| Standard name | |
|---|---|
| Human Ortholog | |
| Description (SGD) | Thiol oxidase required for oxidative protein folding in the ER; essential for maintaining ER redox balance; feedback regulated via reduction and oxidation of regulatory bonds; reduced Pdi1p activates Ero1p by direct reduction of Ero1p regulatory bonds; depletion of thiol substrates and accumulation of oxidized Pdi1p results in inactivation of Ero1p by both Pdi1p-mediated oxidation and autonomous oxidation of Ero1p regulatory bonds; ero1-1 mutation complemented by human ERO1L |
This ORF has not been screened into our collection.
Refer to list of proteins screened in CYCLoPS.
Images
Protein Concentration and Protein Localization Data
| R1 | R2 | R3 | ||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | |
| Concentration | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
| Actin | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
| Bud | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
| Bud Neck | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
| Bud Periphery | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
| Bud Site | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
| Cell Periphery | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
| Cytoplasm | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
| Cytoplasmic Foci | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
| Eisosomes | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
| Endoplasmic Reticulum | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
| Endosome | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
| Golgi | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
| Lipid Particles | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
| Mitochondria | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
| None | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
| Nuclear Periphery | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
| Nucleolus | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
| Nucleus | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
| Peroxisomes | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
| Punctate Nuclear | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
| Vacuole | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
| Vacuole Periphery | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
Sequencing Data
| R1 | R2 | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | |
| Gene Expression | 60.3221 | 44.8883 | 34.1742 | 45.7281 | 45.6578 | 43.6685 | 49.8073 | 50.1264 | 47.2434 | 47.3599 |
| Translational Efficiency | 1.0141 | 1.2527 | 1.1751 | 0.9428 | 0.9756 | 1.3335 | 1.1582 | 0.9429 | 0.9634 | 0.9633 |
Hit Data
| Dataset | Hit |
|---|---|
| Protein Concentration | – |
| Protein Localization | – |
| Gene Expression | ✘ |
| Translational Efficiency | ✘ |
Micrographs
Select an organelle or subcellular structure:
Penetrance Data
Penetrance values (percentage of cells with morphologically abnormal structure) at each time point for each of the subcellular structures monitored.
| TP0 | TP3 | TP6 | TP9 | TP12 | TP15 | TP18 | TP21 | TP24 | |
|---|---|---|---|---|---|---|---|---|---|
| Autophagosome (ATG8) | 26.946108 | 81.034483 | 97.421203 | 95.250000 | 90.769231 | 92.786070 | 87.786260 | 90.243902 | 86.610879 |
| Septin (CDC11) | 17.174515 | 65.150215 | 78.811370 | 80.350877 | 88.414634 | 89.473684 | 89.375000 | 84.366577 | 70.313901 |
| Spindle & SPB (DAD2) | 23.857868 | 60.089021 | 77.428999 | 59.463722 | 61.575563 | 56.297710 | 54.013015 | 65.384615 | 33.206831 |
| P-bodies (DCP2) | 21.104536 | 83.739837 | 96.302521 | 97.474747 | 97.324415 | 98.998331 | 93.157895 | 94.583333 | 85.937500 |
| Inner Nuclear Membrane (HEH2) | 19.610390 | 61.921708 | 75.779376 | 81.784841 | 88.988476 | 94.480946 | 96.070461 | 97.606838 | 95.918367 |
| Metacaspase (MCA1) | 8.517609 | 43.067591 | 93.525686 | 92.214286 | 94.468085 | 94.077449 | 90.458015 | 80.157171 | 72.222222 |
| Plasma Membrane (MID2) | 41.991342 | 77.222222 | 91.236495 | 90.093240 | 95.238095 | 96.260555 | 92.996109 | 88.218391 | 83.689840 |
| Necrosis Factor (NHP6A) | 26.355612 | 83.636364 | 96.039604 | 97.466667 | 97.907324 | 99.693721 | 98.121387 | 96.119929 | 94.148936 |
| Nucleolus (NOP10) | 26.473340 | 40.069384 | 55.614035 | 61.749117 | 85.814978 | 96.157283 | 95.636687 | 97.495528 | 98.612396 |
| Kinetochore (NUF2) | 43.596730 | 56.135770 | 75.609756 | 67.213115 | 59.888579 | 64.285714 | 71.673820 | 68.882175 | 82.608696 |
| Mitochondria (OM45) | 22.103387 | 36.102719 | 83.333333 | 87.136294 | 95.839753 | 98.601399 | 98.422713 | 98.703404 | 98.848369 |
| Eisosomes (PIL1) | 15.118790 | 88.295688 | 98.958333 | 97.198276 | 97.065463 | 99.569892 | 100.000000 | 99.772727 | 100.000000 |
| Proteasome (PRE2) | 18.373812 | 56.145526 | 73.491592 | 78.391960 | 88.877446 | 82.644628 | 78.484438 | 84.975369 | 73.112128 |
| DNA Damage Foci (RAD52) | 20.361991 | 39.488117 | 48.015123 | 52.631579 | 69.565217 | 71.488470 | 71.461187 | 79.080460 | 99.218750 |
| Actin Patches (SAC6) | 28.988764 | 81.551363 | 96.095445 | 98.207171 | 94.957983 | 87.981859 | 91.608392 | 91.831683 | 86.575342 |
| Golgi, Early (SEC21) | 14.702815 | 76.615832 | 89.528024 | 80.718475 | 67.463377 | 76.856919 | 85.477506 | 88.800000 | 85.049020 |
| Golgi, Late (SEC7) | 29.166667 | 82.653061 | 93.320236 | 97.465887 | 99.593496 | 99.343545 | 99.170124 | 96.798030 | 95.054945 |
| Endosomes (SNF7) | 58.482143 | 40.077444 | 53.198653 | 64.583333 | 72.212389 | 85.108303 | 79.980658 | 87.791343 | 79.601990 |
| Endoplasmic Reticulum (SPF1) | 23.192488 | 75.276126 | 92.607313 | 90.047771 | 89.806234 | 89.391304 | 89.184826 | 86.890244 | 76.647287 |
| Lipid Droplets (TGL3) | 15.556319 | 23.968286 | 37.474666 | 44.189354 | 52.870029 | 62.678288 | 68.928200 | 61.538462 | 66.205405 |
| Vacuole (VPH1) | 31.393298 | 43.088235 | 72.378139 | 89.519651 | 94.586466 | 96.691729 | 95.284553 | 96.472393 | 99.645390 |
Endocytosis
| Temp | Actin Patch (Sac6-tdTomato) | Cortical Patch (Sla1-GFP) | Late Endosome (Snf7-GFP) | Vacuole (Vph1-GFP) |
|---|---|---|---|---|
| 37℃ | ||||
| RT |
Cell Cycle Omics
CYCLoPs (Ero1-GFP)
| Gene / Allele | Actin Patch (Sac6-tdTomato) | Cortical Patch (Sla1-GFP) | Late Endosome (Snf7-GFP) | Vacuole (Sac6-tdTomato) |
|---|
| Gene | Images |
|---|
| Gene | Images |
|---|
Images are not yet available
Images are not yet available
