.004282 0.008610 0.007082 0.014160 0.005241
Endosome 0.004614 0.001405 0.010759 0.002957 0.003086 0.001891 0.000749 0.001770 0.003234 0.001690 0.001969 0.002350
Golgi 0.006789 0.002108 0.024171 0.003367 0.004912 0.002032 0.000483 0.003305 0.005094 0.002064 0.003370 0.003335
Lipid Particles 0.002891 0.000595 0.030841 0.002537 0.003903 0.001051 0.002893 0.000608 0.003805 0.000862 0.006300 0.001551
Mitochondria 0.002896 0.003838 0.000184 0.001561 0.006487 0.005560 0.000718 0.001220 0.006139 0.004847 0.000653 0.001387
Mitotic Spindle 0.001020 0.000268 0.000312 0.001716 0.000131 0.000222 0.000432 0.000707 0.000217 0.000241 0.000417 0.001200
None 0.000028 0.000102 0.000026 0.000063 0.000093 0.000049 0.000069 0.000037 0.000087 0.000071 0.000064 0.000050
Nuclear Periphery 0.000127 0.000141 0.000171 0.000101 0.000195 0.000205 0.000293 0.000083 0.000188 0.000179 0.000278 0.000092
Nuclear Periphery Foci 0.000449 0.000082 0.002967 0.000274 0.000077 0.000066 0.000250 0.000122 0.000113 0.000073 0.000581 0.000196
Nucleolus 0.000009 0.000015 0.000075 0.000025 0.000120 0.000022 0.000030 0.000011 0.000109 0.000019 0.000035 0.000018
Nucleus 0.000882 0.000182 0.004822 0.001451 0.000383 0.000297 0.000807 0.000685 0.000431 0.000249 0.001296 0.001060
Peroxisomes 0.000746 0.008076 0.004279 0.002058 0.029555 0.014320 0.002958 0.001173 0.026765 0.011733 0.003119 0.001606
Vacuole 0.013628 0.000656 0.057310 0.006414 0.000692 0.000629 0.003240 0.003094 0.001945 0.000640 0.009830 0.004718
Vacuole Periphery 0.001188 0.000570 0.000332 0.001158 0.000638 0.000435 0.000175 0.001108 0.000691 0.000491 0.000194 0.001133

Localization Changes (T-score)

Change in localization of each mutant relative to its control (e.g. UBP2_WT: ubp2Δ vs wild type). Values highlighted in yellow (increase) or blue (decrease) denote significant changes (marked * in the plot).

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin 2.57 -2.80 -4.38 -11.59 -0.98 -1.98 -6.65 -9.55 -8.20 -5.35 -2.07 -7.32 -15.78 -14.43 -9.99
Bud Neck 1.81 -4.46 -2.58 -6.53 3.42 -0.34 -8.16 -5.01 -4.79 2.92 -0.49 -9.37 -8.20 -8.26 2.74
Bud Site 4.28 -0.34 -1.90 -13.43 -2.13 -1.86 -10.84 -13.97 -12.84 -7.15 -1.36 -9.68 -19.43 -19.00 -11.27
Cell Periphery -6.01 10.54 2.38 18.87 -11.76 -4.09 -0.24 4.44 8.76 5.11 -6.22 4.61 10.44 19.70 5.90
Cytoplasm 3.90 -6.42 -0.85 -11.65 7.57 3.35 0.81 -0.66 -3.99 -1.47 5.75 -2.28 -3.42 -10.86 -0.94
Cytoplasmic Foci 1.29 -5.92 0.80 -1.13 6.89 4.17 8.29 5.81 2.13 -2.24 4.87 2.49 5.08 0.58 2.76
Eisosomes 3.52 -6.56 -5.04 -10.89 3.61 0.05 1.30 0.14 0.10 -1.32 2.09 -1.62 -5.01 -8.35 -3.99
Endoplasmic Reticulum 2.07 -5.58 1.61 -1.25 6.96 -0.14 -0.88 3.26 3.27 4.40 1.31 -3.79 3.08 2.09 7.15
Endosome 1.46 -2.38 0.70 -2.00 4.98 2.37 5.52 2.17 0.23 -2.33 3.27 2.66 1.40 -1.43 -0.83
Golgi 1.10 -3.54 0.80 -1.16 7.71 3.26 6.09 1.26 -1.08 -2.67 3.48 2.04 1.70 -1.60 0.03
Lipid Particles 1.26 -5.26 0.16 -3.40 5.63 4.68 1.13 5.43 1.70 3.23 5.20 -2.41 3.56 -2.23 5.11
Mitochondria -0.62 2.03 0.98 3.03 -5.34 0.89 8.24 7.10 5.36 -1.97 1.54 8.50 7.11 6.10 -4.00
Mitotic Spindle 0.95 0.90 -0.74 -2.21 -2.16 -2.07 -16.17 -1.20 -1.00 -0.57 -0.29 -2.57 -2.41 -2.39 -1.97
None -1.09 0.25 -3.49 0.56 -4.71 2.01 1.08 2.57 2.37 5.57 0.48 1.14 1.84 0.74 2.41
Nuclear Periphery -0.30 -0.86 0.53 4.54 2.89 -0.61 -5.64 9.36 9.64 14.84 0.75 -5.49 8.29 10.40 14.62
Nuclear Periphery Foci 3.51 -9.47 1.42 -4.20 10.75 1.33 -9.51 -4.57 -6.96 7.13 3.20 -11.55 -3.30 -5.36 8.36
Nucleolus -4.02 -1.33 -3.14 -1.91 0.98 1.11 1.02 1.23 5.65 13.97 1.12 0.93 1.14 0.35 2.51
Nucleus 4.24 -6.93 -2.69 -8.56 5.92 0.85 -3.73 -2.57 -6.37 1.58 1.95 -6.89 -5.24 -10.19 1.90
Peroxisomes -7.86 -5.40 -4.55 6.26 3.19 6.29 12.53 13.42 10.93 5.94 7.25 12.26 13.10 12.47 5.38
Vacuole 3.47 -6.64 1.75 -7.43 9.19 0.61 -12.83 -7.78 -8.17 0.39 3.41 -9.06 -5.20 -9.80 5.42
Vacuole Periphery 0.92 1.34 0.02 -1.11 -1.67 1.72 4.82 -0.90 -1.30 -1.81 1.37 4.66 -1.20 -1.75 -2.64
Standard name
Human Ortholog
Description (SGD) Protein required for Stt4-containing PI kinase complex localization; required for Stt4-containing phosphoinositide (PI) kinase patch assembly at plasma membrane; recruited to plasma membrane via conserved basic patch near N-terminus; exhibits synthetic lethal genetic interactions with PHO85; mutations in human homolog EFR3A implicated in autism spectrum disorders
Localization
Cell Percentages cell periphery (86%)
Cell Cycle Regulation No
Subcompartmental Group cell periphery-2

Efr3

Efr3


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)