Standard name
Human Ortholog
Description Glutathione-dependent oxidoreductase; mitochondrial matrix protein involved at an early step in the biogenesis of iron-sulfur centers along with Bol1p; hydroperoxide and superoxide-radical responsive; monothiol glutaredoxin subfamily member along with Grx3p and Grx4p
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.13 0.12 0.11 0 0 0 0 0.05 0.07
Bud 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.06 0 0.06 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.05 0.08 0.07 0 0 0 0 0 0
Cytoplasm 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.07 0 0.05 0 0 0 0 0 0
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0.05 0.1 0.38 0.38 0.32 0.05 0.08 0.05 0.06 0.13 0.11
Mitochondria 0.89 0.86 0.97 0.93 0.92 0.89 0.88 0.81 0.89 0.89 0.94 0.93 0.93 0.94 0.92 0.1 0.12 0.11 0.86 0.75 0.86 0.81 0.67 0.65
Nucleus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0.06 0 0 0.09 0.09 0.08 0.11 0.1 0.08 0.08 0.05 0 0 0 0.06 0.08 0 0 0 0 0 0
Nucleolus 0.06 0 0 0 0.06 0.15 0.15 0.16 0.16 0.13 0.1 0.13 0 0 0 0.1 0.1 0.11 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0.05 0 0 0 0 0 0 0 0 0 0 0.07 0.08 0.05 0 0 0 0 0.06 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vac/Vac Membrane 0.18 0.16 0.07 0 0.05 0 0 0 0 0 0 0 0.09 0.05 0.08 0.14 0.14 0.17 0 0.07 0 0 0 0.05
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 3 1 4 1 2 0 1 1 0 1 1 4 1 5 6 17 14 10 5 1 2 4 18 26
Bud 2 1 5 3 10 3 22 10 14 14 24 22 2 1 8 7 5 5 2 1 0 0 1 4
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 2
Bud Site 0 0 0 1 0 3 3 5 4 3 5 5 0 0 0 0 1 0 – – – – – –
Cell Periphery 14 5 6 7 4 4 4 2 3 0 1 5 6 2 7 6 9 6 0 0 0 0 0 0
Cytoplasm 5 4 2 7 2 10 13 12 6 5 8 4 5 1 2 9 5 4 0 3 0 0 0 0
Endoplasmic Reticulum 2 1 1 1 1 4 2 5 1 0 1 1 2 2 0 1 3 1 0 0 0 0 1 1
Endosome 2 0 1 1 12 4 9 11 2 5 0 3 2 6 4 3 3 1 3 0 2 2 9 14
Golgi 18 2 1 1 4 0 2 0 0 1 1 3 17 23 43 48 45 28 23 9 9 11 49 43
Mitochondria 402 104 186 282 419 394 635 627 489 620 618 804 373 450 401 13 14 10 413 92 162 145 264 258
Nucleus 1 0 1 1 2 4 2 6 3 5 4 2 1 0 0 1 0 1 0 0 0 0 0 2
Nuclear Periphery 17 2 12 11 19 41 67 65 62 68 52 73 19 15 11 1 7 7 4 1 0 0 4 1
Nucleolus 29 3 7 13 27 68 108 125 88 94 68 114 12 21 7 12 12 10 3 1 0 1 4 6
Peroxisomes 3 0 1 6 25 2 18 18 6 12 6 10 13 20 10 9 10 4 2 0 5 6 23 13
SpindlePole 0 0 0 2 6 0 7 11 11 2 2 7 0 2 0 2 3 0 1 0 0 0 2 2
Vac/Vac Membrane 81 19 14 13 21 10 14 23 12 17 8 13 37 26 36 18 16 15 16 8 3 6 12 20
Unique Cell Count 450 121 192 304 457 441 720 774 549 700 657 861 402 481 435 126 118 88 479 123 189 180 395 400
Labelled Cell Count 579 142 241 350 554 547 907 921 701 847 799 1071 490 574 535 147 147 102 479 123 189 180 395 400


Mitochondria

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 13.8 16.5 9.2 11.1 11.8 10.3 10.6 11.1 10.6 11.6 10.2 10.5 14.3 15.4 15.8 19.0 18.8 17.9 14.5 15.4 15.4
Std Deviation (1e-4) 3.0 4.5 2.2 2.7 2.7 2.7 2.9 3.1 2.9 3.1 3.0 3.3 4.0 3.5 3.7 5.5 4.9 4.9 3.7 4.2 4.4
Intensity Change (Log2) – – – 0.26 0.35 0.16 0.2 0.26 0.21 0.33 0.15 0.19 0.63 0.74 0.77 1.05 1.03 0.95 0.65 0.73 0.74


Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 4.0 3.6 0
Bud 0 0 0 0.3 0 0 0 0.7 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cell Periphery -0.6 0 0 0 0 0 0 0 0 0 0 0 0 1.8 0
Cytoplasm 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 0 0 2.5 2.7 4.2 9.1 9.0 8.0
Mitochondria -1.9 -2.4 -3.1 -3.6 -5.4 -3.3 -3.5 -1.5 -1.8 -2.0 -1.7 -2.2 -15.6 -15.2 -14.5
Nucleus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery -1.4 -1.1 1.3 1.3 1.0 2.0 1.5 0.8 1.0 -0.8 -1.9 -2.3 -2.4 -0.1 0.5
Nucleolus 0.3 1.2 4.2 4.2 4.5 4.4 3.8 2.9 3.8 -0.4 0.4 0 2.2 2.3 2.5
Peroxisomes 0 2.9 0 0 0 0 0 0 0 0 2.5 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vacuole -1.4 -1.4 -3.0 -3.8 -2.8 -3.3 -3.3 0 0 0.8 -0.9 0.4 2.0 1.8 2.5

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 11.0022 12.0814 10.3141 9.2009 10.4836 11.2725 9.7064 11.9548 10.5698 9.6259 7.6913 11.5103 16.0654 16.5241 15.6226 15.1594 14.7419 15.6442
Actin 0.0103 0.0076 0.0071 0.0445 0.0002 0.0036 0.0188 0.0034 0.0033 0.0001 0.0061 0.0002 0.0064 0.0056 0.0012 0.0119 0.0013 0.001
Bud 0.0004 0.0004 0.0002 0.0024 0 0.0001 0.0003 0.0001 0.0005 0 0.002 0 0.0001 0.0003 0.0006 0.002 0.0003 0
Bud Neck 0.0013 0.0004 0.0001 0.0009 0 0.001 0.0002 0 0.0001 0 0.0005 0 0 0.0004 0.0001 0.0005 0 0
Bud Periphery 0.001 0.0005 0.0004 0.0063 0.0001 0.0002 0.0005 0.0001 0.0007 0 0.0059 0 0.0004 0.0007 0.0018 0.0057 0.0009 0.0001
Bud Site 0.0141 0.003 0.0003 0.0041 0 0.0001 0.0009 0.0001 0.0017 0 0.0029 0 0.0001 0.0023 0.0003 0.0016 0 0
Cell Periphery 0.0008 0.0006 0.0004 0.0008 0.0001 0.0001 0.0001 0.0001 0.0007 0 0.0004 0 0.0002 0.0026 0.0003 0.0005 0 0.0001
Cytoplasm 0.0027 0.0002 0.0001 0.0003 0 0.0001 0.0033 0 0.0001 0 0.0011 0 0 0.0002 0 0.0006 0 0
Cytoplasmic Foci 0.0142 0.002 0.0025 0.0094 0 0.0005 0.0132 0.0008 0.0037 0 0.0081 0.0001 0.0009 0.0016 0.0004 0.0043 0.0001 0.0012
Eisosomes 0.0004 0.0004 0.0002 0.0002 0.0001 0.0001 0.0003 0.0002 0.0002 0 0.0002 0.0001 0.0003 0.0002 0.0002 0.0003 0.0001 0.0001
Endoplasmic Reticulum 0.001 0.0001 0.0001 0.0006 0 0.0001 0.003 0 0.0001 0 0.001 0 0.0002 0.0003 0.0003 0.0016 0 0.0001
Endosome 0.0147 0.0092 0.0064 0.0084 0.0006 0.0058 0.0157 0.0019 0.003 0.0003 0.0181 0.0005 0.0038 0.008 0.0028 0.0098 0.0005 0.0026
Golgi 0.0155 0.0122 0.0087 0.0104 0.0007 0.0125 0.0284 0.0125 0.0023 0.0004 0.0116 0.0012 0.0046 0.018 0.0065 0.0057 0.0031 0.0123
Lipid Particles 0.02 0.0122 0.0116 0.0548 0.0013 0.0004 0.0307 0.0121 0.0084 0.0004 0.0572 0.0032 0.0178 0.0151 0.0061 0.0129 0.0006 0.0077
Mitochondria 0.8351 0.9086 0.9373 0.7777 0.9817 0.9696 0.8316 0.9549 0.9597 0.9966 0.8008 0.9914 0.9305 0.8934 0.9653 0.9066 0.9879 0.9647
None 0.0129 0 0.0001 0.0001 0 0 0.0017 0 0 0 0.0007 0 0.0001 0.0001 0.0001 0.0017 0 0.0001
Nuclear Periphery 0.014 0.0003 0.0003 0.0006 0.0001 0 0.004 0 0 0 0.0138 0 0.0061 0.0007 0.0008 0.009 0 0.0002
Nucleolus 0.0007 0.0007 0.0002 0.0005 0 0 0.0016 0.0001 0.0001 0 0.002 0.0002 0.0009 0.0055 0.0003 0.0017 0 0.0001
Nucleus 0.0127 0.0003 0.0001 0.0006 0 0 0.004 0 0.0001 0 0.0047 0.0001 0.0002 0.0009 0.0001 0.0019 0 0
Peroxisomes 0.0093 0.0044 0.0037 0.0328 0.0007 0.0026 0.0231 0.0054 0.0057 0.001 0.0074 0.0008 0.0088 0.0034 0.0029 0.0045 0.0044 0.0049
Punctate Nuclear 0.0016 0 0.0002 0.0002 0 0 0.0092 0 0.0001 0 0.0447 0 0 0 0 0.0077 0 0.001
Vacuole 0.0049 0.0145 0.0102 0.0293 0.0012 0.0006 0.0016 0.0025 0.0033 0.0002 0.0059 0.0003 0.0045 0.0143 0.0031 0.0037 0.0001 0.0005
Vacuole Periphery 0.0126 0.0223 0.0099 0.015 0.0132 0.0024 0.0077 0.0057 0.0062 0.0009 0.005 0.0021 0.0141 0.0264 0.007 0.0057 0.0006 0.0033

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 91.3414 65.3229 67.8614 76.1537 97.9006 63.295 78.1567 86.184 97.7311 81.9721
Translational Efficiency 1.3985 1.9016 1.759 1.5963 1.418 2.6277 2.1046 1.5532 1.7336 1.908

Hit Data

Dataset Hit
Protein Concentration ✘
Protein Localization ✘
Gene Expression ✘
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
1270 1474 938 1421 1559 1946 1877 2993 2829 3420 2815 4414

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 957.58 1254.90 1709.00 1569.54 1201.82 1308.69 1477.14 1620.61 1092.18 1285.51 1554.40 1604.17
Standard Deviation 169.63 308.80 347.13 367.76 246.08 280.04 282.34 358.17 247.07 294.00 324.42 362.07
Intensity Change Log 2 — 0.390107 0.835687 0.712877 — 0.122903 0.297586 0.431316 — 0.247535 0.561179 0.562994

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.000561 0.004070 0.003282 0.003611 0.000933 0.002648 0.002408 0.001115 0.000766 0.003261 0.002699 0.001919
Bud Neck 0.002076 0.001514 0.003848 0.002518 0.000479 0.000620 0.002036 0.000234 0.001196 0.001005 0.002640 0.000969
Bud Site 0.002238 0.002472 0.002797 0.004781 0.000719 0.002154 0.002661 0.000627 0.001401 0.002291 0.002706 0.001964
Cell Periphery 0.000335 0.000242 0.000145 0.000209 0.000171 0.000085 0.000094 0.000163 0.000244 0.000152 0.000111 0.000178
Cytoplasm 0.000200 0.001127 0.000452 0.000606 0.000241 0.000391 0.000402 0.000149 0.000223 0.000708 0.000419 0.000296
Cytoplasmic Foci 0.009716 0.012995 0.029259 0.008247 0.003297 0.008425 0.011023 0.000929 0.006179 0.010394 0.017099 0.003285
Eisosomes 0.000089 0.000589 0.000380 0.000219 0.000305 0.000255 0.000209 0.000164 0.000208 0.000399 0.000266 0.000181
Endoplasmic Reticulum 0.000183 0.000183 0.000260 0.000259 0.000063 0.000104 0.000104 0.000039 0.000117 0.000138 0.000156 0.000110
Endosome 0.011888 0.005584 0.005103 0.006055 0.001143 0.003820 0.005363 0.000803 0.005967 0.004580 0.005277 0.002494
Golgi 0.010589 0.023571 0.026930 0.029344 0.003997 0.017713 0.018612 0.004290 0.006956 0.020238 0.021384 0.012356
Lipid Particles 0.006258 0.005453 0.011139 0.003487 0.001882 0.003274 0.003891 0.000248 0.003847 0.004213 0.006306 0.001291
Mitochondria 0.924335* 0.916953* 0.848444* 0.888394* 0.976289* 0.946332* 0.921045* 0.986279* 0.952966* 0.933670* 0.896853* 0.954767*
Mitotic Spindle 0.001726 0.000406 0.008979 0.005591 0.000155 0.000609 0.002965 0.000204 0.000860 0.000521 0.004969 0.001938
None 0.000591 0.001395 0.003142 0.001845 0.001615 0.000821 0.001150 0.000462 0.001155 0.001069 0.001814 0.000907
Nuclear Periphery 0.000293 0.000104 0.004160 0.001511 0.000137 0.000125 0.000740 0.000034 0.000207 0.000116 0.001879 0.000510
Nuclear Periphery Foci 0.000551 0.000286 0.001721 0.000757 0.000134 0.000176 0.000420 0.000016 0.000321 0.000223 0.000853 0.000254
Nucleolus 0.000718 0.002343 0.001132 0.000486 0.000175 0.000124 0.000488 0.000019 0.000419 0.001080 0.000703 0.000169
Nucleus 0.000253 0.002245 0.000173 0.000093 0.000043 0.000051 0.000098 0.000007 0.000137 0.000997 0.000123 0.000035
Peroxisomes 0.014249 0.012956 0.007811 0.004130 0.003630 0.007598 0.008122 0.001438 0.008397 0.009907 0.008019 0.002305
Vacuole 0.006238 0.003242 0.016049 0.014712 0.001577 0.002066 0.007975 0.000993 0.003670 0.002573 0.010665 0.005410
Vacuole Periphery 0.006912 0.002270 0.024794 0.023145 0.003013 0.002610 0.010194 0.001786 0.004764 0.002463 0.015059 0.008662

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin -5.67 -4.25 -5.02 0.52 -0.38 -2.45 -2.17 -0.33 2.73 2.40 -5.26 -4.14 -3.09 2.86 1.69
Bud Neck 0.81 -2.36 -0.60 -1.68 1.88 -0.60 -4.23 1.07 2.70 5.66 0.56 -3.76 0.62 0.12 5.32
Bud Site -0.40 -0.69 -2.27 -1.72 -1.61 -1.75 -2.94 0.13 1.97 3.39 -1.51 -2.49 -1.22 0.53 1.37
Cell Periphery 0.99 2.91 2.04 0.60 -1.78 1.40 1.25 0.12 -3.15 -2.97 1.75 3.03 1.48 -0.69 -3.39
Cytoplasm -1.74 -1.55 -3.02 0.99 -0.73 -0.57 -0.85 0.45 1.28 2.74 -1.80 -1.61 -0.65 1.60 1.35
Cytoplasmic Foci -2.08 -7.17 1.02 3.27 7.92 -5.93 -7.70 4.28 10.35 11.39 -4.96 -9.33 4.41 10.03 12.87
Eisosomes -8.10 -9.77 -5.69 5.88 4.99 1.54 2.63 4.14 3.17 1.35 -5.91 -2.33 1.19 6.71 3.38
Endoplasmic Reticulum -0.08 -1.71 -1.34 -1.22 -0.01 -1.80 -1.86 1.14 2.68 2.73 -1.09 -1.83 0.25 1.10 1.71
Endosome 4.21 4.77 3.89 -0.50 -1.04 -4.43 -6.76 1.02 5.35 7.80 1.83 0.90 5.21 3.93 5.53
Golgi -5.57 -5.72 -6.30 -1.67 -0.63 -8.07 -8.08 -0.32 7.97 7.98 -9.49 -9.29 -4.58 4.88 5.17
Lipid Particles 0.61 -2.96 2.38 1.85 5.32 -2.24 -3.05 4.38 5.84 6.52 -0.55 -3.25 4.81 5.66 8.24
Mitochondria 1.04 7.82 4.49 3.52 -3.87 7.09 11.32 -3.70 -10.65 -14.54 4.75 11.61 -0.45 -5.53 -12.55
Mitotic Spindle 1.62 -3.69 -2.80 -4.56 1.58 -2.18 -5.07 -0.60 1.99 5.00 0.87 -5.19 -2.11 -3.66 3.78
None -4.13 -12.57 -9.20 -1.89 5.43 4.85 2.79 7.22 7.80 12.28 0.67 -5.57 2.47 1.68 10.13
Nuclear Periphery 2.75 -6.45 -3.18 -3.73 3.75 0.28 -5.36 3.72 2.37 6.43 2.29 -7.73 -2.39 -3.18 5.56
Nuclear Periphery Foci 1.39 -4.47 -0.89 -2.08 3.29 -0.72 -4.51 3.50 3.08 7.43 1.05 -5.03 0.71 -0.36 5.80
Nucleolus -1.83 -1.23 0.69 2.18 2.91 1.04 -3.49 3.97 3.77 5.78 -1.72 -1.84 1.74 2.49 5.86
Nucleus -2.12 0.71 1.46 2.30 2.55 -0.46 -2.24 2.61 3.22 4.16 -2.12 0.20 2.08 2.39 4.94
Peroxisomes 0.52 2.79 4.80 5.18 2.76 -3.36 -3.67 2.90 6.51 6.67 -1.15 0.30 5.98 8.51 7.14
Vacuole 3.05 -5.35 -4.95 -7.05 0.57 -1.07 -7.62 1.66 2.57 8.53 2.14 -8.16 -2.73 -4.68 5.66
Vacuole Periphery 5.50 -7.00 -7.77 -10.77 0.52 0.61 -7.16 2.24 1.48 8.98 4.33 -9.32 -4.86 -8.54 5.27
Standard name
Human Ortholog
Description Glutathione-dependent oxidoreductase; mitochondrial matrix protein involved at an early step in the biogenesis of iron-sulfur centers along with Bol1p; hydroperoxide and superoxide-radical responsive; monothiol glutaredoxin subfamily member along with Grx3p and Grx4p
Localization
Cell Percentages mitochondrion (99%)
Cell Cycle Regulation No
Subcompartmental Group mito-2

Grx5

Grx5


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Grx5-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available