Standard name
Human Ortholog
Description DNA photolyase involved in photoreactivation; repairs pyrimidine dimers in the presence of visible light; induced by DNA damage; regulated by transcriptional repressor Rph1p
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 – 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 – 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 – 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 – 0 0 0 0 – 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 0 0 – 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 0.79 0.45 0.83 0.89 0.68 0.49 0.39 – 0.25 0.17 0.12 0.15 – 0.59 0.61 0.23 0.25 0.32 0.58 0.27 0.54 0.65 0.29 0.45
Endoplasmic Reticulum 0 0 0 0 0 0 0 – 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0
Endosome 0 0 0 0 0 0 0 – 0 0 0 0 – 0 0 0 0 0.05 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 – 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0.08 0 0 0 0 0.1 0.09 – 0.28 0.18 0.38 0.15 – 0 0 0 0 0 0.06 0 0.09 0 0 0
Nucleus 0.11 0.45 0.14 0.08 0.25 0.4 0.54 – 0.57 0.69 0.7 0.73 – 0.33 0.35 0.52 0.51 0.32 0.15 0.5 0.12 0.07 0.27 0.19
Nuclear Periphery 0 0 0 0 0 0 0 – 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 – 0 0 0.05 0 – 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 – 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 – 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0.05 0
Vac/Vac Membrane 0.05 0.17 0 0 0.07 0.07 0 – 0 0 0 0 – 0.1 0.05 0.3 0.31 0.35 0.11 0.13 0.16 0.13 0.19 0.22
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 – 0 0 0 0 – 0 0 0 0 0 2 0 3 0 0 0
Bud 0 0 0 1 0 1 3 – 5 4 5 2 – 0 0 0 0 0 1 2 1 0 0 1
Bud Neck 1 0 6 5 4 2 2 – 4 2 3 1 – 0 0 0 0 0 0 0 1 0 0 1
Bud Site 0 0 0 0 0 0 0 – 6 4 19 7 – 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 1 0 0 2 1 – 0 0 0 0 – 0 0 0 0 0 1 0 1 0 0 0
Cytoplasm 176 32 174 262 245 241 226 – 114 86 58 80 – 53 86 34 44 43 150 29 128 15 12 27
Endoplasmic Reticulum 1 0 2 2 1 0 0 – 0 0 0 0 – 0 0 5 5 5 1 0 0 0 1 0
Endosome 0 1 0 0 2 3 0 – 2 0 0 2 – 3 1 2 5 7 3 1 1 0 0 0
Golgi 0 0 0 0 0 0 0 – 0 0 0 0 – 0 2 1 0 1 3 0 0 0 0 0
Mitochondria 18 2 0 2 6 51 53 – 128 91 187 77 – 0 0 5 0 3 15 2 22 0 1 0
Nucleus 25 32 30 25 91 194 309 – 263 338 343 382 – 30 50 76 92 43 37 54 29 1 11 11
Nuclear Periphery 0 0 0 0 0 1 0 – 2 4 0 3 – 0 0 0 1 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 2 3 – 9 14 23 19 – 0 0 0 1 2 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 – 0 0 0 1 – 1 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 2 2 2 7 – 4 2 1 5 – 2 0 0 1 0 3 0 5 1 2 0
Vac/Vac Membrane 12 12 5 4 25 35 16 – 13 13 11 9 – 9 7 44 55 48 28 14 37 3 8 13
Unique Cell Count 222 71 210 295 359 489 575 462 493 489 522 90 142 147 179 136 260 109 239 24 43 61
Labelled Cell Count 233 79 218 303 376 534 620 550 558 650 588 98 146 167 204 152 260 109 239 24 43 61


Cytoplasm, Nucleus

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 3.6 5.1 5.0 4.7 5.5 4.6 5.0 – 4.6 5.1 4.7 5.3 – 6.1 6.0 7.0 6.8 6.9 – – 6.0
Std Deviation (1e-4) 0.8 1.3 0.7 1.2 1.9 1.3 1.5 – 1.3 1.4 1.3 1.6 – 1.8 1.8 1.5 1.4 2.0 – – 1.1
Intensity Change (Log2) – – – -0.1 0.14 -0.13 -0.02 – -0.14 0.03 -0.11 0.08 – 0.27 0.24 0.47 0.42 0.46 – – 0.25


Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches 0 0 0 0 – 0 0 0 0 – 0 0 0 0 0
Bud 0 0 0 0 – 0 0 0 0 – 0 0 0 0 0
Bud Neck 0 0 0 0 – 0 0 0 0 – 0 0 0 0 0
Bud Site 0 0 0 0 – 0 0 0 0 – 0 0 0 0 0
Cell Periphery 0 0 0 0 – 0 0 0 0 – 0 0 0 0 0
Cytoplasm 1.9 -3.8 -8.3 -10.8 – -14.1 -16.4 -18.3 -17.4 – -4.4 -4.7 -11.3 -11.5 -9.6
Endoplasmic Reticulum 0 0 0 0 – 0 0 0 0 – 0 0 0 0 0
Endosome 0 0 0 0 – 0 0 0 0 – 0 0 0 0 0
Golgi 0 0 0 0 – 0 0 0 0 – 0 0 0 0 0
Mitochondria 0 0 0 4.6 – 0 6.7 0 5.9 – 0 0 0 0 0
Nucleus -2.1 3.1 6.6 9.9 – 10.3 13.2 13.6 14.5 – 3.8 4.6 7.6 7.9 3.9
Nuclear Periphery 0 0 0 0 – 0 0 0 0 – 0 0 0 0 0
Nucleolus 0 0 0 0 – 0 0 0 2.8 – 0 0 0 0 0
Peroxisomes 0 0 0 0 – 0 0 0 0 – 0 0 0 0 0
SpindlePole 0 0 0 0 – 0 0 0 0 – 0 0 0 0 0
Vacuole 0 2.4 2.5 0.3 – 0.3 0.2 0 0 – 0 0 7.4 7.7 8.3

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 0.1543 -0.4411 -0.6467 -0.8893 -1.07 -0.5008 -0.0778 0.1286 0.1877 0.1637 0.2591 -0.0638 -0.4317 -0.7469 -0.9916 -0.9422 -1.3226 -0.573
Actin 0.0521 0.0014 0.0025 0.0004 0.0042 0.0199 0.0144 0.0002 0.006 0.0357 0.0051 0.008 0.0343 0.0002 0.035 0.0003 0.0003 0.0142
Bud 0.0018 0.0034 0.0009 0.0019 0.0001 0.0006 0.0005 0.0022 0.0004 0.0017 0.0008 0.001 0.0007 0.0001 0.0001 0.0013 0.0001 0.0009
Bud Neck 0.0105 0.0003 0.0003 0.0004 0.0005 0.0021 0.0019 0.0004 0.0005 0.0029 0.0018 0.004 0.0033 0.0002 0.0006 0.0007 0.0015 0.0075
Bud Periphery 0.0039 0.0029 0.0014 0.0034 0.0001 0.0013 0.0009 0.0013 0.0007 0.0081 0.002 0.0023 0.0008 0.0001 0.0002 0.0013 0.0001 0.0063
Bud Site 0.0215 0.0057 0.0005 0.0003 0.0003 0.0004 0.0065 0.0036 0.0013 0.0017 0.0159 0.0004 0.0079 0.0018 0.0007 0.0009 0.0003 0.0004
Cell Periphery 0.0012 0.0001 0.0001 0.0002 0.0001 0.0001 0.0003 0.0002 0.0004 0.0002 0.0004 0.0001 0.0002 0.0001 0.0001 0.0002 0 0.0008
Cytoplasm 0.0512 0.1097 0.0719 0.0554 0.1484 0.1089 0.044 0.0651 0.0383 0.0101 0.0406 0.0729 0.0787 0.1085 0.1073 0.0702 0.1066 0.0788
Cytoplasmic Foci 0.0288 0.0037 0.0062 0.0071 0.0079 0.0196 0.0247 0.0017 0.0046 0.0146 0.0184 0.0057 0.0383 0.0035 0.0074 0.0045 0.0024 0.0091
Eisosomes 0.0009 0.0004 0.0002 0.0001 0.0002 0.0002 0.0003 0.0001 0.0002 0.0003 0.0001 0.0002 0.0003 0.0001 0.0004 0.0001 0 0.0001
Endoplasmic Reticulum 0.0092 0.0014 0.0027 0.0049 0.0064 0.0025 0.0036 0.0013 0.0021 0.0012 0.0037 0.0024 0.003 0.003 0.0032 0.0024 0.001 0.0149
Endosome 0.0316 0.001 0.0063 0.003 0.0266 0.0048 0.0234 0.0008 0.0117 0.0256 0.0547 0.0107 0.0188 0.0021 0.0023 0.0009 0.0015 0.0035
Golgi 0.0084 0.0001 0.0018 0.0002 0.003 0.003 0.0098 0 0.0049 0.0174 0.0079 0.0051 0.0085 0.0001 0.0031 0.0001 0.0001 0.0005
Lipid Particles 0.0129 0.0003 0.0025 0.0019 0.0198 0.0016 0.0258 0.0003 0.0013 0.0086 0.0216 0.0027 0.0361 0.0007 0.0014 0.0012 0.0001 0.0005
Mitochondria 0.0142 0.0004 0.0018 0.0013 0.0029 0.002 0.0101 0.0007 0.0101 0.0239 0.0087 0.0088 0.0036 0.0007 0.0024 0.0012 0.0004 0.0008
None 0.3335 0.5826 0.4768 0.41 0.489 0.4037 0.4168 0.5424 0.4984 0.2905 0.4069 0.3375 0.4539 0.5581 0.5635 0.6563 0.5757 0.5278
Nuclear Periphery 0.0484 0.0043 0.0262 0.0141 0.0463 0.0061 0.0131 0.0036 0.0083 0.0048 0.0449 0.0079 0.0116 0.0133 0.015 0.0026 0.0027 0.0076
Nucleolus 0.0088 0.0029 0.0038 0.0064 0.0025 0.006 0.004 0.0057 0.0054 0.0043 0.0242 0.008 0.002 0.0034 0.0012 0.003 0.0015 0.0055
Nucleus 0.3184 0.2712 0.3705 0.4717 0.2134 0.3869 0.3624 0.3582 0.3809 0.5108 0.3009 0.4862 0.2483 0.2892 0.242 0.2449 0.2925 0.3049
Peroxisomes 0.0052 0.0003 0.0021 0.0004 0.0024 0.0014 0.0094 0.0001 0.0008 0.0073 0.006 0.0013 0.0334 0.0001 0.0029 0.0002 0.0001 0.0001
Punctate Nuclear 0.0254 0.0066 0.018 0.0114 0.0197 0.0265 0.0231 0.0108 0.0179 0.0254 0.0221 0.0322 0.0135 0.0125 0.0096 0.0058 0.0127 0.0128
Vacuole 0.0083 0.0011 0.0024 0.0044 0.004 0.0018 0.0037 0.0011 0.0047 0.0024 0.0086 0.0019 0.002 0.0018 0.0012 0.0018 0.0005 0.0024
Vacuole Periphery 0.0037 0.0001 0.001 0.0013 0.0023 0.0005 0.0012 0.0001 0.0012 0.0025 0.0049 0.0008 0.001 0.0003 0.0003 0.0002 0.0001 0.0005

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 2.5993 0.5809 3.0174 5.1375 5.8977 9.742 4.552 7.9285 8.4841 5.9768
Translational Efficiency – – – – – – – – – –

Hit Data

Dataset Hit
Protein Concentration ✘
Protein Localization ✘
Gene Expression ✘
Translational Efficiency –

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
71 471 1742 964 1903 1609 92 437 1974 2080 1834 1401

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 639.99 711.17 955.45 902.45 648.08 717.67 1135.27 886.11 647.79 716.20 964.47 897.35
Standard Deviation 98.19 111.01 181.26 136.53 81.10 109.65 161.75 137.98 81.80 110.00 184.55 137.20
Intensity Change Log 2 — 0.152145 0.578131 0.495798 — 0.147149 0.808792 0.451314 — 0.149633 0.698789 0.473588

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.000275 0.000352 0.000537 0.001385 0.000056 0.000596 0.001502 0.000646 0.000063 0.000541 0.000586 0.001155
Bud Neck 0.002096 0.018922 0.019846 0.032263 0.012619 0.031669 0.008087 0.022275 0.012241 0.028783 0.019256 0.029148
Bud Site 0.000494 0.005237 0.001665 0.033478 0.002082 0.014275 0.002406 0.022591 0.002024 0.012228 0.001702 0.030082
Cell Periphery 0.000292 0.000333 0.000174 0.000229 0.000270 0.000340 0.000099 0.000185 0.000270 0.000338 0.000171 0.000216
Cytoplasm 0.074879 0.267617* 0.009924 0.133546* 0.373075* 0.291511* 0.013101 0.174015* 0.362350* 0.286100* 0.010084 0.146169*
Cytoplasmic Foci 0.037362 0.138110 0.000134 0.004077 0.108009 0.138032 0.002201 0.010722 0.105468 0.138050 0.000237 0.006149
Eisosomes 0.000066 0.000098 0.000026 0.000038 0.000089 0.000100 0.000061 0.000049 0.000088 0.000100 0.000028 0.000041
Endoplasmic Reticulum 0.003139 0.002361 0.002982 0.007049 0.000748 0.001757 0.009048 0.005497 0.000834 0.001894 0.003286 0.006565
Endosome 0.000694 0.010202 0.000251 0.004505 0.004617 0.015758 0.001421 0.007327 0.004476 0.014500 0.000310 0.005385
Golgi 0.000201 0.004438 0.000056 0.008101 0.000806 0.003386 0.000091 0.002421 0.000784 0.003624 0.000058 0.006330
Lipid Particles 0.004044 0.006174 0.000084 0.000831 0.006837 0.005997 0.001301 0.001083 0.006737 0.006037 0.000145 0.000910
Mitochondria 0.001198 0.002378 0.001438 0.013014 0.003414 0.014441 0.001487 0.005414 0.003334 0.011709 0.001441 0.010643
Mitotic Spindle 0.001337 0.004597 0.002050 0.082365 0.001591 0.019518 0.014708 0.037274 0.001581 0.016139 0.002685 0.068300
None 0.021012 0.011494 0.002639 0.007160 0.014680 0.006884 0.001559 0.011029 0.014908 0.007928 0.002585 0.008367
Nuclear Periphery 0.000574 0.000980 0.000524 0.003146 0.000831 0.001299 0.000843 0.002168 0.000822 0.001227 0.000540 0.002841
Nuclear Periphery Foci 0.000351 0.001046 0.000124 0.001256 0.000282 0.000586 0.000814 0.000527 0.000285 0.000690 0.000159 0.001029
Nucleolus 0.012810 0.006001 0.004482 0.001743 0.003067 0.004719 0.004654 0.001649 0.003417 0.005009 0.004490 0.001713
Nucleus 0.832598* 0.471120* 0.951130* 0.617427* 0.444050* 0.388708* 0.922599* 0.629923* 0.458025* 0.407369* 0.949699* 0.621325*
Peroxisomes 0.003669 0.007990 0.000138 0.000643 0.003659 0.011276 0.001216 0.001635 0.003660 0.010532 0.000192 0.000952
Vacuole 0.002684 0.039660 0.001656 0.044070 0.018662 0.046862 0.012664 0.058489 0.018088 0.045231 0.002209 0.048567
Vacuole Periphery 0.000225 0.000889 0.000139 0.003675 0.000557 0.002287 0.000136 0.005082 0.000545 0.001970 0.000139 0.004114

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin -0.94 -3.55 -5.27 -5.30 -3.95 -2.03 -7.14 -7.88 -1.93 1.52 -2.33 -23.91 -9.97 -2.71 -4.77
Bud Neck -5.51 -14.74 -10.14 -2.07 -1.80 -8.09 0.94 -3.03 3.29 -3.43 -8.03 -5.78 -5.99 1.56 -1.67
Bud Site -6.05 -5.51 -7.95 -5.83 -7.40 -8.70 -1.07 -4.80 -0.80 -4.42 -9.25 0.28 -8.74 -3.34 -8.78
Cell Periphery -0.37 1.35 1.31 2.51 -0.29 -1.47 4.64 3.33 4.68 -2.42 -1.57 2.60 3.25 5.16 -0.25
Cytoplasm -8.16 3.19 -1.78 11.36 -17.71 8.25 41.31 22.04 14.38 -10.09 8.31 52.85 30.36 21.58 -21.23
Cytoplasmic Foci -6.28 2.65 2.45 15.42 -7.63 -4.59 25.97 25.93 25.78 -1.92 -5.59 28.60 27.44 30.77 -8.14
Eisosomes -2.39 3.04 0.79 6.47 -10.90 -1.25 2.28 2.24 3.34 -0.72 -1.55 11.01 4.73 6.73 -13.56
Endoplasmic Reticulum 0.68 -0.05 -5.18 -12.99 -12.34 -4.96 -9.53 -11.51 -10.03 -0.54 -5.98 -17.55 -20.45 -17.17 -13.95
Endosome -6.62 1.60 -4.69 5.16 -6.80 -8.37 3.46 0.41 7.15 -2.02 -9.04 9.55 2.31 10.40 -6.97
Golgi -1.84 1.43 -1.99 0.60 -2.10 -5.21 4.40 -0.31 3.63 -1.81 -4.37 4.90 -1.54 1.28 -2.39
Lipid Particles -0.95 1.92 1.43 5.00 -13.21 1.24 7.39 9.07 9.43 -0.73 1.06 12.10 10.02 11.46 -14.32
Mitochondria -3.24 -1.37 -3.93 -3.04 -3.70 -6.07 2.97 -0.42 5.07 -1.95 -5.80 3.66 -2.19 3.43 -4.20
Mitotic Spindle -1.80 -1.11 -8.52 -7.69 -8.33 -7.01 -1.46 -4.52 -1.03 -0.95 -7.16 -1.76 -9.63 -5.59 -9.06
None 0.83 1.62 1.34 2.34 -5.99 4.94 7.90 3.32 -0.56 -3.23 4.39 8.63 5.60 1.50 -6.10
Nuclear Periphery -2.56 -0.28 -14.78 -12.64 -15.60 -2.49 -1.80 -8.51 -6.63 -5.14 -2.65 1.91 -16.34 -12.32 -17.59
Nuclear Periphery Foci -2.49 1.64 -4.15 -1.24 -5.33 -1.85 -1.36 -5.44 -3.11 -0.84 -2.89 1.98 -6.02 -3.39 -6.72
Nucleolus 1.73 2.97 4.00 3.60 6.42 -2.79 -1.24 1.25 3.02 1.60 -3.13 -2.72 3.68 5.77 6.15
Nucleus 10.04 -3.46 4.98 -9.91 26.74 4.60 -23.51 -12.41 -14.96 10.74 4.68 -60.60 -17.72 -21.54 32.05
Peroxisomes -1.52 1.28 1.17 6.17 -2.79 -7.55 4.44 5.04 11.38 -0.37 -7.80 7.61 6.53 13.62 -3.84
Vacuole -9.91 0.24 -15.85 -6.56 -16.14 -10.77 0.18 -9.95 -6.61 -8.56 -12.08 12.43 -16.04 -9.21 -19.65
Vacuole Periphery -3.47 1.18 -2.28 -0.97 -2.45 -4.91 4.95 -1.03 0.18 -1.31 -5.10 5.45 -1.84 0.58 -2.57
Standard name
Human Ortholog
Description DNA photolyase involved in photoreactivation; repairs pyrimidine dimers in the presence of visible light; induced by DNA damage; regulated by transcriptional repressor Rph1p
Localization
Cell Percentages nucleus (28%), cytoplasm (12%), mixed (40%)
Cell Cycle Regulation No
Subcompartmental Group N/A

Phr1

Phr1


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Phr1-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available