Standard name
Human Ortholog
Description (SGD) Alpha subunit of the mitochondrial processing protease (MPP); essential processing enzyme that cleaves the N-terminal targeting sequences from mitochondrially imported proteins
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.05 0.06 0 0 0 0 0.07 0.11
Bud 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.06 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.1 0.06 0 0 0 0 0 0
Cytoplasm 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.14 0 0 0 0 0 0 0 0
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.06 0.05 0 0 0 0 0 0 0
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0.06 0.07 0.11 0.45 0.42 0 0.1 0.08 0.07 0.05 0.1
Mitochondria 0.93 0.96 0.95 0.94 0.89 0.91 0.88 0.85 0.93 0.94 0.94 0.92 0.98 0.89 0.92 0.17 0.17 0.12 0.87 0.74 0.79 0.8 0.7 0.62
Nucleus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0.05 0.06 0.06 0.12 0.08 0.07 0.07 0.05 0 0 0.06 0 0.08 0 0 0 0 0 0
Nucleolus 0.09 0.06 0.05 0.07 0.11 0.14 0.13 0.14 0.19 0.11 0.09 0.11 0.06 0 0 0.17 0.14 0.1 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.25 0.07 0 0 0 0.06 0.08 0.11 0.09
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vac/Vac Membrane 0.06 0.07 0 0 0 0 0 0 0 0 0 0 0.05 0.07 0.06 0.14 0.1 0.15 0 0 0 0 0 0
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 1 1 2 5 0 1 1 1 2 0 2 1 1 4 2 1 2 3 7 4 5 2 14 37
Bud 2 0 0 1 6 6 7 8 8 8 4 9 1 0 3 2 0 2 1 0 0 0 1 3
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 1 0 2 0 3 0 0 0 0 0 0 – – – – – –
Cell Periphery 2 2 0 2 3 2 2 1 1 2 1 0 1 3 3 0 4 3 0 1 0 0 0 0
Cytoplasm 2 0 1 7 12 11 13 15 8 4 5 8 0 6 4 5 1 1 0 0 0 0 0 0
Endoplasmic Reticulum 0 2 2 0 1 1 0 1 3 0 1 1 0 1 0 2 2 0 0 0 0 0 0 1
Endosome 0 0 0 0 6 2 2 3 1 1 0 0 0 0 0 0 0 1 0 1 1 0 5 2
Golgi 1 0 2 6 4 1 1 0 1 0 0 2 0 9 16 4 19 22 11 10 15 5 9 31
Mitochondria 241 96 171 189 242 257 359 406 275 364 301 312 64 145 217 6 7 6 228 77 144 70 149 203
Nucleus 0 0 0 0 0 1 3 2 1 1 1 1 0 0 1 0 0 1 0 0 0 0 0 0
Nuclear Periphery 7 4 8 5 7 13 25 31 36 29 22 24 3 5 7 2 1 4 1 0 0 0 0 1
Nucleolus 22 6 9 14 30 40 51 67 56 41 30 37 4 7 7 6 6 5 1 2 0 0 1 1
Peroxisomes 4 0 2 6 2 4 10 11 2 7 3 2 1 4 7 9 3 2 8 1 11 6 23 29
SpindlePole 0 0 0 1 2 2 3 6 0 5 0 3 0 0 0 0 0 1 0 0 0 0 1 0
Vac/Vac Membrane 16 7 7 5 8 1 12 11 8 8 6 9 3 11 14 5 4 8 1 3 2 0 1 6
Unique Cell Count 258 100 180 201 273 281 407 479 297 386 321 338 65 163 236 36 42 52 262 104 184 88 212 326
Labelled Cell Count 298 118 204 241 323 342 489 564 402 472 376 412 78 195 281 42 49 59 262 104 184 88 212 326


Mitochondria

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 16.9 16.3 15.0 17.7 17.1 14.4 14.0 12.9 12.6 11.9 11.3 12.4 18.8 19.5 18.2 16.1 18.6 20.7 17.5 17.3 18.5
Std Deviation (1e-4) 4.4 3.9 4.4 5.1 4.5 4.1 3.8 3.9 3.7 3.5 3.0 3.7 4.3 9.5 4.0 4.7 6.2 5.6 5.0 4.6 4.8
Intensity Change (Log2) – – – 0.24 0.19 -0.06 -0.1 -0.22 -0.25 -0.33 -0.41 -0.27 0.32 0.38 0.28 0.1 0.31 0.46 0.22 0.21 0.3


Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cell Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 0 2.4 0 0 0 0 0 0 0 0 0 0 0 0 0
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 0 0 0 2.3 2.8 0 0 8.6
Mitochondria -0.4 -2.3 -1.4 -2.6 -3.5 -1.0 -0.3 -0.6 -1.2 1.2 -2.1 -1.2 -11.2 -11.5 -12.5
Nucleus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery -1.1 -1.1 0.1 0.8 1.0 2.8 1.4 1.1 1.2 0 -0.7 -0.8 0 0 0
Nucleolus 0.8 2.2 3.1 2.8 3.2 4.3 2.2 1.7 2.3 0 -0.3 -1.1 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vacuole -0.8 -0.6 0 -0.6 0 -0.7 0 0 -0.8 0 1.2 0.9 0 0 0

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 25.1233 26.6518 25.9525 24.7636 23.2103 26.1643 23.641 26.0834 23.0875 23.736 21.6066 23.6813 27.3441 30.1366 28.1674 24.9279 22.2337 26.479
Actin 0.0112 0.0005 0.003 0.0001 0.0145 0.0106 0.0335 0.0013 0.0023 0.0005 0.0087 0.0002 0.0095 0.0056 0.009 0.0007 0.0229 0.0004
Bud 0.0002 0 0.0001 0 0.0005 0 0.0001 0 0.0002 0 0.0006 0 0.0002 0.0001 0 0.0001 0.0002 0
Bud Neck 0.0001 0 0.0001 0 0.0027 0.0001 0.001 0 0 0 0.0004 0 0.0015 0.0002 0.0001 0 0.0001 0
Bud Periphery 0.0003 0 0.0002 0 0.0006 0.0001 0.0002 0.0001 0.0004 0 0.0007 0 0.0003 0.0001 0.0001 0.0001 0.0002 0
Bud Site 0.0003 0 0.0004 0 0.0073 0.0001 0.001 0.0001 0.0013 0 0.005 0 0.003 0.0003 0.0025 0.0003 0.0005 0
Cell Periphery 0.0002 0.0001 0.0003 0 0.0002 0.0001 0.0001 0.0001 0.0003 0 0.0001 0.0001 0.0002 0.0001 0.0001 0.0002 0.0003 0.0001
Cytoplasm 0.0005 0 0.0001 0 0.0004 0 0.0001 0 0 0 0.0008 0 0.0046 0 0.0005 0.0004 0.0009 0
Cytoplasmic Foci 0.0007 0.0001 0.0007 0 0.0013 0.0016 0.0069 0.0002 0.0001 0 0.047 0.0001 0.0188 0.0005 0.0063 0.0198 0.0317 0.0002
Eisosomes 0.0007 0.0002 0.0008 0.0001 0.0002 0.0002 0.0003 0.0003 0.0002 0.0001 0.0003 0.0001 0.0003 0.0003 0.0002 0.0004 0.0008 0.0001
Endoplasmic Reticulum 0.0004 0 0.0004 0 0.0005 0.0001 0 0 0 0 0.0002 0 0.0012 0 0.0001 0.0001 0.0007 0
Endosome 0.0049 0.0005 0.0005 0 0.0035 0.0011 0.0008 0.0007 0.0001 0.0001 0.0032 0.0003 0.0043 0.0004 0.0006 0.0004 0.0096 0.0004
Golgi 0.0021 0.0016 0.0009 0.0001 0.0027 0.0031 0.0024 0.0036 0.0003 0.0001 0.0062 0.0009 0.0025 0.01 0.0045 0.0005 0.006 0.0055
Lipid Particles 0.0054 0.0038 0.0033 0.0015 0.0024 0.0062 0.0113 0.0054 0.0008 0.0022 0.0551 0.0113 0.0229 0.0044 0.0094 0.0283 0.0459 0.0124
Mitochondria 0.947 0.983 0.9758 0.9949 0.95 0.9509 0.9009 0.9781 0.9871 0.9955 0.8131 0.9659 0.8964 0.9705 0.9497 0.9227 0.8015 0.966
None 0.0013 0 0.0005 0 0.0003 0 0.0001 0 0 0 0.0038 0 0.0082 0 0.0052 0.0024 0.0079 0
Nuclear Periphery 0.0023 0 0.0002 0 0.0009 0.0005 0.0001 0 0 0 0.0033 0.0004 0.0068 0 0.0004 0.0009 0.006 0
Nucleolus 0.0026 0.0001 0.0002 0.0001 0.0004 0.0001 0.016 0.0001 0.0001 0 0.0064 0.0001 0.0012 0.0003 0.0011 0.0079 0.0088 0.0001
Nucleus 0.0055 0 0.0001 0 0.0008 0.0001 0.0012 0 0.0001 0 0.0014 0.0001 0.0014 0 0.0007 0.0016 0.0012 0
Peroxisomes 0.0017 0.001 0.0051 0.0002 0.0008 0.004 0.0196 0.0029 0.0022 0.0006 0.0266 0.0003 0.0048 0.0045 0.0017 0.0034 0.0124 0.0012
Punctate Nuclear 0.0033 0 0.0001 0 0.0021 0.0001 0.0004 0 0 0 0.0121 0 0.0075 0 0.0038 0.0024 0.0066 0
Vacuole 0.0018 0.0011 0.0017 0.0002 0.0015 0.0012 0.0004 0.0008 0.0014 0.0001 0.0007 0.0008 0.0011 0.0002 0.0003 0.0008 0.0023 0.0005
Vacuole Periphery 0.0075 0.0077 0.0055 0.0028 0.0061 0.0199 0.0036 0.0064 0.003 0.0005 0.0042 0.0195 0.0034 0.0025 0.0038 0.0066 0.0334 0.0131

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 41.8822 30.6328 44.4515 43.2031 30.113 46.4254 48.1799 45.7577 56.4999 51.0109
Translational Efficiency 0.8544 1.0443 0.7089 0.933 1.0504 1.0822 0.8793 0.8884 0.8619 0.8726

Hit Data

Dataset Hit
Protein Concentration ✔
Protein Localization ✘
Gene Expression ✘
Translational Efficiency ✘

Micrographs

Select an organelle or subcellular structure:


Penetrance Data

Penetrance values (percentage of cells with morphologically abnormal structure) at each time point for each of the subcellular structures monitored.

TP0 TP3 TP6 TP9 TP12 TP15 TP18 TP21 TP24
Autophagosome (ATG8) 57.500000 49.367089 72.222222 65.909091 57.575758 85.714286 69.090909 75.757576 74.074074
Septin (CDC11) 24.427481 31.623932 46.728972 61.818182 69.565217 78.048780 80.000000 82.000000 81.818182
Spindle & SPB (DAD2) 63.265306 60.000000 70.967742 86.274510 88.372093 75.000000 100.000000 95.000000 96.551724
P-bodies (DCP2) 41.176471 85.000000 100.000000 100.000000 97.619048 100.000000 97.297297 100.000000 91.428571
Inner Nuclear Membrane (HEH2) 60.714286 65.822785 66.265060 68.000000 66.000000 100.000000 100.000000 89.473684 97.435897
Metacaspase (MCA1) 15.062762 88.549618 83.734940 87.977099 96.363636 98.207171 94.827586 87.212276 95.322940
Plasma Membrane (MID2) 51.020408 44.615385 63.963964 63.157895 94.117647 96.052632 98.039216 98.000000 100.000000
Necrosis Factor (NHP6A) 52.702703 61.988304 94.086022 98.214286 97.714286 100.000000 97.590361 95.555556 90.909091
Nucleolus (NOP10) 26.697353 28.449198 38.614900 56.656347 58.470588 74.002751 86.412214 89.531250 92.543860
Kinetochore (NUF2) 27.777778 51.851852 52.272727 37.500000 83.333333 75.000000 85.714286 100.000000 100.000000
Mitochondria (OM45) 40.974212 59.610028 81.005587 89.295775 98.442368 97.777778 94.719472 95.638629 97.635135
Eisosomes (PIL1) 23.913043 55.782313 72.847682 79.761905 91.447368 92.857143 95.967742 98.181818 96.875000
Proteasome (PRE2) 43.424318 32.579186 56.097561 76.096491 89.302326 90.322581 87.640449 87.356322 65.818182
DNA Damage Foci (RAD52) 17.021277 15.590200 23.569794 38.095238 46.606335 63.963964 60.367454 82.597403 93.333333
Actin Patches (SAC6) 44.715447 50.505051 51.351351 51.063830 92.307692 100.000000 100.000000 98.648649 100.000000
Golgi, Early (SEC21) 45.360825 38.461538 47.236181 53.773585 45.989305 67.934783 91.463415 91.616766 98.245614
Golgi, Late (SEC7) 23.809524 56.962025 82.745098 92.996109 97.047970 98.031496 97.785978 91.928251 82.113821
Endosomes (SNF7) 29.870130 35.627530 50.592885 67.049808 84.586466 81.509434 74.576271 64.356436 61.224490
Endoplasmic Reticulum (SPF1) 47.619048 46.766169 75.268817 87.951807 87.647059 84.357542 98.113208 96.453901 98.425197
Lipid Droplets (TGL3) 37.037037 61.363636 51.020408 89.655172 80.000000 71.794872 88.888889 70.588235 70.000000
Vacuole (VPH1) 50.152905 31.481481 51.388889 72.569444 88.979592 94.347826 93.859649 95.808383 100.000000

Micrographs

Cell Count

Number of cells analysed for each strain. R1, R2: biological replicates; R1 & R2: both replicates combined.

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
2237 1480 165 1399 1137 1490 175 417 3374 2970 340 1816

Protein Abundance

Mean and standard deviation of cell GFP intensity, and intensity change (log2) of each mutant relative to wild type.

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 1083.62 1716.92 2465.11 1645.56 1609.44 1589.27 2298.88 1590.06 1260.82 1652.88 2379.55 1632.82
Standard Deviation 231.85 429.25 440.35 330.13 349.23 405.28 387.74 409.24 372.17 422.25 422.36 350.66
Intensity Change Log 2 — 0.663964 1.185793 0.602720 — -0.018195 0.514372 -0.017478 — 0.295923 0.822924 0.264796

Localization Score (DeepLoc)

Localization score for each compartment. Values highlighted in green denote significant localization scores (marked * in the plot).

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.001354 0.008024 0.006128 0.005460 0.001995 0.007142 0.007129 0.005558 0.001570 0.007581 0.006643 0.005483
Bud Neck 0.001256 0.001615 0.013681 0.002174 0.001050 0.001273 0.007856 0.006675 0.001187 0.001444 0.010683 0.003208
Bud Site 0.003507 0.001513 0.010396 0.002385 0.000892 0.000931 0.007044 0.019981 0.002626 0.001221 0.008671 0.006426
Cell Periphery 0.000415 0.000068 0.000276 0.000208 0.000060 0.000099 0.000174 0.002537 0.000295 0.000084 0.000223 0.000743
Cytoplasm 0.000437 0.000263 0.000661 0.000290 0.000328 0.000365 0.000522 0.001374 0.000400 0.000314 0.000590 0.000539
Cytoplasmic Foci 0.005675 0.018299 0.110569 0.008569 0.025207 0.017433 0.075695 0.011969 0.012257 0.017865 0.092619 0.009349
Eisosomes 0.000291 0.002025 0.002117 0.000512 0.001167 0.001704 0.001142 0.000498 0.000586 0.001864 0.001615 0.000509
Endoplasmic Reticulum 0.000127 0.000109 0.000205 0.000430 0.000088 0.000116 0.000226 0.001314 0.000114 0.000113 0.000216 0.000633
Endosome 0.002350 0.002036 0.001814 0.004408 0.000926 0.002178 0.002949 0.021061 0.001870 0.002107 0.002398 0.008232
Golgi 0.005180 0.023651 0.014389 0.030355 0.010736 0.025356 0.028995 0.059604 0.007052 0.024507 0.021907 0.037071
Lipid Particles 0.003186 0.005723 0.010994 0.007310 0.006039 0.006817 0.013468 0.006387 0.004148 0.006272 0.012268 0.007098
Mitochondria 0.951001* 0.909734* 0.719688* 0.895421* 0.924586* 0.911730* 0.763001* 0.776772* 0.942100* 0.910735* 0.741981* 0.868176*
Mitotic Spindle 0.000474 0.000642 0.019649 0.004530 0.000490 0.000932 0.018890 0.003309 0.000479 0.000787 0.019259 0.004249
None 0.001571 0.002274 0.003953 0.002505 0.003479 0.002359 0.003793 0.003176 0.002214 0.002317 0.003871 0.002659
Nuclear Periphery 0.000124 0.000156 0.005264 0.001416 0.000365 0.000204 0.004001 0.001441 0.000206 0.000180 0.004614 0.001421
Nuclear Periphery Foci 0.000141 0.000176 0.001669 0.000532 0.000271 0.000196 0.001823 0.000743 0.000185 0.000186 0.001748 0.000580
Nucleolus 0.000537 0.000662 0.006857 0.000586 0.000977 0.000387 0.002557 0.000591 0.000685 0.000524 0.004644 0.000587
Nucleus 0.000195 0.000063 0.000361 0.000579 0.000216 0.000147 0.000275 0.000275 0.000202 0.000105 0.000317 0.000510
Peroxisomes 0.012037 0.017037 0.034865 0.004158 0.012351 0.014025 0.017508 0.007028 0.012143 0.015526 0.025932 0.004817
Vacuole 0.004659 0.003110 0.016155 0.008568 0.003532 0.003093 0.018274 0.031949 0.004279 0.003102 0.017246 0.013937
Vacuole Periphery 0.005481 0.002818 0.020308 0.019603 0.005247 0.003515 0.024678 0.037759 0.005402 0.003168 0.022557 0.023772

Localization Changes (T-score)

Change in localization of each mutant relative to its control (e.g. UBP2_WT: ubp2Δ vs wild type). Values highlighted in yellow (increase) or blue (decrease) denote significant changes (marked * in the plot).

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin -5.99 -4.13 -4.38 1.80 0.45 -4.86 -3.15 -2.13 0.84 0.70 -7.88 -5.06 -4.78 1.94 0.92
Bud Neck -1.00 -5.16 -1.86 -1.05 4.70 -0.80 -5.21 -3.45 -3.31 0.59 -1.10 -7.01 -3.78 -3.24 5.17
Bud Site 2.29 -1.49 1.28 -1.30 1.73 -0.05 -1.53 -4.12 -4.12 -1.89 2.58 -1.99 -3.13 -4.49 0.77
Cell Periphery 2.74 0.72 1.60 -5.19 0.44 -2.03 -2.23 -3.79 -3.73 -3.59 2.52 0.59 -2.58 -4.31 -3.02
Cytoplasm 1.14 -0.94 0.93 -0.54 1.93 -0.31 -1.23 -2.14 -2.05 -1.66 0.72 -1.26 -0.91 -1.76 0.35
Cytoplasmic Foci -8.14 -7.45 -2.60 5.72 7.23 2.84 -5.13 4.05 2.00 6.47 -4.12 -9.45 2.24 6.31 9.78
Eisosomes -10.28 -5.66 -2.69 8.16 4.84 -3.26 0.14 5.32 8.00 3.75 -11.37 -5.69 1.05 10.95 5.88
Endoplasmic Reticulum 0.85 -1.34 -2.99 -3.18 -1.98 -1.60 -2.64 -3.65 -3.57 -3.20 0.09 -2.59 -4.72 -4.75 -3.61
Endosome 0.56 1.17 -3.26 -3.30 -4.03 -3.30 -4.01 -5.65 -5.27 -5.04 -0.66 -1.47 -6.63 -6.25 -5.94
Golgi -8.60 -3.15 -8.79 -1.96 -4.04 -5.70 -3.51 -6.09 -4.18 -3.28 -10.74 -4.92 -10.37 -3.95 -3.73
Lipid Particles -2.99 -3.56 -3.22 -1.20 1.51 -0.67 -2.99 -0.18 0.20 2.33 -3.06 -4.92 -2.70 -0.74 2.74
Mitochondria 6.89 8.91 8.41 1.92 -6.64 1.73 7.24 9.01 8.27 -0.54 6.89 11.77 11.44 6.26 -7.10
Mitotic Spindle -0.74 -3.67 -3.69 -3.49 2.79 -0.85 -2.98 -3.53 -2.62 2.49 -1.11 -4.63 -4.33 -3.84 3.56
None -4.15 -5.52 -5.62 -1.18 3.27 4.50 -0.73 0.35 -0.94 0.66 -0.76 -5.61 -1.84 -1.39 3.38
Nuclear Periphery -1.43 -3.41 -4.99 -4.86 2.52 2.46 -3.76 -2.23 -2.56 2.37 0.83 -4.99 -5.32 -5.42 3.50
Nuclear Periphery Foci -0.89 -5.01 -3.79 -3.36 3.53 1.31 -3.03 -3.57 -4.05 2.05 -0.03 -5.19 -4.64 -4.50 3.73
Nucleolus -0.50 -2.91 -0.21 0.34 2.89 1.83 -2.47 1.10 -1.30 3.38 0.83 -3.57 0.42 -0.48 3.68
Nucleus 1.31 -1.37 -0.78 -1.07 -0.44 0.38 -0.45 -0.43 -0.94 0.01 0.98 -1.28 -0.81 -1.06 -0.51
Peroxisomes -2.09 -3.50 4.85 6.12 4.76 -0.70 -1.26 2.37 3.20 2.62 -2.02 -3.61 5.61 7.35 5.65
Vacuole 2.09 -5.49 -3.38 -4.90 3.34 0.58 -4.86 -6.48 -6.60 -2.61 2.17 -6.95 -7.13 -8.16 1.46
Vacuole Periphery 3.27 -3.20 -7.31 -9.21 0.14 1.95 -3.54 -7.39 -7.86 -1.89 3.59 -4.75 -10.25 -11.89 -0.32
Standard name
Human Ortholog
Description (SGD) Alpha subunit of the mitochondrial processing protease (MPP); essential processing enzyme that cleaves the N-terminal targeting sequences from mitochondrially imported proteins
Localization
Cell Percentages mitochondrion (97%)
Cell Cycle Regulation No
Subcompartmental Group mito-3

Mas2

Mas2


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Mas2-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available