Standard name
Human Ortholog
Description Putative protein; predicted to be an alpha-isopropylmalate carrier; belongs to the sideroblastic-associated protein family; non-tagged protein is detected in purified mitochondria; likely to play a role in iron homeostasis
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0.07 0 0 0 0 0.08 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.06 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.12 0.05 0.07 0 0 0 0 0 0
Cytoplasm 0 0.06 0 0.05 0 0.05 0 0 0 0 0 0 0 0 0.06 0.09 0.06 0.06 0 0 0 0 0 0
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 0 0 0 0 0.09 0.06 0.05 0 0 0 0 0 0 0 0 0
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.05 0 0 0 0 0.07 0 0 0 0
Golgi 0 0.06 0 0 0 0 0 0 0 0 0 0 0.09 0.22 0.32 0.35 0.35 0.38 0.05 0.05 0.05 0 0.06 0.05
Mitochondria 0.88 0.86 0.97 0.94 0.9 0.89 0.91 0.9 0.93 0.92 0.95 0.97 0.79 0.7 0.59 0.09 0.05 0.09 0.81 0.72 0.82 0.8 0.72 0.62
Nucleus 0 0 0 0 0 0 0.06 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0.05 0 0.06 0.09 0.06 0.06 0 0 0 0 0 0.11 0.05 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0.05 0.09 0.08 0.06 0.05 0 0.06 0 0 0 0 0.06 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.06 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vac/Vac Membrane 0.11 0.19 0 0.06 0.1 0.06 0.06 0 0 0.07 0 0 0.12 0.16 0.21 0.28 0.27 0.26 0 0.08 0 0 0.1 0.17
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 1 1 0 0 0 0 0 0 0 0 0 4 7 4 2 2 8 1 3 1 0 4 4
Bud 4 3 1 3 15 12 17 18 13 21 11 20 0 3 5 2 5 1 0 0 0 0 1 4
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 1 1 1
Bud Site 1 0 1 0 2 9 15 9 3 10 7 14 0 0 0 0 0 0 – – – – – –
Cell Periphery 3 2 4 10 10 2 1 1 2 3 2 5 2 10 7 10 4 7 0 1 0 0 0 0
Cytoplasm 7 8 2 14 18 23 20 31 16 20 18 6 1 11 18 7 5 6 1 1 0 0 1 0
Endoplasmic Reticulum 2 3 3 3 4 5 2 1 1 3 6 1 5 17 15 3 2 2 1 0 0 0 2 3
Endosome 6 1 0 1 12 1 1 1 3 3 1 0 0 10 14 2 2 2 6 11 2 4 8 10
Golgi 2 9 0 2 0 0 0 0 0 0 0 0 5 62 88 28 28 37 10 7 5 2 15 13
Mitochondria 165 123 117 271 412 390 552 662 451 660 401 575 45 197 163 7 4 9 152 111 97 102 182 154
Nucleus 4 2 1 1 5 14 37 25 12 10 5 13 1 1 0 1 2 3 0 0 0 1 2 1
Nuclear Periphery 3 0 2 5 7 23 25 47 46 42 26 21 0 5 1 0 9 5 1 0 1 1 0 1
Nucleolus 8 3 2 4 13 21 56 57 28 38 17 34 0 1 1 3 5 3 1 0 0 0 0 1
Peroxisomes 3 1 0 4 10 0 8 6 3 8 3 4 0 7 9 3 3 6 4 2 3 5 4 6
SpindlePole 4 1 1 2 7 2 19 19 11 28 8 11 0 5 2 0 0 1 2 0 0 0 2 2
Vac/Vac Membrane 20 27 4 16 46 28 37 32 18 48 16 12 7 44 57 23 21 25 3 12 1 5 24 42
Unique Cell Count 188 143 121 288 458 437 606 738 486 715 424 592 57 283 278 81 79 98 189 154 120 128 253 251
Labelled Cell Count 232 184 139 336 561 530 790 909 607 894 521 716 70 380 384 91 92 115 189 154 120 128 253 251


Mitochondria

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 6.1 6.0 4.6 5.2 5.2 4.8 4.2 4.3 4.3 4.0 4.1 4.0 7.0 7.1 7.2 11.1 12.2 12.5 7.1 8.0 8.1
Std Deviation (1e-4) 1.0 0.9 0.9 1.3 1.3 1.7 1.3 1.6 1.7 1.2 1.3 1.1 1.1 1.0 1.1 2.7 2.7 3.2 1.0 1.5 1.8
Intensity Change (Log2) – – – 0.18 0.17 0.08 -0.14 -0.09 -0.1 -0.18 -0.16 -0.19 0.61 0.64 0.65 1.28 1.41 1.45 0.63 0.8 0.81


Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Actin – – – – – – – – – – – – – – –
Bud 0 0 0 0 0 – 0 – – 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 – 0 – – 0 0 0 0 0 0
Bud Site 0 0 0 0 0 – 0 – – 0 0 0 0 0 0
Cell Periphery 0 0 0 0 0 – 0 – – 0 0 0 2.5 0 0
Cyto – – – – – – – – – – – – – – –
Endoplasmic Reticulum 0 0 0 0 0 – 0 – – 0 1.5 1.3 0 0 0
Endosome 0 0 0 0 0 – 0 – – 0 0 0 0 0 0
Golgi 0 0 0 0 0 – 0 – – 0 5.6 7.0 7.0 7.1 7.4
Mitochondria -1.1 -2.3 0 0 0 – 0 – – -3.9 -6.0 -7.6 -12.6 -13.0 -13.0
Nuclear Periphery 0 0 0 0 0 – 0 – – 0 0 0 0 0 0
Nuc – – – – – – – – – – – – – – –
Nucleolus 0 0 0 0 0 – 0 – – 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 – 0 – – 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 – 0 – – 0 0 0 0 0 0
Vac – – – – – – – – – – – – – – –
Cortical Patches 0 0 0 0 0 – 0 – – 0 0 0 0 0 0
Cytoplasm 0 0 1.7 0 0 – 0 – – 0 0 2.0 0 0 0
Nucleus 0 0 0 2.4 0 – 0 – – 0 0 0 0 0 0
Vacuole 1.0 2.3 1.3 1.2 0.5 – 1.4 – – 0 3.5 4.4 5.1 4.9 4.8

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 6.1498 7.1188 6.6632 6.4802 5.8142 7.04 6.9554 8.6277 7.7512 7.5501 6.4801 7.7888 6.0834 7.0469 6.2733 6.6831 4.8691 6.7203
Actin 0.0198 0.0104 0.0071 0.0011 0.0255 0.001 0.0042 0.0059 0.0012 0.0001 0.0013 0.0048 0.0069 0.0036 0.015 0.0344 0.0419 0.0001
Bud 0.0011 0.0043 0.0022 0.0013 0.0006 0.001 0.0003 0.0004 0.0001 0 0.0001 0.0001 0.0001 0.0003 0.001 0.0003 0.0006 0
Bud Neck 0.0005 0.0004 0.0006 0.0002 0.0004 0.0001 0.0001 0.0002 0 0 0 0 0.0004 0.0002 0.0005 0.0001 0.0007 0
Bud Periphery 0.0029 0.0097 0.0057 0.0011 0.0011 0.002 0.0007 0.0004 0.0001 0.0001 0.0003 0.0001 0.0002 0.0004 0.0014 0.0006 0.001 0.0001
Bud Site 0.0037 0.0138 0.0076 0.0005 0.0013 0.0001 0.0006 0.001 0.0001 0 0.0001 0.0002 0.0007 0.0011 0.002 0.0007 0.0015 0
Cell Periphery 0.0003 0.0005 0.0003 0.0004 0.0002 0.0002 0.0003 0.0001 0.0001 0 0.0001 0 0.0002 0.0002 0.0005 0.0001 0.0001 0
Cytoplasm 0.0018 0.0008 0.0011 0.0002 0.0064 0.0013 0.0007 0.0004 0.0008 0 0 0.0003 0.0037 0.0004 0 0.0005 0.0005 0
Cytoplasmic Foci 0.0302 0.0033 0.0075 0.0108 0.0104 0.0025 0.0085 0.0117 0.0004 0 0.0078 0.0053 0.0069 0.0029 0.0006 0.0103 0.0101 0
Eisosomes 0.0005 0.0002 0.0002 0.0002 0.0003 0.0001 0.0001 0.0001 0.0002 0.0001 0.0001 0.0001 0.0002 0.0001 0.0003 0.0003 0.0003 0
Endoplasmic Reticulum 0.0007 0.0002 0.0003 0.0001 0.0013 0.0001 0.0013 0.0001 0.0002 0 0.0001 0.0001 0.0025 0.0001 0 0.0007 0.0012 0
Endosome 0.0322 0.013 0.0156 0.0128 0.0543 0.0041 0.0129 0.0273 0.0015 0.0001 0.0056 0.0042 0.0097 0.0113 0.0012 0.0089 0.0223 0.0003
Golgi 0.0306 0.0285 0.0179 0.0099 0.0293 0.0161 0.0095 0.0124 0.004 0.0002 0.0367 0.0114 0.0107 0.0188 0.0028 0.0074 0.0193 0.0012
Lipid Particles 0.0319 0.0026 0.0069 0.0205 0.008 0.0024 0.0338 0.0027 0.0009 0.0002 0.0365 0.0014 0.0244 0.0093 0.0052 0.0222 0.0261 0.0001
Mitochondria 0.7926 0.8844 0.897 0.9207 0.834 0.9466 0.8911 0.9231 0.9715 0.9985 0.8961 0.9626 0.8906 0.926 0.9541 0.8854 0.8511 0.9964
None 0.0102 0.005 0.0105 0.0006 0.0126 0.011 0.0003 0 0.0134 0 0 0.0001 0.0066 0 0.0001 0.0032 0.001 0
Nuclear Periphery 0.0015 0.0004 0.0004 0.0002 0.0005 0.0001 0.0015 0 0.0001 0 0.0001 0.0002 0.0025 0.0002 0 0.0012 0.0044 0
Nucleolus 0.0008 0.0004 0.0007 0.0043 0.0001 0.0015 0.0004 0.0003 0 0 0.0001 0 0.0008 0.0002 0.0009 0.0002 0.0003 0
Nucleus 0.0004 0.0003 0.0003 0.0005 0.0002 0.0007 0.0004 0.0001 0 0 0 0 0.0024 0.0002 0.0002 0.0002 0.0005 0
Peroxisomes 0.0276 0.0047 0.0093 0.0039 0.0028 0.002 0.0093 0.0093 0.0034 0.0002 0.0127 0.0059 0.0083 0.0107 0.0051 0.0174 0.0115 0.0003
Punctate Nuclear 0.0013 0.0002 0.0007 0.0004 0.001 0.0046 0.0011 0 0 0 0.0004 0.0005 0.0052 0 0 0.0024 0.0041 0
Vacuole 0.0037 0.0087 0.0045 0.0047 0.0039 0.0009 0.0066 0.0028 0.0003 0.0001 0.0008 0.0003 0.0041 0.0071 0.005 0.0008 0.0006 0.0001
Vacuole Periphery 0.0059 0.008 0.0034 0.0054 0.0056 0.0018 0.0164 0.0016 0.0017 0.0003 0.001 0.0024 0.0128 0.0069 0.0038 0.0028 0.0008 0.0012

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 110.4526 106.256 84.7972 87.0924 93.0479 91.8995 73.2283 62.5925 70.8803 77.8589
Translational Efficiency 1.1035 1.3214 1.6001 1.6127 1.6238 1.3249 1.3875 1.8898 1.5595 1.4607

Hit Data

Dataset Hit
Protein Concentration ✘
Protein Localization ✘
Gene Expression ✘
Translational Efficiency ✔

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
795 1434 123 230 1511 872 235 1852 2306 2306 358 2082

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 736.40 873.21 1136.84 1084.55 803.70 868.54 1201.83 1021.07 780.50 871.44 1179.50 1028.08
Standard Deviation 112.39 142.60 121.45 128.56 143.99 134.39 163.87 145.53 137.71 139.57 153.78 145.13
Intensity Change Log 2 — 0.245839 0.626468 0.558535 — 0.111935 0.580504 0.345353 — 0.177514 0.602664 0.451221

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.000807 0.003521 0.002713 0.033427 0.001485 0.006441 0.008649 0.007759 0.001251 0.004625 0.006610 0.010595
Bud Neck 0.002730 0.001817 0.007755 0.002179 0.001416 0.001066 0.006103 0.001155 0.001869 0.001533 0.006671 0.001268
Bud Site 0.009955 0.008183 0.026770 0.031586 0.004813 0.004467 0.014368 0.019174 0.006586 0.006778 0.018629 0.020545
Cell Periphery 0.001326 0.000981 0.000557 0.001148 0.000814 0.001106 0.000653 0.001713 0.000991 0.001028 0.000620 0.001650
Cytoplasm 0.002405 0.001795 0.002836 0.005861 0.000755 0.000903 0.001187 0.002541 0.001324 0.001458 0.001754 0.002908
Cytoplasmic Foci 0.020614 0.019057 0.130403 0.052728 0.015947 0.022197 0.053007 0.019574 0.017556 0.020244 0.079598 0.023236
Eisosomes 0.000080 0.000084 0.000084 0.000202 0.000056 0.000089 0.000119 0.000126 0.000064 0.000086 0.000107 0.000134
Endoplasmic Reticulum 0.001768 0.001415 0.007842 0.002074 0.000717 0.000347 0.001467 0.000778 0.001080 0.001011 0.003657 0.000921
Endosome 0.049952 0.043866 0.110007 0.052321 0.037688 0.048084 0.050773 0.025871 0.041916 0.045461 0.071125 0.028793
Golgi 0.061598 0.048248 0.163692* 0.133445* 0.035418 0.048447 0.066962 0.074958 0.044444 0.048323 0.100196 0.081419
Lipid Particles 0.004028 0.002582 0.002220 0.000542 0.005025 0.002672 0.002466 0.000158 0.004681 0.002616 0.002381 0.000201
Mitochondria 0.773443* 0.822755* 0.282830* 0.593513* 0.856314* 0.821838* 0.693650* 0.806741* 0.827744* 0.822408* 0.552503* 0.783185*
Mitotic Spindle 0.004106 0.005263 0.073330 0.029747 0.001839 0.003025 0.026744 0.009154 0.002621 0.004417 0.042750 0.011429
None 0.000505 0.000363 0.000332 0.000299 0.000844 0.000165 0.000522 0.000253 0.000727 0.000288 0.000457 0.000258
Nuclear Periphery 0.000172 0.000149 0.002689 0.000146 0.000185 0.000061 0.000920 0.000046 0.000181 0.000115 0.001528 0.000057
Nuclear Periphery Foci 0.000491 0.000363 0.002940 0.000174 0.000345 0.000141 0.001416 0.000073 0.000395 0.000279 0.001940 0.000084
Nucleolus 0.000671 0.000270 0.001008 0.000038 0.000822 0.000318 0.000203 0.000023 0.000770 0.000288 0.000479 0.000025
Nucleus 0.000410 0.000202 0.002077 0.000128 0.000374 0.000173 0.000208 0.000079 0.000386 0.000191 0.000851 0.000084
Peroxisomes 0.011498 0.014041 0.050350 0.040714 0.013369 0.024443 0.036867 0.012398 0.012724 0.017975 0.041499 0.015527
Vacuole 0.016012 0.011607 0.054414 0.007374 0.007751 0.006536 0.013164 0.006162 0.010599 0.009689 0.027337 0.006296
Vacuole Periphery 0.037429 0.013437 0.075149 0.012353 0.014022 0.007483 0.020551 0.011265 0.022092 0.011185 0.039310 0.011385

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin -4.57 -3.76 -4.44 -4.06 -4.17 -3.19 -3.45 -5.83 -0.72 0.39 -4.75 -3.88 -7.45 -4.22 -2.16
Bud Neck 1.63 -2.44 0.83 -0.73 2.71 0.89 -3.01 0.69 -0.34 3.23 1.00 -3.86 1.86 1.10 4.42
Bud Site 0.86 -2.97 -3.92 -4.32 -0.64 0.29 -2.82 -7.59 -7.44 -1.28 -0.19 -4.06 -7.70 -7.43 -0.57
Cell Periphery 1.13 3.04 0.54 -0.54 -2.29 -0.72 0.85 -2.54 -1.19 -2.88 -0.17 2.43 -2.07 -1.75 -3.25
Cytoplasm 0.58 -0.42 -2.06 -2.67 -1.99 -0.47 -2.40 -7.25 -4.53 -5.23 -0.35 -1.15 -3.95 -3.55 -3.56
Cytoplasmic Foci 0.71 -8.36 -5.29 -5.65 5.45 -2.65 -5.33 -2.00 1.11 4.81 -1.79 -9.26 -3.37 -1.70 8.35
Eisosomes -0.40 -0.37 -4.59 -4.48 -4.37 -3.61 -4.45 -3.29 -1.62 -0.28 -3.31 -4.19 -3.64 -2.44 -1.28
Endoplasmic Reticulum 0.37 -1.22 -0.35 -0.75 1.16 2.47 -1.21 -0.32 -3.36 1.13 0.14 -1.47 0.58 0.20 1.57
Endosome 1.41 -6.29 -0.38 -1.48 5.62 -2.34 -2.09 4.22 5.56 4.16 -1.23 -5.33 5.41 6.58 7.99
Golgi 2.55 -6.52 -5.56 -6.82 1.56 -3.07 -3.71 -9.47 -5.29 -0.90 -1.25 -6.86 -9.18 -8.07 2.19
Lipid Particles 1.19 1.43 3.13 3.69 2.47 1.89 2.11 4.91 3.78 3.28 2.36 2.54 5.95 5.75 4.23
Mitochondria -4.03 15.77 6.79 8.97 -8.11 2.95 6.74 5.37 1.25 -4.68 0.68 12.67 5.16 4.43 -10.48
Mitotic Spindle -0.83 -5.05 -5.94 -5.71 3.05 -2.03 -5.32 -7.56 -5.69 3.70 -2.46 -7.00 -8.48 -6.13 5.40
None 0.97 1.15 1.38 1.40 0.61 1.61 0.79 1.42 -4.43 4.59 1.58 1.00 1.70 1.25 4.68
Nuclear Periphery 0.43 -2.25 0.36 0.03 2.27 1.65 -2.00 1.87 1.20 2.43 1.14 -2.96 2.44 2.07 3.25
Nuclear Periphery Foci 0.61 -1.96 1.92 1.14 2.25 1.43 -1.36 1.98 2.23 1.74 0.81 -2.30 2.94 1.92 2.81
Nucleolus 1.23 -0.53 1.91 2.37 2.60 1.13 1.83 2.40 1.46 3.13 1.78 1.08 3.05 2.64 3.37
Nucleus 1.73 -1.77 2.25 1.21 2.11 1.20 1.28 2.54 0.89 1.66 2.02 -1.37 3.42 1.90 2.36
Peroxisomes -1.15 -3.61 -4.04 -3.70 0.76 -2.99 -3.09 0.44 3.33 3.23 -2.65 -4.63 -1.39 1.15 4.14
Vacuole 2.25 -4.67 4.25 2.57 5.76 0.86 -2.51 1.55 0.27 3.32 0.80 -5.04 4.44 3.37 6.40
Vacuole Periphery 7.99 -3.16 6.67 0.40 5.29 4.83 -1.36 2.00 -3.21 1.95 7.68 -3.22 7.31 -0.19 5.30
Standard name
Human Ortholog
Description Putative protein; predicted to be an alpha-isopropylmalate carrier; belongs to the sideroblastic-associated protein family; non-tagged protein is detected in purified mitochondria; likely to play a role in iron homeostasis
Localization
Cell Percentages mitochondrion (95%)
Cell Cycle Regulation No
Subcompartmental Group mito-2

Fsf1

Fsf1


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Fsf1-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available