Standard name
Human Ortholog
Description Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S18 and bacterial S13; RPS18B has a paralog, RPS18A, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0.05 0 0 0 0 0 0 0.05 0 0.05 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 1.0 0.95 0.93 0.93 0.7 0.78 0.82 0.78 0.57 0.61 0.54 0.59 0.95 0.94 0.92 0.96 1.0 0.96 0.93 0.9 0.89 0.58 0.76 0.74
Endoplasmic Reticulum 0 0 0.07 0 0 0 0 0 0 0 0 0 0 0 0 0 0.08 0 0 0 0.05 0 0 0.06
Endosome 0 0 0 0 0.08 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0 0 0 0 0 0.17 0.13 0.11 0.48 0.39 0.47 0.45 0 0 0 0 0 0 0 0 0 0 0 0
Nucleus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.06 0.06 0.07
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vac/Vac Membrane 0 0 0 0 0.23 0.07 0.06 0.1 0.05 0.07 0.08 0.05 0 0 0 0 0 0 0 0 0 0.1 0.06 0
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 1 1 2 0 1 4 4 8 4 7 0 0 1 0 0 0 0 0 1 0 1 0
Bud 0 0 1 0 1 1 3 1 4 6 8 8 0 1 0 0 0 0 1 0 2 2 4 3
Bud Neck 0 0 0 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 1 0 17 7 9 6 18 13 10 27 10 18 0 3 0 2 1 1 0 0 2 0 0 0
Cytoplasm 31 57 292 229 222 211 419 334 227 308 174 234 57 136 142 123 51 103 78 70 289 37 131 126
Endoplasmic Reticulum 0 1 22 6 4 4 4 14 12 4 9 14 1 5 5 5 4 3 1 0 15 1 2 10
Endosome 0 1 1 0 25 11 12 8 5 11 4 2 0 1 3 1 0 0 0 0 0 1 2 1
Golgi 0 0 0 1 1 0 0 0 0 1 0 0 1 1 1 1 0 1 0 0 0 0 1 0
Mitochondria 0 0 0 2 9 47 68 46 191 195 153 177 0 2 0 4 0 1 0 1 3 0 0 4
Nucleus 0 0 0 0 2 2 2 4 3 1 2 1 1 0 1 0 0 0 0 2 0 3 9 11
Nuclear Periphery 0 0 0 0 0 0 0 0 1 0 0 1 0 0 1 0 0 0 0 0 0 0 0 1
Nucleolus 0 0 0 0 5 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 2 3 2
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0
SpindlePole 0 0 0 0 3 1 0 1 1 0 2 2 0 0 0 0 0 0 0 1 0 0 2 1
Vac/Vac Membrane 0 1 4 7 72 18 33 41 21 37 27 21 0 3 6 4 0 3 1 1 3 6 10 4
Unique Cell Count 31 60 315 245 315 271 511 427 400 501 325 395 60 144 154 128 51 107 84 78 326 65 173 172
Labelled Cell Count 32 60 338 253 355 301 561 467 479 598 393 485 60 152 160 140 56 112 84 78 326 65 173 172


Cytoplasm

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 20.1 20.8 20.8 19.5 10.7 6.2 6.1 6.4 5.5 6.4 6.0 6.4 24.0 22.7 20.5 13.0 17.8 18.2 24.4 23.2 20.6
Std Deviation (1e-4) 3.6 5.2 4.3 4.8 2.3 1.6 1.6 1.5 1.3 1.7 1.3 1.4 7.7 7.1 6.5 3.1 4.8 5.4 12.5 9.0 9.5
Intensity Change (Log2) – – – -0.1 -0.96 -1.74 -1.78 -1.7 -1.91 -1.71 -1.8 -1.69 0.21 0.13 -0.02 -0.67 -0.23 -0.19 0.23 0.16 -0.01


Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cell Periphery -1.5 -1.6 -2.0 -1.3 -1.6 -2.0 0 -1.5 -0.5 0 -1.6 -2.9 -1.8 0 0
Cytoplasm 0.4 -7.2 -5.1 -4.3 -5.4 -10.7 -9.8 -11.1 -10.1 0.6 0.7 -0.2 1.3 2.0 1.3
Endoplasmic Reticulum -2.4 -3.6 -3.2 -5.0 -2.3 -2.5 -4.9 -2.5 -2.1 0 -1.5 -1.6 -1.2 0 -1.6
Endosome 0 4.8 3.2 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0 0 7.7 6.8 6.0 14.3 12.7 14.0 13.7 0 0 0 0 0 0
Nucleus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vacuole 0 8.3 3.4 3.5 4.7 2.9 3.9 4.1 2.9 0 0 0 0 0 0

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration – – – – – – – – – – – – – – – – – –
Actin 0.0406 0.0026 0.0036 0 0.0467 0.0029 0.0034 0.0017 0.0031 0 0.0015 0.0025 0.0294 0.0024 0.0099 0.001 0.0006 0.0089
Bud 0.0032 0.0036 0.0023 0.0001 0.0013 0.003 0.0078 0.0014 0.0019 0.0014 0.0008 0.0012 0.0031 0.0019 0.0007 0.0013 0.0007 0.0015
Bud Neck 0.0029 0.0009 0.0047 0.0001 0.0014 0.0023 0.0005 0.0005 0.0005 0.0005 0.0006 0.001 0.0017 0.0004 0.0005 0.0006 0.0006 0.0072
Bud Periphery 0.0024 0.0022 0.001 0 0.001 0.0021 0.0073 0.0004 0.0005 0.0004 0.0001 0.0011 0.0048 0.0007 0.0003 0.0005 0.0001 0.0022
Bud Site 0.0168 0.0026 0.0017 0 0.0023 0.0007 0.001 0.0029 0.0064 0.0002 0.0003 0.0003 0.0064 0.003 0.0014 0.0012 0.0006 0.0005
Cell Periphery 0.0017 0.0034 0.0011 0 0.0009 0.0008 0.0006 0.0004 0.0003 0.0007 0.0001 0.0005 0.0045 0.0025 0.0005 0.0007 0.0001 0.001
Cytoplasm 0.5112 0.9285 0.7849 0.9355 0.7059 0.7559 0.6801 0.8971 0.7897 0.7699 0.9693 0.8024 0.6401 0.9278 0.8309 0.7925 0.8396 0.777
Cytoplasmic Foci 0.04 0.0056 0.015 0.0017 0.0095 0.0145 0.0087 0.0059 0.0312 0.0072 0.0088 0.0143 0.0193 0.0054 0.0228 0.0169 0.0245 0.0112
Eisosomes 0.0004 0 0.0004 0 0.0002 0.0001 0 0 0.0001 0 0 0 0.0003 0 0.0008 0.0001 0 0.0001
Endoplasmic Reticulum 0.0686 0.0089 0.0364 0.0004 0.0452 0.0647 0.0985 0.0029 0.0324 0.0007 0.0012 0.0732 0.0869 0.021 0.0129 0.0121 0.0116 0.0854
Endosome 0.0639 0.0093 0.036 0.007 0.0419 0.0681 0.0444 0.0113 0.0366 0.0185 0.0091 0.0448 0.0466 0.0054 0.027 0.0379 0.0847 0.0413
Golgi 0.0175 0.0033 0.0067 0 0.015 0.0116 0.0095 0.0014 0.0061 0.0002 0.0011 0.0076 0.0101 0.0005 0.0073 0.0017 0.0135 0.0161
Lipid Particles 0.0326 0.0002 0.0025 0 0.0027 0.0001 0.0001 0.0008 0.0182 0 0 0.0001 0.0048 0.0006 0.0017 0.0073 0.0005 0.0009
Mitochondria 0.0334 0.0014 0.0224 0 0.0786 0.0127 0.1054 0.0006 0.042 0.0001 0.0003 0.0372 0.0107 0.0003 0.0134 0.0007 0.0013 0.02
None 0.014 0.0003 0.023 0.0001 0.0003 0.001 0.0016 0.0003 0.0013 0.0002 0.0002 0.0006 0.0085 0.0023 0.0008 0.0138 0.0022 0.0006
Nuclear Periphery 0.0214 0.0015 0.0053 0.001 0.0033 0.0053 0.0048 0.0239 0.0063 0.0013 0.0008 0.0016 0.0155 0.0031 0.0057 0.0072 0.0027 0.0039
Nucleolus 0.0017 0 0.0005 0 0.0001 0.0002 0.0001 0.0002 0.0042 0.0001 0 0.0001 0.0008 0.0002 0.0002 0.0004 0 0
Nucleus 0.0238 0.0013 0.003 0.0009 0.0017 0.0181 0.0023 0.0029 0.0022 0.0021 0.0011 0.0013 0.0062 0.0018 0.0194 0.0031 0.0016 0.002
Peroxisomes 0.0176 0.0001 0.0018 0 0.0018 0.0002 0.0002 0.0001 0.0015 0 0.0001 0.0002 0.0032 0.0005 0.0062 0.0011 0.0004 0.0081
Punctate Nuclear 0.0169 0.0001 0.0013 0 0.0001 0.0002 0.0001 0.0001 0.0053 0.0001 0.0001 0.0001 0.0027 0.0003 0.0007 0.002 0.0004 0.0002
Vacuole 0.0558 0.0216 0.0376 0.0425 0.0344 0.0241 0.0143 0.0249 0.0073 0.1772 0.0034 0.0053 0.08 0.0185 0.0296 0.0795 0.01 0.0081
Vacuole Periphery 0.0137 0.0027 0.0091 0.0106 0.0054 0.0113 0.0093 0.0202 0.0028 0.0191 0.0011 0.0046 0.0145 0.0014 0.0074 0.0184 0.0043 0.0038

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 1710.1518 1807.238 2009.9131 1848.0879 2066.4397 1812.9827 1564.3964 1526.3638 1617.7998 1534.5361
Translational Efficiency 1.5838 1.5362 1.4998 1.5738 1.4806 1.4713 1.6188 1.7344 1.5174 1.7544

Hit Data

Dataset Hit
Protein Concentration –
Protein Localization ✘
Gene Expression ✘
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
257 954 2250 108 1475 1857 1070 432 1732 2811 3320 540

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 1432.67 1484.22 4107.06 3506.88 1390.56 1696.91 3544.05 3254.26 1396.81 1624.73 3925.61 3304.78
Standard Deviation 269.84 319.12 961.22 1059.04 324.57 346.76 944.00 1135.45 317.40 352.33 991.26 1125.13
Intensity Change Log 2 — 0.050999 1.519400 1.291482 — 0.287244 1.349733 1.226664 — 0.172193 1.438322 1.259920

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.000395 0.000310 0.000050 0.000338 0.000295 0.000166 0.000211 0.000299 0.000310 0.000215 0.000102 0.000307
Bud Neck 0.000514 0.000366 0.000205 0.004128 0.000285 0.000176 0.002270 0.004012 0.000319 0.000240 0.000871 0.004035
Bud Site 0.045102 0.021945 0.003792 0.021500 0.018083 0.014577 0.012929 0.021166 0.022092 0.017077 0.006736 0.021233
Cell Periphery 0.004172 0.001426 0.009373 0.066127 0.001918 0.001082 0.018735 0.011377 0.002253 0.001199 0.012391 0.022327
Cytoplasm 0.445162* 0.805222* 0.778243* 0.416994* 0.716438* 0.783698* 0.515226* 0.502662* 0.676185* 0.791003* 0.693475* 0.485529*
Cytoplasmic Foci 0.281262* 0.078235 0.011575 0.030222 0.084647 0.083065 0.012227 0.024237 0.113821 0.081426 0.011786 0.025434
Eisosomes 0.000007 0.000005 0.000001 0.000006 0.000003 0.000002 0.000004 0.000004 0.000004 0.000003 0.000002 0.000005
Endoplasmic Reticulum 0.018447 0.002672 0.001340 0.000485 0.008845 0.003440 0.000844 0.000651 0.010270 0.003180 0.001180 0.000618
Endosome 0.013572 0.004332 0.000675 0.002072 0.005535 0.004409 0.003357 0.006013 0.006727 0.004383 0.001540 0.005225
Golgi 0.091276 0.043802 0.036989 0.056247 0.048074 0.043670 0.052362 0.063141 0.054485 0.043715 0.041943 0.061763
Lipid Particles 0.002494 0.001857 0.005714 0.056425 0.001927 0.001220 0.021999 0.024336 0.002011 0.001436 0.010962 0.030754
Mitochondria 0.000280 0.000815 0.000462 0.000103 0.001067 0.000800 0.000253 0.000579 0.000950 0.000805 0.000395 0.000483
Mitotic Spindle 0.003299 0.002151 0.000767 0.011061 0.001241 0.002494 0.002962 0.017215 0.001546 0.002378 0.001474 0.015984
None 0.000213 0.000461 0.001052 0.001024 0.000828 0.000749 0.001782 0.001186 0.000737 0.000651 0.001288 0.001154
Nuclear Periphery 0.000324 0.000037 0.000239 0.000741 0.000098 0.000125 0.000682 0.000895 0.000132 0.000095 0.000382 0.000864
Nuclear Periphery Foci 0.002810 0.003095 0.004551 0.015476 0.003210 0.002264 0.013788 0.012388 0.003151 0.002546 0.007528 0.013006
Nucleolus 0.000023 0.000022 0.000051 0.000167 0.000173 0.000085 0.000154 0.000462 0.000151 0.000064 0.000084 0.000403
Nucleus 0.000601 0.001576 0.002748 0.013897 0.002736 0.000947 0.008673 0.011471 0.002419 0.001160 0.004658 0.011956
Peroxisomes 0.000206 0.000255 0.000052 0.000085 0.000142 0.000138 0.000072 0.000231 0.000151 0.000178 0.000058 0.000201
Vacuole 0.014491 0.010298 0.056090 0.235657* 0.022559 0.012590 0.261980* 0.239901* 0.021362 0.011812 0.122446 0.239052*
Vacuole Periphery 0.075352 0.021117 0.086030 0.067246 0.081897 0.044303 0.069492 0.057773 0.080925 0.036434 0.080700 0.059668

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin 0.75 3.89 -0.36 -1.30 -6.13 2.08 0.69 -0.45 -2.59 -1.26 1.64 3.88 -0.61 -2.42 -4.86
Bud Neck 1.26 2.26 -4.17 -4.26 -4.32 3.54 -10.91 -8.24 -8.35 -4.92 2.38 -9.35 -9.25 -9.34 -8.12
Bud Site 4.26 7.94 2.25 -0.95 -4.10 2.44 2.32 -3.17 -4.49 -4.43 3.34 10.93 -2.00 -4.03 -7.96
Cell Periphery 3.39 -5.26 -5.05 -5.37 -4.49 3.92 -11.44 -6.01 -6.84 4.92 4.79 -15.43 -6.85 -7.36 -2.32
Cytoplasm -16.73 -15.93 0.89 12.14 11.41 -6.79 16.09 13.39 17.69 1.82 -12.63 -1.27 13.12 21.41 14.57
Cytoplasmic Foci 12.99 17.80 13.59 3.60 -3.60 0.43 20.77 7.37 7.27 -6.03 7.04 25.39 12.41 8.08 -7.22
Eisosomes 0.50 3.44 0.29 -0.38 -6.11 1.94 -1.53 -2.97 -5.14 -2.09 0.48 3.55 -2.70 -2.08 -7.19
Endoplasmic Reticulum 4.22 4.62 4.87 4.46 7.16 4.72 7.37 7.61 8.12 2.59 6.34 8.41 9.02 9.09 6.57
Endosome 7.31 10.96 9.17 3.46 -5.25 2.83 2.92 -0.19 -1.36 -2.04 5.92 13.24 2.04 -0.86 -4.49
Golgi 6.28 7.68 4.95 -0.10 -1.12 1.51 0.09 0.16 -0.73 0.10 3.97 5.58 1.75 -0.72 -1.52
Lipid Particles 0.98 -4.77 -6.14 -6.23 -5.77 2.03 -12.55 -8.82 -9.21 -0.35 1.79 -13.65 -10.43 -10.70 -6.89
Mitochondria -1.01 -1.86 1.08 1.23 4.84 0.56 1.69 1.06 0.80 -1.23 0.34 1.45 1.16 1.15 -0.52
Mitotic Spindle 0.88 2.19 -2.67 -2.78 -2.89 -2.23 -3.07 -5.31 -5.12 -4.67 -1.77 -1.54 -5.94 -5.80 -5.82
None -4.26 -5.79 -4.73 -3.41 -0.36 0.29 -1.22 -1.28 -1.45 0.77 0.44 -1.88 -1.96 -2.43 0.41
Nuclear Periphery 1.06 0.26 -2.31 -5.19 -4.14 -0.36 -7.16 -4.00 -3.73 -0.77 0.56 -5.58 -4.68 -4.84 -3.13
Nuclear Periphery Foci -0.34 -2.41 -5.62 -5.62 -5.06 1.89 -10.38 -6.48 -7.01 0.92 1.41 -9.86 -8.14 -8.54 -4.39
Nucleolus 0.07 -4.64 -6.44 -6.56 -5.53 1.11 -0.46 -3.69 -5.00 -4.01 1.34 0.77 -3.90 -5.56 -5.24
Nucleus -5.48 -9.22 -4.07 -3.89 -3.64 2.95 -7.92 -6.83 -7.93 -1.63 2.45 -6.01 -7.87 -8.73 -5.98
Peroxisomes -0.93 4.24 1.49 2.45 -3.06 0.44 1.63 -2.29 -3.03 -4.58 -0.02 2.29 -2.05 -2.44 -5.10
Vacuole 1.45 -12.21 -10.27 -10.56 -8.15 6.18 -30.64 -18.60 -19.48 1.66 6.84 -28.51 -21.08 -22.08 -10.54
Vacuole Periphery 7.01 -1.29 1.92 -2.89 3.26 8.13 3.83 6.79 0.25 4.01 11.22 0.59 6.89 -1.99 7.61
Standard name
Human Ortholog
Description Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S18 and bacterial S13; RPS18B has a paralog, RPS18A, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress
Localization
Cell Percentages cytoplasm (98%)
Cell Cycle Regulation No
Subcompartmental Group cytoplasm-7

Rps18b

Rps18b


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Rps18b-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available