Standard name
Human Ortholog
Description Mitochondrial ribosomal protein of the large subunit; conserved in metazoa, with similarity to human mitochondrial ribosomal protein MRPL49

Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.05
Bud 0 0 0.05 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cell Periphery 0 0 0 0 0 0 0 0 0 0 0 0.05 0 0.05 0.12 0.08 0.14 0 0 0 0 0 0
Cytoplasm 0 0 0 0 0.05 0 0 0 0 0 0 0 0 0 0.07 0.09 0.09 0 0 0 0 0 0
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Endosome 0 0.05 0 0 0 0 0 0 0 0 0 0.05 0 0 0 0.05 0 0 0 0.05 0.05 0 0
Golgi 0.06 0.11 0 0 0 0 0 0 0 0 0 0.18 0.25 0.32 0.5 0.34 0.45 0.07 0.07 0 0.1 0.13 0.13
Mitochondria 0.91 0.84 0.96 0.96 0.95 0.94 0.92 0.97 0.95 0.95 0.98 0.86 0.81 0.72 0.08 0.08 0.14 0.79 0.77 0.81 0.66 0.66 0.62
Nucleus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0.07 0.13 0.09 0.14 0.1 0.12 0.1 0.05 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0.08 0.08 0.07 0.06 0.05 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0.05 0 0 0 0 0 0 0 0 0 0.06 0 0 0.07 0.26 0.1 0 0 0.05 0.08 0.06 0.07
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.05 0 0 0 0 0 0 0
Vac/Vac Membrane 0.15 0.14 0.05 0 0.08 0 0 0 0 0 0 0.1 0.08 0.09 0.18 0.15 0.12 0 0 0 0 0 0
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 2 3 1 0 0 0 1 0 0 0 0 1 5 3 4 1 2 11 19 4 6 12 21
Bud 5 2 26 16 9 13 21 24 27 17 15 1 3 0 3 6 5 1 0 0 1 1 2
Bud Neck 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 1 2 1
Bud Site 1 1 12 2 6 3 8 6 6 6 8 0 0 0 1 0 0
Cell Periphery 13 17 12 8 3 7 3 6 8 7 19 14 17 20 21 14 22 0 0 0 0 0 1
Cytoplasm 4 4 15 12 16 11 12 10 17 6 6 8 20 16 13 16 14 0 0 0 0 0 0
Endoplasmic Reticulum 5 1 5 1 6 7 5 4 12 11 6 1 10 2 6 4 7 1 1 6 0 0 2
Endosome 10 24 3 1 1 4 5 0 1 0 1 14 19 19 8 9 4 22 20 26 12 12 18
Golgi 36 54 0 0 0 0 2 1 1 1 1 55 123 139 90 57 70 45 38 15 23 47 63
Mitochondria 567 430 542 428 315 579 850 810 884 541 622 265 395 318 14 14 22 513 428 461 159 237 294
Nucleus 5 5 3 2 7 2 18 3 8 5 2 1 0 1 1 1 1 1 0 0 0 1 0
Nuclear Periphery 26 14 15 13 22 80 82 116 89 69 63 14 18 10 3 3 4 4 2 5 1 3 4
Nucleolus 13 14 11 15 5 47 71 56 55 31 15 4 9 2 4 3 6 0 0 0 0 2 2
Peroxisomes 2 23 4 3 0 0 7 2 7 2 4 18 11 16 12 44 16 24 17 26 19 22 35
SpindlePole 3 2 13 3 2 4 20 4 3 4 5 1 2 3 4 8 7 0 2 2 1 1 1
Vac/Vac Membrane 93 73 31 14 28 23 36 30 24 19 18 30 39 39 33 26 19 19 16 11 8 11 20
Unique Cell Count 623 509 565 445 333 614 925 835 932 569 637 308 490 439 179 170 156 653 554 571 242 358 474
Labelled Cell Count 785 668 693 518 420 780 1141 1072 1142 719 785 427 671 588 217 206 199 653 554 571 242 358 474


Mitochondria

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 8.0 9.1 4.8 5.7 4.0 5.5 5.4 5.1 5.4 5.4 5.1 9.3 8.9 8.8 10.2 10.1 9.5 9.5 9.8 9.8
Std Deviation (1e-4) 1.3 2.3 1.0 1.2 1.0 1.2 1.3 1.4 1.4 1.3 1.2 1.6 1.5 1.6 2.4 7.1 2.3 2.0 2.0 1.8
Intensity Change (Log2) 0.23 -0.28 0.19 0.15 0.08 0.17 0.15 0.07 0.95 0.88 0.87 1.08 1.06 0.99 0.97 1.02 1.02


Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud -0.8 0 -2.4 -2.5 -1.7 -1.7 -1.4 -2.1 -3.5 -4.0 -4.6 -1.8 -0.6 -0.8
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site -2.3 0 -2.5 -2.0 -2.3 -2.5 -1.4 -1.2 0 -3.2 -3.1 0 0 0
Cell Periphery -0.4 0 -1.3 -3.4 -2.3 -2.1 -1.2 0.9 2.0 1.3 2.2 5.4 3.8 6.2
Cytoplasm 0 1.7 -1.0 -1.9 -2.0 -1.1 -2.0 -2.3 -0.1 1.3 0.9 2.8 3.8 3.6
Endoplasmic Reticulum 0 0 0.4 0 0 0.7 1.5 0.1 0 1.6 0 0 0 0
Endosome 0 0 0 0 0 0 0 0 4.1 3.8 4.1 0 0 0
Golgi 0 0 0 0 0 0 0 0 10.4 12.7 14.4 18.0 14.3 16.8
Mitochondria 0.2 0 -1.3 -3.1 1.1 -1.0 -0.7 1.7 -5.3 -7.9 -10.5 -23.6 -23.4 -21.9
Nucleus 0 0 0 2.2 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0.3 0 6.5 4.7 7.1 5.1 6.1 5.1 1.5 0.9 -0.4 0 0 0
Nucleolus 1.4 0 4.5 4.7 4.1 3.6 3.1 0.5 -0.7 -0.1 -2.1 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 4.6 2.1 3.3 0 11.6 0
SpindlePole -2.1 0 -2.4 -0.2 -3.1 -3.6 -2.2 -2.2 0 -2.6 -2.0 0 0 0
Vacuole -1.8 1.7 -1.4 -1.4 -1.7 -2.9 -1.8 -2.3 2.4 1.6 2.1 5.4 4.2 2.9

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 7.0416 6.6772 6.3974 6.4402 5.7326 6.3589 5.6215 5.2114 5.4216 5.1257 4.4373 5.2148 8.1962 7.4145 7.3024 7.9423 6.7454 7.4408
Actin 0.0207 0.0115 0.007 0.0065 0.0015 0.0024 0.0062 0.0044 0.0015 0.0001 0.0006 0.0007 0.0036 0.0045 0.0026 0.0004 0.001 0.0008
Bud 0.0007 0.0008 0.0004 0.0007 0.0002 0.0001 0.0001 0.0002 0.0005 0 0.0001 0 0.0001 0.0003 0.0001 0.0001 0 0
Bud Neck 0.0009 0.0003 0.0004 0.0001 0.0001 0.0002 0.0002 0.0001 0.0001 0 0.0001 0.0001 0 0.0001 0.0001 0 0 0
Bud Periphery 0.0008 0.0014 0.0009 0.0027 0.0005 0.0002 0.0004 0.0005 0.0009 0.0001 0.0002 0.0001 0.0003 0.0007 0.0005 0.0004 0.0001 0.0001
Bud Site 0.0039 0.0019 0.0038 0.0003 0.0002 0.0002 0.001 0.0007 0.0012 0 0.0001 0 0.0002 0.0012 0.0003 0.0001 0 0
Cell Periphery 0.0004 0.0005 0.0011 0.0002 0.0002 0.0001 0.0003 0.0001 0.0005 0.0001 0.0001 0 0.0001 0.0002 0.0001 0.0001 0 0.0001
Cytoplasm 0.0057 0.0002 0.0004 0.0001 0.0001 0.0003 0.0001 0.0001 0.003 0 0.0029 0 0.0001 0.0001 0 0 0 0
Cytoplasmic Foci 0.0129 0.0054 0.0029 0.0032 0.0016 0.0024 0.0041 0.0049 0.0015 0.0008 0.0075 0.0005 0.0018 0.0048 0.0028 0.0007 0.0004 0.0006
Eisosomes 0.0003 0.0004 0.0006 0.0001 0.0003 0.0001 0.0003 0.0001 0.0003 0.0001 0.0001 0.0001 0.0002 0.0002 0.0001 0.0001 0.0001 0.0001
Endoplasmic Reticulum 0.0016 0.0009 0.0004 0.0001 0.0002 0.0003 0.0003 0.0001 0.0013 0 0.0007 0.0001 0.0002 0.0002 0.0001 0.0001 0 0.0001
Endosome 0.0261 0.0277 0.0138 0.0159 0.0166 0.0155 0.0123 0.015 0.0062 0.0019 0.0226 0.0042 0.0134 0.0211 0.0103 0.0055 0.0007 0.0034
Golgi 0.0179 0.058 0.0211 0.0433 0.0344 0.0172 0.0209 0.0287 0.0098 0.0052 0.0339 0.0141 0.0208 0.0335 0.0221 0.0131 0.0027 0.0144
Lipid Particles 0.0197 0.0171 0.0147 0.003 0.0056 0.0033 0.0103 0.0063 0.0008 0.0004 0.0211 0.0045 0.0244 0.0099 0.0048 0.0009 0.0005 0.0066
Mitochondria 0.8281 0.8409 0.9039 0.9006 0.9213 0.9501 0.9228 0.9251 0.9602 0.9844 0.8651 0.97 0.9186 0.8966 0.9397 0.9664 0.9877 0.9651
None 0.0012 0.0001 0.0001 0.0001 0 0.0002 0.0003 0 0.0004 0 0.0007 0 0.0001 0.0001 0 0 0 0
Nuclear Periphery 0.0073 0.0049 0.0003 0.0001 0.0001 0.0006 0.0005 0.0001 0.0007 0 0.0175 0.0001 0.0022 0.0001 0.0001 0.0001 0 0.0001
Nucleolus 0.0014 0.0003 0.0015 0.0001 0.0001 0.0001 0.0003 0.0001 0.0001 0 0.0004 0 0.0003 0.0002 0.0001 0 0 0.0001
Nucleus 0.0046 0.0002 0.0003 0.0001 0.0001 0.0002 0.0002 0.0001 0.0002 0 0.0083 0 0.0002 0.0001 0.0001 0 0 0
Peroxisomes 0.0161 0.0105 0.0094 0.0033 0.0025 0.0024 0.0108 0.0106 0.0043 0.006 0.0127 0.0033 0.0071 0.0136 0.0063 0.0035 0.0057 0.0058
Punctate Nuclear 0.0059 0 0.0001 0 0 0.0007 0.0015 0 0.0001 0 0.0022 0 0.0001 0 0 0 0 0
Vacuole 0.0107 0.0058 0.0064 0.0075 0.0031 0.001 0.0018 0.001 0.0017 0.0002 0.0013 0.0003 0.0015 0.0066 0.0029 0.001 0.0001 0.0005
Vacuole Periphery 0.0132 0.0112 0.0106 0.012 0.0115 0.0024 0.0053 0.0018 0.0046 0.0006 0.0019 0.0016 0.0047 0.0058 0.0069 0.0074 0.0007 0.0022

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 10.0082 11.1834 14.9374 27.424 24.3301 22.506 27.1381 32.8168 32.2684 31.127
Translational Efficiency 4.0694 3.5419 2.7414 1.6967 1.837 2.3793 1.8189 1.8428 2.049 1.7897

Hit Data

Dataset Hit
Protein Concentration
Protein Localization
Gene Expression
Translational Efficiency

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
2215 1229 143 1220 1638 1553 1646 1422 3853 2782 1789 2642

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 821.34 881.60 1223.46 1160.08 703.04 910.80 1061.63 1086.55 771.05 897.90 1074.57 1120.50
Standard Deviation 124.19 165.84 227.35 187.62 120.50 159.05 154.81 185.73 135.87 162.73 167.65 190.17
Intensity Change Log 2 0.102145 0.574915 0.498173 0.373528 0.594602 0.628076 0.233670 0.584028 0.559540

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.001027 0.002764 0.005575 0.007344 0.001256 0.003976 0.002696 0.003581 0.001124 0.003441 0.002926 0.005319
Bud Neck 0.000630 0.001442 0.012206 0.001993 0.000616 0.001400 0.005682 0.001725 0.000624 0.001418 0.006203 0.001848
Bud Site 0.001345 0.003778 0.011813 0.008392 0.002106 0.003983 0.011132 0.009846 0.001668 0.003892 0.011186 0.009175
Cell Periphery 0.000385 0.000317 0.000299 0.000429 0.000495 0.000366 0.000438 0.000505 0.000431 0.000345 0.000427 0.000470
Cytoplasm 0.000321 0.000639 0.000912 0.001132 0.000270 0.000901 0.001671 0.001010 0.000300 0.000785 0.001610 0.001066
Cytoplasmic Foci 0.011129 0.025038 0.063256 0.013721 0.005392 0.014636 0.018395 0.013973 0.008690 0.019231 0.021981 0.013857
Eisosomes 0.000043 0.000083 0.000198 0.000116 0.000036 0.000074 0.000081 0.000093 0.000040 0.000078 0.000090 0.000104
Endoplasmic Reticulum 0.000251 0.000276 0.000745 0.001014 0.000318 0.000198 0.000336 0.000587 0.000279 0.000233 0.000368 0.000784
Endosome 0.029363 0.036911 0.038397 0.017866 0.009932 0.024637 0.032947 0.019387 0.021102 0.030060 0.033383 0.018684
Golgi 0.022783 0.044173 0.056250 0.068794 0.010719 0.025485 0.022273 0.048295 0.017654 0.033741 0.024989 0.057761
Lipid Particles 0.004528 0.007235 0.010136 0.002164 0.003192 0.003815 0.005304 0.003037 0.003960 0.005326 0.005690 0.002634
Mitochondria 0.896915* 0.834966* 0.680165* 0.818642* 0.943357* 0.891518* 0.834729* 0.856395* 0.916659* 0.866535* 0.822375* 0.838962*
Mitotic Spindle 0.001620 0.004939 0.020956 0.009093 0.001293 0.001946 0.018383 0.005385 0.001481 0.003268 0.018589 0.007097
None 0.000218 0.000274 0.001048 0.000613 0.000452 0.000284 0.000396 0.000426 0.000318 0.000280 0.000448 0.000513
Nuclear Periphery 0.000323 0.000094 0.004433 0.000972 0.000049 0.000065 0.000663 0.000423 0.000206 0.000078 0.000964 0.000676
Nuclear Periphery Foci 0.000246 0.000186 0.005314 0.000938 0.000154 0.000101 0.000684 0.000320 0.000207 0.000138 0.001054 0.000605
Nucleolus 0.000186 0.000150 0.001573 0.000303 0.000644 0.000169 0.000683 0.000212 0.000381 0.000161 0.000754 0.000254
Nucleus 0.000276 0.000144 0.000590 0.000139 0.001575 0.000308 0.000443 0.000079 0.000828 0.000236 0.000455 0.000107
Peroxisomes 0.013169 0.028960 0.045804 0.009896 0.013876 0.019293 0.021706 0.011619 0.013470 0.023564 0.023632 0.010823
Vacuole 0.005397 0.003900 0.021581 0.015814 0.001277 0.003500 0.012856 0.009599 0.003645 0.003677 0.013553 0.012469
Vacuole Periphery 0.009847 0.003731 0.018750 0.020625 0.002991 0.003343 0.008505 0.013504 0.006932 0.003514 0.009324 0.016792

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin -3.94 -3.70 -5.13 -3.66 -1.05 -3.08 -2.60 -3.57 0.38 -1.09 -4.35 -3.55 -6.26 -2.31 -2.96
Bud Neck -2.34 -4.78 -4.64 -1.32 4.19 -2.08 -6.12 -2.88 -0.66 4.44 -3.07 -7.14 -4.99 -1.31 5.37
Bud Site -2.93 -2.60 -5.09 -2.97 0.80 -1.76 -5.69 -4.13 -3.04 0.57 -3.35 -6.76 -6.36 -4.18 1.14
Cell Periphery 0.59 0.74 -0.35 -1.11 -1.28 0.96 0.40 -0.08 -1.34 -0.60 0.99 0.03 -0.41 -1.72 -0.46
Cytoplasm -2.12 -3.46 -3.95 -2.15 -0.97 -1.93 -3.80 -3.16 -0.29 1.64 -2.49 -3.88 -4.86 -1.20 1.58
Cytoplasmic Foci -7.01 -5.73 -1.81 5.33 5.43 -6.33 -7.99 -5.95 0.36 2.26 -8.64 -7.92 -4.96 3.87 4.52
Eisosomes -6.27 -6.01 -6.14 -2.66 2.92 -6.11 -4.94 -8.77 -2.40 -1.14 -8.36 -5.91 -9.67 -3.58 -1.29
Endoplasmic Reticulum -0.36 -2.79 -2.76 -2.70 -0.87 1.30 -0.24 -1.64 -2.67 -1.70 0.83 -1.55 -3.28 -3.70 -2.74
Endosome -2.46 -1.40 4.88 6.68 3.22 -6.95 -9.34 -5.10 2.18 5.00 -4.72 -5.10 1.52 6.18 6.21
Golgi -6.53 -3.53 -9.55 -4.51 -1.20 -6.57 -5.46 -10.36 -5.80 -6.75 -8.24 -3.59 -13.44 -7.31 -9.81
Lipid Particles -1.74 -2.59 2.67 3.41 3.76 -0.63 -1.91 0.18 0.75 1.98 -1.52 -1.74 2.05 3.08 3.11
Mitochondria 6.91 7.21 8.34 1.49 -4.47 7.24 13.30 10.68 3.87 -2.23 8.79 12.35 12.49 3.89 -1.92
Mitotic Spindle -3.03 -4.61 -5.49 -2.54 2.66 -1.52 -8.72 -4.86 -3.95 6.22 -3.27 -9.34 -7.19 -4.31 5.82
None -1.24 -4.11 -11.28 -6.52 2.13 0.82 0.30 0.15 -1.89 -0.88 0.40 -1.48 -2.28 -4.90 -1.84
Nuclear Periphery 2.98 -3.02 -2.13 -2.96 2.48 -1.14 -5.64 -3.47 -3.33 1.58 2.91 -4.88 -3.04 -4.01 1.34
Nuclear Periphery Foci 0.98 -2.32 -2.54 -2.78 1.98 0.79 -4.74 -1.93 -3.92 3.48 1.55 -4.25 -2.97 -3.60 1.87
Nucleolus 0.31 -2.32 -0.62 -1.07 2.13 1.44 -0.09 1.30 -0.37 2.29 1.39 -1.56 0.77 -1.02 2.59
Nucleus 0.65 -1.25 0.67 0.04 2.87 1.54 1.38 1.86 1.35 3.39 1.58 0.97 2.00 1.27 3.44
Peroxisomes -4.90 -3.57 1.66 6.01 3.93 -2.10 -3.00 0.96 3.05 3.95 -5.05 -4.51 1.72 6.44 5.73
Vacuole 2.10 -4.06 -5.46 -6.28 1.30 -4.19 -10.71 -7.68 -5.21 2.18 -0.07 -9.23 -8.23 -8.13 0.74
Vacuole Periphery 7.77 -2.22 -6.05 -10.20 -0.44 -0.46 -5.35 -6.94 -7.11 -3.15 6.05 -2.52 -8.44 -12.21 -5.62
Standard name
Human Ortholog
Description Mitochondrial ribosomal protein of the large subunit; conserved in metazoa, with similarity to human mitochondrial ribosomal protein MRPL49
Localization
Cell Percentages mitochondrion (98%)
Cell Cycle Regulation No
Subcompartmental Group mito-2

Img2

Img2


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)

Molecular Function (Gene Ontology)

Cellular Component (Gene Ontology)


Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Img2-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available